C. David James Department of Neurological Surgery University of California, San Francisco - UCSF Biography Publications Institution JoVE Articles C. David James has not added a biography. If you are C. David James and would like to personalize this page please email our Author Liaison for assistance. Publications Challenges in Drug Delivery to Tumors of the Central Nervous System: An Overview of Pharmacological and Surgical Considerations Advanced Drug Delivery Reviews. Jan, 2012 | Pubmed ID: 22306489 An Experimental Xenograft Mouse Model of Diffuse Pontine Glioma Designed for Therapeutic Testing Journal of Neuro-oncology. Jan, 2012 | Pubmed ID: 22231932 Clinical Stratification of Glioblastoma Based on Alterations in Retinoblastoma Tumor Suppressor Protein (RB1) and Association with the Proneural Subtype Journal of Neuropathology and Experimental Neurology. Jan, 2012 | Pubmed ID: 22157621 Hyperpolarized 13C MR Spectroscopic Imaging Can Be Used to Monitor Everolimus Treatment in Vivo in an Orthotopic Rodent Model of Glioblastoma NeuroImage. Jan, 2012 | Pubmed ID: 21807103 Reduced Phosphocholine and Hyperpolarized Lactate Provide Magnetic Resonance Biomarkers of PI3K/Akt/mTOR Inhibition in Glioblastoma Neuro-oncology. Dec, 2011 | Pubmed ID: 22156546 Stimulating Anti-tumor Immune Response: the Problem of Regulatory T-cells Neuro-oncology. Dec, 2011 | Pubmed ID: 22113488 An LXR Agonist Promotes GBM Cell Death Through Inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent Pathway Cancer Discovery. Sep, 2011 | Pubmed ID: 22059152 Targeted Therapy for BRAFV600E Malignant Astrocytoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2011 | Pubmed ID: 22038996 Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma from a Distinct Cell of Origin Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2011 | Pubmed ID: 22025148 Investigation of Intravenous Delivery of Nanoliposomal Topotecan for Activity Against Orthotopic Glioblastoma Xenografts Neuro-oncology. Dec, 2011 | Pubmed ID: 21954443 Phase I Study of Temsirolimus in Combination with EKB-569 in Patients with Advanced Solid Tumors Investigational New Drugs. Sep, 2011 | Pubmed ID: 21881915 Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer Science (New York, N.Y.). Aug, 2011 | Pubmed ID: 21852505 Evolution of Mouse Models for Studying CNS Cancer: a Decade of Progress Neuro-oncology. Jul, 2011 | Pubmed ID: 21727207 Detection of Early Response to Temozolomide Treatment in Brain Tumors Using Hyperpolarized 13C MR Metabolic Imaging Journal of Magnetic Resonance Imaging : JMRI. Jun, 2011 | Pubmed ID: 21590996 Inhibition of PI3K/mTOR Pathways in Glioblastoma and Implications for Combination Therapy with Temozolomide Neuro-oncology. Apr, 2011 | Pubmed ID: 21317208 Akt and Autophagy Cooperate to Promote Survival of Drug-resistant Glioma Science Signaling. 2010 | Pubmed ID: 21062993 Identification of Internalizing Human Single-chain Antibodies Targeting Brain Tumor Sphere Cells Molecular Cancer Therapeutics. Jul, 2010 | Pubmed ID: 20587664 Tumor-initiating Cells: an Influential Paradigm for Xenograft Research Neuro-oncology. Jun, 2010 | Pubmed ID: 20530515 Pleiotropic Role for MYCN in Medulloblastoma Genes & Development. May, 2010 | Pubmed ID: 20478998 A Hierarchy of Self-renewing Tumor-initiating Cell Types in Glioblastoma Cancer Cell. Apr, 2010 | Pubmed ID: 20385361 Pharmacologic Inhibition of Cyclin-dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts Cancer Research. Apr, 2010 | Pubmed ID: 20354191 Morphologic and Molecular Characterization of ATRT Xenografts Adapted for Orthotopic Therapeutic Testing Neuro-oncology. Apr, 2010 | Pubmed ID: 20308314 Hyperpolarized 13C Magnetic Resonance Metabolic Imaging: Application to Brain Tumors Neuro-oncology. Feb, 2010 | Pubmed ID: 20150380 Noninvasive Detection of Target Modulation Following Phosphatidylinositol 3-kinase Inhibition Using Hyperpolarized 13C Magnetic Resonance Spectroscopy Cancer Research. Feb, 2010 | Pubmed ID: 20145128 Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell. Jan, 2010 | Pubmed ID: 20129251 Oncogenic BRAF Mutation with CDKN2A Inactivation is Characteristic of a Subset of Pediatric Malignant Astrocytomas Cancer Research. Jan, 2010 | Pubmed ID: 20068183 Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma Cancer Research. Jan, 2010 | Pubmed ID: 20068170 Immunological Considerations of Modern Animal Models of Malignant Primary Brain Tumors Journal of Translational Medicine. 2009 | Pubmed ID: 19814820 MicroRNAs in Gliomas: Small Regulators of a Big Problem Neuromolecular Medicine. 2009 | Pubmed ID: 19731102 Radiosensitizing Effects of Temozolomide Observed in Vivo Only in a Subset of O6-methylguanine-DNA Methyltransferase Methylated Glioblastoma Multiforme Xenografts International Journal of Radiation Oncology, Biology, Physics. Sep, 2009 | Pubmed ID: 19695438 Fyn and SRC Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients Cancer Research. Sep, 2009 | Pubmed ID: 19690143 Pathologic Correlates of Primary Central Nervous System Lymphoma Defined in an Orthotopic Xenograft Model Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2009 | Pubmed ID: 19276270 Stem Cells for Treating Glioblastoma: How Close to Reality? Neuro-oncology. Apr, 2009 | Pubmed ID: 19237733 EGFR Signals to MTOR Through PKC and Independently of Akt in Glioma Science Signaling. 2009 | Pubmed ID: 19176518 Comparative Analyses of Gene Copy Number and MRNA Expression in Glioblastoma Multiforme Tumors and Xenografts Neuro-oncology. Oct, 2009 | Pubmed ID: 19139420 Phase II Study of Erlotinib Plus Temozolomide During and After Radiation Therapy in Patients with Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2009 | Pubmed ID: 19075262 Evaluation of MGMT Promoter Methylation Status and Correlation with Temozolomide Response in Orthotopic Glioblastoma Xenograft Model Journal of Neuro-oncology. Mar, 2009 | Pubmed ID: 19011762 Induction of MGMT Expression is Associated with Temozolomide Resistance in Glioblastoma Xenografts Neuro-oncology. Jun, 2009 | Pubmed ID: 18952979 P53 Small-molecule Inhibitor Enhances Temozolomide Cytotoxic Activity Against Intracranial Glioblastoma Xenografts Cancer Research. Dec, 2008 | Pubmed ID: 19074867 Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors Cancer Research. Oct, 2008 | Pubmed ID: 18829568 MiR-124 and MiR-137 Inhibit Proliferation of Glioblastoma Multiforme Cells and Induce Differentiation of Brain Tumor Stem Cells BMC Medicine. 2008 | Pubmed ID: 18577219 PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18559622 Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2008 | Pubmed ID: 18483356 Increased Expression of the Glioma-associated Antigen ARF4L After Loss of the Tumor Suppressor PTEN. Laboratory Investigation Journal of Neurosurgery. Feb, 2008 | Pubmed ID: 18240926 An Orthotopic Skull Base Model of Malignant Meningioma Brain Pathology (Zurich, Switzerland). Apr, 2008 | Pubmed ID: 18093250 Disabled-1 is a Large Common Fragile Site Gene, Inactivated in Multiple Cancers Genes, Chromosomes & Cancer. Feb, 2008 | Pubmed ID: 18008369 Combination of Measles Virus Virotherapy and Radiation Therapy Has Synergistic Activity in the Treatment of Glioblastoma Multiforme Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007 | Pubmed ID: 18056196 Bioluminescence Monitoring of Intracranial Glioblastoma Xenograft: Response to Primary and Salvage Temozolomide Therapy Journal of Neurosurgery. Sep, 2007 | Pubmed ID: 17886562 Epidermal Growth Factor Receptor Variant III Status Defines Clinically Distinct Subtypes of Glioblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2007 | Pubmed ID: 17538175 Identification of Molecular Characteristics Correlated with Glioblastoma Sensitivity to EGFR Kinase Inhibition Through Use of an Intracranial Xenograft Test Panel Molecular Cancer Therapeutics. Mar, 2007 | Pubmed ID: 17363510 Epidermal Growth Factor Receptor (EGFR)-retargeted Measles Virus Strains Effectively Target EGFR- or EGFRvIII Expressing Gliomas Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2007 | Pubmed ID: 17299404 Mapping the Future of Neuro-Oncology Neuro-oncology. Jan, 2007 | Pubmed ID: 17170381 Tumor Suppressor P16 Methylation in Multiple Myeloma: Biological and Clinical Implications Blood. Feb, 2007 | Pubmed ID: 16840723 Rarity of PTEN Deletions and EGFR Amplification in Malignant Gliomas of Childhood: Results from the Children's Cancer Group 945 Cohort Journal of Neurosurgery. Nov, 2006 | Pubmed ID: 17328268 Retargeted Oncolytic Measles Strains Entering Via the EGFRvIII Receptor Maintain Significant Antitumor Activity Against Gliomas with Increased Tumor Specificity Cancer Research. Dec, 2006 | Pubmed ID: 17178881 PIK3CA Gene Mutations in Pediatric and Adult Glioblastoma Multiforme Molecular Cancer Research : MCR. Oct, 2006 | Pubmed ID: 17050665 Use of an Orthotopic Xenograft Model for Assessing the Effect of Epidermal Growth Factor Receptor Amplification on Glioblastoma Radiation Response Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2006 | Pubmed ID: 16609043 Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous MTOR and EGFR Inhibition in GBM Cells Neoplasia (New York, N.Y.). Oct, 2005 | Pubmed ID: 16242075 MTOR Controls FLIPS Translation and TRAIL Sensitivity in Glioblastoma Multiforme Cells Molecular and Cellular Biology. Oct, 2005 | Pubmed ID: 16199861 Unique Aspects of Mda-7/IL-24 Antitumor Bystander Activity: Establishing a Role for Secretion of MDA-7/IL-24 Protein by Normal Cells Oncogene. Nov, 2005 | Pubmed ID: 16044151 Patient Tumor EGFR and PDGFRA Gene Amplifications Retained in an Invasive Intracranial Xenograft Model of Glioblastoma Multiforme Neuro-oncology. Apr, 2005 | Pubmed ID: 15831234 Altered Molecular Pathways in Gliomas: an Overview of Clinically Relevant Issues Seminars in Oncology. Oct, 2004 | Pubmed ID: 15497113 Immunohistochemical Detection of EGFRvIII in High Malignancy Grade Astrocytomas and Evaluation of Prognostic Significance Journal of Neuropathology and Experimental Neurology. Jul, 2004 | Pubmed ID: 15290895 Correlation of the Response of Recurrent Malignant Gliomas Treated with Interferon Alpha with Tumor Interferon Alpha Gene Content International Journal of Oncology. Aug, 2004 | Pubmed ID: 15254740 MDA-7 Regulates Cell Growth and Radiosensitivity in Vitro of Primary (non-established) Human Glioma Cells Cancer Biology & Therapy. Aug, 2004 | Pubmed ID: 15197348 Contrasting in Vivo and in Vitro Fates of Glioblastoma Cell Subpopulations with Amplified EGFR Genes, Chromosomes & Cancer. Jan, 2004 | Pubmed ID: 14603439 Genetic and Signaling Pathway Alterations in Glioblastoma: Relevance to Novel Targeted Therapies Frontiers in Bioscience : a Journal and Virtual Library. May, 2003 | Pubmed ID: 12700121 Lanthionine Synthetase Components C-like 2 Increases Cellular Sensitivity to Adriamycin by Decreasing the Expression of P-glycoprotein Through a Transcription-mediated Mechanism Cancer Research. Feb, 2003 | Pubmed ID: 12566319 Combination of Epidermal Growth Factor Receptor Targeted Therapy with Radiation Therapy for Malignant Gliomas Frontiers in Bioscience : a Journal and Virtual Library. Jan, 2003 | Pubmed ID: 12456322 Neuropathology of Genetically Engineered Mice: Consensus Report and Recommendations from an International Forum Oncogene. Oct, 2002 | Pubmed ID: 12386807 Mucosa-associated Lymphoid Tissue Lymphomas with T(11;18)(q21;q21) and Mucosa-associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways The American Journal of Pathology. Jul, 2002 | Pubmed ID: 12107090 A Chromosomal Region 7p11.2 Transcript Map: Its Development and Application to the Study of EGFR Amplicons in Glioblastoma Neuro-oncology. Apr, 2002 | Pubmed ID: 11916499 Kemirgen Modeller Merkezi Sinir Sistemi Hastalıkları Tedavisinde Sistemik ve Yerel İlaç Taşıyıcı Laura Serwer1, Rintaro Hashizume1, Tomoko Ozawa1, C. David James1 1Department of Neurological Surgery, University of California, San Francisco - UCSF JoVE 1992 신경과학 Biyoparlaklık Görüntüleme kullanarak Tümör Büyüme ve Terapi yanıt sonraki Analizi ile İntrakranial Beyin Tümörü Xenografts kurulması Tomoko Ozawa1, C. David James1 1Department of Neurological Surgery, University of California, San Francisco - UCSF JoVE 1986 신경과학
Kemirgen Modeller Merkezi Sinir Sistemi Hastalıkları Tedavisinde Sistemik ve Yerel İlaç Taşıyıcı Laura Serwer1, Rintaro Hashizume1, Tomoko Ozawa1, C. David James1 1Department of Neurological Surgery, University of California, San Francisco - UCSF JoVE 1992 신경과학
Biyoparlaklık Görüntüleme kullanarak Tümör Büyüme ve Terapi yanıt sonraki Analizi ile İntrakranial Beyin Tümörü Xenografts kurulması Tomoko Ozawa1, C. David James1 1Department of Neurological Surgery, University of California, San Francisco - UCSF JoVE 1986 신경과학