Carl W. White Pediatric Airway Research Center, Department of Pediatrics University of Colorado Biography Publications Institution JoVE Articles Carl W. White has not added a biography. If you are Carl W. White and would like to personalize this page please email our Author Liaison for assistance. Publications Antifibrinolytic Mechanisms in Acute Airway Injury Following Sulfur Mustard Analog Inhalation American Journal of Respiratory Cell and Molecular Biology. May, 2014 | Pubmed ID: 24796565 Activation of DNA Damage Repair Pathways in Response to Nitrogen Mustard-induced DNA Damage and Toxicity in Skin Keratinocytes Mutation Research. Apr, 2014 | Pubmed ID: 24732344 Intratracheal Heparin Improves Plastic Bronchitis Due to Sulfur Mustard Analog Pediatric Pulmonology. Apr, 2014 | Pubmed ID: 24692161 Myeloperoxidase Deficiency Attenuates Nitrogen Mustard-induced Skin Injuries Toxicology. Mar, 2014 | Pubmed ID: 24631667 Cutaneous Injury-related Structural Changes and Their Progression Following Topical Nitrogen Mustard Exposure in Hairless and Haired Mice PloS One. 2014 | Pubmed ID: 24416404 Humidifier and Environmental "chILD" Risks American Journal of Respiratory and Critical Care Medicine. Jan, 2014 | Pubmed ID: 24381989 Histopathological and Immunohistochemical Evaluation of Nitrogen Mustard-induced Cutaneous Effects in SKH-1 Hairless and C57BL/6 Mice Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie. Mar, 2014 | Pubmed ID: 24373750 Transcriptome Profiling of the Newborn Mouse Lung Response to Acute Ozone Exposure Toxicological Sciences : an Official Journal of the Society of Toxicology. Mar, 2014 | Pubmed ID: 24336422 Male Contraception Via Simultaneous Knockout of α1A-adrenoceptors and P2X1-purinoceptors in Mice Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013 | Pubmed ID: 24297884 Development of a P2X1-purinoceptor Mediated Contractile Response in the Aged Mouse Prostate Gland Through Slowing Down of ATP Breakdown Neurourology and Urodynamics. Nov, 2013 | Pubmed ID: 24249481 Rho Kinase Activation Mediates Adrenergic and Cholinergic Smooth Muscle Contractile Responses in the Mouse Prostate Gland European Journal of Pharmacology. Dec, 2013 | Pubmed ID: 24055190 Human Tracheobronchial Basal Cells. Normal Versus Remodeling/repairing Phenotypes in Vivo and in Vitro American Journal of Respiratory Cell and Molecular Biology. Dec, 2013 | Pubmed ID: 23927678 Age-related Changes in the Innervation of the Prostate Gland: Implications for Prostate Cancer Initiation and Progression Organogenesis. Jul-Sep, 2013 | Pubmed ID: 23872639 Absence of a P53 Allele Delays Nitrogen Mustard-induced Early Apoptosis and Inflammation of Murine Skin Toxicology. Sep, 2013 | Pubmed ID: 23845566 Clinically-relevant Cutaneous Lesions by Nitrogen Mustard: Useful Biomarkers of Vesicants Skin Injury in SKH-1 Hairless and C57BL/6 Mice PloS One. 2013 | Pubmed ID: 23826320 Tissue Factor Pathway Inhibitor Prevents Airway Obstruction, Respiratory Failure and Death Due to Sulfur Mustard Analog Inhalation Toxicology and Applied Pharmacology. Oct, 2013 | Pubmed ID: 23727623 Adenosine A2A Receptor-dependent Proliferation of Pulmonary Endothelial Cells is Mediated Through Calcium Mobilization, PI3-kinase and ERK1/2 Pathways Biochemical and Biophysical Research Communications. May, 2013 | Pubmed ID: 23583199 Differential Regulation of Pulmonary Vascular Cell Growth by Hypoxia-inducible Transcription Factor-1α and Hypoxia-inducible Transcription Factor-2α American Journal of Respiratory Cell and Molecular Biology. Jul, 2013 | Pubmed ID: 23492195 Tissue Plasminogen Activator Prevents Mortality from Sulfur Mustard Analog-induced Airway Obstruction American Journal of Respiratory Cell and Molecular Biology. Apr, 2013 | Pubmed ID: 23258228 Suicidal Ideation and Thought Disorder Associated with the Formoterol Component of Combined Asthma Medication Pediatric Pulmonology. Jan, 2013 | Pubmed ID: 22489078 Tissue Factor Signals Airway Epithelial Basal Cell Survival Via Coagulation and PAR1/2 American Journal of Respiratory Cell and Molecular Biology. Oct, 2012 | Pubmed ID: 23065128 Silibinin Attenuates Sulfur Mustard Analog-induced Skin Injury by Targeting Multiple Pathways Connecting Oxidative Stress and Inflammation PloS One. 2012 | Pubmed ID: 23029417 Identification and Profiling of Novel α1A-adrenoceptor-CXC Chemokine Receptor 2 Heteromer The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22371491 Interaction and Localization of Synthetic Nanoparticles in Healthy and Cystic Fibrosis Airway Epithelial Cells: Effect of Ozone Exposure Journal of Aerosol Medicine and Pulmonary Drug Delivery. Feb, 2012 | Pubmed ID: 22007674 Airway Tissue Factor-dependent Coagulation Activity in Response to Sulfur Mustard Analog 2-chloroethyl Ethyl Sulfide American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2012 | Pubmed ID: 21964405 Impact of SOD-Mimetic Manganoporphyrins on Spin Trapping of Superoxide and Related Artifacts Applied Magnetic Resonance. Feb, 2011 | Pubmed ID: 23853422 SERCA2 Regulates Non-CF and CF Airway Epithelial Cell Response to Ozone PloS One. 2011 | Pubmed ID: 22096575 Mechanisms of Sulfur Mustard Analog 2-chloroethyl Ethyl Sulfide-induced DNA Damage in Skin Epidermal Cells and Fibroblasts Free Radical Biology & Medicine. Dec, 2011 | Pubmed ID: 21920433 Contractions of the Mouse Prostate Elicited by Acetylcholine Are Mediated by M(3) Muscarinic Receptors The Journal of Pharmacology and Experimental Therapeutics. Dec, 2011 | Pubmed ID: 21885618 Sulfur Mustard Analog, 2-chloroethyl Ethyl Sulfide-induced Skin Injury Involves DNA Damage and Induction of Inflammatory Mediators, in Part Via Oxidative Stress, in SKH-1 Hairless Mouse Skin Toxicology Letters. Sep, 2011 | Pubmed ID: 21722719 Role of Reactive Oxygen and Nitrogen Species in Olfactory Epithelial Injury by the Sulfur Mustard Analogue 2-chloroethyl Ethyl Sulfide American Journal of Respiratory Cell and Molecular Biology. Aug, 2011 | Pubmed ID: 21642592 2-Chloroethyl Ethyl Sulfide Causes Microvesication and Inflammation-related Histopathological Changes in Male Hairless Mouse Skin Toxicology. Apr, 2011 | Pubmed ID: 21295104 AEOL10150: a Novel Therapeutic for Rescue Treatment After Toxic Gas Lung Injury Free Radical Biology & Medicine. Mar, 2011 | Pubmed ID: 21156205 Expression of Transcription Factor GATA-6 in Alveolar Epithelial Cells Is Linked to Neonatal Lung Disease Neonatology. 2011 | Pubmed ID: 21071980 Efficacy of Glutathione in Ameliorating Sulfur Mustard Analog-induced Toxicity in Cultured Skin Epidermal Cells and in SKH-1 Mouse Skin in Vivo The Journal of Pharmacology and Experimental Therapeutics. Feb, 2011 | Pubmed ID: 20974699 Dimethylthiourea Protects Against Chlorine Induced Changes in Airway Function in a Murine Model of Irritant Induced Asthma Respiratory Research. 2010 | Pubmed ID: 20925946 The Residual Nonadrenergic Contractile Response to Nerve Stimulation of the Mouse Prostate is Mediated by Acetylcholine but Not ATP in a Comparison with the Mouse Vas Deferens The Journal of Pharmacology and Experimental Therapeutics. Nov, 2010 | Pubmed ID: 20724483 Airway Obstruction Due to Bronchial Vascular Injury After Sulfur Mustard Analog Inhalation American Journal of Respiratory and Critical Care Medicine. Dec, 2010 | Pubmed ID: 20639443 Chlorine Gas Inhalation: Human Clinical Evidence of Toxicity and Experience in Animal Models Proceedings of the American Thoracic Society. Jul, 2010 | Pubmed ID: 20601629 Biological and Molecular Mechanisms of Sulfur Mustard Analogue-induced Toxicity in JB6 and HaCaT Cells: Possible Role of Ataxia Telangiectasia-mutated/ataxia Telangiectasia-Rad3-related Cell Cycle Checkpoint Pathway Chemical Research in Toxicology. Jun, 2010 | Pubmed ID: 20469912 Characterisation of the Prostanoid Receptor Mediating Inhibition of Smooth Muscle Contractility in the Rat Prostate Gland Naunyn-Schmiedeberg's Archives of Pharmacology. Apr, 2010 | Pubmed ID: 20180098 Treatment with the Catalytic Metalloporphyrin AEOL 10150 Reduces Inflammation and Oxidative Stress Due to Inhalation of the Sulfur Mustard Analog 2-chloroethyl Ethyl Sulfide Free Radical Biology & Medicine. May, 2010 | Pubmed ID: 20138141 Sulfur Mustard Analog Induces Oxidative Stress and Activates Signaling Cascades in the Skin of SKH-1 Hairless Mice Free Radical Biology & Medicine. Dec, 2009 | Pubmed ID: 19761830 Alpha-lipoic Acid Induces Elevated S-adenosylhomocysteine and Depletes S-adenosylmethionine Free Radical Biology & Medicine. Oct, 2009 | Pubmed ID: 19616616 Adenosine A2A Receptor is a Unique Angiogenic Target of HIF-2alpha in Pulmonary Endothelial Cells Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19541651 Bcl-2 Suppresses Sarcoplasmic/endoplasmic Reticulum Ca2+-ATPase Expression in Cystic Fibrosis Airways: Role in Oxidant-mediated Cell Death American Journal of Respiratory and Critical Care Medicine. May, 2009 | Pubmed ID: 19201925 Inflammatory Biomarkers of Sulfur Mustard Analog 2-chloroethyl Ethyl Sulfide-induced Skin Injury in SKH-1 Hairless Mice Toxicological Sciences : an Official Journal of the Society of Toxicology. Mar, 2009 | Pubmed ID: 19075041 A Role for Mitochondrial Oxidative Stress in Sulfur Mustard Analog 2-chloroethyl Ethyl Sulfide-induced Lung Cell Injury and Antioxidant Protection The Journal of Pharmacology and Experimental Therapeutics. Mar, 2009 | Pubmed ID: 19064720 Oxidative Stress-induced Regulation of the Methionine Metabolic Pathway in Human Lung Epithelial-like (A549) Cells Mutation Research. Mar, 2009 | Pubmed ID: 19010443 Lipoic Acid Suppression of Neutrophil Respiratory Burst: Effect of NADPH Antioxidants & Redox Signaling. Feb, 2008 | Pubmed ID: 18158760 HIF Stabilizing Agents: Shotgun or Scalpel? American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2007 | Pubmed ID: 17616644 Reduced Thioredoxin Increases Proinflammatory Cytokines and Neutrophil Influx in Rat Airways: Modulation by Airway Mucus Free Radical Biology & Medicine. May, 2007 | Pubmed ID: 17395017 Hypoxia-inducible Factors HIF-1alpha and HIF-2alpha Are Decreased in an Experimental Model of Severe Respiratory Distress Syndrome in Preterm Lambs American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2007 | Pubmed ID: 17307811 Multislice Computed Tomography for Determination of Coronary Artery Disease in a Symptomatic Patient Population The International Journal of Cardiovascular Imaging. Jun, 2007 | Pubmed ID: 17160425 Effect of Cell Cycle Growth Arrest on Global DNA Methylation Status in Human Lung Epithelial-like (A549) Cells In Vivo (Athens, Greece). Nov-Dec, 2006 | Pubmed ID: 17203780 Improved Lung Growth and Function Through Hypoxia-inducible Factor in Primate Chronic Lung Disease of Prematurity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2006 | Pubmed ID: 16807366 Purinergic Signaling and Kinase Activation for Survival in Pulmonary Oxidative Stress and Disease Free Radical Biology & Medicine. Jul, 2006 | Pubmed ID: 16781450 Enhancement of Angiogenic Effectors Through Hypoxia-inducible Factor in Preterm Primate Lung in Vivo American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2006 | Pubmed ID: 16679381 Endothelial Akt Activation by Hyperoxia: Role in Cell Survival Free Radical Biology & Medicine. Apr, 2006 | Pubmed ID: 16545678 Commentary on "Hypoxia, Hypoxic Signaling, Tissue Damage, and Detection of Reactive Oxygen Species (ROS)" Free Radical Biology & Medicine. Mar, 2006 | Pubmed ID: 16540387 Cholesterol Interferes with the MTT Assay in Human Epithelial-like (A549) and Endothelial (HLMVE and HCAE) Cells International Journal of Toxicology. Jan-Feb, 2006 | Pubmed ID: 16510353 Activation of a Novel Isoform of Methionine Adenosyl Transferase 2A and Increased S-adenosylmethionine Turnover in Lung Epithelial Cells Exposed to Hyperoxia Free Radical Biology & Medicine. Jan, 2006 | Pubmed ID: 16413417 Extracellular Adenosine Triphosphate: a Potential Regulator of Vasa Vasorum Neovascularization in Hypoxia-induced Pulmonary Vascular Remodeling Chest. Dec, 2005 | Pubmed ID: 16373860 Effect of Preterm Birth on Hypoxia-inducible Factors and Vascular Endothelial Growth Factor in Primate Lungs Pediatric Pulmonology. Dec, 2005 | Pubmed ID: 16231377 Thioredoxin and Dihydrolipoic Acid Inhibit Elastase Activity in Cystic Fibrosis Sputum American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2005 | Pubmed ID: 16214824 Activation of Hypoxia-inducible Factors in Hyperoxia Through Prolyl 4-hydroxylase Blockade in Cells and Explants of Primate Lung Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005 | Pubmed ID: 16009933 Lung Epithelial Cells Release ATP During Ozone Exposure: Signaling for Cell Survival Free Radical Biology & Medicine. Jul, 2005 | Pubmed ID: 15964513 Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by Prolyl 4-hydroxylase Inhibition in Human Lung Endothelial and Epithelial Cells Free Radical Biology & Medicine. Apr, 2005 | Pubmed ID: 15780758 Antioxidant Defenses in the Preterm Lung: Role for Hypoxia-inducible Factors in BPD? Toxicology and Applied Pharmacology. Mar, 2005 | Pubmed ID: 15710178 Extracellular ATP-mediated Signaling for Survival in Hyperoxia-induced Oxidative Stress The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14761947 Cigarette Smoke Extract Increases S-adenosylmethionine and Cystathionine in Human Lung Epithelial-like (A549) Cells Chemico-biological Interactions. Jan, 2004 | Pubmed ID: 14726155 Pulmonary Antioxidant Defenses in the Preterm Newborn with Respiratory Distress and Bronchopulmonary Dysplasia in Evolution: Implications for Antioxidant Therapy Antioxidants & Redox Signaling. Feb, 2004 | Pubmed ID: 14713347 Potential Role for Antiangiogenic Proteins in the Evolution of Bronchopulmonary Dysplasia Antioxidants & Redox Signaling. Feb, 2004 | Pubmed ID: 14713345 Hyperoxia-induced DNA Damage Causes Decreased DNA Methylation in Human Lung Epithelial-like A549 Cells Antioxidants & Redox Signaling. Feb, 2004 | Pubmed ID: 14713344 Thioredoxin Liquefies and Decreases the Viscoelasticity of Cystic Fibrosis Sputum American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2004 | Pubmed ID: 14695120 Composition of Coronary Atherosclerotic Plaques in Patients with Acute Myocardial Infarction and Stable Angina Pectoris Determined by Contrast-enhanced Multislice Computed Tomography The American Journal of Cardiology. Mar, 2003 | Pubmed ID: 12633805 Hypoxia Protects Human Lung Microvascular Endothelial and Epithelial-like Cells Against Oxygen Toxicity: Role of Phosphatidylinositol 3-kinase American Journal of Respiratory Cell and Molecular Biology. Feb, 2003 | Pubmed ID: 12540485 Extracellular ATP is an Autocrine/paracrine Regulator of Hypoxia-induced Adventitial Fibroblast Growth. Signaling Through Extracellular Signal-regulated Kinase-1/2 and the Egr-1 Transcription Factor The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12244041 Elevated Expression of Hexokinase II Protects Human Lung Epithelial-like A549 Cells Against Oxidative Injury American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2002 | Pubmed ID: 12169577 Redox Systems of the Cell: Possible Links and Implications Proceedings of the National Academy of Sciences of the United States of America. Jul, 2002 | Pubmed ID: 12122214 Oxidized Phospholipids Derived from Ozone-treated Lung Surfactant Extract Reduce Macrophage and Epithelial Cell Viability Chemical Research in Toxicology. Jul, 2002 | Pubmed ID: 12118999 Cellodling in vitro modell för Toxic Inhalerat Chemical Testing Shama Ahmad1, Aftab Ahmad1, Keith B. Neeves2, Tara Hendry-Hofer1, Joan E. Loader1, Carl W. White1, Livia Veress1 1Pediatric Airway Research Center, Department of Pediatrics, University of Colorado, 2Department of Chemical and Biological Engineering, Colorado School of Mines JoVE 51539 생체공학
Cellodling in vitro modell för Toxic Inhalerat Chemical Testing Shama Ahmad1, Aftab Ahmad1, Keith B. Neeves2, Tara Hendry-Hofer1, Joan E. Loader1, Carl W. White1, Livia Veress1 1Pediatric Airway Research Center, Department of Pediatrics, University of Colorado, 2Department of Chemical and Biological Engineering, Colorado School of Mines JoVE 51539 생체공학