Edwin K. Jackson Department of Pharmacology and Chemical Biology University of Pittsburgh Biography Publications Institution JoVE Articles Edwin K. Jackson has not added a biography. If you are Edwin K. Jackson and would like to personalize this page please email our Author Liaison for assistance. Publications Modulation of Cyclic AMP Levels in Fallopian Tube Cells by Natural and Environmental Estrogens Cells. May, 2021 | Pubmed ID: 34069403 Angiotensin II Augments Renal Vascular Smooth Muscle Soluble GC Expression Via an AT Receptor-forkhead Box Subclass O Transcription Factor Signalling Axis British Journal of Pharmacology. May, 2021 | Pubmed ID: 33963547 Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats Journal of the American Heart Association. Mar, 2021 | Pubmed ID: 33682436 Novel Guidewire Design and Coating for Continuous Delivery of Adenosine During Interventional Procedures Journal of the American Heart Association. Feb, 2021 | Pubmed ID: 33496190 Brief Report: Dipyridamole Decreases Gut Mucosal Regulatory T-Cell Frequencies Among People With HIV on Antiretroviral Therapy Journal of Acquired Immune Deficiency Syndromes (1999). 12, 2020 | Pubmed ID: 33177477 A Uro-protective Agent with Restorative Actions on Urethral and Striated Muscle Morphology World Journal of Urology. Oct, 2020 | Pubmed ID: 33078215 Purine Nucleoside Phosphorylase Inhibition Ameliorates Age-associated Lower Urinary Tract Dysfunctions JCI Insight. 10, 2020 | Pubmed ID: 32910805 Alkaline Phosphatase Activity Is a Key Determinant of Vascular Responsiveness to Norepinephrine Hypertension (Dallas, Tex. : 1979). 10, 2020 | Pubmed ID: 32829665 Author Correction: Simultaneous Inhibition of Glycolysis and Oxidative Phosphorylation Triggers a Multi-Fold Increase in Secretion of Exosomes: Possible Role of 2',3'-cAMP Scientific Reports. Aug, 2020 | Pubmed ID: 32807847 Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer Cancers. Jul, 2020 | Pubmed ID: 32708274 Purine Metabolites in Tumor-Derived Exosomes May Facilitate Immune Escape of Head and Neck Squamous Cell Carcinoma Cancers. Jun, 2020 | Pubmed ID: 32560461 Role of Exosome-associated Adenosine in Promoting Angiogenesis Vessel Plus. 2020 | Pubmed ID: 32490359 Adenosine Receptors Regulate Exosome Production Purinergic Signalling. 06, 2020 | Pubmed ID: 32440820 -Adrenoceptors: Challenges and Opportunities-Enlightenment from the Kidney Cardiovascular Therapeutics. 2020 | Pubmed ID: 32426035 Tumor-derived Exosomes Promote Angiogenesis Via Adenosine A Receptor Signaling Angiogenesis. 11, 2020 | Pubmed ID: 32419057 Characterization of the N-etheno-bridge Method to Assess Extracellular Metabolism of Adenine Nucleotides: Detection of a Possible Role for Purine Nucleoside Phosphorylase in Adenosine Metabolism Purinergic Signalling. 06, 2020 | Pubmed ID: 32367441 Identification of Novel Targets of RBM5 in the Healthy and Injured Brain Neuroscience. 08, 2020 | Pubmed ID: 32335213 Simultaneous Inhibition of Glycolysis and Oxidative Phosphorylation Triggers a Multi-Fold Increase in Secretion of Exosomes: Possible Role of 2'3'-cAMP Scientific Reports. 04, 2020 | Pubmed ID: 32332778 Intercalated Cell BKα Subunit is Required for Flow-induced K+ Secretion JCI Insight. 04, 2020 | Pubmed ID: 32255763 Activation of AMP-activated Protein Kinase During Sepsis/inflammation Improves Survival by Preserving Cellular Metabolic Fitness FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 05, 2020 | Pubmed ID: 32246808 Adenosine-producing Regulatory B Cells in Head and Neck Cancer Cancer Immunology, Immunotherapy : CII. Jul, 2020 | Pubmed ID: 32146518 DPP4 Inhibition, NPY, PYY, SDF-1, and a Hypertensive Genetic Background Conspire to Augment Cell Proliferation and Collagen Production: Effects That Are Abolished by Low Concentrations of 2-Methoxyestradiol The Journal of Pharmacology and Experimental Therapeutics. 04, 2020 | Pubmed ID: 32015161 Adenosine, Via A Receptors, Inhibits Human (P-SMC) Progenitor Smooth Muscle Cell Growth Hypertension (Dallas, Tex. : 1979). 01, 2020 | Pubmed ID: 31786976 A Randomized, Placebo-Controlled, Pilot Clinical Trial of Dipyridamole to Decrease Human Immunodeficiency Virus-Associated Chronic Inflammation The Journal of Infectious Diseases. 04, 2020 | Pubmed ID: 31282542 Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision Journal of Neurotrauma. 11, 2020 | Pubmed ID: 30520681 Estradiol Metabolism: Crossroads in Pulmonary Arterial Hypertension International Journal of Molecular Sciences. Dec, 2019 | Pubmed ID: 31877978 Mechanism of 17β-estradiol Stimulated Integration of Human Mesenchymal Stem Cells in Heart Tissue Journal of Molecular and Cellular Cardiology. 08, 2019 | Pubmed ID: 31201797 2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury Journal of Cardiovascular Pharmacology. 03, 2019 | Pubmed ID: 30839510 2',3'-cGMP Exists in Vivo and Comprises a 2',3'-cGMP-guanosine Pathway American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 06, 2019 | Pubmed ID: 30789788 Oxidative Stress Induces Release of 2'-AMP from Microglia Brain Research. 03, 2019 | Pubmed ID: 30395838 Aging Increases the Expression of Vasopressin Receptors in Both the Kidney and Urinary Bladder Neurourology and Urodynamics. 01, 2019 | Pubmed ID: 30311671 8-Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1 Journal of the American Heart Association. 11, 2018 | Pubmed ID: 30608204 Extracellular Ubiquitin(1-76) and Ubiquitin(1-74) Regulate Cardiac Fibroblast Proliferation Hypertension (Dallas, Tex. : 1979). 10, 2018 | Pubmed ID: 30354710 Experimental Intravascular Hemolysis Induces Hemodynamic and Pathological Pulmonary Hypertension: Association with Accelerated Purine Metabolism Pulmonary Circulation. Jul-Sep, 2018 | Pubmed ID: 30003836 Adenosine Receptors Influence Hypertension in Dahl Salt-Sensitive Rats: Dependence on Receptor Subtype, Salt Diet, and Sex Hypertension (Dallas, Tex. : 1979). 08, 2018 | Pubmed ID: 29941515 Acute Physiology and Neurologic Outcomes After Brain Injury in SCOP/PHLPP1 KO Mice Scientific Reports. 05, 2018 | Pubmed ID: 29739983 Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction Journal of Cardiovascular Pharmacology. 04, 2018 | Pubmed ID: 29620605 The Influence of Chemotherapy on Adenosine-producing B Cells in Patients with Head and Neck Squamous Cell Carcinoma Oncotarget. Jan, 2018 | Pubmed ID: 29464038 BrainPhys® Increases Neurofilament Levels in CNS Cultures, and Facilitates Investigation of Axonal Damage After a Mechanical Stretch-injury in Vitro Experimental Neurology. 02, 2018 | Pubmed ID: 29199132 SDF-1α (Stromal Cell-Derived Factor 1α) Induces Cardiac Fibroblasts, Renal Microvascular Smooth Muscle Cells, and Glomerular Mesangial Cells to Proliferate, Cause Hypertrophy, and Produce Collagen Journal of the American Heart Association. Nov, 2017 | Pubmed ID: 29114002 Circulating Exosomes Carrying an Immunosuppressive Cargo Interfere with Cellular Immunotherapy in Acute Myeloid Leukemia Scientific Reports. 10, 2017 | Pubmed ID: 29089618 8-Aminoguanosine Exerts Diuretic, Natriuretic, and Glucosuric Activity Via Conversion to 8-Aminoguanine, Yet Has Direct Antikaliuretic Effects The Journal of Pharmacology and Experimental Therapeutics. 12, 2017 | Pubmed ID: 28928119 Human Tumor-derived Exosomes (TEX) Regulate Treg Functions Via Cell Surface Signaling Rather Than Uptake Mechanisms Oncoimmunology. 2017 | Pubmed ID: 28919985 Proximal Tubule Apical Endocytosis is Modulated by Fluid Shear Stress Via an MTOR-dependent Pathway Molecular Biology of the Cell. Sep, 2017 | Pubmed ID: 28720662 Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2017 | Pubmed ID: 28400428 Adenosine Production by Brain Cells Journal of Neurochemistry. 06, 2017 | Pubmed ID: 28294336 Editorial for "Hypertension's 3 Dilemmas & 3 Solutions: Pharmacology of the Kidney in Hypertension" Journal of Cardiovascular Pharmacology. 03, 2017 | Pubmed ID: 28267686 Alkaline Phosphatase Inhibitors Attenuate Renovascular Responses to Norepinephrine Hypertension (Dallas, Tex. : 1979). 03, 2017 | Pubmed ID: 28137984 RACK1 Regulates Angiotensin II-induced Contractions of SHR Preglomerular Vascular Smooth Muscle Cells American Journal of Physiology. Renal Physiology. 04, 2017 | Pubmed ID: 28100502 Context-dependent Effects of Dipeptidyl Peptidase 4 Inhibitors Current Opinion in Nephrology and Hypertension. 03, 2017 | Pubmed ID: 27898522 Adenosine Metabolism of Human Mesenchymal Stromal Cells Isolated from Patients with Head and Neck Squamous Cell Carcinoma Immunobiology. 01, 2017 | Pubmed ID: 26898925 Discovery and Roles of 2',3'-cAMP in Biological Systems Handbook of Experimental Pharmacology. 2017 | Pubmed ID: 26721674 The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney PLoS Pathogens. Nov, 2016 | Pubmed ID: 27814401 8-Aminoguanosine and 8-Aminoguanine Exert Diuretic, Natriuretic, Glucosuric, and Antihypertensive Activity The Journal of Pharmacology and Experimental Therapeutics. Dec, 2016 | Pubmed ID: 27679494 Estrogens in Men: Another Layer of Complexity of Estradiol Metabolism in Pulmonary Hypertension American Journal of Respiratory and Critical Care Medicine. 05, 2016 | Pubmed ID: 27174480 Purines: Forgotten Mediators in Traumatic Brain Injury Journal of Neurochemistry. Apr, 2016 | Pubmed ID: 26809224 2-Methoxyestradiol, an Endogenous 17β-estradiol Metabolite, Inhibits Microglial Proliferation and Activation Via an Estrogen Receptor-independent Mechanism American Journal of Physiology. Endocrinology and Metabolism. Mar, 2016 | Pubmed ID: 26732685 Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction The Journal of Pharmacology and Experimental Therapeutics. Feb, 2016 | Pubmed ID: 26585572 Renal 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Is an Important Determinant of AKI Severity After Ischemia-Reperfusion Journal of the American Society of Nephrology : JASN. 07, 2016 | Pubmed ID: 26574047 2-Methoxyestradiol Blocks the RhoA/ROCK1 Pathway in Human Aortic Smooth Muscle Cells American Journal of Physiology. Endocrinology and Metabolism. Dec, 2015 | Pubmed ID: 26487003 Adenosine Attenuates Human Coronary Artery Smooth Muscle Cell Proliferation by Inhibiting Multiple Signaling Pathways That Converge on Cyclin D Hypertension (Dallas, Tex. : 1979). Dec, 2015 | Pubmed ID: 26416848 NPY1-36 and PYY1-36 Activate Cardiac Fibroblasts: an Effect Enhanced by Genetic Hypertension and Inhibition of Dipeptidyl Peptidase 4 American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2015 | Pubmed ID: 26371160 Cold Stress Protein RBM3 Responds to Temperature Change in an Ultra-sensitive Manner in Young Neurons Neuroscience. Oct, 2015 | Pubmed ID: 26265550 Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues Journal of Virology. Sep, 2015 | Pubmed ID: 26178986 Genetic Variation in the Adenosine Regulatory Cycle is Associated with Posttraumatic Epilepsy Development Epilepsia. Aug, 2015 | Pubmed ID: 26040919 Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome B5 Reductase 3 That Increase Nitric Oxide Bioavailability The Journal of Biological Chemistry. Jul, 2015 | Pubmed ID: 26001785 Schwann Cells Metabolize Extracellular 2',3'-cAMP to 2'-AMP The Journal of Pharmacology and Experimental Therapeutics. Aug, 2015 | Pubmed ID: 25998049 Detection of PHLPP1α/β in Human and Mouse Brain by Different Anti-PHLPP1 Antibodies Scientific Reports. Apr, 2015 | Pubmed ID: 25827478 Immunological Mechanisms of the Antitumor Effects of Supplemental Oxygenation Science Translational Medicine. Mar, 2015 | Pubmed ID: 25739764 Emerging Therapies in Traumatic Brain Injury Seminars in Neurology. Feb, 2015 | Pubmed ID: 25714870 The Nuclear Splicing Factor RNA Binding Motif 5 Promotes Caspase Activation in Human Neuronal Cells, and Increases After Traumatic Brain Injury in Mice Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Apr, 2015 | Pubmed ID: 25586139 Blockade of ENaCs by Amiloride Induces C-Fos Activation of the Area Postrema Brain Research. Mar, 2015 | Pubmed ID: 25557402 2',3'-cAMP, 3'-AMP, 2'-AMP and Adenosine Inhibit TNF-α and CXCL10 Production from Activated Primary Murine Microglia Via A2A Receptors Brain Research. Jan, 2015 | Pubmed ID: 25451117 Effect of Dipeptidyl Peptidase 4 Inhibition on Arterial Blood Pressure is Context Dependent Hypertension (Dallas, Tex. : 1979). Jan, 2015 | Pubmed ID: 25368027 Prevention of Skin Carcinogenesis by the β-blocker Carvedilol Cancer Prevention Research (Philadelphia, Pa.). Jan, 2015 | Pubmed ID: 25367979 Systemic Oxygenation Weakens the Hypoxia and Hypoxia Inducible Factor 1α-dependent and Extracellular Adenosine-mediated Tumor Protection Journal of Molecular Medicine (Berlin, Germany). Dec, 2014 | Pubmed ID: 25120128 Angiotensin II Type 2 Receptor Regulates ROMK-like K⁺ Channel Activity in the Renal Cortical Collecting Duct During High Dietary K⁺ Adaptation American Journal of Physiology. Renal Physiology. Oct, 2014 | Pubmed ID: 25100281 The Guanosine-adenosine Interaction Exists in Vivo The Journal of Pharmacology and Experimental Therapeutics. Sep, 2014 | Pubmed ID: 25002416 Interactive Roles of CD73 and Tissue Nonspecific Alkaline Phosphatase in the Renal Vascular Metabolism of 5'-AMP American Journal of Physiology. Renal Physiology. Sep, 2014 | Pubmed ID: 24990899 Guanosine Regulates Adenosine Levels in the Kidney Physiological Reports. May, 2014 | Pubmed ID: 24872359 Role of 2',3'-cyclic Nucleotide 3'-phosphodiesterase in the Renal 2',3'-cAMP-adenosine Pathway American Journal of Physiology. Renal Physiology. Jul, 2014 | Pubmed ID: 24808540 Hemorrhagic Shock Shifts the Serum Cytokine Profile from Pro- to Anti-inflammatory After Experimental Traumatic Brain Injury in Mice Journal of Neurotrauma. Aug, 2014 | Pubmed ID: 24773520 A Novel Adenosine Precursor 2',3'-cyclic Adenosine Monophosphate Inhibits Formation of Post-surgical Adhesions Digestive Diseases and Sciences. Sep, 2014 | Pubmed ID: 24711075 Role of CD73 in Renal Sympathetic Neurotransmission in the Mouse Kidney Physiological Reports. Aug, 2013 | Pubmed ID: 24066228 Pharmacological Inhibition of Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase is Neuroprotective: Differential Effects on Astrocytes The Journal of Pharmacology and Experimental Therapeutics. Nov, 2013 | Pubmed ID: 24023368 CD4⁺CD73⁺ T Cells Are Associated with Lower T-cell Activation and C Reactive Protein Levels and Are Depleted in HIV-1 Infection Regardless of Viral Suppression AIDS (London, England). Jun, 2013 | Pubmed ID: 24005375 The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist PloS One. 2013 | Pubmed ID: 23977191 Regulation of Cell Proliferation by the Guanosine-Adenosine Mechanism: Role of Adenosine Receptors Physiological Reports. Aug, 2013 | Pubmed ID: 23956837 Role of CNPase in the Oligodendrocytic Extracellular 2',3'-cAMP-adenosine Pathway Glia. Oct, 2013 | Pubmed ID: 23922219 Adenosine and Prostaglandin E2 Production by Human Inducible Regulatory T Cells in Health and Disease Frontiers in Immunology. 2013 | Pubmed ID: 23898333 CD39 Expression by Hepatic Myeloid Dendritic Cells Attenuates Inflammation in Liver Transplant Ischemia-reperfusion Injury in Mice Hepatology (Baltimore, Md.). Dec, 2013 | Pubmed ID: 23813862 In Vivo Cardiovascular Pharmacology of 2',3'-cAMP, 2'-AMP, and 3'-AMP in the Rat The Journal of Pharmacology and Experimental Therapeutics. Aug, 2013 | Pubmed ID: 23759508 Adenosine Production by Human B Cells and B Cell-mediated Suppression of Activated T Cells Blood. Jul, 2013 | Pubmed ID: 23678003 Screening of Biochemical and Molecular Mechanisms of Secondary Injury and Repair in the Brain After Experimental Blast-induced Traumatic Brain Injury in Rats Journal of Neurotrauma. Jun, 2013 | Pubmed ID: 23496248 Role of RACK1 in the Differential Proliferative Effects of Neuropeptide Y(1-36) and Peptide YY(1-36) in SHR Vs. WKY Preglomerular Vascular Smooth Muscle Cells American Journal of Physiology. Renal Physiology. Mar, 2013 | Pubmed ID: 23303411 Extracellular Guanosine Regulates Extracellular Adenosine Levels American Journal of Physiology. Cell Physiology. Mar, 2013 | Pubmed ID: 23242185 Extracellular 2',3'-cAMP-adenosine Pathway in Proximal Tubular, Thick Ascending Limb, and Collecting Duct Epithelial Cells American Journal of Physiology. Renal Physiology. Jan, 2013 | Pubmed ID: 23077101 CD26 Expression and Adenosine Deaminase Activity in Regulatory T Cells (Treg) and CD4(+) T Effector Cells in Patients with Head and Neck Squamous Cell Carcinoma Oncoimmunology. Aug, 2012 | Pubmed ID: 22934258 Role of A1 Receptors in Renal Sympathetic Neurotransmission in the Mouse Kidney American Journal of Physiology. Renal Physiology. Oct, 2012 | Pubmed ID: 22874760 Dipeptidyl Peptidase IV Regulates Proliferation of Preglomerular Vascular Smooth Muscle and Mesangial Cells Hypertension (Dallas, Tex. : 1979). Sep, 2012 | Pubmed ID: 22802229 Extracellular 2',3'-cAMP and 3',5'-cAMP Stimulate Proliferation of Preglomerular Vascular Endothelial Cells and Renal Epithelial Cells American Journal of Physiology. Renal Physiology. Oct, 2012 | Pubmed ID: 22791337 Modulation of Bladder Function by Luminal Adenosine Turnover and A1 Receptor Activation American Journal of Physiology. Renal Physiology. Jul, 2012 | Pubmed ID: 22552934 The Brain in Vivo Expresses the 2',3'-cAMP-adenosine Pathway Journal of Neurochemistry. Jul, 2012 | Pubmed ID: 22360621 Endogenous Adenosine Contributes to Renal Sympathetic Neurotransmission Via Postjunctional A1 Receptor-mediated Coincident Signaling American Journal of Physiology. Renal Physiology. Feb, 2012 | Pubmed ID: 22114202 Microglial Depletion Using Intrahippocampal Injection of Liposome-encapsulated Clodronate in Prolonged Hypothermic Cardiac Arrest in Rats Resuscitation. Apr, 2012 | Pubmed ID: 21970817 Increased Adenosine Concentration in Bronchoalveolar Lavage Fluid of Horses with Lower Airway Inflammation Veterinary Journal (London, England : 1997). Dec, 2011 | Pubmed ID: 22206730 Hypertension, Tachycardia, and Reversible Cardiomyopathy Temporally Associated with Milnacipran Use Texas Heart Institute Journal. 2011 | Pubmed ID: 22199446 The 2',3'-cAMP-adenosine Pathway American Journal of Physiology. Renal Physiology. Dec, 2011 | Pubmed ID: 21937608 Receptor for Activated Protein Kinase C1 Regulates Cell Proliferation by Modulating Calcium Signaling Hypertension. Oct, 2011 | Pubmed ID: 21844488 Expression of the 2',3'-cAMP-adenosine Pathway in Astrocytes and Microglia Journal of Neurochemistry. Sep, 2011 | Pubmed ID: 21777245 Extracellular CAMP-adenosine Pathways in the Mouse Kidney American Journal of Physiology. Renal Physiology. Sep, 2011 | Pubmed ID: 21653635 2',3'-cAMP, 3'-AMP, and 2'-AMP Inhibit Human Aortic and Coronary Vascular Smooth Muscle Cell Proliferation Via A2B Receptors American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2011 | Pubmed ID: 21622827 Role of Sphingosine-1-phosphate in the Renal Medulla American Journal of Physiology. Renal Physiology. Jul, 2011 | Pubmed ID: 21511695 Blast Exposure in Rats with Body Shielding is Characterized Primarily by Diffuse Axonal Injury Journal of Neurotrauma. Jun, 2011 | Pubmed ID: 21449683 2'-AMP and 3'-AMP Inhibit Proliferation of Preglomerular Vascular Smooth Muscle Cells and Glomerular Mesangial Cells Via A2B Receptors The Journal of Pharmacology and Experimental Therapeutics. May, 2011 | Pubmed ID: 21270135 Receptor Desensitization and Blockade of the Suppressive Effects of Prostaglandin E(2) and Adenosine on the Cytotoxic Activity of Human Melanoma-infiltrating T Lymphocytes Cancer Immunology, Immunotherapy : CII. Jan, 2011 | Pubmed ID: 20960188 Regulation of 3',5'-cAMP in Preglomerular Smooth Muscle and Endothelial Cells from Genetically Hypertensive Rats Hypertension (Dallas, Tex. : 1979). Dec, 2010 | Pubmed ID: 20975032 Candidate Genes and Mechanisms for 2-methoxyestradiol-mediated Vasoprotection Hypertension (Dallas, Tex. : 1979). Nov, 2010 | Pubmed ID: 20921434 Synergistic Therapeutic Effects of 2-methoxyestradiol with Either Sildenafil or Bosentan on Amelioration of Monocrotaline-induced Pulmonary Hypertension and Vascular Remodeling Journal of Cardiovascular Pharmacology. Nov, 2010 | Pubmed ID: 20881615 Estradiol Stimulates Capillary Formation by Human Endothelial Progenitor Cells: Role of Estrogen Receptor-{alpha}/{beta}, Heme Oxygenase 1, and Tyrosine Kinase Hypertension. Sep, 2010 | Pubmed ID: 20644008 Adenosine and Prostaglandin E2 Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells The Journal of Biological Chemistry. Sep, 2010 | Pubmed ID: 20558731 Resveratrol, a Red Wine Constituent, Blocks the Antimitogenic Effects of Estradiol on Human Female Coronary Artery Smooth Muscle Cells The Journal of Clinical Endocrinology and Metabolism. Sep, 2010 | Pubmed ID: 20534756 Extracellular 2,3-cyclic Adenosine Monophosphate is a Potent Inhibitor of Preglomerular Vascular Smooth Muscle Cell and Mesangial Cell Growth [corrected] Hypertension (Dallas, Tex. : 1979). Jul, 2010 | Pubmed ID: 20516392 Sitagliptin Augments Angiotensin II-induced Renal Vasoconstriction in Kidneys from Rats with Metabolic Syndrome Clinical and Experimental Pharmacology & Physiology. Jul, 2010 | Pubmed ID: 20374254 Extracellular 3',5'-cAMP-adenosine Pathway Inhibits Glomerular Mesangial Cell Growth The Journal of Pharmacology and Experimental Therapeutics. Jun, 2010 | Pubmed ID: 20194527 Adenosine A1 Receptor Activation As a Brake on the Microglial Response After Experimental Traumatic Brain Injury in Mice Journal of Neurotrauma. May, 2010 | Pubmed ID: 20121416 Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+ Regulatory T Cells The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 19858205 Multidrug Resistance Protein 4 Mediates CAMP Efflux from Rat Preglomerular Vascular Smooth Muscle Cells Clinical and Experimental Pharmacology & Physiology. Feb, 2010 | Pubmed ID: 19671067 Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2009 | Pubmed ID: 19825957 Extracellular 2',3'-cAMP is a Source of Adenosine The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19801686 Effects of Estradiol Metabolites on CAMP Production and Degradation Prilozi. Jul, 2009 | Pubmed ID: 19736528 Potential Vascular Actions of 2-methoxyestradiol Trends in Endocrinology and Metabolism: TEM. Oct, 2009 | Pubmed ID: 19734053 2-methoxyestradiol Attenuates Bleomycin-induced Pulmonary Hypertension and Fibrosis in Estrogen-deficient Rats Vascular Pharmacology. Aug-Sep, 2009 | Pubmed ID: 19540933 Regulation of Renovascular Adenosine 3',5'-cyclic Monophosphate in Spontaneously Hypertensive Rats Hypertension (Dallas, Tex. : 1979). Aug, 2009 | Pubmed ID: 19528365 Adenosine Deaminase-adenosine Pathway in Hemolysis-associated Pulmonary Hypertension Medical Hypotheses. Jun, 2009 | Pubmed ID: 19237250 Nonresolving Inflammation in Gp91phox-/- Mice, a Model of Human Chronic Granulomatous Disease, Has Lower Adenosine and Cyclic Adenosine 5'-monophosphate Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19234224 Identification and Quantification of 2',3'-cAMP Release by the Kidney The Journal of Pharmacology and Experimental Therapeutics. Mar, 2009 | Pubmed ID: 19033554 Treating Acute "no-reflow" with Intracoronary Adenosine in 4 Patients During Percutaneous Coronary Intervention Texas Heart Institute Journal. 2008 | Pubmed ID: 19156238 Sitagliptin Augments Sympathetic Enhancement of the Renovascular Effects of Angiotensin II in Genetic Hypertension Hypertension (Dallas, Tex. : 1979). Jun, 2008 | Pubmed ID: 18443229 2-Ethoxyestradiol is Antimitogenic and Attenuates Monocrotaline-induced Pulmonary Hypertension and Vascular Remodeling Vascular Pharmacology. Apr-Jun, 2008 | Pubmed ID: 18373958 Assessment of Nerve Stimulation-induced Release of Purines from Mouse Kidneys by Tandem Mass Spectrometry The Journal of Pharmacology and Experimental Therapeutics. Jun, 2008 | Pubmed ID: 18322147 Alpha2-adrenoceptors Enhance Angiotensin II-induced Renal Vasoconstriction: Role for NADPH Oxidase and RhoA Hypertension (Dallas, Tex. : 1979). Mar, 2008 | Pubmed ID: 18250367 Regulation of Renal Ectophosphodiesterase by Protein Kinase C and Sodium Diet The Journal of Pharmacology and Experimental Therapeutics. Apr, 2008 | Pubmed ID: 18223197 Chronic Noradrenaline Increases Renal Expression of NHE-3, NBC-1, BSC-1 and Aquaporin-2 Clinical and Experimental Pharmacology & Physiology. May, 2008 | Pubmed ID: 18177483 Effects of Dipeptidyl Peptidase Iv Inhibition on Arterial Blood Pressure Clinical and Experimental Pharmacology & Physiology. Jan, 2008 | Pubmed ID: 18047624 Increases in Cerebrospinal Fluid Caffeine Concentration Are Associated with Favorable Outcome After Severe Traumatic Brain Injury in Humans Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2008 | Pubmed ID: 17684518 Emergency Preservation and Resuscitation with Profound Hypothermia, Oxygen, and Glucose Allows Reliable Neurological Recovery After 3 H of Cardiac Arrest from Rapid Exsanguination in Dogs Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2008 | Pubmed ID: 17622254 Multiplex Assessment of Cytokine and Chemokine Levels in Cerebrospinal Fluid Following Severe Pediatric Traumatic Brain Injury: Effects of Moderate Hypothermia Journal of Neurotrauma. Nov, 2007 | Pubmed ID: 18001201 Importance of Tissue Perfusion in ST Segment Elevation Myocardial Infarction Patients Undergoing Reperfusion Strategies: Role of Adenosine Clinical Cardiology. Nov, 2007 | Pubmed ID: 18000974 Early Renal Injury Induced by Caffeine Consumption in Obese, Diabetic ZSF1 Rats Renal Failure. 2007 | Pubmed ID: 17994459 Cellular Distribution of the Renal Bumetanide-sensitive Na-K-2Cl Cotransporter BSC-1 in the Inner Stripe of the Outer Medulla During the Development of Hypertension in the Spontaneously Hypertensive Rat Clinical and Experimental Pharmacology & Physiology. Dec, 2007 | Pubmed ID: 17973873 Inhibition of Renal Dipeptidyl Peptidase IV Enhances Peptide YY1-36-induced Potentiation of Angiotensin II-mediated Renal Vasoconstriction in Spontaneously Hypertensive Rats The Journal of Pharmacology and Experimental Therapeutics. Nov, 2007 | Pubmed ID: 17726157 Inhibition of Cytokine Production and Cytotoxic Activity of Human Antimelanoma Specific CD8+ and CD4+ T Lymphocytes by Adenosine-protein Kinase A Type I Signaling Cancer Research. Jun, 2007 | Pubmed ID: 17575165 Norepinephrine, Via Beta-adrenoceptors, Regulates Bumetanide-sensitive Cotransporter Type 1 Expression in Thick Ascending Limb Cells Hypertension (Dallas, Tex. : 1979). Jun, 2007 | Pubmed ID: 17438304 The Pancreatohepatorenal CAMP-adenosine Mechanism The Journal of Pharmacology and Experimental Therapeutics. May, 2007 | Pubmed ID: 17314200 Phospholipase C and Src Modulate Angiotensin II-induced Cyclic AMP Production in Preglomerular Microvascular Smooth-muscle Cells from Spontaneously Hypertensive Rats Journal of Cardiovascular Pharmacology. Feb, 2007 | Pubmed ID: 17312452 Characterization of Renal Ecto-phosphodiesterase The Journal of Pharmacology and Experimental Therapeutics. May, 2007 | Pubmed ID: 17308037 PPAR Alpha Agonists Improve Renal Preservation in Kidneys Subjected to Chronic in Vitro Perfusion: Interaction with Mannitol Transplant International : Official Journal of the European Society for Organ Transplantation. Mar, 2007 | Pubmed ID: 17291221 2-Methoxyestradiol and 2-ethoxyestradiol Retard the Progression of Renal Disease in Aged, Obese, Diabetic ZSF1 Rats Journal of Cardiovascular Pharmacology. Jan, 2007 | Pubmed ID: 17261964 The Extracellular CAMP-adenosine Pathway Significantly Contributes to the in Vivo Production of Adenosine The Journal of Pharmacology and Experimental Therapeutics. Jan, 2007 | Pubmed ID: 17028245 Adenosine-mediated Inhibition of Cytotoxic Activity and Cytokine Production by IL-2/NKp46-activated NK Cells: Involvement of Protein Kinase A Isozyme I (PKA I) Immunologic Research. 2006 | Pubmed ID: 17337770 Conversion of Tibolone to 7alpha-methyl-ethinyl Estradiol Using Gas Chromatography-mass Spectrometry and Liquid Chromatography-mass Spectrometry: Interpretation and Clinical Implications Menopause (New York, N.Y.). Nov-Dec, 2006 | Pubmed ID: 17006378 A2A Adenosine Receptor Protects Tumors from Antitumor T Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16916931 Adenosine-mediated Inhibition of the Cytotoxic Activity and Cytokine Production by Activated Natural Killer Cells Cancer Research. Aug, 2006 | Pubmed ID: 16885379 2-Methoxyestradiol Mediates the Protective Effects of Estradiol in Monocrotaline-induced Pulmonary Hypertension Vascular Pharmacology. Dec, 2006 | Pubmed ID: 16872912 Role of Renal Sympathetic Nerves in Regulating Renovascular Responses to Angiotensin II in Spontaneously Hypertensive Rats The Journal of Pharmacology and Experimental Therapeutics. Jun, 2006 | Pubmed ID: 16537795 CAMP-adenosine Pathway in the Proximal Tubule The Journal of Pharmacology and Experimental Therapeutics. Jun, 2006 | Pubmed ID: 16527902 Pancreatic Polypeptide-fold Peptide Receptors and Angiotensin II-induced Renal Vasoconstriction Hypertension (Dallas, Tex. : 1979). Mar, 2006 | Pubmed ID: 16365188 Adenosine A1 Receptor Knockout Mice Develop Lethal Status Epilepticus After Experimental Traumatic Brain Injury Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Apr, 2006 | Pubmed ID: 16121125 Gs Protein-coupled Adenosine Receptor Signaling and Lytic Function of Activated NK Cells Journal of Immunology (Baltimore, Md. : 1950). Oct, 2005 | Pubmed ID: 16177079 Estradiol Metabolites Attenuate Monocrotaline-induced Pulmonary Hypertension in Rats Journal of Cardiovascular Pharmacology. Oct, 2005 | Pubmed ID: 16160593 Adenosine Inhibits PDGF-induced Growth of Human Glomerular Mesangial Cells Via A(2B) Receptors Hypertension (Dallas, Tex. : 1979). Sep, 2005 | Pubmed ID: 16103269 Estradiol Metabolites Attenuate Renal and Cardiovascular Injury Induced by Chronic Nitric Oxide Synthase Inhibition Journal of Cardiovascular Pharmacology. Jul, 2005 | Pubmed ID: 15965351 Characterization of the Effects of Adenosine Receptor Agonists on Cerebral Blood Flow in Uninjured and Traumatically Injured Rat Brain Using Continuous Arterial Spin-labeled Magnetic Resonance Imaging Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Dec, 2005 | Pubmed ID: 15931163 Mechanism of the Vascular Angiotensin II/alpha2-adrenoceptor Interaction The Journal of Pharmacology and Experimental Therapeutics. Sep, 2005 | Pubmed ID: 15901799 Vascular Consequences of Menopause and Hormone Therapy: Importance of Timing of Treatment and Type of Estrogen Cardiovascular Research. May, 2005 | Pubmed ID: 15820198 Enhanced Activation of RhoA by Angiotensin II in SHR Preglomerular Microvascular Smooth Muscle Cells Journal of Cardiovascular Pharmacology. Apr, 2005 | Pubmed ID: 15772513 Intraperitoneal Administration of Adenosine Inhibits Formation of Abdominal Adhesions Diseases of the Colon and Rectum. Aug, 2004 | Pubmed ID: 15484355 Hormone Replacement Therapy and Cardiovascular Disease: What Went Wrong and Where Do We Go from Here? Hypertension (Dallas, Tex. : 1979). Dec, 2004 | Pubmed ID: 15477384 Continuous Versus Intermittent Cerebrospinal Fluid Drainage After Severe Traumatic Brain Injury in Children: Effect on Biochemical Markers Journal of Neurotrauma. Sep, 2004 | Pubmed ID: 15453982 Increased Expression of the Sodium Transporter BSC-1 in Spontaneously Hypertensive Rats The Journal of Pharmacology and Experimental Therapeutics. Dec, 2004 | Pubmed ID: 15340004 A Gas Chromatography/mass Spectrometry Assay to Measure Estradiol, Catecholestradiols, and Methoxyestradiols in Plasma Steroids. Apr, 2004 | Pubmed ID: 15183691 Modulation of Cyclic AMP Production by Signal Transduction Pathways in Preglomerular Microvessels and Microvascular Smooth Muscle Cells The Journal of Pharmacology and Experimental Therapeutics. Jul, 2004 | Pubmed ID: 15087474 Vascular Endothelial Growth Factor is Increased in Cerebrospinal Fluid After Traumatic Brain Injury in Infants and Children Neurosurgery. Mar, 2004 | Pubmed ID: 15028134 The Extracellular Cyclic AMP-adenosine Pathway in Renal Physiology Annual Review of Physiology. 2004 | Pubmed ID: 14977414 2-hydroxyestradiol is a Prodrug of 2-methoxyestradiol The Journal of Pharmacology and Experimental Therapeutics. Jun, 2004 | Pubmed ID: 14872091 AT2 Receptors Attenuate AT1 Receptor-induced Phospholipase D Activation in Vascular Smooth Muscle Cells The Journal of Pharmacology and Experimental Therapeutics. Apr, 2004 | Pubmed ID: 14722318 Methoxyestradiols Mediate the Antimitogenic Effects of 17beta-estradiol: Direct Evidence from Catechol-O-methyltransferase-knockout Mice Circulation. Dec, 2003 | Pubmed ID: 14662705 Adenosine Biosynthesis in the Collecting Duct The Journal of Pharmacology and Experimental Therapeutics. Dec, 2003 | Pubmed ID: 14560043 Renal Extraction of Angiotensin II The Journal of Pharmacology and Experimental Therapeutics. Dec, 2003 | Pubmed ID: 14534364 Rat Models of the Metabolic Syndrome Methods in Molecular Medicine. 2003 | Pubmed ID: 12886760 Methylation of 2-hydroxyestradiol in Isolated Organs Hypertension (Dallas, Tex. : 1979). Jul, 2003 | Pubmed ID: 12771046 Oviduct Cells Express the Cyclic AMP-adenosine Pathway Biology of Reproduction. Sep, 2003 | Pubmed ID: 12724271 Type IV Phosphodiesterase Inhibition Improves Cardiac Contractility in Endotoxemic Rats European Journal of Pharmacology. Mar, 2003 | Pubmed ID: 12650842 Role of EGFR Transactivation in Angiotensin II Signaling to Extracellular Regulated Kinase in Preglomerular Smooth Muscle Cells Hypertension (Dallas, Tex. : 1979). Mar, 2003 | Pubmed ID: 12623996 Alpha 2-Adrenoceptors Potentiate Angiotensin II- and Vasopressin-induced Renal Vasoconstriction in Spontaneously Hypertensive Rats The Journal of Pharmacology and Experimental Therapeutics. May, 2003 | Pubmed ID: 12606648 2-Hydroxyestradiol Attenuates Renal Disease in Chronic Puromycin Aminonucleoside Nephropathy Journal of the American Society of Nephrology : JASN. Nov, 2002 | Pubmed ID: 12397044 Administration of Adenosine Receptor Agonists or Antagonists After Controlled Cortical Impact in Mice: Effects on Function and Histopathology Brain Research. Oct, 2002 | Pubmed ID: 12270497 Expression of Adenosine Receptors in the Preglomerular Microcirculation American Journal of Physiology. Renal Physiology. Jul, 2002 | Pubmed ID: 12060585 Catecholamines Block 2-hydroxyestradiol-induced Antimitogenesis in Mesangial Cells Hypertension (Dallas, Tex. : 1979). Apr, 2002 | Pubmed ID: 11967239 Long-term Caffeine Consumption Exacerbates Renal Failure in Obese, Diabetic, ZSF1 (fa-fa(cp)) Rats Kidney International. Apr, 2002 | Pubmed ID: 11918750 A(2B) Adenosine Receptors Stimulate Growth of Porcine and Rat Arterial Endothelial Cells Hypertension (Dallas, Tex. : 1979). Feb, 2002 | Pubmed ID: 11882603 Sex Hormones and Hypertension Cardiovascular Research. Feb, 2002 | Pubmed ID: 11861040 Bröst epitelial och endotelcellssfäroider som en potentiell funktionell in vitro-modell för bröstcancerforskning Giovanna Azzarito1, Marta Ewa Szutkowska1, Annalisa Saltari2, Edwin K. Jackson3, Brigitte Leeners1, Marinella Rosselli1, Raghvendra K. Dubey1,3 1Department of Reproductive Endocrinology, Wagistrasse 14, University of Zurich and University Hospital Zurich, 2Department of Dermatology, Wagistrasse 18, University of Zurich and University Hospital Zurich, 3Department of Pharmacology and Chemical Biology, University of Pittsburgh JoVE 62940 암 연구학
Bröst epitelial och endotelcellssfäroider som en potentiell funktionell in vitro-modell för bröstcancerforskning Giovanna Azzarito1, Marta Ewa Szutkowska1, Annalisa Saltari2, Edwin K. Jackson3, Brigitte Leeners1, Marinella Rosselli1, Raghvendra K. Dubey1,3 1Department of Reproductive Endocrinology, Wagistrasse 14, University of Zurich and University Hospital Zurich, 2Department of Dermatology, Wagistrasse 18, University of Zurich and University Hospital Zurich, 3Department of Pharmacology and Chemical Biology, University of Pittsburgh JoVE 62940 암 연구학