Elena Aikawa Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine Brigham and Women’s Hospital, Harvard Medical School Biography Publications Institution JoVE Articles Elena Aikawa has not added a biography. If you are Elena Aikawa and would like to personalize this page please email our Author Liaison for assistance. Publications Elevated Lipoprotein(a) As a Predictor for Coronary Events in Older Men Journal of Lipid Research. Aug, 2022 | Pubmed ID: 35724702 A Disease-driver Population Within Interstitial Cells of Human Calcific Aortic Valves Identified Via Single-cell and Proteomic Profiling Cell Reports. Apr, 2022 | Pubmed ID: 35417712 Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition Journal of the American Heart Association. Apr, 2022 | Pubmed ID: 35348006 Controlled Delivery of Gold Nanoparticle-coupled MiRNA Therapeutics an Injectable Self-healing Hydrogel Nanoscale. Dec, 2021 | Pubmed ID: 34817483 Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging Journal of the American Heart Association. Oct, 2021 | Pubmed ID: 34632804 Nanoanalytical Analysis of Bisphosphonate-driven Alterations of Microcalcifications Using a 3D Hydrogel System and in Vivo Mouse Model Proceedings of the National Academy of Sciences of the United States of America. Apr, 2021 | Pubmed ID: 33795519 ApoC-III is a Novel Inducer of Calcification in Human Aortic Valves The Journal of Biological Chemistry. 2021 | Pubmed ID: 33334888 Annexin A1-dependent Tethering Promotes Extracellular Vesicle Aggregation Revealed with Single-extracellular Vesicle Analysis Science Advances. Sep, 2020 | Pubmed ID: 32938681 Innate and Adaptive Immunity in Cardiovascular Calcification Atherosclerosis. Aug, 2020 | Pubmed ID: 32222287 Complex Association of Lipoprotein(a) with Aortic Stenosis Heart (British Cardiac Society). May, 2020 | Pubmed ID: 32086294 Cardiovascular Calcification: Artificial Intelligence and Big Data Accelerate Mechanistic Discovery Nature Reviews. Cardiology. May, 2019 | Pubmed ID: 30531869 Transcriptional Control of Intestinal Cholesterol Absorption, Adipose Energy Expenditure and Lipid Handling by Sortilin Scientific Reports. Jun, 2018 | Pubmed ID: 29899496 Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics Nanomaterials (Basel, Switzerland). May, 2018 | Pubmed ID: 29751516 Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles International Journal of Molecular Sciences. Feb, 2018 | Pubmed ID: 29495441 Dimerization of Sortilin Regulates Its Trafficking to Extracellular Vesicles The Journal of Biological Chemistry. Mar, 2018 | Pubmed ID: 29382723 Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2018 | Pubmed ID: 29191923 Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues Circulation Research. Jun, 2017 | Pubmed ID: 28642321 Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress Circulation Research. Jul, 2017 | Pubmed ID: 28607103 Zooming in on the Genesis of Atherosclerotic Plaque Microcalcifications The Journal of Physiology. Apr, 2016 | Pubmed ID: 27040360 Simulation of Early Calcific Aortic Valve Disease in a 3D Platform: A Role for Myofibroblast Differentiation Journal of Molecular and Cellular Cardiology. May, 2016 | Pubmed ID: 26996755 3D Ultrasound: Seeing is Understanding-from Imaging to Pathophysiology to Developing Therapies in Secondary MR European Heart Journal Cardiovascular Imaging. May, 2016 | Pubmed ID: 26976355 Sortilin Mediates Vascular Calcification Via Its Recruitment into Extracellular Vesicles The Journal of Clinical Investigation. Apr, 2016 | Pubmed ID: 26950419 Extracellular Vesicles in Cardiovascular Calcification: Expanding Current Paradigms The Journal of Physiology. Jan, 2016 | Pubmed ID: 26824781 Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response Via Transforming Growth Factor-β Signaling Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2016 | Pubmed ID: 26800565 Myocardial Infarction Alters Adaptation Of the Tethered Mitral Valve Journal of the American College of Cardiology. Jan, 2016 | Pubmed ID: 26796392 Genesis and Growth of Extracellular-vesicle-derived Microcalcification In atherosclerotic Plaques Nature Materials. Mar, 2016 | Pubmed ID: 26752654 Mitral Valve Disease--morphology and Mechanisms Nature Reviews. Cardiology. Dec, 2015 | Pubmed ID: 26483167 Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease PloS One. 2015 | Pubmed ID: 26367531 Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach Seminars in Cell & Developmental Biology. Oct, 2015 | Pubmed ID: 26358815 Valvular Interstitial Cells Suppress Calcification of Valvular Endothelial Cells Atherosclerosis. Sep, 2015 | Pubmed ID: 26232165 A Not-So-Little Role for Lipoprotein(a) in the Development of Calcific Aortic Valve Disease Circulation. Aug, 2015 | Pubmed ID: 26224809 Cardiovascular Calcification: Current Controversies and Novel Concepts Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. Jul-Aug, 2015 | Pubmed ID: 25797772 Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-deficient Mice with Chronic Renal Disease The American Journal of Pathology. Apr, 2015 | Pubmed ID: 25680278 EVpedia: a Community Web Portal for Extracellular Vesicles Research Bioinformatics (Oxford, England). Mar, 2015 | Pubmed ID: 25388151 Directing Valvular Interstitial Cell Myofibroblast-like Differentiation in a Hybrid Hydrogel Platform Advanced Healthcare Materials. Jan, 2015 | Pubmed ID: 24958085 Enrichment of Calcifying Extracellular Vesicles Using Density-based Ultracentrifugation Protocol Journal of Extracellular Vesicles. 2014 | Pubmed ID: 25491249 Calcific Aortic Valve Disease: a Consensus Summary from the Alliance of Investigators on Calcific Aortic Valve Disease Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2014 | Pubmed ID: 25189570 Small Entities with Large Impact: Microcalcifications and Atherosclerotic Plaque Vulnerability Current Opinion in Lipidology. Oct, 2014 | Pubmed ID: 25188916 Parathyroid Hormone: Critical Bridge Between Bone Metabolism and Cardiovascular Disease Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2014 | Pubmed ID: 24951650 Modifying Vascular Calcification in Diabetes Mellitus: Contribution of O-GlcNAcylation Circulation Research. Mar, 2014 | Pubmed ID: 24677232 A Novel Quantitative Approach for Eliminating Sample-to-sample Variation Using a Hue Saturation Value Analysis Program PloS One. 2014 | Pubmed ID: 24595280 Potential Drug Targets for Calcific Aortic Valve Disease Nature Reviews. Cardiology. Apr, 2014 | Pubmed ID: 24445487 Cystathionine γ-lyase Accelerates Osteoclast Differentiation: Identification of a Novel Regulator of Osteoclastogenesis by Proteomic Analysis Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2014 | Pubmed ID: 24357058 International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013) Journal of Extracellular Vesicles. 2013 | Pubmed ID: 26082318 Medial and Intimal Calcification in Chronic Kidney Disease: Stressing the Contributions Journal of the American Heart Association. Oct, 2013 | Pubmed ID: 24060959 Role of Extracellular Vesicles in De Novo Mineralization: an Additional Novel Mechanism of Cardiovascular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2013 | Pubmed ID: 23766262 Revised Microcalcification Hypothesis for Fibrous Cap Rupture in Human Coronary Arteries Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23733926 Leukocyte-derived Microparticles As Proinflammatory Mediators in Atherosclerosis Journal of the American College of Cardiology. Oct, 2013 | Pubmed ID: 23707315 Elastogenesis at the Onset of Human Cardiac Valve Development Development (Cambridge, England). Jun, 2013 | Pubmed ID: 23637335 Macrophage-derived Matrix Vesicles: an Alternative Novel Mechanism for Microcalcification in Atherosclerotic Plaques Circulation Research. Jun, 2013 | Pubmed ID: 23616621 Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation International Journal of Inflammation. 2013 | Pubmed ID: 23555068 MicroRNA in Cardiovascular Calcification: Focus on Targets and Extracellular Vesicle Delivery Mechanisms Circulation Research. Mar, 2013 | Pubmed ID: 23538277 Visualizing Novel Concepts of Cardiovascular Calcification Trends in Cardiovascular Medicine. Apr, 2013 | Pubmed ID: 23290463 Statins Suppress Apolipoprotein CIII-induced Vascular Endothelial Cell Activation and Monocyte Adhesion European Heart Journal. Feb, 2013 | Pubmed ID: 22927557 Vesiclepedia: a Compendium for Extracellular Vesicles with Continuous Community Annotation PLoS Biology. 2012 | Pubmed ID: 23271954 Notch Ligand Delta-like 4 Blockade Attenuates Atherosclerosis and Metabolic Disorders Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22699504 Cardiovascular Inflammation International Journal of Inflammation. 2012 | Pubmed ID: 22518345 Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2012 | Pubmed ID: 22223731 Look More Closely at the Valve: Imaging Calcific Aortic Valve Disease Circulation. Jan, 2012 | Pubmed ID: 22090164 Vasculitis: Molecular Imaging by Targeting the Inflammatory Enzyme Myeloperoxidase Radiology. Jan, 2012 | Pubmed ID: 22084204 Cyclic Strain Induces Dual-mode Endothelial-mesenchymal Transformation of the Cardiac Valve Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22123981 The Osteoclast-associated Receptor (OSCAR) is a Novel Receptor Regulated by Oxidized Low-density Lipoprotein in Human Endothelial Cells Endocrinology. Dec, 2011 | Pubmed ID: 22009730 Calcific Aortic Valve Disease: Not Simply a Degenerative Process: A Review and Agenda for Research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive Summary: Calcific Aortic Valve Disease-2011 Update Circulation. Oct, 2011 | Pubmed ID: 22007101 Selective Inhibition of Matrix Metalloproteinase-13 Increases Collagen Content of Established Mouse Atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2011 | Pubmed ID: 21903941 In Vivo Detection of Staphylococcus Aureus Endocarditis by Targeting Pathogen-specific Prothrombin Activation Nature Medicine. Sep, 2011 | Pubmed ID: 21857652 Progenitor Cells Confer Plasticity to Cardiac Valve Endothelium Journal of Cardiovascular Translational Research. Dec, 2011 | Pubmed ID: 21789724 Molecular Imaging Insights into Early Inflammatory Stages of Arterial and Aortic Valve Calcification Circulation Research. May, 2011 | Pubmed ID: 21617135 Indocyanine Green Enables Near-infrared Fluorescence Imaging of Lipid-rich, Inflamed Atherosclerotic Plaques Science Translational Medicine. May, 2011 | Pubmed ID: 21613624 Cardiovascular Calcification: an Inflammatory Disease Circulation Journal : Official Journal of the Japanese Circulation Society. 2011 | Pubmed ID: 21566338 Fibroblast Activation Protein is Induced by Inflammation and Degrades Type I Collagen in Thin-cap Fibroatheromata European Heart Journal. Nov, 2011 | Pubmed ID: 21292680 Mitral Valve Endothelial Cells with Osteogenic Differentiation Potential Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2011 | Pubmed ID: 21164078 Pioglitazone Suppresses Inflammation in Vivo in Murine Carotid Atherosclerosis: Novel Detection by Dual-target Fluorescence Molecular Imaging Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2010 | Pubmed ID: 20689078 Arterial and Aortic Valve Calcification Inversely Correlates with Osteoporotic Bone Remodelling: a Role for Inflammation European Heart Journal. Aug, 2010 | Pubmed ID: 20601388 Impaired Infarct Healing in Atherosclerotic Mice with Ly-6C(hi) Monocytosis Journal of the American College of Cardiology. Apr, 2010 | Pubmed ID: 20378083 In Vivo Monitoring of Function of Autologous Engineered Pulmonary Valve The Journal of Thoracic and Cardiovascular Surgery. Mar, 2010 | Pubmed ID: 20176213 The Role of Organ Level Conditioning on the Promotion of Engineered Heart Valve Tissue Development In-vitro Using Mesenchymal Stem Cells Biomaterials. Feb, 2010 | Pubmed ID: 19944458 Intravital Molecular Imaging of Small-diameter Tissue-engineered Vascular Grafts in Mice: a Feasibility Study Tissue Engineering. Part C, Methods. Aug, 2010 | Pubmed ID: 19751103 Endothelial Progenitor Cells As a Sole Source for Ex Vivo Seeding of Tissue-engineered Heart Valves Tissue Engineering. Part A. Jan, 2010 | Pubmed ID: 19698056 Unbiased Discovery of in Vivo Imaging Probes Through in Vitro Profiling of Nanoparticle Libraries Integrative Biology : Quantitative Biosciences from Nano to Macro. Apr, 2009 | Pubmed ID: 20023731 Molecular MRI Detects Low Levels of Cardiomyocyte Apoptosis in a Transgenic Model of Chronic Heart Failure Circulation. Cardiovascular Imaging. Nov, 2009 | Pubmed ID: 19920045 Molecular MRI of Cardiomyocyte Apoptosis with Simultaneous Delayed-enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes in Vivo: Potential for Midmyocardial Salvage in Acute Ischemia Circulation. Cardiovascular Imaging. Nov, 2009 | Pubmed ID: 19920044 18F-4V for PET-CT Imaging of VCAM-1 Expression in Atherosclerosis JACC. Cardiovascular Imaging. Oct, 2009 | Pubmed ID: 19833312 Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation Journal of the American Chemical Society. Nov, 2009 | Pubmed ID: 19817443 Diffusion Spectrum MRI Tractography Reveals the Presence of a Complex Network of Residual Myofibers in Infarcted Myocardium Circulation. Cardiovascular Imaging. May, 2009 | Pubmed ID: 19808594 Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites Science (New York, N.Y.). Jul, 2009 | Pubmed ID: 19644120 Chronic Hypoxia Activates the Akt and Beta-catenin Pathways in Human Macrophages Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2009 | Pubmed ID: 19644051 Hybrid in Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis with Customized Nanosensors Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2009 | Pubmed ID: 19608968 Active Adaptation of the Tethered Mitral Valve: Insights into a Compensatory Mechanism for Functional Mitral Regurgitation Circulation. Jul, 2009 | Pubmed ID: 19597052 The Antiproliferative Cytostatic Effects of a Self-activating Viridin Prodrug Molecular Cancer Therapeutics. Jun, 2009 | Pubmed ID: 19509266 Molecular Imaging of Innate Immune Cell Function in Transplant Rejection Circulation. Apr, 2009 | Pubmed ID: 19332470 Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease Circulation. Apr, 2009 | Pubmed ID: 19307473 Combined Magnetic Resonance and Fluorescence Imaging of the Living Mouse Brain Reveals Glioma Response to Chemotherapy NeuroImage. Apr, 2009 | Pubmed ID: 19154791 Genetically Engineered Resistance for MMP Collagenases Promotes Abdominal Aortic Aneurysm Formation in Mice Infused with Angiotensin II Laboratory Investigation; a Journal of Technical Methods and Pathology. Mar, 2009 | Pubmed ID: 19153555 Notch Signaling in Cardiovascular Disease and Calcification Current Cardiology Reviews. Aug, 2008 | Pubmed ID: 19936191 Early Photon Tomography Allows Fluorescence Detection of Lung Carcinomas and Disease Progression in Mice in Vivo Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19015534 Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008 | Pubmed ID: 19011099 Real-time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis Circulation. Oct, 2008 | Pubmed ID: 18852366 Simplified Syntheses of Complex Multifunctional Nanomaterials Chemical Communications (Cambridge, England). Oct, 2008 | Pubmed ID: 18830495 Transglutaminase Activity in Acute Infarcts Predicts Healing Outcome and Left Ventricular Remodelling: Implications for FXIII Therapy and Antithrombin Use in Myocardial Infarction European Heart Journal. Feb, 2008 | Pubmed ID: 18276618 Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-reperfusion Injury Circulation. Mar, 2008 | Pubmed ID: 18268141 Myeloperoxidase-targeted Imaging of Active Inflammatory Lesions in Murine Experimental Autoimmune Encephalomyelitis Brain : a Journal of Neurology. Apr, 2008 | Pubmed ID: 18234693 Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis Circulation. Jan, 2008 | Pubmed ID: 18158358 Osteogenesis Associates with Inflammation in Early-stage Atherosclerosis Evaluated by Molecular Imaging in Vivo Circulation. Dec, 2007 | Pubmed ID: 18040026 The Healing Myocardium Sequentially Mobilizes Two Monocyte Subsets with Divergent and Complementary Functions The Journal of Experimental Medicine. Nov, 2007 | Pubmed ID: 18025128 Healing and Remodeling of Bioengineered Pulmonary Artery Patches Implanted in Sheep Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. Sep-Oct, 2007 | Pubmed ID: 17868878 Optical Visualization of Cathepsin K Activity in Atherosclerosis with a Novel, Protease-activatable Fluorescence Sensor Circulation. May, 2007 | Pubmed ID: 17420353 Dual Channel Optical Tomographic Imaging of Leukocyte Recruitment and Protease Activity in the Healing Myocardial Infarct Circulation Research. Apr, 2007 | Pubmed ID: 17379832 Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium in Vivo Circulation. Mar, 2007 | Pubmed ID: 17339546 Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease Circulation. Jan, 2007 | Pubmed ID: 17224478 Ly-6Chi Monocytes Dominate Hypercholesterolemia-associated Monocytosis and Give Rise to Macrophages in Atheromata The Journal of Clinical Investigation. Jan, 2007 | Pubmed ID: 17200719 Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis Circulation. Oct, 2006 | Pubmed ID: 17000904 Human Pulmonary Valve Progenitor Cells Exhibit Endothelial/mesenchymal Plasticity in Response to Vascular Endothelial Growth Factor-A and Transforming Growth Factor-beta2 Circulation Research. Oct, 2006 | Pubmed ID: 16973908 Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials Molecular Imaging. Apr-Jun, 2006 | Pubmed ID: 16954022 Monocyte Accumulation in Mouse Atherogenesis is Progressive and Proportional to Extent of Disease Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16801531 Inflammation in Atherosclerosis: Visualizing Matrix Metalloproteinase Action in Macrophages in Vivo Circulation. Jul, 2006 | Pubmed ID: 16801460 Chemokine CXCL10 Promotes Atherogenesis by Modulating the Local Balance of Effector and Regulatory T Cells Circulation. May, 2006 | Pubmed ID: 16682613 Detection of Macrophage Activity in Atherosclerosis in Vivo Using Multichannel, High-resolution Laser Scanning Fluorescence Microscopy Journal of Biomedical Optics. Mar-Apr, 2006 | Pubmed ID: 16674184 Human Semilunar Cardiac Valve Remodeling by Activated Cells from Fetus to Adult: Implications for Postnatal Adaptation, Pathology, and Tissue Engineering Circulation. Mar, 2006 | Pubmed ID: 16534030 Matrix Metalloproteinase-13/collagenase-3 Deletion Promotes Collagen Accumulation and Organization in Mouse Atherosclerotic Plaques Circulation. Oct, 2005 | Pubmed ID: 16230484 Characterization of Human Atherosclerotic Plaques by Intravascular Magnetic Resonance Imaging Circulation. Oct, 2005 | Pubmed ID: 16203910 Inhibition of Atherogenesis in BLT1-deficient Mice Reveals a Role for LTB4 and BLT1 in Smooth Muscle Cell Recruitment Circulation. Jul, 2005 | Pubmed ID: 16043658 Author Spotlight: Effective Reuse of Polycarbonate Tubes for Extracellular Vesicle Isolation Rachel M. E. Cahalane*1,2, Mandy E. Turner*1, Cassandra L. Clift1, Mark C. Blaser1, Gabrielle Bogut1, Sydney Levy1, Taku Kasai1, Tom A. P. Driedonks3,4, Esther N. M. Nolte-‘t Hoen4, Masanori Aikawa1,5, Sasha A. Singh1,5, Elena Aikawa1,5 1Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 2Mechanobiology and Medical Device Research Group (MMDRG), Biomedical Engineering, College of Science and Engineering, University of Galway, 3Department of CDL Research, University Medical Center Utrecht, 4Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 5Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School JoVE 66126 생물학 تكلس الأوعية الدموية خلايا العضلات الملساء والتصوير من الأورطي تكلس والتهاب Caitlin O'Rourke*1, Georgia Shelton*1,2, Joshua D. Hutcheson3,4, Megan F. Burke2, Trejeeve Martyn1, Timothy E. Thayer2, Hannah R. Shakartzi1, Mary D. Buswell1, Robert E. Tainsh1, Binglan Yu1,4, Aranya Bagchi1,4, David K. Rhee2,4, Connie Wu1,2,4, Matthias Derwall5, Emmanuel S. Buys1,4, Paul B. Yu3,4, Kenneth D. Bloch1,2,4, Elena Aikawa3,4, Donald B. Bloch1,5,6, Rajeev Malhotra2,4 1Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 2Cardiovascular Research Center and Cardiology Division of the Department of Medicine, Massachusetts General Hospital, 3Cardiovascular Division, Brigham and Women's Hospital, 4Harvard Medical School, 5Department of Anesthesiology, Uniklinik RWTH Aachen, RWTH Aachen University, 6Center for Immunology and Inflammatory Diseases and the Division of Rheumatology, Allergy, and Immunology of the Department of Medicine, Massachusetts General Hospital 의학
Author Spotlight: Effective Reuse of Polycarbonate Tubes for Extracellular Vesicle Isolation Rachel M. E. Cahalane*1,2, Mandy E. Turner*1, Cassandra L. Clift1, Mark C. Blaser1, Gabrielle Bogut1, Sydney Levy1, Taku Kasai1, Tom A. P. Driedonks3,4, Esther N. M. Nolte-‘t Hoen4, Masanori Aikawa1,5, Sasha A. Singh1,5, Elena Aikawa1,5 1Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 2Mechanobiology and Medical Device Research Group (MMDRG), Biomedical Engineering, College of Science and Engineering, University of Galway, 3Department of CDL Research, University Medical Center Utrecht, 4Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 5Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School JoVE 66126 생물학
تكلس الأوعية الدموية خلايا العضلات الملساء والتصوير من الأورطي تكلس والتهاب Caitlin O'Rourke*1, Georgia Shelton*1,2, Joshua D. Hutcheson3,4, Megan F. Burke2, Trejeeve Martyn1, Timothy E. Thayer2, Hannah R. Shakartzi1, Mary D. Buswell1, Robert E. Tainsh1, Binglan Yu1,4, Aranya Bagchi1,4, David K. Rhee2,4, Connie Wu1,2,4, Matthias Derwall5, Emmanuel S. Buys1,4, Paul B. Yu3,4, Kenneth D. Bloch1,2,4, Elena Aikawa3,4, Donald B. Bloch1,5,6, Rajeev Malhotra2,4 1Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 2Cardiovascular Research Center and Cardiology Division of the Department of Medicine, Massachusetts General Hospital, 3Cardiovascular Division, Brigham and Women's Hospital, 4Harvard Medical School, 5Department of Anesthesiology, Uniklinik RWTH Aachen, RWTH Aachen University, 6Center for Immunology and Inflammatory Diseases and the Division of Rheumatology, Allergy, and Immunology of the Department of Medicine, Massachusetts General Hospital 의학