Elizabeth E. Howell Department of Biochemistry, Cellular and Molecular Biology University of Tennessee Biography Publications Institution JoVE Articles Elizabeth E. Howell has not added a biography. If you are Elizabeth E. Howell and would like to personalize this page please email our Author Liaison for assistance. Publications Thermodynamics and Solvent Effects on Substrate and Cofactor Binding in Escherichia Coli Chromosomal Dihydrofolate Reductase Biochemistry. May, 2011 | Pubmed ID: 21462996 A Survey of Aspartate-phenylalanine and Glutamate-phenylalanine Interactions in the Protein Data Bank: Searching for Anion-Ï€ Pairs Biochemistry. Apr, 2011 | Pubmed ID: 21366334 The Tail Wagging the Dog: Insights into Catalysis in R67 Dihydrofolate Reductase Biochemistry. Oct, 2010 | Pubmed ID: 20795731 Radical Redesign of a Tandem Array of Four R67 Dihydrofolate Reductase Genes Yields a Functional, Folded Protein Possessing 45 Substitutions Biochemistry. Aug, 2010 | Pubmed ID: 20684560 The Effect of Electrostatic Shielding on H Tunneling in R67 Dihydrofolate Reductase Chembiochem : a European Journal of Chemical Biology. Nov, 2009 | Pubmed ID: 19774544 Tuning of the H-transfer Coordinate in Primitive Versus Well-evolved Enzymes Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. May, 2008 | Pubmed ID: 18444258 A Balancing Act Between Net Uptake of Water During Dihydrofolate Binding and Net Release of Water Upon NADPH Binding in R67 Dihydrofolate Reductase The Journal of Biological Chemistry. Feb, 2008 | Pubmed ID: 18086667 R67, the Other Dihydrofolate Reductase: Rational Design of an Alternate Active Site Configuration Biochemistry. Jan, 2008 | Pubmed ID: 18085798 Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex Biochemistry. Dec, 2007 | Pubmed ID: 18052202 A Preference for Edgewise Interactions Between Aromatic Rings and Carboxylate Anions: the Biological Relevance of Anion-quadrupole Interactions The Journal of Physical Chemistry. B. Jul, 2007 | Pubmed ID: 17580852 Neutron Diffraction Studies of Escherichia Coli Dihydrofolate Reductase Complexed with Methotrexate Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17130456 Effects of Temperature and Viscosity on R67 Dihydrofolate Reductase Catalysis Biochemistry. May, 2006 | Pubmed ID: 16716070 Calorimetric Studies of Ligand Binding in R67 Dihydrofolate Reductase Biochemistry. Sep, 2005 | Pubmed ID: 16156655 Preliminary Neutron Diffraction Studies of Escherichia Coli Dihydrofolate Reductase Bound to the Anticancer Drug Methotrexate Acta Crystallographica. Section D, Biological Crystallography. May, 2005 | Pubmed ID: 15858267 Searching Sequence Space: Two Different Approaches to Dihydrofolate Reductase Catalysis Chembiochem : a European Journal of Chemical Biology. Apr, 2005 | Pubmed ID: 15812782 "Catch 222," the Effects of Symmetry on Ligand Binding and Catalysis in R67 Dihydrofolate Reductase As Determined by Mutations at Tyr-69 The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15333637 Role of Lys-32 Residues in R67 Dihydrofolate Reductase Probed by Asymmetric Mutations The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15333636 Defining the Binding Site of Homotetrameric R67 Dihydrofolate Reductase and Correlating Binding Enthalpy with Catalysis Biochemistry. Jun, 2004 | Pubmed ID: 15182183 NMR Studies of the Interaction of a Type II Dihydrofolate Reductase with Pyridine Nucleotides Reveal Unexpected Phosphatase and Reductase Activity Biochemistry. Sep, 2003 | Pubmed ID: 14503865 Role of Ionic Interactions in Ligand Binding and Catalysis of R67 Dihydrofolate Reductase Biochemistry. Sep, 2003 | Pubmed ID: 12962480 Breaking Symmetry: Mutations Engineered into R67 Dihydrofolate Reductase, a D2 Symmetric Homotetramer Possessing a Single Active Site Pore Biochemistry. Dec, 2002 | Pubmed ID: 12501195 Intact Protein Analysis for Site-directed Mutagenesis Overexpression Products: Plasmid-encoded R67 Dihydrofolate Reductase Analytical Biochemistry. Jun, 2002 | Pubmed ID: 12018947 Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity Michael R. Duff, Jr.1, Jordan Grubbs1, Elizabeth E. Howell1 1Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee JoVE 2796 생물학
Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity Michael R. Duff, Jr.1, Jordan Grubbs1, Elizabeth E. Howell1 1Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee JoVE 2796 생물학