Gavin J. Wright Cell Surface Signalling Laboratory Wellcome Trust Sanger Institute Biography Publications Institution JoVE Articles Gavin J. Wright has not added a biography. If you are Gavin J. Wright and would like to personalize this page please email our Author Liaison for assistance. Publications TMEM95 is a Sperm Membrane Protein Essential for Mammalian Fertilization ELife. Jun, 2020 | Pubmed ID: 32484434 Establishment, Optimisation and Quantitation of a Bioluminescent Murine Infection Model of Visceral Leishmaniasis for Systematic Vaccine Screening Scientific Reports. Mar, 2020 | Pubmed ID: 32170135 A Panel of Recombinant Proteins from Human-infective Plasmodium Species for Serological Surveillance Malaria Journal. Jan, 2020 | Pubmed ID: 31952523 High-Content Imaging for Large-Scale Detection of Low-Affinity Extracellular Protein Interactions SLAS Discovery : Advancing Life Sciences R & D. 12, 2019 | Pubmed ID: 31578119 Heparan Sulfates Are Critical Regulators of the Inhibitory Megakaryocyte-platelet Receptor G6b-B ELife. 08, 2019 | Pubmed ID: 31436532 Antibody Reactivity to Merozoite Antigens in Ghanaian Adults Correlates With Growth Inhibitory Activity Against in Culture Open Forum Infectious Diseases. Jul, 2019 | Pubmed ID: 31294045 Human Antibodies That Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies Cell. 06, 2019 | Pubmed ID: 31204103 A Defined Mechanistic Correlate of Protection Against Plasmodium Falciparum Malaria in Non-human Primates Nature Communications. 04, 2019 | Pubmed ID: 31028254 Important Extracellular Interactions Between Plasmodium Sporozoites and Host Cells Required for Infection Trends in Parasitology. 02, 2019 | Pubmed ID: 30583849 Approaches to Identify Extracellular Receptor-ligand Interactions Current Opinion in Structural Biology. 06, 2019 | Pubmed ID: 30469141 A Library of Recombinant Babesia Microti Cell Surface and Secreted Proteins for Diagnostics Discovery and Reverse Vaccinology International Journal for Parasitology. 02, 2019 | Pubmed ID: 30367868 Robust Adaptive Immune Response Against Infection Marked by Low Parasitemia in a Murine Model of Sickle Cell Disease Blood Advances. 12, 2018 | Pubmed ID: 30518538 Pooled Extracellular Receptor-ligand Interaction Screening Using CRISPR Activation Genome Biology. 11, 2018 | Pubmed ID: 30477585 Genome-scale Identification of Cellular Pathways Required for Cell Surface Recognition Genome Research. 09, 2018 | Pubmed ID: 29914970 Alpha-v-containing Integrins Are Host Receptors for the Sporozoite Surface Protein, TRAP Proceedings of the National Academy of Sciences of the United States of America. 04, 2018 | Pubmed ID: 29632205 Human Vaccination Against RH5 Induces Neutralizing Antimalarial Antibodies That Inhibit RH5 Invasion Complex Interactions JCI Insight. 11, 2017 | Pubmed ID: 29093263 Synergistic Malaria Vaccine Combinations Identified by Systematic Antigen Screening Proceedings of the National Academy of Sciences of the United States of America. 11, 2017 | Pubmed ID: 29078270 P113 is a Merozoite Surface Protein That Binds the N Terminus of Plasmodium Falciparum RH5 Nature Communications. 02, 2017 | Pubmed ID: 28186186 EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality Developmental Cell. 11, 2016 | Pubmed ID: 27825440 Sperm Meets Egg: The Genetics of Mammalian Fertilization Annual Review of Genetics. Nov, 2016 | Pubmed ID: 27617973 The Structure of Sperm Izumo1 Reveals Unexpected Similarities with Plasmodium Invasion Proteins Current Biology : CB. 07, 2016 | Pubmed ID: 27374339 Binding of Plasmodium Falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved Among Broadly Diverged Sequence Variants The Journal of Biological Chemistry. Jul, 2016 | Pubmed ID: 27226583 Divergent Evolution of Vitamin B9 Binding Underlies Juno-mediated Adhesion of Mammalian Gametes Current Biology : CB. Feb, 2016 | Pubmed ID: 26859261 The Challenges Involved in Elucidating the Molecular Basis of Sperm-egg Recognition in Mammals and Approaches to Overcome Them Cell and Tissue Research. Jan, 2016 | Pubmed ID: 26224538 A Library of Plasmodium Vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions PLoS Neglected Tropical Diseases. Dec, 2015 | Pubmed ID: 26701602 The LRR Receptor Islr2 is Required for Retinal Axon Routing at the Vertebrate Optic Chiasm Neural Development. Oct, 2015 | Pubmed ID: 26492970 Processing of Plasmodium Falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs Cell Host & Microbe. Oct, 2015 | Pubmed ID: 26468747 Basigin is a Druggable Target for Host-oriented Antimalarial Interventions The Journal of Experimental Medicine. Jul, 2015 | Pubmed ID: 26195724 P-selectin is a Host Receptor for Plasmodium MSP7 Ligands Malaria Journal. Jun, 2015 | Pubmed ID: 26045295 Quantification of Plasmodium-host Protein Interactions on Intact, Unmodified Erythrocytes by Back-scattering Interferometry Malaria Journal. Feb, 2015 | Pubmed ID: 25889240 Revealing the Sequence and Resulting Cellular Morphology of Receptor-ligand Interactions During Plasmodium Falciparum Invasion of Erythrocytes PLoS Pathogens. Feb, 2015 | Pubmed ID: 25723550 A Human Platelet Receptor Protein Microarray Identifies the High Affinity Immunoglobulin E Receptor Subunit α (FcεR1α) As an Activating Platelet Endothelium Aggregation Receptor 1 (PEAR1) Ligand Molecular & Cellular Proteomics : MCP. May, 2015 | Pubmed ID: 25713122 A PfRH5-based Vaccine is Efficacious Against Heterologous Strain Blood-stage Plasmodium Falciparum Infection in Aotus Monkeys Cell Host & Microbe. Jan, 2015 | Pubmed ID: 25590760 Cross-species Fertilization: the Hamster Egg Receptor, Juno, Binds the Human Sperm Ligand, Izumo1 Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Feb, 2015 | Pubmed ID: 25533103 A Panel of Recombinant Monoclonal Antibodies Against Zebrafish Neural Receptors and Secreted Proteins Suitable for Wholemount Immunostaining Biochemical and Biophysical Research Communications. Jan, 2015 | Pubmed ID: 25490391 New Antigens for a Multicomponent Blood-stage Malaria Vaccine Science Translational Medicine. Jul, 2014 | Pubmed ID: 25080477 Izumo Meets Juno: Preventing Polyspermy in Fertilization Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 24906131 Juno is the Egg Izumo Receptor and is Essential for Mammalian Fertilization Nature. Apr, 2014 | Pubmed ID: 24739963 Plasmodium Falciparum Erythrocyte Invasion: Combining Function with Immune Evasion PLoS Pathogens. Mar, 2014 | Pubmed ID: 24651270 Towards a Comprehensive Plasmodium Falciparum Merozoite Cell Surface and Secreted Recombinant Protein Library Malaria Journal. Mar, 2014 | Pubmed ID: 24620899 Cloning of Recombinant Monoclonal Antibodies from Hybridomas in a Single Mammalian Expression Plasmid Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24515469 Development of an Antigen Microarray for High Throughput Monoclonal Antibody Selection Biochemical and Biophysical Research Communications. Mar, 2014 | Pubmed ID: 24472540 Neutralization of Plasmodium Falciparum Merozoites by Antibodies Against PfRH5 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2014 | Pubmed ID: 24293631 Naturally Acquired Antibodies Specific for Plasmodium Falciparum Reticulocyte-binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection from Malaria The Journal of Infectious Diseases. Mar, 2014 | Pubmed ID: 24133188 RH5-Basigin Interaction Plays a Major Role in the Host Tropism of Plasmodium Falciparum Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013 | Pubmed ID: 24297912 Biochemical Analysis of the Plasmodium Falciparum Erythrocyte-binding Antigen-175 (EBA175)-glycophorin-A Interaction: Implications for Vaccine Design The Journal of Biological Chemistry. Nov, 2013 | Pubmed ID: 24043627 A Library of Functional Recombinant Cell-surface and Secreted P. Falciparum Merozoite Proteins Molecular & Cellular Proteomics : MCP. Dec, 2013 | Pubmed ID: 24043421 Identifying Novel Plasmodium Falciparum Erythrocyte Invasion Receptors Using Systematic Extracellular Protein Interaction Screens Cellular Microbiology. Aug, 2013 | Pubmed ID: 23617720 Detecting Low-affinity Extracellular Protein Interactions Using Protein Microarrays Current Protocols in Protein Science. Apr, 2013 | Pubmed ID: 23546623 A Full-length Recombinant Plasmodium Falciparum PfRH5 Protein Induces Inhibitory Antibodies That Are Effective Across Common PfRH5 Genetic Variants Vaccine. Jan, 2013 | Pubmed ID: 23146673 Semaphorin-7A is an Erythrocyte Receptor for P. Falciparum Merozoite-specific TRAP Homolog, MTRAP PLoS Pathogens. 2012 | Pubmed ID: 23166499 Enhancing Blockade of Plasmodium Falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies Against PfRH5 and Other Merozoite Antigens PLoS Pathogens. 2012 | Pubmed ID: 23144611 Biochemical and Functional Analysis of Two Plasmodium Falciparum Blood-stage 6-cys Proteins: P12 and P41 PloS One. 2012 | Pubmed ID: 22848665 Genomic Organisation, Embryonic Expression and Biochemical Interactions of the Zebrafish Junctional Adhesion Molecule Family of Receptors PloS One. 2012 | Pubmed ID: 22815827 Do Muscle Founder Cells Exist in Vertebrates? Trends in Cell Biology. Aug, 2012 | Pubmed ID: 22710008 A Benchmarked Protein Microarray-based Platform for the Identification of Novel Low Affinity Extracellular Protein Interactions Analytical Biochemistry. Feb, 2012 | Pubmed ID: 22342946 The Blood-stage Malaria Antigen PfRH5 is Susceptible to Vaccine-inducible Cross-strain Neutralizing Antibody Nature Communications. 2011 | Pubmed ID: 22186897 Jamb and Jamc Are Essential for Vertebrate Myocyte Fusion PLoS Biology. Dec, 2011 | Pubmed ID: 22180726 Basigin is a Receptor Essential for Erythrocyte Invasion by Plasmodium Falciparum Nature. Dec, 2011 | Pubmed ID: 22080952 Neurexins, Neuroligins and LRRTMs: Synaptic Adhesion Getting Fishy Journal of Neurochemistry. Jun, 2011 | Pubmed ID: 21155806 The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways Molecular & Cellular Proteomics : MCP. Dec, 2010 | Pubmed ID: 20935258 Construction of a Large Extracellular Protein Interaction Network and Its Resolution by Spatiotemporal Expression Profiling Molecular & Cellular Proteomics : MCP. Dec, 2010 | Pubmed ID: 20802085 High-throughput Identification of Transient Extracellular Protein Interactions Biochemical Society Transactions. Aug, 2010 | Pubmed ID: 20658977 A Rapid and Scalable Method for Selecting Recombinant Mouse Monoclonal Antibodies BMC Biology. 2010 | Pubmed ID: 20525357 Developmentally Regulated Impediments to Skin Reinnervation by Injured Peripheral Sensory Axon Terminals Current Biology : CB. Dec, 2009 | Pubmed ID: 19962310 A Cell Surface Interaction Network of Neural Leucine-rich Repeat Receptors Genome Biology. 2009 | Pubmed ID: 19765300 Signal Initiation in Biological Systems: the Properties and Detection of Transient Extracellular Protein Interactions Molecular BioSystems. Dec, 2009 | Pubmed ID: 19593473 Large-scale Screening for Novel Low-affinity Extracellular Protein Interactions Genome Research. Apr, 2008 | Pubmed ID: 18296487 Cell Surface Reseptor identifikasjon ved hjelp av genom-skala CRISPR / Cas9 genetiske skjermer Sumana Sharma1,2, Gavin J. Wright1 1Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, 2EMBL-EBI, Wellcome Genome Campus JoVE 60803 유전학
Cell Surface Reseptor identifikasjon ved hjelp av genom-skala CRISPR / Cas9 genetiske skjermer Sumana Sharma1,2, Gavin J. Wright1 1Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, 2EMBL-EBI, Wellcome Genome Campus JoVE 60803 유전학