Irena Levitan Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy University of Illinois at Chicago Biography Publications Institution JoVE Articles Irena Levitan has not added a biography. If you are Irena Levitan and would like to personalize this page please email our Author Liaison for assistance. Publications Shear-Stress Sensitive Inwardly-Rectifying K Channels Regulate Developmental Retinal Angiogenesis by Vessel Regression Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2019 | Pubmed ID: 31145841 Comparative Docking Analysis of Cholesterol Analogs to Ion Channels to Discriminate Between Stereospecific Binding Vs. Stereospecific Response Channels (Austin, Tex.). Dec, 2019 | Pubmed ID: 31033379 Endothelial Stiffening in Dyslipidemia Aging. Jan, 2019 | Pubmed ID: 30674709 Chiral Specificity of Cholesterol Orientation Within Cholesterol Binding Sites in Inwardly Rectifying K Channels Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 30649756 Role of Matrix Metalloproteinases and Histone Deacetylase in Oxidative Stress-induced Degradation of the Endothelial Glycocalyx American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2019 | Pubmed ID: 30632766 Potential Strategies to Reduce Blood Pressure in Treatment-Resistant Hypertension Using Food and Drug Administration-Approved Nanodrug Delivery Platforms Hypertension (Dallas, Tex. : 1979). Feb, 2019 | Pubmed ID: 30624988 Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus Current Topics in Membranes. 2018 | Pubmed ID: 30243442 Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules Biophysical Journal. 10, 2018 | Pubmed ID: 30205899 Comparative Analysis of Endothelial Cell and Sub-endothelial Cell Elastic Moduli in Young and Aged Mice: Role of CD36 Journal of Biomechanics. 07, 2018 | Pubmed ID: 29954596 Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K Channels Journal of the American Heart Association. 03, 2018 | Pubmed ID: 29502106 Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force Biophysical Journal. 02, 2018 | Pubmed ID: 29490252 Proatherogenic Flow Increases Endothelial Stiffness Via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins Arteriosclerosis, Thrombosis, and Vascular Biology. 01, 2018 | Pubmed ID: 29025707 Differential Effects of Sterols on Ion Channels: Stereospecific Binding Vs Stereospecific Response Current Topics in Membranes. 2017 | Pubmed ID: 28863819 OxLDL Induces Endothelial Cell Proliferation Via Rho/ROCK/Akt/p27 Signaling: Opposite Effects of OxLDL and Cholesterol Loading American Journal of Physiology. Cell Physiology. Sep, 2017 | Pubmed ID: 28701359 Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids Biophysical Journal. Jan, 2017 | Pubmed ID: 28122218 Orthogonal Lipid Sensors Identify Transbilayer Asymmetry of Plasma Membrane Cholesterol Nature Chemical Biology. 03, 2017 | Pubmed ID: 28024150 Inwardly Rectifying K Channels Are Major Contributors to Flow-induced Vasodilatation in Resistance Arteries The Journal of Physiology. 04, 2017 | Pubmed ID: 27859264 Paradoxical Impact of Cholesterol on Lipid Packing and Cell Stiffness Frontiers in Bioscience (Landmark Edition). 06, 2016 | Pubmed ID: 27100504 Oxidized LDL Signals Through Rho-GTPase to Induce Endothelial Cell Stiffening and Promote Capillary Formation Journal of Lipid Research. 05, 2016 | Pubmed ID: 26989083 Cholesterol Increases the Open Probability of Cardiac KACh Currents Biochimica Et Biophysica Acta. Oct, 2015 | Pubmed ID: 26196595 Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2 Computational and Structural Biotechnology Journal. Sep, 2014 | Pubmed ID: 25408847 Silencing of Kir2 Channels by Caveolin-1: Cross-talk with Cholesterol The Journal of Physiology. Sep, 2014 | Pubmed ID: 25038242 Cholesterol Binding to Ion Channels Frontiers in Physiology. 2014 | Pubmed ID: 24616704 Upregulated Copper Transporters in Hypoxia-induced Pulmonary Hypertension PloS One. 2014 | Pubmed ID: 24614111 Oxidized Low-density Lipoprotein Alters the Effect of Matrix Stiffness on the Formation of Endothelial Networks and Capillary Lumens Pulmonary Circulation. Sep, 2013 | Pubmed ID: 24618546 Identification of Novel Cholesterol-binding Regions in Kir2 Channels The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24019518 Cholesterol Sensitivity of KIR2.1 Depends on Functional Inter-links Between the N and C Termini Channels (Austin, Tex.). Jul-Aug, 2013 | Pubmed ID: 23807091 Regulation of Ion Channels by Membrane Lipids Comprehensive Physiology. Jan, 2012 | Pubmed ID: 23728970 Distant Cytosolic Residues Mediate a Two-way Molecular Switch That Controls the Modulation of Kir Channels by Cholesterol and PI(4,5)P2 The Journal of Biological Chemistry. Sep, 2012 | Pubmed ID: 22995912 OxLDL and Substrate Stiffness Promote Neutrophil Transmigration by Enhanced Endothelial Cell Contractility and ICAM-1 Journal of Biomechanics. Jun, 2012 | Pubmed ID: 22560286 The Role of Oxysterols in Control of Endothelial Stiffness Journal of Lipid Research. Jul, 2012 | Pubmed ID: 22496390 New Mechanisms of Pulmonary Arterial Hypertension: Role of Ca²⺠Signaling American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2012 | Pubmed ID: 22245772 Hypercholesterolemia Induces Up-regulation of KACh Cardiac Currents Via a Mechanism Independent of Phosphatidylinositol 4,5-bisphosphate and Gβγ The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22174416 Novel Role of P66Shc in ROS-dependent VEGF Signaling and Angiogenesis in Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2012 | Pubmed ID: 22101521 Cholesterol Depletion Facilitates Recovery from Hypotonic Cell Swelling in CHO Cells Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2011 | Pubmed ID: 22179012 Cholesterol Regulates Prokaryotic Kir Channel by Direct Binding to Channel Protein Biochimica Et Biophysica Acta. Oct, 2011 | Pubmed ID: 21798234 Impact of OxLDL on Cholesterol-Rich Membrane Rafts Journal of Lipids. 2011 | Pubmed ID: 21490811 Anthrax Lethal Factor Activates K(+) Channels to Induce IL-1β Secretion in Macrophages Journal of Immunology (Baltimore, Md. : 1950). May, 2011 | Pubmed ID: 21421849 Cholesterol Sensitivity of KIR2.1 is Controlled by a Belt of Residues Around the Cytosolic Pore Biophysical Journal. Jan, 2011 | Pubmed ID: 21244834 Modification of Cellular Cholesterol Content Affects Traction Force, Adhesion and Cell Spreading Cellular and Molecular Bioengineering. Jun, 2010 | Pubmed ID: 21461187 OxLDL-induced Decrease in Lipid Order of Membrane Domains is Inversely Correlated with Endothelial Stiffness and Network Formation American Journal of Physiology. Cell Physiology. Aug, 2010 | Pubmed ID: 20410437 Cholesterol and Ion Channels Sub-cellular Biochemistry. 2010 | Pubmed ID: 20213557 Comparative Analysis of Cholesterol Sensitivity of Kir Channels: Role of the CD Loop Channels (Austin, Tex.). Jan-Feb, 2010 | Pubmed ID: 19923917 Oxidized LDL: Diversity, Patterns of Recognition, and Pathophysiology Antioxidants & Redox Signaling. Jul, 2010 | Pubmed ID: 19888833 Direct Regulation of Prokaryotic Kir Channel by Cholesterol The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19740741 Cholesterol and Kir Channels IUBMB Life. Aug, 2009 | Pubmed ID: 19548316 Identification of a C-terminus Domain Critical for the Sensitivity of Kir2.1 to Cholesterol Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19416905 Endothelial Actin and Cell Stiffness is Modulated by Substrate Stiffness in 2D and 3D Journal of Biomechanics. May, 2009 | Pubmed ID: 19356760 OxLDL Facilitates Flow-induced Realignment of Aortic Endothelial Cells American Journal of Physiology. Cell Physiology. Aug, 2008 | Pubmed ID: 18562483 Lipid Rafts in Membrane-cytoskeleton Interactions and Control of Cellular Biomechanics: Actions of OxLDL Antioxidants & Redox Signaling. Sep, 2007 | Pubmed ID: 17576163 The Effect of Cellular Cholesterol on Membrane-cytoskeleton Adhesion Journal of Cell Science. Jul, 2007 | Pubmed ID: 17550968 Use of Cyclodextrins to Manipulate Plasma Membrane Cholesterol Content: Evidence, Misconceptions and Control Strategies Biochimica Et Biophysica Acta. Jun, 2007 | Pubmed ID: 17493580 Hypercholesterolemia Suppresses Kir Channels in Porcine Bone Marrow Progenitor Cells in Vivo Biochemical and Biophysical Research Communications. Jun, 2007 | Pubmed ID: 17482574 Relationship Between Kir2.1/Kir2.3 Activity and Their Distributions Between Cholesterol-rich and Cholesterol-poor Membrane Domains American Journal of Physiology. Cell Physiology. Jul, 2007 | Pubmed ID: 17459945 Hypercholesterolemia Suppresses Inwardly Rectifying K+ Channels in Aortic Endothelium in Vitro and in Vivo Circulation Research. Apr, 2006 | Pubmed ID: 16556870 OxLDL Increases Endothelial Stiffness, Force Generation, and Network Formation Journal of Lipid Research. Apr, 2006 | Pubmed ID: 16418538 Functional Expression of Kir2.x in Human Aortic Endothelial Cells: the Dominant Role of Kir2.2 American Journal of Physiology. Cell Physiology. Nov, 2005 | Pubmed ID: 15958527 Cholesterol Sensitivity and Lipid Raft Targeting of Kir2.1 Channels Biophysical Journal. Dec, 2004 | Pubmed ID: 15465867 Cholesterol Depletion Increases Membrane Stiffness of Aortic Endothelial Cells Biophysical Journal. Nov, 2004 | Pubmed ID: 15347591 Plasma Membrane Surface Increases with Tonic Stretch of Alveolar Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. Aug, 2004 | Pubmed ID: 15016618 Sensitivity of Volume-regulated Anion Current to Cholesterol Structural Analogues The Journal of General Physiology. Jan, 2004 | Pubmed ID: 14699079 Shear Stress Increases Expression of a KATP Channel in Rat and Bovine Pulmonary Vascular Endothelial Cells American Journal of Physiology. Cell Physiology. Oct, 2003 | Pubmed ID: 12826604 Modulation of Endothelial Inward-rectifier K+ Current by Optical Isomers of Cholesterol Biophysical Journal. Dec, 2002 | Pubmed ID: 12496090 Dual Effect of Fluid Shear Stress on Volume-regulated Anion Current in Bovine Aortic Endothelial Cells American Journal of Physiology. Cell Physiology. Apr, 2002 | Pubmed ID: 11880259 التسجيلات الكهرولوجية للتيارات الأيونية أحادية الخلية تحت ضغط القص المحدد جيداً Ibra S. Fancher1, Irena Levitan1 1Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago JoVE 59776 면역학 및 감염병학 شفط Micropipette من خلايا الركيزة المرفقة لتقدير تصلب الخليوي Myung-Jin Oh1, Frank Kuhr1, Fitzroy Byfield2, Irena Levitan1 1Section of Respiratory, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois, 2Institute for Medicine and Engineering, University of Pennsylvania JoVE 3886 생체공학
التسجيلات الكهرولوجية للتيارات الأيونية أحادية الخلية تحت ضغط القص المحدد جيداً Ibra S. Fancher1, Irena Levitan1 1Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago JoVE 59776 면역학 및 감염병학
شفط Micropipette من خلايا الركيزة المرفقة لتقدير تصلب الخليوي Myung-Jin Oh1, Frank Kuhr1, Fitzroy Byfield2, Irena Levitan1 1Section of Respiratory, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois, 2Institute for Medicine and Engineering, University of Pennsylvania JoVE 3886 생체공학