Jerome Zack David Geffen School of Medicine University of California, Los Angeles Biography Publications Institution JoVE Articles Jerome Zack has not added a biography. If you are Jerome Zack and would like to personalize this page please email our Author Liaison for assistance. Publications HIV-1-Specific Chimeric Antigen Receptors Based on Broadly-Neutralizing Antibodies Journal of Virology. May, 2016 | Pubmed ID: 27226366 Medial HOXA Genes Demarcate Haematopoietic Stem Cell Fate During Human Development Nature Cell Biology. Jun, 2016 | Pubmed ID: 27183470 A Single CRISPR-Cas9 Deletion Strategy That Targets the Majority of DMD Patients Restores Dystrophin Function in HiPSC-Derived Muscle Cells Cell Stem Cell. Apr, 2016 | Pubmed ID: 26877224 Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary AIDS Research and Human Retroviruses. Feb, 2016 | Pubmed ID: 26670361 Disruption of Type I Interferon Induction by HIV Infection of T Cells PloS One. 2015 | Pubmed ID: 26375588 Corrigendum: Cocaine Exposure Impairs Multilineage Hematopoiesis of Human Hematopoietic Progenitor Cells Mediated by the Sigma-1 Receptor Scientific Reports. 2015 | Pubmed ID: 26166708 Cocaine-mediated Impact on HIV Infection in Humanized BLT Mice Scientific Reports. 2015 | Pubmed ID: 26084721 HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2015 | Pubmed ID: 26050990 Noninvasive Detection of Tumor-infiltrating T Cells by PET Reporter Imaging The Journal of Clinical Investigation. May, 2015 | Pubmed ID: 25822024 Lymphoid Regeneration from Gene-corrected SCID-X1 Subject-derived IPSCs Cell Stem Cell. Apr, 2015 | Pubmed ID: 25772073 Cocaine Exposure Impairs Multilineage Hematopoiesis of Human Hematopoietic Progenitor Cells Mediated by the Sigma-1 Receptor [corrected] Scientific Reports. 2015 | Pubmed ID: 25728014 RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice Molecular Therapy. Nucleic Acids. 2015 | Pubmed ID: 25689223 Studies of Retroviral Infection in Humanized Mice Virology. May, 2015 | Pubmed ID: 25680625 Double Trouble: HIV Latency and CTL Escape Cell Host & Microbe. Feb, 2015 | Pubmed ID: 25674977 Neutralizing the HIV Reservoir Cell. Aug, 2014 | Pubmed ID: 25171398 Bioengineered Vaults: Self-assembling Protein Shell-lipophilic Core Nanoparticles for Drug Delivery ACS Nano. Aug, 2014 | Pubmed ID: 25061969 CD4 Ligation on Human Blood Monocytes Triggers Macrophage Differentiation and Enhances HIV Infection Journal of Virology. Sep, 2014 | Pubmed ID: 24942581 Adoptive Transfer of MART-1 T-cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2014 | Pubmed ID: 24634374 Generation and Characterization of Transgene-free Human Induced Pluripotent Stem Cells and Conversion to Putative Clinical-grade Status Stem Cell Research & Therapy. Jul, 2013 | Pubmed ID: 23890092 HIV-1 Infection of Hematopoietic Progenitor Cells in Vivo in Humanized Mice Blood. Sep, 2013 | Pubmed ID: 23886835 Cocaine Exposure Enhances Permissiveness of Quiescent T Cells to HIV Infection Journal of Leukocyte Biology. Oct, 2013 | Pubmed ID: 23817564 Highly Potent, Synthetically Accessible Prostratin Analogs Induce Latent HIV Expression in Vitro and Ex Vivo Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23812750 HIV/AIDS Eradication Bioorganic & Medicinal Chemistry Letters. Jul, 2013 | Pubmed ID: 23735743 HIV Restriction in Quiescent CD4⁺ T Cells Retrovirology. 2013 | Pubmed ID: 23557201 Introduction of Exogenous T-cell Receptors into Human Hematopoietic Progenitors Results in Exclusion of Endogenous T-cell Receptor Expression Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2013 | Pubmed ID: 23481324 Interferon-inducible Cholesterol-25-hydroxylase Broadly Inhibits Viral Entry by Production of 25-hydroxycholesterol Immunity. Jan, 2013 | Pubmed ID: 23273844 From Skin Biopsy to Neurons Through a Pluripotent Intermediate Under Good Manufacturing Practice Protocols Stem Cells Translational Medicine. Jan, 2012 | Pubmed ID: 23197638 Designed, Synthetically Accessible Bryostatin Analogues Potently Induce Activation of Latent HIV Reservoirs in Vitro Nature Chemistry. Sep, 2012 | Pubmed ID: 22914190 Virological Evidence Supporting the Use of Raltegravir in HIV Post-exposure Prophylaxis Regimens Antiviral Therapy. 2012 | Pubmed ID: 22820096 In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells PLoS Pathogens. 2012 | Pubmed ID: 22511873 HIV Latency in the Humanized BLT Mouse Journal of Virology. Jan, 2012 | Pubmed ID: 22072769 Antitumor Activity from Antigen-specific CD8 T Cells Generated in Vivo from Genetically Engineered Human Hematopoietic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22123951 Genome-wide Binding Map of the HIV-1 Tat Protein to the Human Genome PloS One. 2011 | Pubmed ID: 22073215 HIV Latency is Influenced by Regions of the Viral Genome Outside of the Long Terminal Repeats and Regulatory Genes Virology. Sep, 2011 | Pubmed ID: 21777932 Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt Stem Cells International. 2011 | Pubmed ID: 21716651 Single Mutations in HIV Integrase Confer High-level Resistance to Raltegravir in Primary Human Macrophages Antimicrobial Agents and Chemotherapy. Aug, 2011 | Pubmed ID: 21628534 Activation of Latent HIV Using Drug-loaded Nanoparticles PloS One. 2011 | Pubmed ID: 21483687 Stem Cell-based Approaches to Treating HIV Infection Current Opinion in HIV and AIDS. Jan, 2011 | Pubmed ID: 21242896 Establishment and Maintenance of HIV Latency: Model Systems and Opportunities for Intervention Future Virology. Jan, 2010 | Pubmed ID: 21318097 Female Human IPSCs Retain an Inactive X Chromosome Cell Stem Cell. Sep, 2010 | Pubmed ID: 20727844 Quiescent T Cells and HIV: an Unresolved Relationship Immunologic Research. Dec, 2010 | Pubmed ID: 20725862 CD40 Ligand (CD154) Incorporated into HIV Virions Induces Activation-induced Cytidine Deaminase (AID) Expression in Human B Lymphocytes PloS One. 2010 | Pubmed ID: 20625427 Gene Expression and Transcription Factor Profiling Reveal Inhibition of Transcription Factor CAMP-response Element-binding Protein by Gamma-herpesvirus Replication and Transcription Activator The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20516076 Differential Expression and Interaction of Host Factors Augment HIV-1 Gene Expression in Neonatal Mononuclear Cells Virology. Apr, 2010 | Pubmed ID: 20138641 A Highly Efficient Short Hairpin RNA Potently Down-regulates CCR5 Expression in Systemic Lymphoid Organs in the Hu-BLT Mouse Model Blood. Feb, 2010 | Pubmed ID: 20018916 Macrophage Differentiation from Embryoid Bodies Derived from Human Embryonic Stem Cells Journal of Stem Cells. 2009 | Pubmed ID: 20498689 Engineering Antigen-specific T Cells from Genetically Modified Human Hematopoietic Stem Cells in Immunodeficient Mice PloS One. 2009 | Pubmed ID: 19997617 Human Immunodeficiency Virus Integration Efficiency and Site Selection in Quiescent CD4+ T Cells Journal of Virology. Jun, 2009 | Pubmed ID: 19369341 CD4+ NK Cells Can Be Productively Infected with HIV, Leading to Downregulation of CD4 Expression and Changes in Function Virology. Apr, 2009 | Pubmed ID: 19251297 A Self-renewal Program Controls the Expansion of Genetically Unstable Cancer Stem Cells in Pluripotent Stem Cell-derived Tumors Stem Cells (Dayton, Ohio). Jan, 2009 | Pubmed ID: 19224508 Phase 2 Gene Therapy Trial of an Anti-HIV Ribozyme in Autologous CD34+ Cells Nature Medicine. Mar, 2009 | Pubmed ID: 19219022 Differentially Stimulated CD4+ T Cells Display Altered Human Immunodeficiency Virus Infection Kinetics: Implications for the Efficacy of Antiviral Agents Journal of Virology. Apr, 2009 | Pubmed ID: 19129455 Eradication of HIV: Current Challenges and New Directions The Journal of Antimicrobial Chemotherapy. Jan, 2009 | Pubmed ID: 18984648 Generation of T Lineage Cells from Human Embryonic Stem Cells in a Feeder Free System Stem Cells (Dayton, Ohio). Jan, 2009 | Pubmed ID: 18974209 A Functional Link Between Wnt Signaling and SKP2-independent P27 Turnover in Mammary Tumors Genes & Development. Nov, 2008 | Pubmed ID: 19056892 Short Communication: Activating Stimuli Enhance Immunotoxin-mediated Killing of HIV-infected Macrophages AIDS Research and Human Retroviruses. Nov, 2008 | Pubmed ID: 19000022 Primary Cell Model for Activation-inducible Human Immunodeficiency Virus Journal of Virology. Jul, 2007 | Pubmed ID: 17475639 Human Immunodeficiency Virus Bearing a Disrupted Central DNA Flap is Pathogenic in Vivo Journal of Virology. Jun, 2007 | Pubmed ID: 17392373 Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-induced Decrease in Virus Level in Simian Immunodeficiency Virus Mac251-infected Macaques Journal of Immunology (Baltimore, Md. : 1950). Mar, 2007 | Pubmed ID: 17339444 Immediate Activation Fails to Rescue Efficient Human Immunodeficiency Virus Replication in Quiescent CD4+ T Cells Journal of Virology. Apr, 2007 | Pubmed ID: 17229711 Animal Models of HIV-1 Latency and Persistence Current Opinion in HIV and AIDS. Mar, 2006 | Pubmed ID: 19372792 A Plea for Justice for Jailed Medical Workers Science (New York, N.Y.). Nov, 2006 | Pubmed ID: 17062652 CD4 Expression on Activated NK Cells: Ligation of CD4 Induces Cytokine Expression and Cell Migration Journal of Immunology (Baltimore, Md. : 1950). Sep, 2006 | Pubmed ID: 16951326 T Lineage Differentiation from Human Embryonic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16844782 Rapid Expression of Human Immunodeficiency Virus Following Activation of Latently Infected Cells Journal of Virology. Feb, 2006 | Pubmed ID: 16415036 PTEN Negatively Regulates Neural Stem Cell Self-renewal by Modulating G0-G1 Cell Cycle Entry Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16373498 Serum Levels of the Homeostatic B Cell Chemokine, CXCL13, Are Elevated During HIV Infection Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Nov, 2005 | Pubmed ID: 16318584 Rapid Size Dependent Deletion of Foreign Gene Sequences Inserted into Attenuated HIV-1 Upon Infection in Vivo: Implications for Vaccine Development Current HIV Research. Oct, 2005 | Pubmed ID: 16250884 Beta-Adrenoreceptors Reactivate Kaposi's Sarcoma-associated Herpesvirus Lytic Replication Via PKA-dependent Control of Viral RTA Journal of Virology. Nov, 2005 | Pubmed ID: 16227274 Prostratin and Bortezomib Are Novel Inducers of Latent Kaposi's Sarcoma-associated Herpesvirus Antiviral Therapy. 2005 | Pubmed ID: 16218174 The CD4 Molecule on CD8+ T Lymphocytes Directly Enhances the Immune Response to Viral and Cellular Antigens Proceedings of the National Academy of Sciences of the United States of America. Mar, 2005 | Pubmed ID: 15731353 Expression-based Monitoring of Transcription Factor Activity: the TELiS Database Bioinformatics (Oxford, England). Mar, 2005 | Pubmed ID: 15374858 Alcohol Enhances HIV Type 1 Infection in Normal Human Oral Keratinocytes by Up-regulating Cell-surface CXCR4 Coreceptor AIDS Research and Human Retroviruses. May, 2004 | Pubmed ID: 15186526 CD4 on CD8(+) T Cells Directly Enhances Effector Function and is a Target for HIV Infection Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15173593 Stress-induced Enhancement of NF-kappaB DNA-binding in the Peripheral Blood Leukocyte Pool: Effects of Lymphocyte Redistribution Brain, Behavior, and Immunity. May, 2004 | Pubmed ID: 15050650 Anti-human Immunodeficiency Virus Hematopoietic Progenitor Cell-delivered Ribozyme in a Phase I Study: Myeloid and Lymphoid Reconstitution in Human Immunodeficiency Virus Type-1-infected Patients Human Gene Therapy. Mar, 2004 | Pubmed ID: 15018734 The CCR5 and CXCR4 Coreceptors--central to Understanding the Transmission and Pathogenesis of Human Immunodeficiency Virus Type 1 Infection AIDS Research and Human Retroviruses. Jan, 2004 | Pubmed ID: 15000703 Public Health. A Sound Rationale Needed for Phase III HIV-1 Vaccine Trials Science (New York, N.Y.). Jan, 2004 | Pubmed ID: 14726576 Impacts of Epitope Expression Kinetics and Class I Downregulation on the Antiviral Activity of Human Immunodeficiency Virus Type 1-specific Cytotoxic T Lymphocytes Journal of Virology. Jan, 2004 | Pubmed ID: 14694087 Psychological Risk Factors for HIV Pathogenesis: Mediation by the Autonomic Nervous System Biological Psychiatry. Dec, 2003 | Pubmed ID: 14675810 Identification of T Cell-signaling Pathways That Stimulate Latent HIV in Primary Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2003 | Pubmed ID: 14569007 Controlling False-negative Errors in Microarray Differential Expression Analysis: a PRIM Approach Bioinformatics (Oxford, England). Sep, 2003 | Pubmed ID: 14512352 Molecular Characterization, Reactivation, and Depletion of Latent HIV Immunity. Sep, 2003 | Pubmed ID: 14499116 HIV-1 Infection in Peripheral Blood Lymphocytes (PBLs) Exposed to Alcohol Virology. Mar, 2003 | Pubmed ID: 12667812 Human Immunodeficiency Virus Type 1 Infection and Replication in Normal Human Oral Keratinocytes Journal of Virology. Mar, 2003 | Pubmed ID: 12610122 HIV Type 1 Infection Alters Cytokine MRNA Expression in Thymus AIDS Research and Human Retroviruses. Jan, 2003 | Pubmed ID: 12581511 Interleukin-7 Induces Expression of Latent Human Immunodeficiency Virus Type 1 with Minimal Effects on T-cell Phenotype Journal of Virology. Dec, 2002 | Pubmed ID: 12438635 Effects of Prostratin on T-cell Activation and Human Immunodeficiency Virus Latency Journal of Virology. Aug, 2002 | Pubmed ID: 12134017 Cocaine Enhances Human Immunodeficiency Virus Replication in a Model of Severe Combined Immunodeficient Mice Implanted with Human Peripheral Blood Leukocytes The Journal of Infectious Diseases. Mar, 2002 | Pubmed ID: 11865430 Retrocyclin: a Primate Peptide That Protects Cells from Infection by T- and M-tropic Strains of HIV-1 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11854483 Effect of Latent Human Immunodeficiency Virus Infection on Cell Surface Phenotype Journal of Virology. Feb, 2002 | Pubmed ID: 11799162 Activation of CD8 T Cells Induces Expression of CD4, Which Functions As a Chemotactic Receptor Blood. Jan, 2002 | Pubmed ID: 11756173 Stamcel-Based Engineered immuniteit tegen HIV infectie in het gehumaniseerde muismodel Anjie Zhen1, Valerie Rezek1, Cindy Youn1, Jonathan Rick1, Brianna Lam1, Nelson Chang1, Jerome Zack1, Masakazu Kamata1, Scott Kitchen1 1David Geffen School of Medicine, University of California, Los Angeles 의학
Stamcel-Based Engineered immuniteit tegen HIV infectie in het gehumaniseerde muismodel Anjie Zhen1, Valerie Rezek1, Cindy Youn1, Jonathan Rick1, Brianna Lam1, Nelson Chang1, Jerome Zack1, Masakazu Kamata1, Scott Kitchen1 1David Geffen School of Medicine, University of California, Los Angeles 의학