Johannes B. Huppa Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna Biography Publications Institution JoVE Articles Johannes B. Huppa has not added a biography. If you are Johannes B. Huppa and would like to personalize this page please email our Author Liaison for assistance. Publications Three-Dimensional Single Molecule Localization Microscopy Reveals the Topography of the Immunological Synapse at Isotropic Precision Below 15 Nm Nano Letters. Nov, 2021 | Pubmed ID: 34709845 Strategies for the Site-Specific Decoration of DNA Origami Nanostructures with Functionally Intact Proteins ACS Nano. 09, 2021 | Pubmed ID: 34463486 Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus Frontiers in Immunology. 2021 | Pubmed ID: 34194424 Temporal Analysis of T-cell Receptor-imposed Forces Via Quantitative Single Molecule FRET Measurements Nature Communications. 05, 2021 | Pubmed ID: 33947864 Adjuvants and Vaccines Used in Allergen-Specific Immunotherapy Induce Neutrophil Extracellular Traps Vaccines. Apr, 2021 | Pubmed ID: 33915724 SARS-CoV-2 Mutations in MHC-I-restricted Epitopes Evade CD8 T Cell Responses Science Immunology. 03, 2021 | Pubmed ID: 33664060 Histone Deacetylase 1 Controls CD4 T Cell Trafficking in Autoinflammatory Diseases Journal of Autoimmunity. 05, 2021 | Pubmed ID: 33621930 A Multimodal Platform for Simultaneous T-Cell Imaging, Defined Activation, and Mechanobiological Characterization Cells. 01, 2021 | Pubmed ID: 33504075 DNA Origami Demonstrate the Unique Stimulatory Power of Single PMHCs As T Cell Antigens Proceedings of the National Academy of Sciences of the United States of America. 01, 2021 | Pubmed ID: 33468643 Functionalized Bead Assay to Measure Three-dimensional Traction Forces During T-cell Activation Nano Letters. 01, 2021 | Pubmed ID: 33305952 Unscrambling Fluorophore Blinking for Comprehensive Cluster Detection Via Photoactivated Localization Microscopy Nature Communications. 10, 2020 | Pubmed ID: 33020470 Engineering AvidCARs for Combinatorial Antigen Recognition and Reversible Control of CAR Function Nature Communications. 08, 2020 | Pubmed ID: 32820173 The Cytoskeletal Regulator HEM1 Governs B Cell Development and Prevents Autoimmunity Science Immunology. 07, 2020 | Pubmed ID: 32646852 Inefficient CAR-proximal Signaling Blunts Antigen Sensitivity Nature Immunology. 08, 2020 | Pubmed ID: 32632291 TIM-3 and CEACAM1 Do Not Interact in Cis and in Trans European Journal of Immunology. 08, 2020 | Pubmed ID: 32222966 Getting CD19 Into Shape: Expression of Natively Folded "Difficult-to- Express" CD19 for Staining and Stimulation of CAR-T Cells Frontiers in Bioengineering and Biotechnology. 2020 | Pubmed ID: 32117929 Homo- and Heteroassociations Drive Activation Of ErbB3 Biophysical Journal. 11, 2019 | Pubmed ID: 31653451 How Drag Sharpens a T Cell's View on Antigen Proceedings of the National Academy of Sciences of the United States of America. 08, 2019 | Pubmed ID: 31371492 TCRs Are Randomly Distributed on the Plasma Membrane of Resting Antigen-experienced T Cells Nature Immunology. 08, 2018 | Pubmed ID: 30013143 Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances Frontiers in Immunology. 2018 | Pubmed ID: 29780382 Mutations Affecting the Actin Regulator WD Repeat-containing Protein 1 Lead to Aberrant Lymphoid Immunity The Journal of Allergy and Clinical Immunology. 11, 2018 | Pubmed ID: 29751004 Monomeric TCRs Drive T Cell Antigen Recognition Nature Immunology. May, 2018 | Pubmed ID: 29662172 A Cellular Platform for the Evaluation of Immune Checkpoint Molecules Oncotarget. Sep, 2017 | Pubmed ID: 29029399 Förster Resonance Energy Transfer to Study TCR-pMHC Interactions in the Immunological Synapse Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28255705 RASGRP1 Deficiency Causes Immunodeficiency with Impaired Cytoskeletal Dynamics Nature Immunology. Dec, 2016 | Pubmed ID: 27776107 Assessment of Costimulation and Coinhibition in a Triple Parameter T Cell Reporter Line: Simultaneous Measurement of NF-κB, NFAT and AP-1 Journal of Immunological Methods. Mar, 2016 | Pubmed ID: 26780292 Rapid Multiplex Analysis of Lipid Raft Components with Single-cell Resolution Science Signaling. 2015 | Pubmed ID: 26396269 The Interdisciplinary Science of T-cell Recognition Advances in Immunology. 2013 | Pubmed ID: 23886063 Distinct TCR Signaling Pathways Drive Proliferation and Cytokine Production in T Cells Nature Immunology. Feb, 2013 | Pubmed ID: 23377202 Determination of Interaction Kinetics Between the T Cell Receptor and Peptide-loaded MHC Class II Via Single-molecule Diffusion Measurements Biophysical Journal. Jul, 2012 | Pubmed ID: 22853916 Photocrosslinkable PMHC Monomers Stain T Cells Specifically and Cause Ligand-bound TCRs to Be 'preferentially' Transported to the CSMAC Nature Immunology. Jul, 2012 | Pubmed ID: 22660579 Functional Development of the T Cell Receptor for Antigen Progress in Molecular Biology and Translational Science. 2010 | Pubmed ID: 20800817 Evidence for a Functional Sidedness to the AlphabetaTCR Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20202921 TCR-peptide-MHC Interactions in Situ Show Accelerated Kinetics and Increased Affinity Nature. Feb, 2010 | Pubmed ID: 20164930 TCR and Lat Are Expressed on Separate Protein Islands on T Cell Membranes and Concatenate During Activation Nature Immunology. Jan, 2010 | Pubmed ID: 20010844 A Hybrid Machine-learning Approach for Segmentation of Protein Localization Data Bioinformatics (Oxford, England). Oct, 2005 | Pubmed ID: 16091410 Agonist/endogenous Peptide-MHC Heterodimers Drive T Cell Activation and Sensitivity Nature. Mar, 2005 | Pubmed ID: 15724150 Quantitative Imaging of Lymphocyte Membrane Protein Reorganization and Signaling Biophysical Journal. Jan, 2005 | Pubmed ID: 15501943 CD4 Enhances T Cell Sensitivity to Antigen by Coordinating Lck Accumulation at the Immunological Synapse Nature Immunology. Aug, 2004 | Pubmed ID: 15247914 T Cell Killing Does Not Require the Formation of a Stable Mature Immunological Synapse Nature Immunology. May, 2004 | Pubmed ID: 15048111 Linking Molecular and Cellular Events in T-cell Activation and Synapse Formation Seminars in Immunology. Dec, 2003 | Pubmed ID: 15001169 T-cell-antigen Recognition and the Immunological Synapse Nature Reviews. Immunology. Dec, 2003 | Pubmed ID: 14647479 Dynamics of Cell Surface Molecules During T Cell Recognition Annual Review of Biochemistry. 2003 | Pubmed ID: 14527326 Continuous T Cell Receptor Signaling Required for Synapse Maintenance and Full Effector Potential Nature Immunology. Aug, 2003 | Pubmed ID: 12858171 Automatiseret todimensionel Spatiotemporal Analyse af Mobile Enkeltmolekyle FRET Probes Lukas Schrangl1, Janett Göhring2, Florian Kellner2, Johannes B. Huppa2, Gerhard J. Schütz1 1Institute of Applied Physics, TU Wien, 2Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna JoVE 63124 생체공학 Single Molecule Fluorescens Mikroskopi på Planar Understøttet dobbeltlag Markus Axmann1, Gerhard J. Schütz1, Johannes B. Huppa2 1Institute of Applied Physics - Biophysics, Vienna University of Technology, 2Institute for Hygiene and Applied Immunology, Immune Recognition Unit, Medical University of Vienna 생체공학 Måling TCR-pMHC Binding Markus Axmann1, Gerhard J. Schütz1, Johannes B. Huppa2 1Institute for Applied Physics - Biophysics, Vienna University of Technology, 2Institute for Hygiene and Applied Immunology, Medical University of Vienna 생체공학
Automatiseret todimensionel Spatiotemporal Analyse af Mobile Enkeltmolekyle FRET Probes Lukas Schrangl1, Janett Göhring2, Florian Kellner2, Johannes B. Huppa2, Gerhard J. Schütz1 1Institute of Applied Physics, TU Wien, 2Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna JoVE 63124 생체공학
Single Molecule Fluorescens Mikroskopi på Planar Understøttet dobbeltlag Markus Axmann1, Gerhard J. Schütz1, Johannes B. Huppa2 1Institute of Applied Physics - Biophysics, Vienna University of Technology, 2Institute for Hygiene and Applied Immunology, Immune Recognition Unit, Medical University of Vienna 생체공학
Måling TCR-pMHC Binding Markus Axmann1, Gerhard J. Schütz1, Johannes B. Huppa2 1Institute for Applied Physics - Biophysics, Vienna University of Technology, 2Institute for Hygiene and Applied Immunology, Medical University of Vienna 생체공학