John S. Condeelis Department of Anatomy and Structural Biology Albert Einstein College of Medicine Biography Publications Institution JoVE Articles John S. Condeelis has not added a biography. If you are John S. Condeelis and would like to personalize this page please email our Author Liaison for assistance. Publications Ribosome Biogenesis During Cell Cycle Arrest Fuels EMT in Development and Disease Nature Communications. 05, 2019 | Pubmed ID: 31068593 Optimizing Leading Edge F-actin Labeling Using Multiple Actin Probes, Fixation Methods and Imaging Modalities BioTechniques. Mar, 2019 | Pubmed ID: 30869550 The Emerging Roles of Macrophages in Cancer Metastasis and Response to Chemotherapy Journal of Leukocyte Biology. Feb, 2019 | Pubmed ID: 30720887 Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models Cancer Discovery. 01, 2019 | Pubmed ID: 30361447 Loss of Amphiregulin Reduces Myoepithelial Cell Coverage of Mammary Ducts and Alters Breast Tumor Growth Breast Cancer Research : BCR. 10, 2018 | Pubmed ID: 30367629 Black Race and Distant Recurrence After Neoadjuvant or Adjuvant Chemotherapy in Breast Cancer Clinical & Experimental Metastasis. 10, 2018 | Pubmed ID: 30136072 The Different Routes to Metastasis Via Hypoxia-Regulated Programs Trends in Cell Biology. 11, 2018 | Pubmed ID: 30041830 Myosin-IIA Heavy Chain Phosphorylation on S1943 Regulates Tumor Metastasis Experimental Cell Research. Sep, 2018 | Pubmed ID: 29953877 Targeting Invadopodia-mediated Breast Cancer Metastasis by Using ABL Kinase Inhibitors Oncotarget. Apr, 2018 | Pubmed ID: 29774130 A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation Cell Reports. May, 2018 | Pubmed ID: 29719241 A Novel Neuregulin - Jagged1 Paracrine Loop in Breast Cancer Transendothelial Migration Breast Cancer Research : BCR. 04, 2018 | Pubmed ID: 29636067 Chemotherapy-induced Metastasis: Mechanisms and Translational Opportunities Clinical & Experimental Metastasis. 04, 2018 | Pubmed ID: 29307118 Pyk2 and FAK Differentially Regulate Invadopodia Formation and Function in Breast Cancer Cells The Journal of Cell Biology. 01, 2018 | Pubmed ID: 29133485 Chemotherapy-induced Metastasis in Breast Cancer Oncotarget. Dec, 2017 | Pubmed ID: 29340008 Rac3 Regulates Breast Cancer Invasion and Metastasis by Controlling Adhesion and Matrix Degradation The Journal of Cell Biology. 12, 2017 | Pubmed ID: 29061650 The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2 Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors Molecular Cancer Therapeutics. 11, 2017 | Pubmed ID: 28838996 Neoadjuvant Chemotherapy Induces Breast Cancer Metastasis Through a TMEM-mediated Mechanism Science Translational Medicine. Jul, 2017 | Pubmed ID: 28679654 Tumor Cell Invadopodia: Invasive Protrusions That Orchestrate Metastasis Trends in Cell Biology. 08, 2017 | Pubmed ID: 28412099 Macrophage-dependent Tumor Cell Transendothelial Migration is Mediated by Notch1/Mena(INV)-initiated Invadopodium Formation Scientific Reports. Nov, 2016 | Pubmed ID: 27901093 Mena Dysregulates Cortactin Phosphorylation to Promote Invadopodium Maturation Scientific Reports. 11, 2016 | Pubmed ID: 27824079 Validation of a Device for the Active Manipulation of the Tumor Microenvironment During Intravital Imaging Intravital. 2016 | Pubmed ID: 27790386 The Alternatively-included 11a Sequence Modifies the Effects of Mena on Actin Cytoskeletal Organization and Cell Behavior Scientific Reports. Oct, 2016 | Pubmed ID: 27748415 Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells EBioMedicine. 11, 2016 | Pubmed ID: 27743905 Signatures of Breast Cancer Metastasis at a Glance Journal of Cell Science. May, 2016 | Pubmed ID: 27084578 GPCR Signaling Mediates Tumor Metastasis Via PI3Kβ Cancer Research. May, 2016 | Pubmed ID: 27013201 3-D Individual Cell Based Computational Modeling of Tumor Cell-macrophage Paracrine Signaling Mediated by EGF and CSF-1 Gradients Integrative Biology : Quantitative Biosciences from Nano to Macro. Jan, 2016 | Pubmed ID: 26686751 Characterization of the Expression of the Pro-metastatic Mena(INV) Isoform During Breast Tumor Progression Clinical & Experimental Metastasis. Mar, 2016 | Pubmed ID: 26680363 PTP1B-dependent Regulation of Receptor Tyrosine Kinase Signaling by the Actin-binding Protein Mena Molecular Biology of the Cell. Nov, 2015 | Pubmed ID: 26337385 Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA Cancer Discovery. Sep, 2015 | Pubmed ID: 26269515 Menacalc, a Quantitative Method of Metastasis Assessment, As a Prognostic Marker for Axillary Node-negative Breast Cancer BMC Cancer. 2015 | Pubmed ID: 26112005 Profilin1 Regulates Invadopodium Maturation in Human Breast Cancer Cells European Journal of Cell Biology. Feb, 2015 | Pubmed ID: 25613364 Autocrine CSF1R Signaling Mediates Switching Between Invasion and Proliferation Downstream of TGFβ in Claudin-low Breast Tumor Cells Oncogene. May, 2015 | Pubmed ID: 25088194 Invasive Breast Carcinoma Cells from Patients Exhibit MenaINV- and Macrophage-dependent Transendothelial Migration Science Signaling. Nov, 2014 | Pubmed ID: 25429076 Digging a Little Deeper: the Stages of Invadopodium Formation and Maturation European Journal of Cell Biology. Oct, 2014 | Pubmed ID: 25113547 An in Vitro One-dimensional Assay to Study Growth Factor-regulated Tumor Cell-macrophage Interaction Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24908299 Metastatic Cells: Moving Onco-targets Oncotarget. Jun, 2014 | Pubmed ID: 24907202 Tumor Microenvironment of Metastasis and Risk of Distant Metastasis of Breast Cancer Journal of the National Cancer Institute. Aug, 2014 | Pubmed ID: 24895374 Talin Regulates Moesin-NHE-1 Recruitment to Invadopodia and Promotes Mammary Tumor Metastasis The Journal of Cell Biology. Jun, 2014 | Pubmed ID: 24891603 Invadopodia in Context Cell Adhesion & Migration. 2014 | Pubmed ID: 24713806 Spatial Regulation of Tumor Cell Protrusions by RhoC Cell Adhesion & Migration. 2014 | Pubmed ID: 24642482 Filamin A Interacting Protein 1-like Inhibits WNT Signaling and MMP Expression to Suppress Cancer Cell Invasion and Metastasis International Journal of Cancer. Jul, 2014 | Pubmed ID: 24327474 Autocrine HBEGF Expression Promotes Breast Cancer Intravasation, Metastasis and Macrophage-independent Invasion in Vivo Oncogene. Jul, 2014 | Pubmed ID: 24013225 Intravital Multiphoton Imaging Reveals Multicellular Streaming As a Crucial Component of in Vivo Cell Migration in Human Breast Tumors Intravital. Apr, 2013 | Pubmed ID: 25013744 Wiskott-Aldrich Syndrome Protein Regulates Leukocyte-dependent Breast Cancer Metastasis Cell Reports. Aug, 2013 | Pubmed ID: 23911287 Dysregulation of PAD4-mediated Citrullination of Nuclear GSK3β Activates TGF-β Signaling and Induces Epithelial-to-mesenchymal Transition in Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23818587 Arg/Abl2 Promotes Invasion and Attenuates Proliferation of Breast Cancer in Vivo Oncogene. May, 2013 | Pubmed ID: 22777352 Development Path and Current Status of the NANIVID: a New Device for Cancer Cell Studies Journal of Micro/nanolithography, MEMS, and MOEMS : JM3. Mar, 2012 | Pubmed ID: 25419258 Reconstitution of in Vivo Macrophage-tumor Cell Pairing and Streaming Motility on One-dimensional Micro-patterned Substrates Intravital. Jul, 2012 | Pubmed ID: 24634804 Selective Gene-expression Profiling of Migratory Tumor Cells in Vivo Predicts Clinical Outcome in Breast Cancer Patients Breast Cancer Research : BCR. 2012 | Pubmed ID: 23113900 Quantitative Assessment of Invasive Mena Isoforms (Menacalc) As an Independent Prognostic Marker in Breast Cancer Breast Cancer Research : BCR. 2012 | Pubmed ID: 22971274 A FRET-facilitated Photoswitching Using an Orange Fluorescent Protein with the Fast Photoconversion Kinetics Journal of the American Chemical Society. Sep, 2012 | Pubmed ID: 22900938 Three-dimensional Microfluidic Model for Tumor Cell Intravasation and Endothelial Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22869695 Korreliert Immunhistochemische Und Zytologischen Proben Für Die Vorhersage Der Hämatogene Verbreitung Von Brustkrebs The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jan, 2012 | Pubmed ID: 22215635 Phosphoinositide 3-kinase Signaling is Critical for ErbB3-driven Breast Cancer Cell Motility and Metastasis Oncogene. Feb, 2012 | Pubmed ID: 21725367 Gegensätzlichen Rollen Von CXCR4 Und CXCR7 in Brust Krebsmetastase Breast Cancer Research : BCR. Dec, 2011 | Pubmed ID: 22152016 Ein EMT-gesteuerte Alternatives Spleißen Programm Tritt Im Menschlichen Brustkrebs Und Moduliert Zelluläre Phänotyp PLoS Genetics. Aug, 2011 | Pubmed ID: 21876675 Eine Photoswitchable-zu Weit-orangerot Fluoreszierenden Proteins, PSmOrange Nature Methods. Sep, 2011 | Pubmed ID: 21804536 Chemotaxis Bei Krebs Nature Reviews. Cancer. Aug, 2011 | Pubmed ID: 21779009 Mena Invasive (MenaINV) Fördert Die Vielzelligen Streaming Motilität Und Transendothelial Migration in Einem Mausmodell an Brustkrebs Journal of Cell Science. Jul, 2011 | Pubmed ID: 21670198 Mena Invasive (Mena(INV)) Und Mena11a Isoformen Spielen Unterschiedliche Rollen Im Brust-Krebs Zelle Zusammenhalt Und Zusammenarbeit Mit TMEM Clinical & Experimental Metastasis. Aug, 2011 | Pubmed ID: 21484349 Mena-Mangel Verzögert Tumor Fortschreiten Und Metastasierung in Polyoma Mitte-T Transgenen Maus Milch-Tumoren Verringert Breast Cancer Research : BCR. 2010 | Pubmed ID: 21108830 Ein Neues Chemotaxis-Gerät Für Zelle Migrationsforschung Integrative Biology : Quantitative Biosciences from Nano to Macro. Nov, 2010 | Pubmed ID: 20938544 AACR Sonderkonferenz Auf Epitheliale-Mesenchymale Transition Und Krebs Fortschreiten Und Behandlung Cancer Research. Oct, 2010 | Pubmed ID: 20823151 Genexpressionsanalyse Der Makrophagen, Die Erleichterung Der Tumorinvasion Unterstützt Eine Rolle Für Wnt-Signalisierung Bei Der Vermittlung Ihrer Aktivität in Primären Mamma-Tumoren Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010 | Pubmed ID: 20018620 Invasion Von Menschlichen Brustkrebszellen In-vivo Erfordert Parakrine Und Autocrine Schleifen Mit Den Kolonie-stimulierende Faktor-1-Rezeptor Cancer Research. Dec, 2009 | Pubmed ID: 19934330 Differenzielle Verstärkung Der Brust Krebs Zelle Motilität Und Metastasierung Von Kegelrad Und Kinase-Domäne-Mutationen Der Klasse IA Phosphoinositid-3-Kinase Cancer Research. Dec, 2009 | Pubmed ID: 19903845 Tumor Mikromilieu Der Metastasierung in Menschlichen Mammakarzinom: Möglicher Prognostischer Marker Mit Hämatogene Verbreitung Verknüpft Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009 | Pubmed ID: 19318480 Identifikation Der Invasion Bestimmte Splice Varianten Des Zytoskelett Proteins Mena in Milch-Tumorzellen Während Invasion In-vivo Clinical & Experimental Metastasis. 2009 | Pubmed ID: 18985426 Ein Mena-Invasion-Isoform Spurenelement EGF-induzierte Karzinom Invasion Und Metastasierung Developmental Cell. Dec, 2008 | Pubmed ID: 19081071 Mechanismen Und Zellulare Rollen Der Lokalen Proteinsynthese in Den Säugetier-Zellen Current Opinion in Cell Biology. Apr, 2008 | Pubmed ID: 18378131 RhoA/ROCK-vermittelte Umschalten Zwischen Cdc42 - Und Rac1-abhängigen Vorwölbung in MTLn3-Karzinom-Zellen Experimental Cell Research. Apr, 2008 | Pubmed ID: 18316075 Imaging in Echtzeit Genexpression in Lebenden Systemen Mit Einzel-Transcript Auflösung: Entwurf Und Imaging System-Setup Zu Erstellen CSH Protocols. 2007 | Pubmed ID: 21356986 Echtzeit-Genexpression in Lebenden Systemen Mit Single-Transcript Resolution Imaging: Einzelne MRNA Particle Tracking Mit ImageJ-basierte Analyse CSH Protocols. 2007 | Pubmed ID: 21356980 Imaging in Echtzeit Genexpression in Lebenden Systemen Mit Einzel-Transcript Auflösung: Bildanalyse Der Einzigen MRNA Transkripte CSH Protocols. 2007 | Pubmed ID: 21356979 Bildgebung in Echtzeit Genexpression in Der Lebenden Hefe CSH Protocols. 2007 | Pubmed ID: 21356978 Imaging in Echtzeit Genexpression in Den Säugetier-Zellen Mit Einzel-Transcript Auflösung CSH Protocols. 2007 | Pubmed ID: 21356977 EGF-induzierte PIP2 Hydrolyse Frei Und Aktiviert Cofilin Lokal in Karzinom-Zellen The Journal of Cell Biology. Dec, 2007 | Pubmed ID: 18086920 ZBP1 Verbessert Die Zellpolarität Und Reduziert Die Chemotaxis Journal of Cell Science. Sep, 2007 | Pubmed ID: 17878234 Cdc42 Ist Für EGF-stimuliert Körper Und Motilität in MTLn3-Karzinom-Zellen Erforderlich Journal of Cell Science. Oct, 2007 | Pubmed ID: 17855387 Die Unterschiedlichen Rollen Von Ras Und Rac in PI 3-Kinase-abhängigen Körper Während Der EGF-stimuliert Zellmigration Journal of Cell Science. Sep, 2007 | Pubmed ID: 17698922 Koordinierte Regulierung Der Wege Für Verstärkte Zelle Motilität Und Chemotaxis Ist in Ratte Und Maus Mamma-Tumoren Konserviert Cancer Research. Apr, 2007 | Pubmed ID: 17440055 Molekulares Klonen Von HMena (ENAH) Und Seine Spleißstelle Variant HMena + 11a: Epidermaler Wachstumsfaktor Erhöht Ihren Ausdruck Und Stimuliert HMena + 11a Phosphorylierung in Brust-Krebs-Zelllinien Cancer Research. Mar, 2007 | Pubmed ID: 17363586 ROCK - Und Myosin-abhängigen Matrix Verformung Ermöglicht Protease-unabhängige Tumor-Zell-Einmarsch In-vivo Current Biology : CB. Aug, 2006 | Pubmed ID: 16890527 Einleitung Von Cofilin Aktivität Als Reaktion Auf EGF Ist Abgekoppelt Von Cofilin Phosphorylierung Und Dephosphorylierung in Karzinom-Zellen Journal of Cell Science. Jul, 2006 | Pubmed ID: 16803871 Der Status Der Aktivität Von Cofilin Bezieht Sich Direkt Auf Invasion, Intravasation Und Metastasierung Von Mamma-Tumoren The Journal of Cell Biology. May, 2006 | Pubmed ID: 16651380 Makrophagen Fördert Die Invasion Von Brustkarzinomzellen über Einen Kolonie-stimulierenden Factor-1/epidermal Wachstumsfaktor Parakrine Schleife Cancer Research. Jun, 2005 | Pubmed ID: 15958574 Tumorzellen Auf Frischer Tat Ertappt Von Eindringenden: Ihre Strategie Für Eine Verstärkte Zell-Motilität Trends in Cell Biology. Mar, 2005 | Pubmed ID: 15752977 Identifizierung Und Prüfung Eines Gensignatur Der Invasiven Karzinom-Zellen in Primären Brusttumoren Cancer Research. Dec, 2004 | Pubmed ID: 15574765 Brustkrebs-Zellen Durch Chemotaxis Von Primären Tumoren Isoliert Wurden, Zeigen Erhöhte Überlebensrate Und Resistenz Gegenüber Chemotherapie Cancer Research. Nov, 2004 | Pubmed ID: 15520165 Die Überexpression Des P110beta Aber Nicht P110alpha Isoform Der PI-3-Kinase Hemmt Motilität in Brustkrebszellen Cell Motility and the Cytoskeleton. Nov, 2004 | Pubmed ID: 15468162 Cofilin Fördert Aktin-Polymerisation Und Definiert Die Richtung Der Zellbewegung Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15118165 Genexpressionsanalyse Auf Eine Kleine Anzahl Von Invasiven Zellen Durch Chemotaxis Von Primären Brusttumoren Der Maus Gesammelt BMC Biotechnology. Aug, 2003 | Pubmed ID: 12914671 GFP-Expression in Der Brustdrüse Zum Abbilden Von Mamma-Tumor-Zellen in Transgenen Mäusen Cancer Research. Dec, 2002 | Pubmed ID: 12499251 Einzel-Zell-Verhalten Bei Metastasiertem Primären Brusttumoren Mit Genexpressionsmuster Korreliert Offenbart Durch Molekulare Profiling Cancer Research. Nov, 2002 | Pubmed ID: 12414658 Eine Neue Strategie Für Käfighaltung Proteine durch Kinasen Reguliert Journal of the American Chemical Society. Mar, 2002 | Pubmed ID: 11890784 Protein Tyrosine Phosphatase Phi Regulates Paxillin Tyrosine Phosphorylation and Mediates Colony-stimulating Factor 1-induced Morphological Changes in Macrophages Molecular and Cellular Biology. Mar, 2001 | Pubmed ID: 11238916 Phosphorylation of ADF/cofilin Abolishes EGF-induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension The Journal of Cell Biology. Nov, 2000 | Pubmed ID: 11086013 Role of Cofilin in Epidermal Growth Factor-stimulated Actin Polymerization and Lamellipod Protrusion The Journal of Cell Biology. Feb, 2000 | Pubmed ID: 10662778 Relationship Between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells After Epidermal Growth Factor Stimulation The Journal of Cell Biology. Apr, 1999 | Pubmed ID: 10209028 Beurteilung der Tumormikroumgebung von Metastasierung Doorway-Vermittelte Vaskuläre Durchlässigkeit im Zusammenhang mit der Krebszellverbreitung mit Intravital Imaging und Fixed Tissue Analysis George S. Karagiannis1,2,3, Jessica M. Pastoriza1,2,4, Lucia Borriello1,2, Rojin Jafari1,2, Anouchka Coste1,2,4, John S. Condeelis1,2,3,4, Maja H. Oktay1,2,3,5, David Entenberg1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 3Integrated Imaging Program, Albert Einstein College of Medicine, 4Department of Surgery, Montefiore Medical Center, 5Department of Pathology, Montefiore Medical Center JoVE 59633 암 연구학
Beurteilung der Tumormikroumgebung von Metastasierung Doorway-Vermittelte Vaskuläre Durchlässigkeit im Zusammenhang mit der Krebszellverbreitung mit Intravital Imaging und Fixed Tissue Analysis George S. Karagiannis1,2,3, Jessica M. Pastoriza1,2,4, Lucia Borriello1,2, Rojin Jafari1,2, Anouchka Coste1,2,4, John S. Condeelis1,2,3,4, Maja H. Oktay1,2,3,5, David Entenberg1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 3Integrated Imaging Program, Albert Einstein College of Medicine, 4Department of Surgery, Montefiore Medical Center, 5Department of Pathology, Montefiore Medical Center JoVE 59633 암 연구학