John S. Condeelis Department of Anatomy and Structural Biology Albert Einstein College of Medicine Biography Publications Institution JoVE Articles John S. Condeelis has not added a biography. If you are John S. Condeelis and would like to personalize this page please email our Author Liaison for assistance. Publications Ribosome Biogenesis During Cell Cycle Arrest Fuels EMT in Development and Disease Nature Communications. 05, 2019 | Pubmed ID: 31068593 Optimizing Leading Edge F-actin Labeling Using Multiple Actin Probes, Fixation Methods and Imaging Modalities BioTechniques. Mar, 2019 | Pubmed ID: 30869550 The Emerging Roles of Macrophages in Cancer Metastasis and Response to Chemotherapy Journal of Leukocyte Biology. Feb, 2019 | Pubmed ID: 30720887 Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models Cancer Discovery. 01, 2019 | Pubmed ID: 30361447 Loss of Amphiregulin Reduces Myoepithelial Cell Coverage of Mammary Ducts and Alters Breast Tumor Growth Breast Cancer Research : BCR. 10, 2018 | Pubmed ID: 30367629 Black Race and Distant Recurrence After Neoadjuvant or Adjuvant Chemotherapy in Breast Cancer Clinical & Experimental Metastasis. 10, 2018 | Pubmed ID: 30136072 The Different Routes to Metastasis Via Hypoxia-Regulated Programs Trends in Cell Biology. 11, 2018 | Pubmed ID: 30041830 Myosin-IIA Heavy Chain Phosphorylation on S1943 Regulates Tumor Metastasis Experimental Cell Research. Sep, 2018 | Pubmed ID: 29953877 Targeting Invadopodia-mediated Breast Cancer Metastasis by Using ABL Kinase Inhibitors Oncotarget. Apr, 2018 | Pubmed ID: 29774130 A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation Cell Reports. May, 2018 | Pubmed ID: 29719241 A Novel Neuregulin - Jagged1 Paracrine Loop in Breast Cancer Transendothelial Migration Breast Cancer Research : BCR. 04, 2018 | Pubmed ID: 29636067 Chemotherapy-induced Metastasis: Mechanisms and Translational Opportunities Clinical & Experimental Metastasis. 04, 2018 | Pubmed ID: 29307118 Pyk2 and FAK Differentially Regulate Invadopodia Formation and Function in Breast Cancer Cells The Journal of Cell Biology. 01, 2018 | Pubmed ID: 29133485 Chemotherapy-induced Metastasis in Breast Cancer Oncotarget. Dec, 2017 | Pubmed ID: 29340008 Rac3 Regulates Breast Cancer Invasion and Metastasis by Controlling Adhesion and Matrix Degradation The Journal of Cell Biology. 12, 2017 | Pubmed ID: 29061650 The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2 Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors Molecular Cancer Therapeutics. 11, 2017 | Pubmed ID: 28838996 Neoadjuvant Chemotherapy Induces Breast Cancer Metastasis Through a TMEM-mediated Mechanism Science Translational Medicine. Jul, 2017 | Pubmed ID: 28679654 Tumor Cell Invadopodia: Invasive Protrusions That Orchestrate Metastasis Trends in Cell Biology. 08, 2017 | Pubmed ID: 28412099 Macrophage-dependent Tumor Cell Transendothelial Migration is Mediated by Notch1/Mena(INV)-initiated Invadopodium Formation Scientific Reports. Nov, 2016 | Pubmed ID: 27901093 Mena Dysregulates Cortactin Phosphorylation to Promote Invadopodium Maturation Scientific Reports. 11, 2016 | Pubmed ID: 27824079 Validation of a Device for the Active Manipulation of the Tumor Microenvironment During Intravital Imaging Intravital. 2016 | Pubmed ID: 27790386 The Alternatively-included 11a Sequence Modifies the Effects of Mena on Actin Cytoskeletal Organization and Cell Behavior Scientific Reports. Oct, 2016 | Pubmed ID: 27748415 Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells EBioMedicine. 11, 2016 | Pubmed ID: 27743905 Signatures of Breast Cancer Metastasis at a Glance Journal of Cell Science. May, 2016 | Pubmed ID: 27084578 GPCR Signaling Mediates Tumor Metastasis Via PI3Kβ Cancer Research. May, 2016 | Pubmed ID: 27013201 3-D Individual Cell Based Computational Modeling of Tumor Cell-macrophage Paracrine Signaling Mediated by EGF and CSF-1 Gradients Integrative Biology : Quantitative Biosciences from Nano to Macro. Jan, 2016 | Pubmed ID: 26686751 Characterization of the Expression of the Pro-metastatic Mena(INV) Isoform During Breast Tumor Progression Clinical & Experimental Metastasis. Mar, 2016 | Pubmed ID: 26680363 PTP1B-dependent Regulation of Receptor Tyrosine Kinase Signaling by the Actin-binding Protein Mena Molecular Biology of the Cell. Nov, 2015 | Pubmed ID: 26337385 Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA Cancer Discovery. Sep, 2015 | Pubmed ID: 26269515 Menacalc, a Quantitative Method of Metastasis Assessment, As a Prognostic Marker for Axillary Node-negative Breast Cancer BMC Cancer. 2015 | Pubmed ID: 26112005 Profilin1 Regulates Invadopodium Maturation in Human Breast Cancer Cells European Journal of Cell Biology. Feb, 2015 | Pubmed ID: 25613364 Autocrine CSF1R Signaling Mediates Switching Between Invasion and Proliferation Downstream of TGFβ in Claudin-low Breast Tumor Cells Oncogene. May, 2015 | Pubmed ID: 25088194 Invasive Breast Carcinoma Cells from Patients Exhibit MenaINV- and Macrophage-dependent Transendothelial Migration Science Signaling. Nov, 2014 | Pubmed ID: 25429076 Digging a Little Deeper: the Stages of Invadopodium Formation and Maturation European Journal of Cell Biology. Oct, 2014 | Pubmed ID: 25113547 An in Vitro One-dimensional Assay to Study Growth Factor-regulated Tumor Cell-macrophage Interaction Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24908299 Metastatic Cells: Moving Onco-targets Oncotarget. Jun, 2014 | Pubmed ID: 24907202 Tumor Microenvironment of Metastasis and Risk of Distant Metastasis of Breast Cancer Journal of the National Cancer Institute. Aug, 2014 | Pubmed ID: 24895374 Talin Regulates Moesin-NHE-1 Recruitment to Invadopodia and Promotes Mammary Tumor Metastasis The Journal of Cell Biology. Jun, 2014 | Pubmed ID: 24891603 Invadopodia in Context Cell Adhesion & Migration. 2014 | Pubmed ID: 24713806 Spatial Regulation of Tumor Cell Protrusions by RhoC Cell Adhesion & Migration. 2014 | Pubmed ID: 24642482 Filamin A Interacting Protein 1-like Inhibits WNT Signaling and MMP Expression to Suppress Cancer Cell Invasion and Metastasis International Journal of Cancer. Jul, 2014 | Pubmed ID: 24327474 Autocrine HBEGF Expression Promotes Breast Cancer Intravasation, Metastasis and Macrophage-independent Invasion in Vivo Oncogene. Jul, 2014 | Pubmed ID: 24013225 Intravital Multiphoton Imaging Reveals Multicellular Streaming As a Crucial Component of in Vivo Cell Migration in Human Breast Tumors Intravital. Apr, 2013 | Pubmed ID: 25013744 Wiskott-Aldrich Syndrome Protein Regulates Leukocyte-dependent Breast Cancer Metastasis Cell Reports. Aug, 2013 | Pubmed ID: 23911287 Dysregulation of PAD4-mediated Citrullination of Nuclear GSK3β Activates TGF-β Signaling and Induces Epithelial-to-mesenchymal Transition in Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23818587 Arg/Abl2 Promotes Invasion and Attenuates Proliferation of Breast Cancer in Vivo Oncogene. May, 2013 | Pubmed ID: 22777352 Development Path and Current Status of the NANIVID: a New Device for Cancer Cell Studies Journal of Micro/nanolithography, MEMS, and MOEMS : JM3. Mar, 2012 | Pubmed ID: 25419258 Reconstitution of in Vivo Macrophage-tumor Cell Pairing and Streaming Motility on One-dimensional Micro-patterned Substrates Intravital. Jul, 2012 | Pubmed ID: 24634804 Selective Gene-expression Profiling of Migratory Tumor Cells in Vivo Predicts Clinical Outcome in Breast Cancer Patients Breast Cancer Research : BCR. 2012 | Pubmed ID: 23113900 Quantitative Assessment of Invasive Mena Isoforms (Menacalc) As an Independent Prognostic Marker in Breast Cancer Breast Cancer Research : BCR. 2012 | Pubmed ID: 22971274 A FRET-facilitated Photoswitching Using an Orange Fluorescent Protein with the Fast Photoconversion Kinetics Journal of the American Chemical Society. Sep, 2012 | Pubmed ID: 22900938 Three-dimensional Microfluidic Model for Tumor Cell Intravasation and Endothelial Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22869695 Correlato Immunohistochemical E Citologici Dosaggi Per La Previsione Della Diffusione Ematogena Di Cancro Al Seno The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jan, 2012 | Pubmed ID: 22215635 Phosphoinositide 3-kinase Signaling is Critical for ErbB3-driven Breast Cancer Cell Motility and Metastasis Oncogene. Feb, 2012 | Pubmed ID: 21725367 Ruoli Opposti Di CXCR4 E CXCR7 in Metastasi Del Cancro Al Seno Breast Cancer Research : BCR. Dec, 2011 | Pubmed ID: 22152016 Un Programma Di Splicing Alternativo EMT-driven Si Verifica Nel Cancro Al Seno Umano E Modula Il Fenotipo Cellulare PLoS Genetics. Aug, 2011 | Pubmed ID: 21876675 Una Photoswitchable-a-lontano-rosso Arancio Proteina Fluorescente, PSmOrange Nature Methods. Sep, 2011 | Pubmed ID: 21804536 Chemiotassi in Cancro Nature Reviews. Cancer. Aug, 2011 | Pubmed ID: 21779009 Mena Invasiva (MenaINV) Promuove Pluricellulare Streaming Migrazione Transendoteliale E Motilità in Un Modello Murino Di Cancro Al Seno Journal of Cell Science. Jul, 2011 | Pubmed ID: 21670198 Mena Invasivi (Mena(INV)) E Mena11a Isoforme Gioco Distinti Ruoli in Associazione Con TMEM E Coesione Di Cellule Cancro Al Seno Clinical & Experimental Metastasis. Aug, 2011 | Pubmed ID: 21484349 Mena Deficit Ritarda La Progressione Del Tumore E Metastasi Nei Tumori Mammari Polyoma Mouse Transgenici Medio-T Si Riduce Breast Cancer Research : BCR. 2010 | Pubmed ID: 21108830 Un Nuovo Dispositivo Di Chemiotassi Per Gli Studi Di Migrazione Delle Cellule Integrative Biology : Quantitative Biosciences from Nano to Macro. Nov, 2010 | Pubmed ID: 20938544 Conferenza Speciale AACR Sulla Progressione Di Transizione E Cancro Epiteliale-mesenchimale E Trattamento Cancer Research. Oct, 2010 | Pubmed ID: 20823151 Analisi Di Espressione Genica Dei Macrofagi Che Facilitano L'invasione Tumorale Sostiene Un Ruolo Per Segnalazione Wnt Nella Mediazione Della Loro Attività Nei Tumori Mammari Primari Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010 | Pubmed ID: 20018620 Invasione Di Cellule Di Cancro Al Seno Umano in Vivo Richiede Sia Paracrina E Autocrino Loop Che Coinvolge Il Recettore Del Colony-stimulating Factor-1 Cancer Research. Dec, 2009 | Pubmed ID: 19934330 Differenziale Miglioramento Della Motilità Di Cellule Cancro Al Seno E Metastasi Da Elicoidale E Le Mutazioni Del Dominio Chinasi Della Classe IA Fosfoinositide 3-chinasi Cancer Research. Dec, 2009 | Pubmed ID: 19903845 Microambiente Tumorale Di Metastasi Nel Carcinoma Mammario Umano: Un Potenziale Marker Prognostico Legati Alla Diffusione Ematogena Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009 | Pubmed ID: 19318480 Identificazione Dell'invasione Specifico Splice Varianti Della Proteina Del Citoscheletro Mena Presente Nelle Cellule Tumorali Mammarie Durante L'invasione in Vivo Clinical & Experimental Metastasis. 2009 | Pubmed ID: 18985426 Un'isoforma Di Invasione Mena Potenzia Metastasi Ed Invasione Di Carcinoma EGF-indotta Delle Cellule Developmental Cell. Dec, 2008 | Pubmed ID: 19081071 Meccanismi E Ruoli Cellulari Della Sintesi Proteica Locale in Cellule Di Mammifero Current Opinion in Cell Biology. Apr, 2008 | Pubmed ID: 18378131 RhoA/ROCK-mediata Di Commutazione Tra Protrusione Cdc42 E Rac1-dipendente Nelle Cellule Di Carcinoma MTLn3 Experimental Cell Research. Apr, 2008 | Pubmed ID: 18316075 Espressione Genica in Tempo Reale Di Imaging in Sistemi Viventi Con Single-trascrizione Risoluzione: Costruire La Progettazione E L'installazione Del Sistema Di Imaging CSH Protocols. 2007 | Pubmed ID: 21356986 Imaging in Tempo Reale Espressione Genica in Sistemi Viventi Con Single-trascrizione Risoluzione: Singola Particella Di MRNA Di Rilevamento Con Analisi Basata Su ImageJ CSH Protocols. 2007 | Pubmed ID: 21356980 Espressione Genica in Tempo Reale Di Imaging in Sistemi Viventi Con Single-trascrizione Risoluzione: Immagine Di Analisi Dei Trascritti Di MRNA Singolo CSH Protocols. 2007 | Pubmed ID: 21356979 Espressione Genica in Tempo Reale Nella Vita Lievito Di Imaging CSH Protocols. 2007 | Pubmed ID: 21356978 Espressione Genica in Tempo Reale in Cellule Di Mammifero Con Risoluzione Di Singolo-trascrizione Di Imaging CSH Protocols. 2007 | Pubmed ID: 21356977 EGF-indotta PIP2 Idrolisi Rilascia E Attiva Cofilin Localmente in Cellule Di Carcinoma The Journal of Cell Biology. Dec, 2007 | Pubmed ID: 18086920 ZBP1 Migliora La Polarità Delle Cellule E Riduce La Chemiotassi Journal of Cell Science. Sep, 2007 | Pubmed ID: 17878234 Cdc42 è Richiesto Per La Protrusione EGF-stimolata E Motilità in Cellule Di Carcinoma MTLn3 Journal of Cell Science. Oct, 2007 | Pubmed ID: 17855387 I Ruoli Distinti Di Ras E Rac in Protrusione Di PI 3-chinasi-dipendente Durante La Migrazione Cellulare EGF-stimolata Journal of Cell Science. Sep, 2007 | Pubmed ID: 17698922 Regolazione Coordinata Di Percorsi Per Chemiotassi E Motilità Cellulare Avanzata è Conservato in Tumori Mammari Mouse E Del Ratto Cancer Research. Apr, 2007 | Pubmed ID: 17440055 Clonazione Molecolare Di HMena (ENAH) E Il Suo Splice Variante HMena + 11a: Fattore Di Crescita Epidermico Aumenta La Loro Espressione E Stimola HMena + 11a Fosforilazione in Linee Di Cellule Di Cancro Al Seno Cancer Research. Mar, 2007 | Pubmed ID: 17363586 Deformazione Di Matrice ROCK - E Miosina-dipendente Consente Di Invasione Di Proteasi-indipendente-cellula Tumorale in Vivo Current Biology : CB. Aug, 2006 | Pubmed ID: 16890527 Avvio Di Attività Cofilin in Risposta a EGF è Disgiunto Da Cofilin Fosforilazione E Defosforilazione in Cellule Di Carcinoma Journal of Cell Science. Jul, 2006 | Pubmed ID: 16803871 Lo Stato Dell'attività Di Cofilin è Direttamente Correlato All'invasione, Intravasation E Le Metastasi Di Tumori Mammari The Journal of Cell Biology. May, 2006 | Pubmed ID: 16651380 Macrofagi Promuovere L'invasione Delle Cellule Di Carcinoma Del Seno Tramite Un Colony-stimulating Factor-1/epidermal Growth Factor Paracrina Loop Cancer Research. Jun, 2005 | Pubmed ID: 15958574 Le Cellule Tumorali Caught in the Act Di Invadere: Loro Strategia Per Motilità Cellulare Avanzata Trends in Cell Biology. Mar, 2005 | Pubmed ID: 15752977 Identificazione E Verifica Di Una Firma Di Espressione Genica Delle Cellule Di Carcinoma Invasivo All'interno Dei Tumori Mammari Primari Cancer Research. Dec, 2004 | Pubmed ID: 15574765 Cellule Di Cancro Al Seno Isolate Da Chemiotassi Da Tumori Primari Mostrano Aumento Di Sopravvivenza E Di Resistenza Alla Chemioterapia Cancer Research. Nov, 2004 | Pubmed ID: 15520165 Sovraespressione Della P110beta Ma Non P110alpha Isoforma Di PI 3-chinasi Inibisce La Motilità in Cellule Di Cancro Al Seno Cell Motility and the Cytoskeleton. Nov, 2004 | Pubmed ID: 15468162 Cofilin Promuove La Polimerizzazione Dell'actina E Definisce La Direzione Di Motilità Cellulare Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15118165 Analisi Di Espressione Genica Su Un Piccolo Numero Di Cellule Invasive Raccolti Da Chemiotassi Da Tumori Mammari Primari Del Mouse BMC Biotechnology. Aug, 2003 | Pubmed ID: 12914671 Espressione Di GFP Nella Ghiandola Mammaria Per L'imaging Delle Cellule Del Tumore Mammario Nei Topi Transgenici Cancer Research. Dec, 2002 | Pubmed ID: 12499251 Comportamento Di Singola Cellula in Tumori Mammari Metastatici Primari Correlata Con Modelli Di Espressione Genica Ha Rivelati Dall'analisi Molecolare Cancer Research. Nov, 2002 | Pubmed ID: 12414658 Una Nuova Strategia Per Proteine Regolate Da Chinasi Di Ingabbiamento Journal of the American Chemical Society. Mar, 2002 | Pubmed ID: 11890784 Protein Tyrosine Phosphatase Phi Regulates Paxillin Tyrosine Phosphorylation and Mediates Colony-stimulating Factor 1-induced Morphological Changes in Macrophages Molecular and Cellular Biology. Mar, 2001 | Pubmed ID: 11238916 Phosphorylation of ADF/cofilin Abolishes EGF-induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension The Journal of Cell Biology. Nov, 2000 | Pubmed ID: 11086013 Role of Cofilin in Epidermal Growth Factor-stimulated Actin Polymerization and Lamellipod Protrusion The Journal of Cell Biology. Feb, 2000 | Pubmed ID: 10662778 Relationship Between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells After Epidermal Growth Factor Stimulation The Journal of Cell Biology. Apr, 1999 | Pubmed ID: 10209028 Valutazione del microambiente tumorale della permeabilità vascolare mediata da Metastasi Doorway associata alla dissemimassione delle cellule tumorali utilizzando l'imaging intravitale e l'analisi dei tessuti fissi George S. Karagiannis1,2,3, Jessica M. Pastoriza1,2,4, Lucia Borriello1,2, Rojin Jafari1,2, Anouchka Coste1,2,4, John S. Condeelis1,2,3,4, Maja H. Oktay1,2,3,5, David Entenberg1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 3Integrated Imaging Program, Albert Einstein College of Medicine, 4Department of Surgery, Montefiore Medical Center, 5Department of Pathology, Montefiore Medical Center JoVE 59633 암 연구학
Valutazione del microambiente tumorale della permeabilità vascolare mediata da Metastasi Doorway associata alla dissemimassione delle cellule tumorali utilizzando l'imaging intravitale e l'analisi dei tessuti fissi George S. Karagiannis1,2,3, Jessica M. Pastoriza1,2,4, Lucia Borriello1,2, Rojin Jafari1,2, Anouchka Coste1,2,4, John S. Condeelis1,2,3,4, Maja H. Oktay1,2,3,5, David Entenberg1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 3Integrated Imaging Program, Albert Einstein College of Medicine, 4Department of Surgery, Montefiore Medical Center, 5Department of Pathology, Montefiore Medical Center JoVE 59633 암 연구학