John S. Condeelis Department of Anatomy and Structural Biology Albert Einstein College of Medicine Biography Publications Institution JoVE Articles John S. Condeelis has not added a biography. If you are John S. Condeelis and would like to personalize this page please email our Author Liaison for assistance. Publications Ribosome Biogenesis During Cell Cycle Arrest Fuels EMT in Development and Disease Nature Communications. 05, 2019 | Pubmed ID: 31068593 Optimizing Leading Edge F-actin Labeling Using Multiple Actin Probes, Fixation Methods and Imaging Modalities BioTechniques. Mar, 2019 | Pubmed ID: 30869550 The Emerging Roles of Macrophages in Cancer Metastasis and Response to Chemotherapy Journal of Leukocyte Biology. Feb, 2019 | Pubmed ID: 30720887 Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models Cancer Discovery. 01, 2019 | Pubmed ID: 30361447 Loss of Amphiregulin Reduces Myoepithelial Cell Coverage of Mammary Ducts and Alters Breast Tumor Growth Breast Cancer Research : BCR. 10, 2018 | Pubmed ID: 30367629 Black Race and Distant Recurrence After Neoadjuvant or Adjuvant Chemotherapy in Breast Cancer Clinical & Experimental Metastasis. 10, 2018 | Pubmed ID: 30136072 The Different Routes to Metastasis Via Hypoxia-Regulated Programs Trends in Cell Biology. 11, 2018 | Pubmed ID: 30041830 Myosin-IIA Heavy Chain Phosphorylation on S1943 Regulates Tumor Metastasis Experimental Cell Research. Sep, 2018 | Pubmed ID: 29953877 Targeting Invadopodia-mediated Breast Cancer Metastasis by Using ABL Kinase Inhibitors Oncotarget. Apr, 2018 | Pubmed ID: 29774130 A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation Cell Reports. May, 2018 | Pubmed ID: 29719241 A Novel Neuregulin - Jagged1 Paracrine Loop in Breast Cancer Transendothelial Migration Breast Cancer Research : BCR. 04, 2018 | Pubmed ID: 29636067 Chemotherapy-induced Metastasis: Mechanisms and Translational Opportunities Clinical & Experimental Metastasis. 04, 2018 | Pubmed ID: 29307118 Pyk2 and FAK Differentially Regulate Invadopodia Formation and Function in Breast Cancer Cells The Journal of Cell Biology. 01, 2018 | Pubmed ID: 29133485 Chemotherapy-induced Metastasis in Breast Cancer Oncotarget. Dec, 2017 | Pubmed ID: 29340008 Rac3 Regulates Breast Cancer Invasion and Metastasis by Controlling Adhesion and Matrix Degradation The Journal of Cell Biology. 12, 2017 | Pubmed ID: 29061650 The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2 Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors Molecular Cancer Therapeutics. 11, 2017 | Pubmed ID: 28838996 Neoadjuvant Chemotherapy Induces Breast Cancer Metastasis Through a TMEM-mediated Mechanism Science Translational Medicine. Jul, 2017 | Pubmed ID: 28679654 Tumor Cell Invadopodia: Invasive Protrusions That Orchestrate Metastasis Trends in Cell Biology. 08, 2017 | Pubmed ID: 28412099 Macrophage-dependent Tumor Cell Transendothelial Migration is Mediated by Notch1/Mena(INV)-initiated Invadopodium Formation Scientific Reports. Nov, 2016 | Pubmed ID: 27901093 Mena Dysregulates Cortactin Phosphorylation to Promote Invadopodium Maturation Scientific Reports. 11, 2016 | Pubmed ID: 27824079 Validation of a Device for the Active Manipulation of the Tumor Microenvironment During Intravital Imaging Intravital. 2016 | Pubmed ID: 27790386 The Alternatively-included 11a Sequence Modifies the Effects of Mena on Actin Cytoskeletal Organization and Cell Behavior Scientific Reports. Oct, 2016 | Pubmed ID: 27748415 Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells EBioMedicine. 11, 2016 | Pubmed ID: 27743905 Signatures of Breast Cancer Metastasis at a Glance Journal of Cell Science. May, 2016 | Pubmed ID: 27084578 GPCR Signaling Mediates Tumor Metastasis Via PI3Kβ Cancer Research. May, 2016 | Pubmed ID: 27013201 3-D Individual Cell Based Computational Modeling of Tumor Cell-macrophage Paracrine Signaling Mediated by EGF and CSF-1 Gradients Integrative Biology : Quantitative Biosciences from Nano to Macro. Jan, 2016 | Pubmed ID: 26686751 Characterization of the Expression of the Pro-metastatic Mena(INV) Isoform During Breast Tumor Progression Clinical & Experimental Metastasis. Mar, 2016 | Pubmed ID: 26680363 PTP1B-dependent Regulation of Receptor Tyrosine Kinase Signaling by the Actin-binding Protein Mena Molecular Biology of the Cell. Nov, 2015 | Pubmed ID: 26337385 Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA Cancer Discovery. Sep, 2015 | Pubmed ID: 26269515 Menacalc, a Quantitative Method of Metastasis Assessment, As a Prognostic Marker for Axillary Node-negative Breast Cancer BMC Cancer. 2015 | Pubmed ID: 26112005 Profilin1 Regulates Invadopodium Maturation in Human Breast Cancer Cells European Journal of Cell Biology. Feb, 2015 | Pubmed ID: 25613364 Autocrine CSF1R Signaling Mediates Switching Between Invasion and Proliferation Downstream of TGFβ in Claudin-low Breast Tumor Cells Oncogene. May, 2015 | Pubmed ID: 25088194 Invasive Breast Carcinoma Cells from Patients Exhibit MenaINV- and Macrophage-dependent Transendothelial Migration Science Signaling. Nov, 2014 | Pubmed ID: 25429076 Digging a Little Deeper: the Stages of Invadopodium Formation and Maturation European Journal of Cell Biology. Oct, 2014 | Pubmed ID: 25113547 An in Vitro One-dimensional Assay to Study Growth Factor-regulated Tumor Cell-macrophage Interaction Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24908299 Metastatic Cells: Moving Onco-targets Oncotarget. Jun, 2014 | Pubmed ID: 24907202 Tumor Microenvironment of Metastasis and Risk of Distant Metastasis of Breast Cancer Journal of the National Cancer Institute. Aug, 2014 | Pubmed ID: 24895374 Talin Regulates Moesin-NHE-1 Recruitment to Invadopodia and Promotes Mammary Tumor Metastasis The Journal of Cell Biology. Jun, 2014 | Pubmed ID: 24891603 Invadopodia in Context Cell Adhesion & Migration. 2014 | Pubmed ID: 24713806 Spatial Regulation of Tumor Cell Protrusions by RhoC Cell Adhesion & Migration. 2014 | Pubmed ID: 24642482 Filamin A Interacting Protein 1-like Inhibits WNT Signaling and MMP Expression to Suppress Cancer Cell Invasion and Metastasis International Journal of Cancer. Jul, 2014 | Pubmed ID: 24327474 Autocrine HBEGF Expression Promotes Breast Cancer Intravasation, Metastasis and Macrophage-independent Invasion in Vivo Oncogene. Jul, 2014 | Pubmed ID: 24013225 Intravital Multiphoton Imaging Reveals Multicellular Streaming As a Crucial Component of in Vivo Cell Migration in Human Breast Tumors Intravital. Apr, 2013 | Pubmed ID: 25013744 Wiskott-Aldrich Syndrome Protein Regulates Leukocyte-dependent Breast Cancer Metastasis Cell Reports. Aug, 2013 | Pubmed ID: 23911287 Dysregulation of PAD4-mediated Citrullination of Nuclear GSK3β Activates TGF-β Signaling and Induces Epithelial-to-mesenchymal Transition in Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23818587 Arg/Abl2 Promotes Invasion and Attenuates Proliferation of Breast Cancer in Vivo Oncogene. May, 2013 | Pubmed ID: 22777352 Development Path and Current Status of the NANIVID: a New Device for Cancer Cell Studies Journal of Micro/nanolithography, MEMS, and MOEMS : JM3. Mar, 2012 | Pubmed ID: 25419258 Reconstitution of in Vivo Macrophage-tumor Cell Pairing and Streaming Motility on One-dimensional Micro-patterned Substrates Intravital. Jul, 2012 | Pubmed ID: 24634804 Selective Gene-expression Profiling of Migratory Tumor Cells in Vivo Predicts Clinical Outcome in Breast Cancer Patients Breast Cancer Research : BCR. 2012 | Pubmed ID: 23113900 Quantitative Assessment of Invasive Mena Isoforms (Menacalc) As an Independent Prognostic Marker in Breast Cancer Breast Cancer Research : BCR. 2012 | Pubmed ID: 22971274 A FRET-facilitated Photoswitching Using an Orange Fluorescent Protein with the Fast Photoconversion Kinetics Journal of the American Chemical Society. Sep, 2012 | Pubmed ID: 22900938 Three-dimensional Microfluidic Model for Tumor Cell Intravasation and Endothelial Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22869695 免疫組織化学的および細胞学的アッセイ血行性播種乳癌の予測の相関。 The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jan, 2012 | Pubmed ID: 22215635 Phosphoinositide 3-kinase Signaling is Critical for ErbB3-driven Breast Cancer Cell Motility and Metastasis Oncogene. Feb, 2012 | Pubmed ID: 21725367 乳癌転移における CXCR4 と CXCR7 の役割に反対します。 Breast Cancer Research : BCR. Dec, 2011 | Pubmed ID: 22152016 EMT 駆動別のスプライシング プログラムひと乳癌でを発生し、細胞表現型を変調します。 PLoS Genetics. Aug, 2011 | Pubmed ID: 21876675 Photoswitchable オレンジに遠赤色蛍光蛋白質、PSmOrange。 Nature Methods. Sep, 2011 | Pubmed ID: 21804536 走化性癌で。 Nature Reviews. Cancer. Aug, 2011 | Pubmed ID: 21779009 Mena 侵襲 （MenaINV） 乳癌のマウスモデルにおける多細胞ストリーミング運動と内皮移行を促進します。 Journal of Cell Science. Jul, 2011 | Pubmed ID: 21670198 Mena 侵襲 (Mena(INV)) と Mena11a アイソ フォーム プレイにおいて異なる役割乳房癌細胞凝集と TMEM との関連付け。 Clinical & Experimental Metastasis. Aug, 2011 | Pubmed ID: 21484349 Mena 欠乏は腫瘍進行を遅らせるし、polyoma 中間 T トランスジェニック マウスの乳腺腫瘍の転移を減少します。 Breast Cancer Research : BCR. 2010 | Pubmed ID: 21108830 新しいの走化性デバイス セル移民研究。 Integrative Biology : Quantitative Biosciences from Nano to Macro. Nov, 2010 | Pubmed ID: 20938544 AACR 上皮間葉転移と癌の進行および治療上の特別な会議。 Cancer Research. Oct, 2010 | Pubmed ID: 20823151 遺伝子発現解析への腫瘍浸潤を促進するマクロファージの役割プライマリ乳腺腫瘍で彼らの活動を媒介に Wnt シグナル伝達をサポートします。 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010 | Pubmed ID: 20018620 ひと乳癌細胞 in Vivo での侵攻コロニー刺激因子 1 レセプターを含むパラクリンとオートクリン ループが必要です。 Cancer Research. Dec, 2009 | Pubmed ID: 19934330 差動強化の乳房のがん細胞の運動性と転移によるヘリカルおよびクラス IA ホスホイノシチド 3-キナーゼのキナーゼ ドメインの変異。 Cancer Research. Dec, 2009 | Pubmed ID: 19903845 ひと乳癌における転移の腫瘍微小環境： 潜在的な予後マーカー リンク血行性播種します。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009 | Pubmed ID: 19318480 In Vivo での侵攻中に特定の侵略の同定スプライスの骨格タンパク質メナ乳腺腫瘍細胞内に存在の亜種。 Clinical & Experimental Metastasis. 2009 | Pubmed ID: 18985426 Mena 侵略アイソ EGF による癌細胞の浸潤・転移を増強します。 Developmental Cell. Dec, 2008 | Pubmed ID: 19081071 メカニズムと哺乳類細胞における局所的なタンパク質合成の細胞の役割。 Current Opinion in Cell Biology. Apr, 2008 | Pubmed ID: 18378131 RhoA/岩介した Cdc42 と Rac1 依存突起 MTLn3 癌細胞間の切り替え。 Experimental Cell Research. Apr, 2008 | Pubmed ID: 18316075 リビング システム シングル トラン スクリプトの解像度でリアルタイムの遺伝子発現イメージング: イメージング システム セットアップ デザインを構築します。 CSH Protocols. 2007 | Pubmed ID: 21356986 リビング システム シングル トラン スクリプトの解像度でリアルタイムの遺伝子発現イメージング: 単一の MRNA 粒子 ImageJ ベースの分析とを追跡します。 CSH Protocols. 2007 | Pubmed ID: 21356980 リビング システム シングル トラン スクリプトの解像度でリアルタイムの遺伝子発現イメージング: 単一 Mrna の解析, 画像します。 CSH Protocols. 2007 | Pubmed ID: 21356979 リビング酵母におけるリアルタイム遺伝子発現をイメージング。 CSH Protocols. 2007 | Pubmed ID: 21356978 シングル-トラン スクリプトの解像度を持つ哺乳類細胞におけるリアルタイム遺伝子発現をイメージング。 CSH Protocols. 2007 | Pubmed ID: 21356977 癌細胞におけるローカルEGF誘起PIP2の加水分解リリースとアクティブにコフィリン The Journal of Cell Biology. Dec, 2007 | Pubmed ID: 18086920 ZBP1 細胞極性を高め、走化性を低減します。 Journal of Cell Science. Sep, 2007 | Pubmed ID: 17878234 Cdc42 は EGF 刺激前突および MTLn3 癌細胞の運動性が必要です。 Journal of Cell Science. Oct, 2007 | Pubmed ID: 17855387 Ras と Rac の個別の役割 PI 3-キナーゼ依存突起 EGF 刺激細胞の移行中に。 Journal of Cell Science. Sep, 2007 | Pubmed ID: 17698922 強化された細胞運動と走化性のための経路の協調調節ラットおよびマウスの乳腺腫瘍で保存されています。 Cancer Research. Apr, 2007 | Pubmed ID: 17440055 HMena (ENAH) とそのスプライス バリアント HMena + 11 a はバードケージのクローニング: 上皮成長因子の表現が増加し、刺激 HMena + 11a 乳房癌細胞株におけるリン酸化。 Cancer Research. Mar, 2007 | Pubmed ID: 17363586 岩とミオシン依存行列変形プロテアーゼ独立した腫瘍細胞浸潤の in Vivo でことができます。 Current Biology : CB. Aug, 2006 | Pubmed ID: 16890527 EGF に応えてコフィリン活動の開始がからコフィリン リン酸化と脱燐酸化癌細胞に結合されます。 Journal of Cell Science. Jul, 2006 | Pubmed ID: 16803871 コフィリンのアクティビティの状態の侵略、intravasation、および乳腺腫瘍の転移に直接関連しています。 The Journal of Cell Biology. May, 2006 | Pubmed ID: 16651380 マクロファージは、乳癌細胞コロニー刺激経由での侵入を促進する因子 1/表皮成長因子パラクリン ループ。 Cancer Research. Jun, 2005 | Pubmed ID: 15958574 腫瘍細胞浸潤の行為にキャッチ： 強化された細胞運動のための彼らの戦略。 Trends in Cell Biology. Mar, 2005 | Pubmed ID: 15752977 同定とプライマリ乳腺腫瘍内浸潤癌細胞の遺伝子発現シグネチャのテストします。 Cancer Research. Dec, 2004 | Pubmed ID: 15574765 乳房のがん細胞の走化性原発性腫瘍から分離された生存率の増加と化学療法への抵抗を示します。 Cancer Research. Nov, 2004 | Pubmed ID: 15520165 P110beta の過剰発現がない P110alpha アイソ フォーム PI 3-キナーゼの乳がん細胞の運動性を阻害します。 Cell Motility and the Cytoskeleton. Nov, 2004 | Pubmed ID: 15468162 コフィリンはアクチン重合を促進し、細胞運動の方向を定義します。 Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15118165 侵襲的な細胞の走化性マウスの乳腺原発から収集の小さな数字での遺伝子発現の分析。 BMC Biotechnology. Aug, 2003 | Pubmed ID: 12914671 乳腺のイメージングにおける GFP 発現トランスジェニック マウスにおける乳腺腫瘍細胞は。 Cancer Research. Dec, 2002 | Pubmed ID: 12499251 分子プロファイリングによって明らかにされた遺伝子発現パターンと相関転移プライマリ乳腺腫瘍の単一細胞の挙動 Cancer Research. Nov, 2002 | Pubmed ID: 12414658 蛋白質キナーゼによって規制されてケージングための新しい戦略。 Journal of the American Chemical Society. Mar, 2002 | Pubmed ID: 11890784 Protein Tyrosine Phosphatase Phi Regulates Paxillin Tyrosine Phosphorylation and Mediates Colony-stimulating Factor 1-induced Morphological Changes in Macrophages Molecular and Cellular Biology. Mar, 2001 | Pubmed ID: 11238916 Phosphorylation of ADF/cofilin Abolishes EGF-induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension The Journal of Cell Biology. Nov, 2000 | Pubmed ID: 11086013 Role of Cofilin in Epidermal Growth Factor-stimulated Actin Polymerization and Lamellipod Protrusion The Journal of Cell Biology. Feb, 2000 | Pubmed ID: 10662778 Relationship Between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells After Epidermal Growth Factor Stimulation The Journal of Cell Biology. Apr, 1999 | Pubmed ID: 10209028 インビタルイメージングと固定組織解析を用いた癌細胞播種に伴う転移戸管媒介血管透過性の腫瘍微小環境の評価 George S. Karagiannis1,2,3, Jessica M. Pastoriza1,2,4, Lucia Borriello1,2, Rojin Jafari1,2, Anouchka Coste1,2,4, John S. Condeelis1,2,3,4, Maja H. Oktay1,2,3,5, David Entenberg1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 3Integrated Imaging Program, Albert Einstein College of Medicine, 4Department of Surgery, Montefiore Medical Center, 5Department of Pathology, Montefiore Medical Center JoVE 59633 암 연구학
インビタルイメージングと固定組織解析を用いた癌細胞播種に伴う転移戸管媒介血管透過性の腫瘍微小環境の評価 George S. Karagiannis1,2,3, Jessica M. Pastoriza1,2,4, Lucia Borriello1,2, Rojin Jafari1,2, Anouchka Coste1,2,4, John S. Condeelis1,2,3,4, Maja H. Oktay1,2,3,5, David Entenberg1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 3Integrated Imaging Program, Albert Einstein College of Medicine, 4Department of Surgery, Montefiore Medical Center, 5Department of Pathology, Montefiore Medical Center JoVE 59633 암 연구학
