John J. Tentler Medicine University of Colorado Denver Anschutz Medical Campus Biography Publications Institution JoVE Articles John J. Tentler has not added a biography. If you are John J. Tentler and would like to personalize this page please email our Author Liaison for assistance. Publications Antitumor Activity of the Aurora a Selective Kinase Inhibitor, Alisertib, Against Preclinical Models of Colorectal Cancer Oncotarget. Jul, 2016 | Pubmed ID: 27385211 An Integrated Bioinformatics Analysis to Dissect Kinase Dependency in Triple Negative Breast Cancer BMC Genomics. 2015 | Pubmed ID: 26681397 Antitumor Activity of a Potent MEK Inhibitor, TAK-733, Against Colorectal Cancer Cell Lines and Patient Derived Xenografts Oncotarget. Oct, 2015 | Pubmed ID: 26439693 Combined Inhibition of MEK and Aurora A Kinase in KRAS/PIK3CA Double-mutant Colorectal Cancer Models Frontiers in Pharmacology. 2015 | Pubmed ID: 26136684 P53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer Molecular Cancer Therapeutics. May, 2015 | Pubmed ID: 25758253 Antitumor Activity of the MEK Inhibitor TAK-733 Against Melanoma Cell Lines and Patient-derived Tumor Explants Molecular Cancer Therapeutics. Feb, 2015 | Pubmed ID: 25376610 Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer PloS One. 2014 | Pubmed ID: 25401499 Triple-negative Breast Cancer: Bridging the Gap from Cancer Genomics to Predictive Biomarkers Therapeutic Advances in Medical Oncology. May, 2014 | Pubmed ID: 24790649 Overcoming IGF1R/IR Resistance Through Inhibition of MEK Signaling in Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013 | Pubmed ID: 24045180 Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23757356 MERTK Receptor Tyrosine Kinase is a Therapeutic Target in Melanoma The Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23585477 Association of the Epithelial-to-mesenchymal Transition Phenotype with Responsiveness to the P21-activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models Frontiers in Pharmacology. 2013 | Pubmed ID: 23543898 Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2013 | Pubmed ID: 23358974 CtBP1 is Expressed in Melanoma and Represses the Transcription of P16INK4a and Brca1 The Journal of Investigative Dermatology. May, 2013 | Pubmed ID: 23303449 Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2013 | Pubmed ID: 23136197 ATM and MET Kinases Are Synthetic Lethal with Nongenotoxic Activation of P53 Nature Chemical Biology. Jul, 2012 | Pubmed ID: 22660439 Patient-derived Tumour Xenografts As Models for Oncology Drug Development Nature Reviews. Clinical Oncology. Jun, 2012 | Pubmed ID: 22508028 Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-mutant Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2012 | Pubmed ID: 22173548 Mapping of ESE-1 Subdomains Required to Initiate Mammary Epithelial Cell Transformation Via a Cytoplasmic Mechanism Molecular Cancer. 2011 | Pubmed ID: 21871131 The Insulin-like Growth Factor I Receptor/insulin Receptor Tyrosine Kinase Inhibitor PQIP Exhibits Enhanced Antitumor Effects in Combination with Chemotherapy Against Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2010 | Pubmed ID: 20943761 Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras-mutated Colorectal Cancer Molecular Cancer Therapeutics. Dec, 2010 | Pubmed ID: 20923857 Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2010 | Pubmed ID: 20530704 Assessment of the in Vivo Antitumor Effects of ENMD-2076, a Novel Multitargeted Kinase Inhibitor, Against Primary and Cell Line-derived Human Colorectal Cancer Xenograft Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2010 | Pubmed ID: 20406842 Targeting Vascular Endothelial Growth Factor Receptor-1 and -3 with Cediranib (AZD2171): Effects on Migration and Invasion of Gastrointestinal Cancer Cell Lines Molecular Cancer Therapeutics. Sep, 2009 | Pubmed ID: 19755510 Vorinostat and Bortezomib Exert Synergistic Antiproliferative and Proapoptotic Effects in Colon Cancer Cell Models Molecular Cancer Therapeutics. Feb, 2009 | Pubmed ID: 19174560 Structural and Functional Analysis of the Differential Effects of C-Jun and V-Jun on Prolactin Gene Expression Molecular Endocrinology (Baltimore, Md.). Oct, 2004 | Pubmed ID: 15231872 ESX Induces Transformation and Functional Epithelial to Mesenchymal Transition in MCF-12A Mammary Epithelial Cells Oncogene. Mar, 2004 | Pubmed ID: 14767472 The Epithelial-specific ETS Transcription Factor ESX/ESE-1/Elf-3 Modulates Breast Cancer-associated Gene Expression DNA and Cell Biology. Feb, 2003 | Pubmed ID: 12713734 Selective Repression of Rat Prolactin Gene by Stable Expression of Dominant-negative Ets in GH4 Pituitary Cells Endocrine. Feb-Mar, 2003 | Pubmed ID: 12668863 Udvikling og vedligeholdelse af et præklinisk Patient Afledt Tumor xenograftmodel for undersøgelse af Novel Anti-Cancer Therapies Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 암 연구학
Udvikling og vedligeholdelse af et præklinisk Patient Afledt Tumor xenograftmodel for undersøgelse af Novel Anti-Cancer Therapies Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 암 연구학