Jose Antonio Enriquez Cardiovascular regeneration Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Biography Publications Institution JoVE Articles Jose Antonio Enriquez José Antonio Enríquez graduated in Biochemistry and Molecular Biology from the Autonomous University of Madrid and received his doctorate from the University of Zaragoza (UniZar) in 1992. During his thesis he studied various aspects of mitochondrial DNA biogenesis (mtDNA). Between 1993 and 1997 he worked with G. Attardi at the California Institute of Technology, where he investigated the pathogenic action of mutated mitochondrial tRNAs. His work during this period helped define the molecular mechanism underlying this phenomenon and helped establish a general methodology for the study of mitochondrial tRNAs. This methodology has been applied in mitochondrial biogenesis studies, as well as in the analysis of diseases related to mtDNA. In 1997 José Antonio returned to UniZar as Assistant Professor to initiate his independent research group (GENOXPHOS), in 1999 he become Associated Professor and in 2007 Full Professor at UniZar. Dr. Enriquez joined the CNIC in 2009, where he focuses on elucidating the molecular mechanisms of mitochondrial dysfunction in cardiovascular disease and ischemic processes. Publications Variant Pathogenic Prediction by Locus Variability: the Importance of the Current Picture of Evolution European Journal of Human Genetics : EJHG. 05, 2022 | Pubmed ID: 35079159 Sodium in Mitochondrial Redox Signaling Antioxidants & Redox Signaling. Mar, 2022 | Pubmed ID: 35072521 Generation of Reactive Oxygen Species by Mitochondria Antioxidants (Basel, Switzerland). Mar, 2021 | Pubmed ID: 33803273 Functional Segmentation of CoQ and Cyt C Pools by Respiratory Complex Superassembly Free Radical Biology & Medicine. 05, 2021 | Pubmed ID: 33722627 Digitonin Concentration is Determinant for Mitochondrial Supercomplexes Analysis by BlueNative Page Biochimica Et Biophysica Acta. Bioenergetics. 01, 2021 | Pubmed ID: 33129827 Fgr Kinase is Required for Proinflammatory Macrophage Activation During Diet-induced Obesity Nature Metabolism. 09, 2020 | Pubmed ID: 32943786 A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart Cell. 10, 2020 | Pubmed ID: 32937105 Na Controls Hypoxic Signalling by the Mitochondrial Respiratory Chain Nature. 10, 2020 | Pubmed ID: 32728214 Analyzing Electron Transport Chain Supercomplexes Methods in Cell Biology. Month, 2020 | Pubmed ID: 32183958 Mind Your Mouse Strain Nature Metabolism. 01, 2019 | Pubmed ID: 32694816 Regulation of Mother-to-Offspring Transmission of MtDNA Heteroplasmy Cell Metabolism. 12, 2019 | Pubmed ID: 31588014 Ablation of the Stress Protease OMA1 Protects Against Heart Failure in Mice Science Translational Medicine. 03, 2018 | Pubmed ID: 29593106 Mitochondria in Endothelial Cells: Sensors and Integrators of Environmental Cues Redox Biology. 08, 2017 | Pubmed ID: 28448943 Building a Beautiful Beast: Mammalian Respiratory Complex I Cell Metabolism. 01, 2017 | Pubmed ID: 28076765 Hypothesis Driven Versus Hypothesis-free: Filling the Gaps in CoQ Biosynthesis Cell Metabolism. 10, 2016 | Pubmed ID: 27732833 Respiratory Supercomplexes and the Functional Segmentation of the CoQ Pool Free Radical Biology & Medicine. 11, 2016 | Pubmed ID: 27105951 The CoQH2/CoQ Ratio Serves As a Sensor of Respiratory Chain Efficiency Cell Reports. Apr, 2016 | Pubmed ID: 27052170 Supramolecular Organization of Respiratory Complexes Annual Review of Physiology. Month, 2016 | Pubmed ID: 26734886 The Complex Crosstalk Between Mitochondria and the Nucleus: What Goes in Between? The International Journal of Biochemistry & Cell Biology. Jun, 2015 | Pubmed ID: 25666554 ROS-triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use Cell Metabolism. Jun, 2014 | Pubmed ID: 24856931 The Function of the Respiratory Supercomplexes: the Plasticity Model Biochimica Et Biophysica Acta. Apr, 2014 | Pubmed ID: 24368156 İç Mitokondriyal Membranın Na+' ya Duyarlılığı Kısmen Segmente Edilmiş Fonksiyonel CoQ Havuzlarını Ortaya Çıkarır Pablo Hernansanz-Agustín1, José Antonio Enríquez1,2 1Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, 2Centro de Investigaciones Biomédica en Red de Fragilidad y Envejecimiento, Saludable-CIBERFES JoVE 63729 생화학
İç Mitokondriyal Membranın Na+' ya Duyarlılığı Kısmen Segmente Edilmiş Fonksiyonel CoQ Havuzlarını Ortaya Çıkarır Pablo Hernansanz-Agustín1, José Antonio Enríquez1,2 1Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, 2Centro de Investigaciones Biomédica en Red de Fragilidad y Envejecimiento, Saludable-CIBERFES JoVE 63729 생화학