Kensuke Osada Department of Bioengineering, School of Engineering The University of Tokyo Biography Publications Institution JoVE Articles Kensuke Osada has not added a biography. If you are Kensuke Osada and would like to personalize this page please email our Author Liaison for assistance. Publications Block Copolymer Micellization As a Protection Strategy for DNA Origami Angewandte Chemie (International Ed. in English). Mar, 2017 | Pubmed ID: 28295864 Effect of Shear Stress on Structure and Function of Polyplex Micelles from Poly(ethylene Glycol)-poly(l-lysine) Block Copolymers As Systemic Gene Delivery Carrier Biomaterials. May, 2017 | Pubmed ID: 28254691 Happy Birthday Kataoka-sensei! Macromolecular Bioscience. Jan, 2017 | Pubmed ID: 28079310 Poly(ethylene Glycol) Crowding As Critical Factor To Determine PDNA Packaging Scheme into Polyplex Micelles for Enhanced Gene Expression Biomacromolecules. Jan, 2017 | Pubmed ID: 27990798 Polyplex Micelle Installing Intracellular Self-processing Functionalities Without Free Catiomers for Safe and Efficient Systemic Gene Therapy Through Tumor Vasculature Targeting Biomaterials. Jan, 2017 | Pubmed ID: 27835820 Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers Macromolecular Rapid Communications. Mar, 2016 | Pubmed ID: 26765970 Systemic Delivery of Messenger RNA for the Treatment of Pancreatic Cancer Using Polyplex Nanomicelles with a Cholesterol Moiety Biomaterials. Mar, 2016 | Pubmed ID: 26763736 Polyplex Micelles with Double-Protective Compartments of Hydrophilic Shell and Thermoswitchable Palisade of Poly(oxazoline)-Based Block Copolymers for Promoted Gene Transfection Biomacromolecules. Jan, 2016 | Pubmed ID: 26682466 Enhanced Target Recognition of Nanoparticles by Cocktail PEGylation with Chains of Varying Lengths Chemical Communications (Cambridge, England). Jan, 2016 | Pubmed ID: 26658952 Rod-to-Globule Transition of PDNA/PEG-Poly(l-Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness Small (Weinheim an Der Bergstrasse, Germany). Mar, 2016 | Pubmed ID: 26426541 Toroidal Packaging of PDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression Biomacromolecules. Sep, 2015 | Pubmed ID: 26226080 Ternary Polyplex Micelles with PEG Shells and Intermediate Barrier to Complexed DNA Cores for Efficient Systemic Gene Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2015 | Pubmed ID: 25912408 Feasibility of a Subcutaneously Administered Block/homo-mixed Polyplex Micelle As a Carrier for DNA Vaccination in a Mouse Tumor Model Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2015 | Pubmed ID: 25819159 A Tadpole-shaped Gene Carrier with Distinct Phase Segregation in a Ternary Polymeric Micelle Soft Matter. Apr, 2015 | Pubmed ID: 25711768 Intraperitoneal Administration of a Tumor-associated Antigen SART3, CD40L, and GM-CSF Gene-loaded Polyplex Micelle Elicits a Vaccine Effect in Mouse Tumor Models PloS One. 2014 | Pubmed ID: 25013909 Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency Against Pancreatic Tumor ACS Nano. Jul, 2014 | Pubmed ID: 24927216 Optimized Rod Length of Polyplex Micelles for Maximizing Transfection Efficiency and Their Performance in Systemic Gene Therapy Against Stroma-rich Pancreatic Tumors Biomaterials. Jul, 2014 | Pubmed ID: 24720877 Three-layered Polyplex Micelle As a Multifunctional Nanocarrier Platform for Light-induced Systemic Gene Transfer Nature Communications. Apr, 2014 | Pubmed ID: 24694458 Targeted Gene Delivery by Polyplex Micelles with Crowded PEG Palisade and CRGD Moiety for Systemic Treatment of Pancreatic Tumors Biomaterials. Mar, 2014 | Pubmed ID: 24439417 In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle PloS One. 2013 | Pubmed ID: 23418537 Bioactive Polymeric Metallosomes Self-assembled Through Block Copolymer-metal Complexation Journal of the American Chemical Society. Aug, 2012 | Pubmed ID: 22834643 NanoPARCEL: a Method for Controlling Cellular Behavior with External Light Chemical Communications (Cambridge, England). Aug, 2012 | Pubmed ID: 22798992 Pancreatic Cancer Therapy by Systemic Administration of VEGF SiRNA Contained in Calcium Phosphate/charge-conversional Polymer Hybrid Nanoparticles Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2012 | Pubmed ID: 22580114 Targeted Polymeric Micelles for SiRNA Treatment of Experimental Cancer by Intravenous Injection ACS Nano. Jun, 2012 | Pubmed ID: 22575090 Effective Transgene Expression Without Toxicity by Intraperitoneal Administration of PEG-detachable Polyplex Micelles in Mice with Peritoneal Dissemination Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2012 | Pubmed ID: 22484197 Homo-catiomer Integration into PEGylated Polyplex Micelle from Block-catiomer for Systemic Anti-angiogenic Gene Therapy for Fibrotic Pancreatic Tumors Biomaterials. Jun, 2012 | Pubmed ID: 22444644 PEGylated Polyplex with Optimized PEG Shielding Enhances Gene Introduction in Lungs by Minimizing Inflammatory Responses Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2012 | Pubmed ID: 22334020 Enhanced Gene Expression Promoted by the Quantized Folding of PDNA Within Polyplex Micelles Biomaterials. Jan, 2012 | Pubmed ID: 21993237 Effect of Polymer Structure on Micelles Formed Between SiRNA and Cationic Block Copolymer Comprising Thiols and Amidines Biomacromolecules. Sep, 2011 | Pubmed ID: 21863796 Combination of Chondroitin Sulfate and Polyplex Micelles from Poly(ethylene Glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} Block Copolymer for Prolonged in Vivo Gene Transfection with Reduced Toxicity Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2011 | Pubmed ID: 21571018 Enhanced Endosomal Escape of SiRNA-incorporating Hybrid Nanoparticles from Calcium Phosphate and PEG-block Charge-conversional Polymer for Efficient Gene Knockdown with Negligible Cytotoxicity Biomaterials. Apr, 2011 | Pubmed ID: 21272932 Polyplex Micelles Prepared from ω-cholesteryl PEG-polycation Block Copolymers for Systemic Gene Delivery Biomaterials. Jan, 2011 | Pubmed ID: 20932567 Enhanced in Vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties Macromolecular Rapid Communications. Sep, 2010 | Pubmed ID: 21567561 Quantized Folding of Plasmid DNA Condensed with Block Catiomer into Characteristic Rod Structures Promoting Transgene Efficacy Journal of the American Chemical Society. Sep, 2010 | Pubmed ID: 20712309 Polyplex Nanomicelle Promotes Hydrodynamic Gene Introduction to Skeletal Muscle Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2010 | Pubmed ID: 20043959 Polymeric Micelles from Poly(ethylene Glycol)-poly(amino Acid) Block Copolymer for Drug and Gene Delivery Journal of the Royal Society, Interface. Jun, 2009 | Pubmed ID: 19364722 Charge-conversional Polyionic Complex Micelles-efficient Nanocarriers for Protein Delivery into Cytoplasm Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19294716 Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: a Physiologically Available Oxygen Carrier Angewandte Chemie (International Ed. in English). 2007 | Pubmed ID: 17628476 Semipermeable Polymer Vesicle (PICsome) Self-assembled in Aqueous Medium from a Pair of Oppositely Charged Block Copolymers: Physiologically Stable Micro-/nanocontainers of Water-soluble Macromolecules Journal of the American Chemical Society. May, 2006 | Pubmed ID: 16669639 A Synthetic Block Copolymer Regulates S1 Nuclease Fragmentation of Supercoiled Plasmid DNA Angewandte Chemie (International Ed. in English). Jun, 2005 | Pubmed ID: 15880738 Methoden zur Selbst Integration von Megamolecular Biopolymere auf der Trocknungsluft-LC-Schnittstelle Kosuke Okeyoshi1, Kensuke Osada2, Maiko K. Okajima1, Tatsuo Kaneko1 1Japan Advanced Institute of Science and Technology, 2Department of Bioengineering, School of Engineering, The University of Tokyo JoVE 55274 생체공학
Methoden zur Selbst Integration von Megamolecular Biopolymere auf der Trocknungsluft-LC-Schnittstelle Kosuke Okeyoshi1, Kensuke Osada2, Maiko K. Okajima1, Tatsuo Kaneko1 1Japan Advanced Institute of Science and Technology, 2Department of Bioengineering, School of Engineering, The University of Tokyo JoVE 55274 생체공학