Mansoor Amiji Department of Pharmaceutical Sciences, School of Pharmacy Northeastern University Biography Publications Institution JoVE Articles Mansoor Amiji has not added a biography. If you are Mansoor Amiji and would like to personalize this page please email our Author Liaison for assistance. Publications Multi-Compartmental Nanoparticles-in-Emulsion Formulation for Macrophage-Specific Anti-Inflammatory Gene Delivery Pharmaceutical Research. Jan, 2012 | Pubmed ID: 22281760 Fluorescence-guided Optical Coherence Tomography Imaging for Colon Cancer Screening: a Preliminary Mouse Study Biomedical Optics Express. Jan, 2012 | Pubmed ID: 22254178 Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine Pharmaceutical Research. Nov, 2011 | Pubmed ID: 22072053 Photodynamic Effects of Methylene Blue-loaded Polymeric Nanoparticles on Dental Plaque Bacteria Lasers in Surgery and Medicine. Sep, 2011 | Pubmed ID: 22057487 Therapeutic Strategies for Endothelial Dysfunction Expert Opinion on Biological Therapy. Dec, 2011 | Pubmed ID: 21992579 'Click' Synthesis of Dextran Macrostructures for Combinatorial-designed Self-assembled Nanoparticles Encapsulating Diverse Anticancer Therapeutics Bioorganic & Medicinal Chemistry. Nov, 2011 | Pubmed ID: 21978947 Therapeutic Efficacy and Safety of Paclitaxel/lonidamine Loaded EGFR-targeted Nanoparticles for the Treatment of Multi-drug Resistant Cancer PloS One. 2011 | Pubmed ID: 21931642 Combinatorial-designed Multifunctional Polymeric Nanosystems for Tumor-targeted Therapeutic Delivery Accounts of Chemical Research. Oct, 2011 | Pubmed ID: 21761902 Anti-angiogenic Effects of Betulinic Acid Administered in Nanoemulsion Formulation Using Chorioallantoic Membrane Assay Journal of Biomedical Nanotechnology. Apr, 2011 | Pubmed ID: 21702370 Non-condensing Polymeric Nanoparticles for Targeted Gene and SiRNA Delivery International Journal of Pharmaceutics. May, 2011 | Pubmed ID: 21621597 Mucoadhesive Nanomedicines: Characterization and Modulation of Mucoadhesion at the Nanoscale Expert Opinion on Drug Delivery. Aug, 2011 | Pubmed ID: 21599564 Mucoadhesive Nanosystems for Vaginal Microbicide Development: Friend or Foe? Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. Jul-Aug, 2011 | Pubmed ID: 21506290 Multi-modal Strategies for Overcoming Tumor Drug Resistance: Hypoxia, the Warburg Effect, Stem Cells, and Multifunctional Nanotechnology Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2011 | Pubmed ID: 21497176 Role of Hypoxia and Glycolysis in the Development of Multi-drug Resistance in Human Tumor Cells and the Establishment of an Orthotopic Multi-drug Resistant Tumor Model in Nude Mice Using Hypoxic Pre-conditioning Cancer Cell International. 2011 | Pubmed ID: 21320311 Pharmacokinetics and Biodistribution of Lonidamine/paclitaxel Loaded, EGFR-targeted Nanoparticles in an Orthotopic Animal Model of Multi-drug Resistant Breast Cancer Nanomedicine : Nanotechnology, Biology, and Medicine. Aug, 2011 | Pubmed ID: 21220050 Oral TNF-α Gene Silencing Using a Polymeric Microsphere-based Delivery System for the Treatment of Inflammatory Bowel Disease Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2011 | Pubmed ID: 20959130 Development of EGFR-targeted Polymer Blend Nanocarriers for Combination Paclitaxel/lonidamine Delivery to Treat Multi-drug Resistance in Human Breast and Ovarian Tumor Cells Molecular Pharmaceutics. Feb, 2011 | Pubmed ID: 20942457 Nanomedicine for Cancer Therapy Pharmaceutical Research. Feb, 2011 | Pubmed ID: 20845066 Nanoparticles: a Promising Modality in the Treatment of Sarcomas Pharmaceutical Research. Feb, 2011 | Pubmed ID: 20505985 Preliminary Evaluation of a Nanotechnology-based Approach for the More Effective Diagnosis of Colon Cancers Nanomedicine (London, England). Nov, 2010 | Pubmed ID: 21128727 A Review of Multifunctional Nanoemulsion Systems to Overcome Oral and CNS Drug Delivery Barriers Molecular Membrane Biology. Oct, 2010 | Pubmed ID: 20929336 Non-viral ENOS Gene Delivery and Transfection with Stents for the Treatment of Restenosis Biomedical Engineering Online. 2010 | Pubmed ID: 20875110 Curcumin Enhances Oral Bioavailability and Anti-tumor Therapeutic Efficacy of Paclitaxel Upon Administration in Nanoemulsion Formulation Journal of Pharmaceutical Sciences. Nov, 2010 | Pubmed ID: 20845461 Inhibition of ABCB1 (MDR1) Expression by an SiRNA Nanoparticulate Delivery System to Overcome Drug Resistance in Osteosarcoma PloS One. 2010 | Pubmed ID: 20520719 Targeting Stents with Local Delivery of Paclitaxel-loaded Magnetic Nanoparticles Using Uniform Fields Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20404175 Augmentation of Therapeutic Efficacy in Drug-resistant Tumor Models Using Ceramide Coadministration in Temporal-controlled Polymer-blend Nanoparticle Delivery Systems The AAPS Journal. Jun, 2010 | Pubmed ID: 20143195 Development and Validation of a Rapid Reversed-phase HPLC Method for the Determination of the Non-nucleoside Reverse Transcriptase Inhibitor Dapivirine from Polymeric Nanoparticles Journal of Pharmaceutical and Biomedical Analysis. Jun, 2010 | Pubmed ID: 20117900 Nanoparticle-based Endodontic Antimicrobial Photodynamic Therapy Journal of Endodontics. Feb, 2010 | Pubmed ID: 20113801 Sustained Drug Release from Non-eroding Nanoporous Templates Small (Weinheim an Der Bergstrasse, Germany). Jan, 2010 | Pubmed ID: 19967712 Nanotechnology Solutions for Mucosal Immunization Advanced Drug Delivery Reviews. Mar, 2010 | Pubmed ID: 19931581 Nanoporous Inorganic Membranes or Coatings for Sustained Drug Delivery in Implantable Devices Advanced Drug Delivery Reviews. Mar, 2010 | Pubmed ID: 19922749 Nanotechnology-based Systems for the Treatment and Prevention of HIV/AIDS Advanced Drug Delivery Reviews. Mar, 2010 | Pubmed ID: 19914314 Nanotechnology Solutions for Infectious Diseases in Developing Nations. Preface Advanced Drug Delivery Reviews. Mar, 2010 | Pubmed ID: 19913580 Brain Delivery of Proteins by the Intranasal Route of Administration: a Comparison of Cationic Liposomes Versus Aqueous Solution Formulations Journal of Pharmaceutical Sciences. Apr, 2010 | Pubmed ID: 19774660 In Vitro and in Vivo Studies of Local Arterial Gene Delivery and Transfection Using Lipopolyplexes-embedded Stents Journal of Biomedical Materials Research. Part A. Apr, 2010 | Pubmed ID: 19569206 Doxorubicin Loaded Polymeric Nanoparticulate Delivery System to Overcome Drug Resistance in Osteosarcoma BMC Cancer. 2009 | Pubmed ID: 19917123 Label-free Raman Spectral Imaging of Intracellular Delivery and Degradation of Polymeric Nanoparticle Systems ACS Nano. Nov, 2009 | Pubmed ID: 19863088 Delivery Strategies to Enhance Mucosal Vaccination Expert Opinion on Biological Therapy. Apr, 2009 | Pubmed ID: 19344280 Challenges and Opportunities in CNS Delivery of Therapeutics for Neurodegenerative Diseases Expert Opinion on Drug Delivery. Mar, 2009 | Pubmed ID: 19290842 Coadministration of Paclitaxel and Curcumin in Nanoemulsion Formulations to Overcome Multidrug Resistance in Tumor Cells Molecular Pharmaceutics. May-Jun, 2009 | Pubmed ID: 19278222 Evaluations of Combination MDR-1 Gene Silencing and Paclitaxel Administration in Biodegradable Polymeric Nanoparticle Formulations to Overcome Multidrug Resistance in Cancer Cells Cancer Chemotherapy and Pharmacology. Mar, 2009 | Pubmed ID: 18618115 Protein Nanospheres for Gene Delivery CSH Protocols. 2008 | Pubmed ID: 21356682 Cell Transfection and Analysis Using DNA-Loaded Gelatin Nanoparticles CSH Protocols. 2008 | Pubmed ID: 21356669 Intracellular Trafficking Studies Using Gold-encapsulated Gelatin Nanoparticles CSH Protocols. 2008 | Pubmed ID: 21356668 Preparation and Loading of Gelatin Nanoparticles CSH Protocols. 2008 | Pubmed ID: 21356667 Epidermal Growth Factor Receptor-targeted Gelatin-based Engineered Nanocarriers for DNA Delivery and Transfection in Human Pancreatic Cancer Cells The AAPS Journal. Dec, 2008 | Pubmed ID: 19034673 Biodistribution and Pharmacokinetic Analysis of Paclitaxel and Ceramide Administered in Multifunctional Polymer-blend Nanoparticles in Drug Resistant Breast Cancer Model Molecular Pharmaceutics. Jul-Aug, 2008 | Pubmed ID: 18616278 A Model Predicting Delivery of Saquinavir in Nanoparticles to Human Monocyte/macrophage (Mo/Mac) Cells Biotechnology and Bioengineering. Dec, 2008 | Pubmed ID: 18553495 Multi-functional Nanocarriers for Targeted Delivery of Drugs and Genes Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2008 | Pubmed ID: 18538887 Multi-functional Nanocarriers to Overcome Tumor Drug Resistance Cancer Treatment Reviews. Nov, 2008 | Pubmed ID: 18538481 Modulation of Drug Resistance in Ovarian Adenocarcinoma by Enhancing Intracellular Ceramide Using Tamoxifen-loaded Biodegradable Polymeric Nanoparticles Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2008 | Pubmed ID: 18483388 Enhancement in Anti-proliferative Effects of Paclitaxel in Aortic Smooth Muscle Cells Upon Co-administration with Ceramide Using Biodegradable Polymeric Nanoparticles Pharmaceutical Research. Aug, 2008 | Pubmed ID: 18480968 Enhanced Mucosal and Systemic Immune Response with Squalane Oil-containing Multiple Emulsions Upon Intranasal and Oral Administration in Mice Journal of Drug Targeting. May, 2008 | Pubmed ID: 18446609 Development of Novel Biodegradable Polymeric Nanoparticles-in-microsphere Formulation for Local Plasmid DNA Delivery in the Gastrointestinal Tract AAPS PharmSciTech. 2008 | Pubmed ID: 18446494 Poly(beta-amino Ester) and Cationic Phospholipid-based Lipopolyplexes for Gene Delivery and Transfection in Human Aortic Endothelial and Smooth Muscle Cells Biomacromolecules. Apr, 2008 | Pubmed ID: 18307309 A Review of Stimuli-responsive Nanocarriers for Drug and Gene Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2008 | Pubmed ID: 18261822 Cytotoxicity and Apoptosis Enhancement in Brain Tumor Cells Upon Coadministration of Paclitaxel and Ceramide in Nanoemulsion Formulations Journal of Pharmaceutical Sciences. Jul, 2008 | Pubmed ID: 17854074 Improved Oral Bioavailability and Brain Transport of Saquinavir Upon Administration in Novel Nanoemulsion Formulations International Journal of Pharmaceutics. Jan, 2008 | Pubmed ID: 17651927 An Overview of Condensing and Noncondensing Polymeric Systems for Gene Delivery CSH Protocols. 2007 | Pubmed ID: 21357090 Nanocarriers for Systemic and Mucosal Vaccine Delivery Recent Patents on Drug Delivery & Formulation. 2007 | Pubmed ID: 19075870 Nanoparticulate Carriers for the Treatment of Coronary Restenosis International Journal of Nanomedicine. 2007 | Pubmed ID: 17722543 Role of Nanotechnology in Pharmaceutical Product Development Journal of Pharmaceutical Sciences. Oct, 2007 | Pubmed ID: 17688284 Synthesis and Evaluation of Tripodal Peptide Analogues for Cellular Delivery of Phosphopeptides Journal of Medicinal Chemistry. Jul, 2007 | Pubmed ID: 17580848 Paclitaxel and Ceramide Co-administration in Biodegradable Polymeric Nanoparticulate Delivery System to Overcome Drug Resistance in Ovarian Cancer International Journal of Cancer. Journal International Du Cancer. Oct, 2007 | Pubmed ID: 17557285 Modulation of Intracellular Ceramide Using Polymeric Nanoparticles to Overcome Multidrug Resistance in Cancer Cancer Research. May, 2007 | Pubmed ID: 17510414 Polymeric Nano- and Microparticle Technologies for Oral Gene Delivery Expert Opinion on Drug Delivery. May, 2007 | Pubmed ID: 17489649 Gastrointestinal Distribution and in Vivo Gene Transfection Studies with Nanoparticles-in-microsphere Oral System (NiMOS) Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2007 | Pubmed ID: 17475358 Poly(ethylene Glycol)-modified Nanocarriers for Tumor-targeted and Intracellular Delivery Pharmaceutical Research. Aug, 2007 | Pubmed ID: 17393074 Poly(ethylene Glycol)-modified Thiolated Gelatin Nanoparticles for Glutathione-responsive Intracellular DNA Delivery Nanomedicine : Nanotechnology, Biology, and Medicine. Mar, 2007 | Pubmed ID: 17379167 Biodistribution and Pharmacokinetic Analysis of Long-circulating Thiolated Gelatin Nanoparticles Following Systemic Administration in Breast Cancer-bearing Mice Journal of Pharmaceutical Sciences. Feb, 2007 | Pubmed ID: 17075865 Poly(ethylene Oxide)-modified Poly(beta-amino Ester) Nanoparticles As a PH-sensitive System for Tumor-targeted Delivery of Hydrophobic Drugs: Part 3. Therapeutic Efficacy and Safety Studies in Ovarian Cancer Xenograft Model Cancer Chemotherapy and Pharmacology. Mar, 2007 | Pubmed ID: 16862429 Formulation and Physiological Factors Influencing CNS Delivery Upon Intranasal Administration Critical Reviews in Therapeutic Drug Carrier Systems. 2006 | Pubmed ID: 17341201 Role of Nanotechnology in HIV/AIDS Treatment: Potential to Overcome the Viral Reservoir Challenge Discovery Medicine. Aug, 2006 | Pubmed ID: 17234137 Improved Oral Delivery of Paclitaxel Following Administration in Nanoemulsion Formulations Journal of Nanoscience and Nanotechnology. Sep-Oct, 2006 | Pubmed ID: 17048539 Intracellular Delivery of Saquinavir in Biodegradable Polymeric Nanoparticles for HIV/AIDS Pharmaceutical Research. Nov, 2006 | Pubmed ID: 16969696 Nanoparticulate Drug Carriers for Delivery of HIV/AIDS Therapy to Viral Reservoir Sites Expert Opinion on Drug Delivery. Sep, 2006 | Pubmed ID: 16948557 A Review of Nanocarrier-based CNS Delivery Systems Current Drug Delivery. Apr, 2006 | Pubmed ID: 16611008 Multi-functional Polymeric Nanoparticles for Tumour-targeted Drug Delivery Expert Opinion on Drug Delivery. Mar, 2006 | Pubmed ID: 16506948 Surface Functionalization of Gold Nanoparticles Using Hetero-bifunctional Poly(ethylene Glycol) Spacer for Intracellular Tracking and Delivery International Journal of Nanomedicine. 2006 | Pubmed ID: 16467923 Formulation Optimization for the Nanoparticles-in-microsphere Hybrid Oral Delivery System Using Factorial Design Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2006 | Pubmed ID: 16338017 Long-circulating Polymeric Nanovectors for Tumor-selective Gene Delivery Technology in Cancer Research & Treatment. Dec, 2005 | Pubmed ID: 16292881 Preparation and Evaluation of Thiol-modified Gelatin Nanoparticles for Intracellular DNA Delivery in Response to Glutathione Bioconjugate Chemistry. Nov-Dec, 2005 | Pubmed ID: 16287238 Poly(ethylene Oxide)-modified Poly(beta-amino Ester) Nanoparticles As a PH-sensitive System for Tumor-targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies Pharmaceutical Research. Dec, 2005 | Pubmed ID: 16254763 An Approach to Heterobifunctional Poly(ethyleneglycol) Bioconjugates Bioorganic & Medicinal Chemistry Letters. Dec, 2005 | Pubmed ID: 16236512 Poly(ethylene Oxide)-modified Poly(beta-amino Ester) Nanoparticles As a PH-sensitive System for Tumor-targeted Delivery of Hydrophobic Drugs. 1. In Vitro Evaluations Molecular Pharmaceutics. Sep-Oct, 2005 | Pubmed ID: 16196488 Tumor-targeted Gene Delivery Using Poly(ethylene Glycol)-modified Gelatin Nanoparticles: in Vitro and in Vivo Studies Pharmaceutical Research. Jun, 2005 | Pubmed ID: 15948039 Poly(ethylene Oxide)-modified Poly(epsilon-caprolactone) Nanoparticles for Targeted Delivery of Tamoxifen in Breast Cancer International Journal of Pharmaceutics. Apr, 2005 | Pubmed ID: 15778064 Cellular Interactions and in Vitro DNA Transfection Studies with Poly(ethylene Glycol)-modified Gelatin Nanoparticles Journal of Pharmaceutical Sciences. Jan, 2005 | Pubmed ID: 15761942 Biodistribution and Targeting Potential of Poly(ethylene Glycol)-modified Gelatin Nanoparticles in Subcutaneous Murine Tumor Model Journal of Drug Targeting. 2004 | Pubmed ID: 15621684 Poly-N-acetyl Glucosamine-mediated Red Blood Cell Interactions The Journal of Trauma. Jul, 2004 | Pubmed ID: 15280744 Stomach-specific Anti-H. Pylori Therapy; Part III: Effect of Chitosan Microspheres Crosslinking on the Gastric Residence and Local Tetracycline Concentrations in Fasted Gerbils International Journal of Pharmaceutics. Mar, 2004 | Pubmed ID: 15019073 Enzyme Immobilization in Novel Alginate-chitosan Core-shell Microcapsules Biomaterials. May, 2004 | Pubmed ID: 14738858 Stomach-specific Anti-H. Pylori Therapy. II. Gastric Residence Studies of Tetracycline-loaded Chitosan Microspheres in Gerbils Pharmaceutical Development and Technology. Aug, 2003 | Pubmed ID: 12901691 Cellular Uptake and Concentrations of Tamoxifen Upon Administration in Poly(epsilon-caprolactone) Nanoparticles AAPS PharmSci. 2003 | Pubmed ID: 12713275 Chitosan-based Gastrointestinal Delivery Systems Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2003 | Pubmed ID: 12711440 Poly(ethylene Oxide)-modified Poly(beta-amino Ester) Nanoparticles As a PH-sensitive Biodegradable System for Paclitaxel Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2003 | Pubmed ID: 12526819 Biodegradable Poly(epsilon -caprolactone) Nanoparticles for Tumor-targeted Delivery of Tamoxifen International Journal of Pharmaceutics. Dec, 2002 | Pubmed ID: 12433441 Long-circulating Poly(ethylene Glycol)-modified Gelatin Nanoparticles for Intracellular Delivery Pharmaceutical Research. Jul, 2002 | Pubmed ID: 12180540 Intratumoral Administration of Paclitaxel in an in Situ Gelling Poloxamer 407 Formulation Pharmaceutical Development and Technology. May, 2002 | Pubmed ID: 12066574 Localized Delivery of Paclitaxel in Solid Tumors from Biodegradable Chitin Microparticle Formulations Biomaterials. Jul, 2002 | Pubmed ID: 12059022 Stomach-specific Anti-H. Pylori Therapy. I: Preparation and Characterization of Tetracyline-loaded Chitosan Microspheres International Journal of Pharmaceutics. Mar, 2002 | Pubmed ID: 11879743 PH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material Within the Range of Intracellular PH Financial Support Was Provided by the NSF (Cooperative Agreement No. ECC9843342 to the MIT Biotechnology Process Engineering Center), the NIH (GM26698), and the Department of the Army (Cooperative Agreement DAMD 17-99-2-9-001 to the Center for Innovative Minimally Invasive Therapy). D.M.L. Wishes to Thank the NIH for a Postdoctoral Fellowship (NRSA Fellowship No. 1 F32 GM20227-01). Scanning Electron Microscopy and Confocal Microscopy Images Were Acquired by William Fowle at the Northeastern University Center for Electron Microscopy. Dr. David Putnam, David Ting, and Tommy Thomas Are Thanked for Helpful Discussions Angewandte Chemie (International Ed. in English). May, 2001 | Pubmed ID: 11353487 Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles Jing Xu1, Mansoor Amiji1 1Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University JoVE 3612 생체공학
Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles Jing Xu1, Mansoor Amiji1 1Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University JoVE 3612 생체공학