Mark J. Crabtree BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital University of Oxford Biography Publications Institution JoVE Articles Mark J. Crabtree has not added a biography. If you are Mark J. Crabtree and would like to personalize this page please email our Author Liaison for assistance. Publications Atrial Nitroso-redox Balance and Refractoriness Following On-pump Cardiac Surgery: a Randomized Trial of Atorvastatin Cardiovascular Research. 01, 2022 | Pubmed ID: 33098411 Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth Hypertension (Dallas, Tex. : 1979). 12, 2021 | Pubmed ID: 34689592 Itaconate As an Inflammatory Mediator and Therapeutic Target in Cardiovascular Medicine Biochemical Society Transactions. 11, 2021 | Pubmed ID: 34665229 Hepatic MiR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity Gastroenterology. 12, 2021 | Pubmed ID: 34425095 Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis Circulation. 09, 2021 | Pubmed ID: 34255973 Isolation and Culture of Murine Bone Marrow-derived Macrophages for Nitric Oxide and Redox Biology Nitric Oxide : Biology and Chemistry. 08, 2020 | Pubmed ID: 32339668 Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages Through TCA Cycle Regulation and Itaconate Accumulation Cell Reports. 07, 2019 | Pubmed ID: 31269442 Regulation of Mycobacterial Infection by Macrophage Gch1 and Tetrahydrobiopterin Nature Communications. 12, 2018 | Pubmed ID: 30573728 Tetrahydrobiopterin Modulates Ubiquitin Conjugation to UBC13/UBE2N and Proteasome Activity by S-nitrosation Scientific Reports. 09, 2018 | Pubmed ID: 30254268 Roles for Endothelial Cell and Macrophage Gch1 and Tetrahydrobiopterin in Atherosclerosis Progression Cardiovascular Research. 08, 2018 | Pubmed ID: 29596571 A Key Role for Tetrahydrobiopterin-dependent Endothelial NOS Regulation in Resistance Arteries: Studies in Endothelial Cell Tetrahydrobiopterin-deficient Mice British Journal of Pharmacology. 04, 2017 | Pubmed ID: 28128438 A Novel Role for Endothelial Tetrahydrobiopterin in Mitochondrial Redox Balance Free Radical Biology & Medicine. 03, 2017 | Pubmed ID: 28104455 Protection Against Ventricular Fibrillation Via Cholinergic Receptor Stimulation and the Generation of Nitric Oxide The Journal of Physiology. 07, 2016 | Pubmed ID: 26752781 CAPON Modulates Neuronal Calcium Handling and Cardiac Sympathetic Neurotransmission During Dysautonomia in Hypertension Hypertension (Dallas, Tex. : 1979). Jun, 2015 | Pubmed ID: 25916729 A Requirement for Gch1 and Tetrahydrobiopterin in Embryonic Development Developmental Biology. Mar, 2015 | Pubmed ID: 25557619 Regulation of INOS Function and Cellular Redox State by Macrophage Gch1 Reveals Specific Requirements for Tetrahydrobiopterin in NRF2 Activation Free Radical Biology & Medicine. Feb, 2015 | Pubmed ID: 25451639 Parkinson's Disease in GTP Cyclohydrolase 1 Mutation Carriers Brain : a Journal of Neurology. May, 2015 | Pubmed ID: 25398233 Endothelial Cell-specific Reactive Oxygen Species Production Increases Susceptibility to Aortic Dissection Circulation. Jun, 2014 | Pubmed ID: 24807872 Cell-autonomous Role of Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation Hypertension (Dallas, Tex. : 1979). Sep, 2014 | Pubmed ID: 24777984 Tetrahydrobiopterin in Cardiovascular Health and Disease Antioxidants & Redox Signaling. Jun, 2014 | Pubmed ID: 24294830 α-Synuclein and Mitochondrial Bioenergetics Regulate Tetrahydrobiopterin Levels in a Human Dopaminergic Model of Parkinson Disease Free Radical Biology & Medicine. Feb, 2014 | Pubmed ID: 24148766 A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): Effects on Tetrahydrobiopterin-dependent Catalysis and ENOS Dimerization The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 23965989 Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23139420 Nitric Oxide Synthases in Heart Failure Antioxidants & Redox Signaling. Mar, 2013 | Pubmed ID: 22871241 Regulation of Endothelial Nitric-oxide Synthase (NOS) S-glutathionylation by Neuronal NOS: Evidence of a Functional Interaction Between Myocardial Constitutive NOS Isoforms The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23091050 내 피 세포 Repopulation Stenting 결정에 스텐 Neointima 형성 후: 효과 약 Eluting 스텐 트 대 완전 하 고 유전자의 내 피 세포 수정 European Heart Journal. Sep, 2012 | Pubmed ID: 23008511 Cardiomyocyte GTP Cyclohydrolase 1 and Tetrahydrobiopterin Increase NOS1 Activity and Accelerate Myocardial Relaxation Circulation Research. Aug, 2012 | Pubmed ID: 22798524 Recoupling the Cardiac Nitric Oxide Synthases: Tetrahydrobiopterin Synthesis and Recycling Current Heart Failure Reports. Sep, 2012 | Pubmed ID: 22711313 Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients with Coronary Artery Disease Circulation. Mar, 2012 | Pubmed ID: 22315282 Endothelial-specific Nox2 Overexpression Increases Vascular Superoxide and Macrophage Recruitment in ApoE⁻/⁻ Mice Cardiovascular Research. Apr, 2012 | Pubmed ID: 22287576 Synthesis and Recycling of Tetrahydrobiopterin in Endothelial Function and Vascular Disease Nitric Oxide : Biology and Chemistry. Aug, 2011 | Pubmed ID: 21550412 Dihydrofolate Reductase Protects Endothelial Nitric Oxide Synthase from Uncoupling in Tetrahydrobiopterin Deficiency Free Radical Biology & Medicine. Jun, 2011 | Pubmed ID: 21402147 Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling: Relative Importance of the De Novo Biopterin Synthesis Versus Salvage Pathways The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19666465 GTP Cyclohydrolase I Expression, Protein, and Activity Determine Intracellular Tetrahydrobiopterin Levels, Independent of GTP Cyclohydrolase Feedback Regulatory Protein Expression The Journal of Biological Chemistry. May, 2009 | Pubmed ID: 19286659 Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status: Insights from Cells with Tet-regulated GTP Cyclohydrolase I Expression The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 19011239 NO-Redox 생물학의 연구를 위한 골수 유래 대식세포의 분리 및 시험관내 배양 Marina Diotallevi*1,2, Thomas Nicol*1,2, Faseeha Ayaz1,2, Jade Bailey1,2, Andrew Shaw1,2, Eileen McNeill1,2, Ben Davies1,2, Keith M. Channon1,2, Mark J. Crabtree1,2 1BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, 2Wellcome Centre for Human Genetics, University of Oxford JoVE 62834 면역학 및 감염병학
NO-Redox 생물학의 연구를 위한 골수 유래 대식세포의 분리 및 시험관내 배양 Marina Diotallevi*1,2, Thomas Nicol*1,2, Faseeha Ayaz1,2, Jade Bailey1,2, Andrew Shaw1,2, Eileen McNeill1,2, Ben Davies1,2, Keith M. Channon1,2, Mark J. Crabtree1,2 1BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, 2Wellcome Centre for Human Genetics, University of Oxford JoVE 62834 면역학 및 감염병학
