Martin Hirst Department of Microbiology and Immunology, Michael Smith Laboratories Centre for High-Throughput Biology University of British Columbia Biography Publications Institution JoVE Articles Martin Hirst has not added a biography. If you are Martin Hirst and would like to personalize this page please email our Author Liaison for assistance. Publications Fate Mapping of Human Glioblastoma Reveals an Invariant Stem Cell Hierarchy Nature. Sep, 2017 | Pubmed ID: 28854171 The [PSI +] Yeast Prion Does Not Wildly Affect Proteome Composition Whereas Selective Pressure Exerted on [PSI +] Cells Can Promote Aneuploidy Scientific Reports. Aug, 2017 | Pubmed ID: 28814753 Characterization of the Human Thyroid Epigenome The Journal of Endocrinology. Nov, 2017 | Pubmed ID: 28808080 Vitamin C Induces Specific Demethylation of H3K9me2 in Mouse Embryonic Stem Cells Via Kdm3a/b Epigenetics & Chromatin. 2017 | Pubmed ID: 28706564 Increasing Quality, Throughput and Speed of Sample Preparation for Strand-specific Messenger RNA Sequencing BMC Genomics. Jul, 2017 | Pubmed ID: 28679365 Whole-genome Analysis Reveals Unexpected Dynamics of Mutant Subclone Development in a Patient with JAK2-V617F-positive Chronic Myeloid Leukemia Experimental Hematology. Sep, 2017 | Pubmed ID: 28602946 Automated High Throughput Nucleic Acid Purification from Formalin-fixed Paraffin-embedded Tissue Samples for Next Generation Sequence Analysis PloS One. 2017 | Pubmed ID: 28570594 Draft Genome Sequence of the Pelagic Photoferrotroph Chlorobium Phaeoferrooxidans Genome Announcements. Mar, 2017 | Pubmed ID: 28360175 Atrophin Controls Developmental Signaling Pathways Via Interactions with Trithorax-like ELife. Mar, 2017 | Pubmed ID: 28327288 SnapShot: Epigenomic Assays Cell. Nov, 2016 | Pubmed ID: 27863253 The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery Cell. Nov, 2016 | Pubmed ID: 27863232 Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility Cell Reports. Nov, 2016 | Pubmed ID: 27851972 Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks Cell Reports. Nov, 2016 | Pubmed ID: 27851968 Robust High-performance Nanoliter-volume Single-cell Multiple Displacement Amplification on Planar Substrates Proceedings of the National Academy of Sciences of the United States of America. 07, 2016 | Pubmed ID: 27412862 Putative BRAF Activating Fusion in a Medullary Thyroid Cancer Cold Spring Harbor Molecular Case Studies. Mar, 2016 | Pubmed ID: 27148585 Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways Cancer Cell. Mar, 2016 | Pubmed ID: 26977886 The Genomic and Transcriptomic Landscape of Anaplastic Thyroid Cancer: Implications for Therapy BMC Cancer. Dec, 2015 | Pubmed ID: 26680454 Barcoding Reveals Complex Clonal Dynamics of De Novo Transformed Human Mammary Cells Nature. Dec, 2015 | Pubmed ID: 26633636 MEF2B Mutations in Non-Hodgkin Lymphoma Dysregulate Cell Migration by Decreasing MEF2B Target Gene Activation Nature Communications. Aug, 2015 | Pubmed ID: 26245647 Epigenome Data Release: a Participant-centered Approach to Privacy Protection Genome Biology. Jul, 2015 | Pubmed ID: 26185018 Integrative Analysis of 111 Reference Human Epigenomes Nature. Feb, 2015 | Pubmed ID: 25693563 Multifocal Endometriotic Lesions Associated with Cancer Are Clonal and Carry a High Mutation Burden The Journal of Pathology. Jun, 2015 | Pubmed ID: 25692284 Intermediate DNA Methylation is a Conserved Signature of Genome Regulation Nature Communications. 2015 | Pubmed ID: 25691127 Epigenetic and Transcriptional Determinants of the Human Breast Nature Communications. Feb, 2015 | Pubmed ID: 25690954 Loss of the Notch Effector RBPJ Promotes Tumorigenesis The Journal of Experimental Medicine. Jan, 2015 | Pubmed ID: 25512468 DNA Barcoding Reveals Diverse Growth Kinetics of Human Breast Tumour Subclones in Serially Passaged Xenografts Nature Communications. Dec, 2014 | Pubmed ID: 25532760 Regulatory Network Decoded from Epigenomes of Surface Ectoderm-derived Cell Types Nature Communications. Nov, 2014 | Pubmed ID: 25421844 A Transgenic Mouse Model Demonstrating the Oncogenic Role of Mutations in the Polycomb-group Gene EZH2 in Lymphomagenesis Blood. Jun, 2014 | Pubmed ID: 24802772 Draft Genome Sequences of Six Rhodobacter Capsulatus Strains, YW1, YW2, B6, Y262, R121, and DE442 Genome Announcements. Feb, 2014 | Pubmed ID: 24526637 Clonal Analysis Via Barcoding Reveals Diverse Growth and Differentiation of Transplanted Mouse and Human Mammary Stem Cells Cell Stem Cell. Feb, 2014 | Pubmed ID: 24440600 Regulatory Variation: an Emerging Vantage Point for Cancer Biology Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Jan-Feb, 2014 | Pubmed ID: 24254976 Complete Bordetella Avium, Bordetella Hinzii and Bordetella Trematum Lipid A Structures and Genomic Sequence Analyses of the Loci Involved in Their Modifications Innate Immunity. Aug, 2014 | Pubmed ID: 24127384 A Clinically Validated Diagnostic Second-generation Sequencing Assay for Detection of Hereditary BRCA1 and BRCA2 Mutations The Journal of Molecular Diagnostics : JMD. Nov, 2013 | Pubmed ID: 24094589 Analysis of the Clonal Growth and Differentiation Dynamics of Primitive Barcoded Human Cord Blood Cells in NSG Mice Blood. Oct, 2013 | Pubmed ID: 24030380 Vitamin C Induces Tet-dependent DNA Demethylation and a Blastocyst-like State in ES Cells Nature. Aug, 2013 | Pubmed ID: 23812591 Estimating Absolute Methylation Levels at Single CpG Resolution from Methylation Enrichment and Restriction Enzyme Sequencing Methods Genome Research. Jun, 2013 | Pubmed ID: 23804401 Functional DNA Methylation Differences Between Tissues, Cell Types, and Across Individuals Discovered Using the M&M Algorithm Genome Research. Jun, 2013 | Pubmed ID: 23804400 DNA Hypomethylation Within Specific Transposable Element Families Associates with Tissue-specific Enhancer Landscape Nature Genetics. Jul, 2013 | Pubmed ID: 23708189 Epigenomics: Sequencing the Methylome Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23412782 The Genetic Landscape of High-risk Neuroblastoma Nature Genetics. Mar, 2013 | Pubmed ID: 23334666 DNA Template Strand Sequencing of Single-cells Maps Genomic Rearrangements at High Resolution Nature Methods. Nov, 2012 | Pubmed ID: 23042453 Spark: a Navigational Paradigm for Genomic Data Exploration Genome Research. Nov, 2012 | Pubmed ID: 22960372 Mutation Discovery in Regions of Segmental Cancer Genome Amplifications with CoNAn-SNV: a Mixture Model for Next Generation Sequencing of Tumors PloS One. 2012 | Pubmed ID: 22916110 Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-risk Acute Lymphoblastic Leukemia Cancer Cell. Aug, 2012 | Pubmed ID: 22897847 Use of Mutation Profiles to Refine the Classification of Endometrial Carcinomas The Journal of Pathology. Sep, 2012 | Pubmed ID: 22653804 Integrative Analysis of Genome-wide Loss of Heterozygosity and Monoallelic Expression at Nucleotide Resolution Reveals Disrupted Pathways in Triple-negative Breast Cancer Genome Research. Oct, 2012 | Pubmed ID: 22637570 The Clonal and Mutational Evolution Spectrum of Primary Triple-negative Breast Cancers Nature. Apr, 2012 | Pubmed ID: 22495314 Integrated Genome and Transcriptome Sequencing Identifies a Novel Form of Hybrid and Aggressive Prostate Cancer The Journal of Pathology. May, 2012 | Pubmed ID: 22294438 JointSNVMix: a Probabilistic Model for Accurate Detection of Somatic Mutations in Normal/tumour Paired Next-generation Sequencing Data Bioinformatics (Oxford, England). Apr, 2012 | Pubmed ID: 22285562 Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase, an Exploitable Tumor Target Molecular Cancer Therapeutics. Mar, 2012 | Pubmed ID: 22252602 Feature-based Classifiers for Somatic Mutation Detection in Tumour-normal Paired Sequencing Data Bioinformatics (Oxford, England). Jan, 2012 | Pubmed ID: 22084253 Concurrent CIC Mutations, IDH Mutations, and 1p/19q Loss Distinguish Oligodendrogliomas from Other Cancers The Journal of Pathology. Jan, 2012 | Pubmed ID: 22072542 Retrotransposon-induced Heterochromatin Spreading in the Mouse Revealed by Insertional Polymorphisms PLoS Genetics. Sep, 2011 | Pubmed ID: 21980304 Frequent Mutation of Histone-modifying Genes in Non-Hodgkin Lymphoma Nature. Aug, 2011 | Pubmed ID: 21796119 Using Next-generation Sequencing for the Diagnosis of Rare Disorders: a Family with Retinitis Pigmentosa and Skeletal Abnormalities The Journal of Pathology. Sep, 2011 | Pubmed ID: 21792934 Cell of Origin in AML: Susceptibility to MN1-induced Transformation is Regulated by the MEIS1/AbdB-like HOX Protein Complex Cancer Cell. Jul, 2011 | Pubmed ID: 21741595 DeFuse: an Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data PLoS Computational Biology. May, 2011 | Pubmed ID: 21625565 DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in MESCs Cell Stem Cell. Jun, 2011 | Pubmed ID: 21624812 Genome and Transcriptome Analyses of the Mountain Pine Beetle-fungal Symbiont Grosmannia Clavigera, a Lodgepole Pine Pathogen Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21262841 Next Generation Sequencing Based Approaches to Epigenomics Briefings in Functional Genomics. Dec, 2010 | Pubmed ID: 21266347 ARID1A Mutations in Endometriosis-associated Ovarian Carcinomas The New England Journal of Medicine. Oct, 2010 | Pubmed ID: 20942669 System-level Analysis of Neuroblastoma Tumor-initiating Cells Implicates AURKB As a Novel Drug Target for Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2010 | Pubmed ID: 20651058 Locus Co-occupancy, Nucleosome Positioning, and H3K4me1 Regulate the Functionality of FOXA2-, HNF4A-, and PDX1-bound Loci in Islets and Liver Genome Research. Aug, 2010 | Pubmed ID: 20551221 Whole-genome Profiling of Mutagenesis in Caenorhabditis Elegans Genetics. Jun, 2010 | Pubmed ID: 20439774 Digital Gene Expression by Tag Sequencing on the Illumina Genome Analyzer Current Protocols in Human Genetics. Apr, 2010 | Pubmed ID: 20373513 SNVMix: Predicting Single Nucleotide Variants from Next-generation Sequencing of Tumors Bioinformatics (Oxford, England). Mar, 2010 | Pubmed ID: 20130035 Somatic Mutations Altering EZH2 (Tyr641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal-center Origin Nature Genetics. Feb, 2010 | Pubmed ID: 20081860 De Novo Genome Sequence Assembly of a Filamentous Fungus Using Sanger, 454 and Illumina Sequence Data Genome Biology. 2009 | Pubmed ID: 19747388 ELT-2 is the Predominant Transcription Factor Controlling Differentiation and Function of the C. Elegans Intestine, from Embryo to Adult Developmental Biology. Mar, 2009 | Pubmed ID: 19111532 In-depth Characterization of the MicroRNA Transcriptome in a Leukemia Progression Model Genome Research. Nov, 2008 | Pubmed ID: 18849523 Transcriptome Analysis for Caenorhabditis Elegans Based on Novel Expressed Sequence Tags BMC Biology. Jul, 2008 | Pubmed ID: 18611272 A Mouse Atlas of Gene Expression: Large-scale Digital Gene-expression Profiles from Precisely Defined Developing C57BL/6J Mouse Tissues and Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005 | Pubmed ID: 16352711 Novel Avian Influenza H7N3 Strain Outbreak, British Columbia Emerging Infectious Diseases. Dec, 2004 | Pubmed ID: 15663859 Isolation and Identification of L-dopa Decarboxylase As a Protein That Binds to and Enhances Transcriptional Activity of the Androgen Receptor Using the Repressed Transactivator Yeast Two-hybrid System The Biochemical Journal. Oct, 2003 | Pubmed ID: 12864730 A Two-hybrid System for Transactivator Bait Proteins Proceedings of the National Academy of Sciences of the United States of America. Jul, 2001 | Pubmed ID: 11447261 Generation of Native Chromatin Immunoprecipitation Sequencing Libraries for Nucleosome Density Analysis Alireza Lorzadeh1, Rodrigo Lopez Gutierrez1, Linda Jackson1, Michelle Moksa1, Martin Hirst1,2 1Department of Microbiology and Immunology, Michael Smith Laboratories Centre for High-Throughput Biology, University of British Columbia, 2Canada's Michael Smith Genome Science Center, BC Cancer Agency JoVE 56085 유전학
Generation of Native Chromatin Immunoprecipitation Sequencing Libraries for Nucleosome Density Analysis Alireza Lorzadeh1, Rodrigo Lopez Gutierrez1, Linda Jackson1, Michelle Moksa1, Martin Hirst1,2 1Department of Microbiology and Immunology, Michael Smith Laboratories Centre for High-Throughput Biology, University of British Columbia, 2Canada's Michael Smith Genome Science Center, BC Cancer Agency JoVE 56085 유전학