Meenhard Herlyn Biography Publications JoVE Articles Meenhard Herlyn has not added a biography. If you are Meenhard Herlyn and would like to personalize this page please email our Author Liaison for assistance. Publications Author Correction: Loss of Phd2 Cooperates with BRAF to Drive Melanomagenesis Nature Communications. 03, 2019 | Pubmed ID: 30858377 Genome-wide Prediction of Synthetic Rescue Mediators of Resistance to Targeted and Immunotherapy Molecular Systems Biology. Mar, 2019 | Pubmed ID: 30858180 BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2019 | Pubmed ID: 30765391 ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma Cancer Discovery. 03, 2019 | Pubmed ID: 30563872 Author Correction: PAK Signalling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas Nature. 01, 2019 | Pubmed ID: 30532003 PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer Cancer Discovery. 02, 2019 | Pubmed ID: 30442709 Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility Cancer Discovery. 01, 2019 | Pubmed ID: 30279173 Loss of Phd2 Cooperates with BRAF to Drive Melanomagenesis Nature Communications. 12, 2018 | Pubmed ID: 30575721 A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade Cell. Nov, 2018 | Pubmed ID: 30388455 Publisher Correction: Robust Prediction of Response to Immune Checkpoint Blockade Therapy in Metastatic Melanoma Nature Medicine. Dec, 2018 | Pubmed ID: 30333558 Frontiers in Pigment Cell and Melanoma Research Pigment Cell & Melanoma Research. 11, 2018 | Pubmed ID: 30281213 Targeting the Warburg Effect Via LDHA Inhibition Engages ATF4 Signaling for Cancer Cell Survival The EMBO Journal. Oct, 2018 | Pubmed ID: 30209241 Robust Prediction of Response to Immune Checkpoint Blockade Therapy in Metastatic Melanoma Nature Medicine. 10, 2018 | Pubmed ID: 30127394 Exosomal PD-L1 Contributes to Immunosuppression and is Associated with Anti-PD-1 Response Nature. 08, 2018 | Pubmed ID: 30089911 Tumor Innate Immunity Primed by Specific Interferon-stimulated Endogenous Retroviruses Nature Medicine. 08, 2018 | Pubmed ID: 30038220 Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2018 | Pubmed ID: 29898988 Endogenous Authentic OCT4A Proteins Directly Regulate FOS/AP-1 Transcription in Somatic Cancer Cells Cell Death & Disease. May, 2018 | Pubmed ID: 29789579 Co-targeting BET and MEK As Salvage Therapy for MAPK and Checkpoint Inhibitor-resistant Melanoma EMBO Molecular Medicine. 05, 2018 | Pubmed ID: 29650805 Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2018 | Pubmed ID: 29563139 Distinct Histone Modifications Denote Early Stress-induced Drug Tolerance in Cancer Oncotarget. Feb, 2018 | Pubmed ID: 29492189 Acetylsalicylic Acid Governs the Effect of Sorafenib in -Mutant Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 03, 2018 | Pubmed ID: 29196297 MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression The Journal of Investigative Dermatology. 01, 2018 | Pubmed ID: 28927893 Hypoxia-activated Prodrug Enhances Therapeutic Effect of Sunitinib in Melanoma Oncotarget. Dec, 2017 | Pubmed ID: 29383148 Melanoma Therapeutic Strategies That Select Against Resistance by Exploiting MYC-Driven Evolutionary Convergence Cell Reports. Dec, 2017 | Pubmed ID: 29212027 PAK Signalling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas Nature. 10, 2017 | Pubmed ID: 28953887 Tumor-associated B-cells Induce Tumor Heterogeneity and Therapy Resistance Nature Communications. 09, 2017 | Pubmed ID: 28928360 A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles Cancer Discovery. 11, 2017 | Pubmed ID: 28899863 MEK'ing the Most of P53 Reactivation Therapy in Melanoma The Journal of Investigative Dermatology. Feb, 2012 | Pubmed ID: 22241441 Isolation and Characterization of Mouse and Human Esophageal Epithelial Cells in 3D Organotypic Culture Nature Protocols. 2012 | Pubmed ID: 22240585 Isolation and Cultivation of Dermal Stem Cells That Differentiate into Functional Epidermal Melanocytes Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22057442 Resistance to BRAF Inhibitors: Unraveling Mechanisms and Future Treatment Options Cancer Research. Dec, 2011 | Pubmed ID: 22131348 The Molecular Pathology of Cutaneous Melanoma Cancer Biomarkers : Section A of Disease Markers. 2011 | Pubmed ID: 22112480 Fibroblasts Contribute to Melanoma Tumor Growth and Drug Resistance Molecular Pharmaceutics. Dec, 2011 | Pubmed ID: 22067046 Direct Reprogramming of Melanocytes to Neural Crest Stem-like Cells by One Defined Factor Stem Cells (Dayton, Ohio). Nov, 2011 | Pubmed ID: 21948558 Organometallic Pyridylnaphthalimide Complexes As Protein Kinase Inhibitors Organometallics. Jul, 2011 | Pubmed ID: 21918590 Sorting Through the Many Opportunities for Melanoma Therapy Pigment Cell & Melanoma Research. Oct, 2011 | Pubmed ID: 21899726 A NOTCH3-mediated Squamous Cell Differentiation Program Limits Expansion of EMT-competent Cells That Express the ZEB Transcription Factors Cancer Research. Nov, 2011 | Pubmed ID: 21890822 From Cancer Stem Cells to Tumor Maintenance in Melanoma The Journal of Investigative Dermatology. Aug, 2011 | Pubmed ID: 21654838 Detecting and Targeting Mesenchymal-like Subpopulations Within Squamous Cell Carcinomas Cell Cycle (Georgetown, Tex.). Jun, 2011 | Pubmed ID: 21558812 Will Engineered T Cells Expressing CD20 ScFv Eradicate Melanoma? Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2011 | Pubmed ID: 21455210 Targeting BRAF in Advanced Melanoma: a First Step Toward Manageable Disease Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2011 | Pubmed ID: 21447722 Dermis-derived Stem Cells: a Source of Epidermal Melanocytes and Melanoma? Pigment Cell & Melanoma Research. Jun, 2011 | Pubmed ID: 21410654 Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K Cancer Cell. Dec, 2010 | Pubmed ID: 21156289 A Systems Biology Analysis of Metastatic Melanoma Using In-depth Three-dimensional Protein Profiling Proteomics. Dec, 2010 | Pubmed ID: 21136598 Taking the Guesswork out of Uveal Melanoma The New England Journal of Medicine. Dec, 2010 | Pubmed ID: 21083377 A Systems Biology Analysis of Metastatic Melanoma Using In-depth Three-dimensional Protein Profiling Proteomics. Oct, 2010 | Pubmed ID: 21082759 Boris Bastian Pigment Cell & Melanoma Research. Dec, 2010 | Pubmed ID: 20973934 PLX4032, a Potent Inhibitor of the B-Raf V600E Oncogene, Selectively Inhibits V600E-positive Melanomas Pigment Cell & Melanoma Research. Dec, 2010 | Pubmed ID: 20973932 Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth Via Activation of the PRMT5 Methyltransferase Cancer Cell. Oct, 2010 | Pubmed ID: 20951943 BRAF Inhibitor Unveils Its Potential Against Advanced Melanoma Cancer Cell. Oct, 2010 | Pubmed ID: 20951940 NOTCH1 and NOTCH3 Coordinate Esophageal Squamous Differentiation Through a CSL-dependent Transcriptional Network Gastroenterology. Dec, 2010 | Pubmed ID: 20801121 The Ups and Downs of Transcription Factors in Melanoma Journal of the National Cancer Institute. Aug, 2010 | Pubmed ID: 20660367 Fibroblast-secreted Hepatocyte Growth Factor Plays a Functional Role in Esophageal Squamous Cell Carcinoma Invasion Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20534479 Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-invasive Signature in Esophageal Cancer Cancer Research. Jul, 2010 | Pubmed ID: 20516120 Insulin-like Growth Factor-binding Protein-3 Promotes Transforming Growth Factor-{beta}1-mediated Epithelial-to-mesenchymal Transition and Motility in Transformed Human Esophageal Cells Carcinogenesis. Aug, 2010 | Pubmed ID: 20513670 A Temporarily Distinct Subpopulation of Slow-cycling Melanoma Cells is Required for Continuous Tumor Growth Cell. May, 2010 | Pubmed ID: 20478252 Epidermal Growth Factor Receptor and Mutant P53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-mesenchymal Transition Through ZEB Transcription Factors Cancer Research. May, 2010 | Pubmed ID: 20424117 What is a Good Model for Melanoma? The Journal of Investigative Dermatology. Apr, 2010 | Pubmed ID: 20231823 Human Dermal Stem Cells Differentiate into Functional Epidermal Melanocytes Journal of Cell Science. Mar, 2010 | Pubmed ID: 20159965 Embryonic Stem Cells As a Model for Studying Melanocyte Development Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 19907984 Distinct MHC Gene Expression Patterns During Progression of Melanoma Genes, Chromosomes & Cancer. Feb, 2010 | Pubmed ID: 19862823 Placental Gene Transfer: Transgene Screening in Mice for Trophic Effects on the Placenta American Journal of Obstetrics and Gynecology. Nov, 2009 | Pubmed ID: 19716119 Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes Cancer Research. Jul, 2009 | Pubmed ID: 19549918 The Role of BRAF Mutation and P53 Inactivation During Transformation of a Subpopulation of Primary Human Melanocytes The American Journal of Pathology. Jun, 2009 | Pubmed ID: 19389934 Driving in the Melanoma Landscape Experimental Dermatology. Jun, 2009 | Pubmed ID: 19366372 Defining Microenvironments Within Mouse Models That Enhance Tumor Aggressiveness Cancer Biology & Therapy. Feb, 2009 | Pubmed ID: 19182538 Cancer Stem Cells Are Everywhere Nature Medicine. Jan, 2009 | Pubmed ID: 19129778 Integrating Tumor-initiating Cells into the Paradigm for Melanoma Targeted Therapy International Journal of Cancer. Journal International Du Cancer. Mar, 2009 | Pubmed ID: 19089923 Cracking the System: Melanoma Complexity Demands New Therapeutic Approaches Pigment Cell & Melanoma Research. Feb, 2009 | Pubmed ID: 19054340 Matricellular Proteins Produced by Melanocytes and Melanomas: in Search for Functions Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society. Dec, 2008 | Pubmed ID: 19308688 A Subpopulation of Mouse Esophageal Basal Cells Has Properties of Stem Cells with the Capacity for Self-renewal and Lineage Specification The Journal of Clinical Investigation. Dec, 2008 | Pubmed ID: 19033657 Cleavage of MCM2 Licensing Protein Fosters Senescence in Human Keratinocytes Cell Cycle (Georgetown, Tex.). Nov, 2008 | Pubmed ID: 19001876 Endothelin-3 Stimulates Survival of Goblet Cells in Organotypic Cultures of Fetal Human Colonic Epithelium American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2008 | Pubmed ID: 18832450 Increased Cyclin D1 Expression Can Mediate BRAF Inhibitor Resistance in BRAF V600E-mutated Melanomas Molecular Cancer Therapeutics. Sep, 2008 | Pubmed ID: 18790768 Bortezomib Induces Apoptosis in Esophageal Squamous Cell Carcinoma Cells Through Activation of the P38 Mitogen-activated Protein Kinase Pathway Molecular Cancer Therapeutics. Sep, 2008 | Pubmed ID: 18790767 Melanoma and the Tumor Microenvironment Current Oncology Reports. Sep, 2008 | Pubmed ID: 18706274 Identification of a Novel Subgroup of Melanomas with KIT/cyclin-dependent Kinase-4 Overexpression Cancer Research. Jul, 2008 | Pubmed ID: 18632627 Melanoma Stem Cells: the Dark Seed of Melanoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2008 | Pubmed ID: 18539969 Structure-based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity ACS Chemical Biology. May, 2008 | Pubmed ID: 18484710 Cytotoxicity of the Matrix Metalloproteinase-activated Anthrax Lethal Toxin is Dependent on Gelatinase Expression and B-RAF Status in Human Melanoma Cells Molecular Cancer Therapeutics. May, 2008 | Pubmed ID: 18483309 Unraveling the Mysteries of IGF-1 Signaling in Melanoma The Journal of Investigative Dermatology. Jun, 2008 | Pubmed ID: 18478012 The Essential Role of Fibroblasts in Esophageal Squamous Cell Carcinoma-induced Angiogenesis Gastroenterology. Jun, 2008 | Pubmed ID: 18439605 Similar Biological Activities of Two Isostructural Ruthenium and Osmium Complexes Chemistry (Weinheim an Der Bergstrasse, Germany). 2008 | Pubmed ID: 18425743 Salmonella Typhimurium As a Novel RNA Interference Vector for Cancer Gene Therapy Cancer Biology & Therapy. Jan, 2008 | Pubmed ID: 18347415 Learning the ABCs of Melanoma-initiating Cells Cancer Cell. Mar, 2008 | Pubmed ID: 18328422 Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18287029 The Differential Role of L1 in Ovarian Carcinoma and Normal Ovarian Surface Epithelium Cancer Research. Feb, 2008 | Pubmed ID: 18281486 Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma Cancer Research. Feb, 2008 | Pubmed ID: 18245465 Cancer Testis Antigens in Human Melanoma Stem Cells: Expression, Distribution, and Methylation Status Journal of Cellular Physiology. May, 2008 | Pubmed ID: 18205182 Microscale Solution IEF Combined with 2-D DIGE Substantially Enhances Analysis Depth of Complex Proteomes Such As Mammalian Cell and Tissue Extracts Electrophoresis. Feb, 2008 | Pubmed ID: 18186533 The Mitogen-activated Protein/extracellular Signal-regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression when Combined with Docetaxel Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2008 | Pubmed ID: 18172275 Permissive Environment in Postnatal Wounds Induced by Adenoviral-mediated Overexpression of the Anti-inflammatory Cytokine Interleukin-10 Prevents Scar Formation Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. Jan-Feb, 2008 | Pubmed ID: 18086289 Roadmap for New Opportunities in Melanoma Research Seminars in Oncology. Dec, 2007 | Pubmed ID: 18083380 The Functional Interplay Between EGFR Overexpression, HTERT Activation, and P53 Mutation in Esophageal Epithelial Cells with Activation of Stromal Fibroblasts Induces Tumor Development, Invasion, and Differentiation Genes & Development. Nov, 2007 | Pubmed ID: 17974918 The Many Faces of Notch Signaling in Skin-derived Cells Pigment Cell Research / Sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society. Dec, 2007 | Pubmed ID: 17935489 Unraveling Mysteries of the Multifunctional Protein SPARC The Journal of Investigative Dermatology. Nov, 2007 | Pubmed ID: 17934501 Raf Inhibitor Stabilizes Receptor for the Type I Interferon but Inhibits Its Anti-proliferative Effects in Human Malignant Melanoma Cells Cancer Biology & Therapy. Sep, 2007 | Pubmed ID: 17873516 Old Disease, New Culprit: Tumor Stem Cells in Cancer Journal of Cellular Physiology. Dec, 2007 | Pubmed ID: 17786956 Association of Polymorphisms of FAS-1377, FAS-670, and FASL-844 Genes with Risk Factors for Cutaneous Malignant Melanoma Cancer Journal (Sudbury, Mass.). Jul-Aug, 2007 | Pubmed ID: 17762755 Expression of Integrin Alpha10 is Induced in Malignant Melanoma Cellular Oncology : the Official Journal of the International Society for Cellular Oncology. 2007 | Pubmed ID: 17726260 Application of a BRAF Pyrosequencing Assay for Mutation Detection and Copy Number Analysis in Malignant Melanoma The Journal of Molecular Diagnostics : JMD. Sep, 2007 | Pubmed ID: 17690212 Rewired ERK-JNK Signaling Pathways in Melanoma Cancer Cell. May, 2007 | Pubmed ID: 17482134 Mutant V600E BRAF Increases Hypoxia Inducible Factor-1alpha Expression in Melanoma Cancer Research. Apr, 2007 | Pubmed ID: 17409425 Farming Cells to Rebuild Skin and Melanoma Cancer Biology & Therapy. Mar, 2007 | Pubmed ID: 17374983 Profiles of Chemokine Receptors in Melanocytic Lesions: De Novo Expression of CXCR6 in Melanoma Human Pathology. May, 2007 | Pubmed ID: 17306330 High-throughput Oncogene Mutation Profiling in Human Cancer Nature Genetics. Mar, 2007 | Pubmed ID: 17293865 Dysregulation of Claudin-7 Leads to Loss of E-cadherin Expression and the Increased Invasion of Esophageal Squamous Cell Carcinoma Cells The American Journal of Pathology. Feb, 2007 | Pubmed ID: 17255337 An Organometallic Protein Kinase Inhibitor Pharmacologically Activates P53 and Induces Apoptosis in Human Melanoma Cells Cancer Research. Jan, 2007 | Pubmed ID: 17210701 Microenvironmental Influences in Melanoma Progression Journal of Cellular Biochemistry. Jul, 2007 | Pubmed ID: 17171636 Life Isn't Flat: Taking Cancer Biology to the Next Dimension In Vitro Cellular & Developmental Biology. Animal. Sep-Oct, 2006 | Pubmed ID: 17163781 Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885 Cancer Research. Dec, 2006 | Pubmed ID: 17145850 CCN3 Controls 3D Spatial Localization of Melanocytes in the Human Skin Through DDR1 The Journal of Cell Biology. Nov, 2006 | Pubmed ID: 17101694 Coordinated Functions of E-cadherin and Transforming Growth Factor Beta Receptor II in Vitro and in Vivo Cancer Research. Oct, 2006 | Pubmed ID: 17047049 Differentiation of Normal Skin and Melanoma Using High Resolution Hyperspectral Imaging Cancer Biology & Therapy. Aug, 2006 | Pubmed ID: 16931902 Embryogenesis Meets Tumorigenesis Nature Medicine. Aug, 2006 | Pubmed ID: 16892028 Metastatic Potential of Melanomas Defined by Specific Gene Expression Profiles with No BRAF Signature Pigment Cell Research / Sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society. Aug, 2006 | Pubmed ID: 16827748 A New Organotypic Model to Study Cell Interactions in the Intestinal Mucosa European Journal of Gastroenterology & Hepatology. Aug, 2006 | Pubmed ID: 16825910 Multiple Signaling Pathways Must Be Targeted to Overcome Drug Resistance in Cell Lines Derived from Melanoma Metastases Molecular Cancer Therapeutics. May, 2006 | Pubmed ID: 16731745 Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles The American Journal of Pathology. Jun, 2006 | Pubmed ID: 16723703 Cancer Interaction with the Bone Microenvironment: a Workshop of the National Institutes of Health Tumor Microenvironment Study Section The American Journal of Pathology. May, 2006 | Pubmed ID: 16651608 Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-activated Protein Kinase/phosphatidylinositol 3-kinase-Akt Pathways and Up-regulating N-cadherin Expression Cancer Research. Apr, 2006 | Pubmed ID: 16618740 Defining the Conditions for the Generation of Melanocytes from Human Embryonic Stem Cells Stem Cells (Dayton, Ohio). Jul, 2006 | Pubmed ID: 16574754 Inhibition of Endothelial Cell Proliferation by Notch1 Signaling is Mediated by Repressing MAPK and PI3K/Akt Pathways and Requires MAML1 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2006 | Pubmed ID: 16571776 Expression of PKC Isoforms in Human Melanocytic Cells in Situ Journal of Dermatological Science. Feb, 2006 | Pubmed ID: 16406501 Molecular Targets in Melanoma: Strategies and Challenges for Diagnosis and Therapy International Journal of Cancer. Journal International Du Cancer. Feb, 2006 | Pubmed ID: 16258898 Targeting Intracellular Signaling Pathways As a Novel Strategy in Melanoma Therapeutics Annals of the New York Academy of Sciences. Nov, 2005 | Pubmed ID: 16382039 Normal Human Melanocyte Homeostasis As a Paradigm for Understanding Melanoma The Journal of Investigative Dermatology. Symposium Proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research. Nov, 2005 | Pubmed ID: 16358819 Targeting the Stromal Fibroblasts: a Novel Approach to Melanoma Therapy Expert Review of Anticancer Therapy. Dec, 2005 | Pubmed ID: 16336098 Activation of Notch1 Signaling is Required for Beta-catenin-mediated Human Primary Melanoma Progression The Journal of Clinical Investigation. Nov, 2005 | Pubmed ID: 16239965 A Tumorigenic Subpopulation with Stem Cell Properties in Melanomas Cancer Research. Oct, 2005 | Pubmed ID: 16230395 Selective Evolutionary Pressure from the Tissue Microenvironment Drives Tumor Progression Seminars in Cancer Biology. Dec, 2005 | Pubmed ID: 16043361 Information Sharing and Collateral Damage Trends in Molecular Medicine. Aug, 2005 | Pubmed ID: 16002338 Bone Morphogenetic Proteins in Melanoma: Angel or Devil? Cancer Metastasis Reviews. Jun, 2005 | Pubmed ID: 15986135 Metastatic Melanoma Cells. Introduction Cancer Metastasis Reviews. Jun, 2005 | Pubmed ID: 15986131 The RAS/RAF/MEK/ERK and PI3K/AKT Signaling Pathways Present Molecular Targets for the Effective Treatment of Advanced Melanoma Frontiers in Bioscience : a Journal and Virtual Library. 2005 | Pubmed ID: 15970553 Adhesion, Migration and Communication in Melanocytes and Melanoma Pigment Cell Research / Sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society. Jun, 2005 | Pubmed ID: 15892711 Up-regulated Expression of Zonula Occludens Protein-1 in Human Melanoma Associates with N-cadherin and Contributes to Invasion and Adhesion The American Journal of Pathology. May, 2005 | Pubmed ID: 15855653 The Prevalence of Interferon-alpha Transcription Defects in Malignant Melanoma Melanoma Research. Apr, 2005 | Pubmed ID: 15846141 CXC Chemokine Ligand 12 (stromal Cell-derived Factor 1 Alpha) and CXCR4-dependent Migration of CTLs Toward Melanoma Cells in Organotypic Culture Journal of Immunology (Baltimore, Md. : 1950). May, 2005 | Pubmed ID: 15843590 Activation of the DNA Damage Checkpoint and Genomic Instability in Human Precancerous Lesions Nature. Apr, 2005 | Pubmed ID: 15829965 Functional Erythropoietin Autocrine Loop in Melanoma The American Journal of Pathology. Mar, 2005 | Pubmed ID: 15743794 Gene Expression Profiling of Melanoma Cells - Searching the Haystack Journal of Translational Medicine. Jan, 2005 | Pubmed ID: 15649323 Cultivation of Normal Human Epidermal Melanocytes in the Absence of Phorbol Esters Methods in Molecular Medicine. 2005 | Pubmed ID: 15492362 Clinical Protocol. Phase I Trial to Evaluate the Safety of H5.020CMV.PDGF-b and Limb Compression Bandage for the Treatment of Venous Leg Ulcer: Trial A Human Gene Therapy. Oct, 2004 | Pubmed ID: 15585116 Adenoviral Mediated Gene Transfer of PDGF-B Enhances Wound Healing in Type I and Type II Diabetic Wounds Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. Sep-Oct, 2004 | Pubmed ID: 15453831 Loitering with Intent: New Evidence for the Role of BRAF Mutations in the Proliferation of Melanocytic Lesions The Journal of Investigative Dermatology. Oct, 2004 | Pubmed ID: 15373800 The Role of Altered Cell-cell Communication in Melanoma Progression Journal of Molecular Histology. Mar, 2004 | Pubmed ID: 15339050 Rapid Apoptosis in the Pulmonary Vasculature Distinguishes Non-metastatic from Metastatic Melanoma Cells Cancer Letters. Sep, 2004 | Pubmed ID: 15327836 Akt/protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt Cancer Research. Jul, 2004 | Pubmed ID: 15231645 Cyclin D1 is Essential for Neoplastic Transformation Induced by Both E6/E7 and E6/E7/ErbB-2 Cooperation in Normal Cells Oncogene. Jul, 2004 | Pubmed ID: 15229656 Death Induction by Recombinant Native TRAIL and Its Prevention by a Caspase 9 Inhibitor in Primary Human Esophageal Epithelial Cells The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15226295 Reversal of Melanocytic Malignancy by Keratinocytes is an E-cadherin-mediated Process Overriding Beta-catenin Signaling Experimental Cell Research. Jul, 2004 | Pubmed ID: 15194432 Truncation of Activated Leukocyte Cell Adhesion Molecule: a Gateway to Melanoma Metastasis The Journal of Investigative Dermatology. May, 2004 | Pubmed ID: 15140234 Recent Advances in Melanoma Biology The Oncologist. 2004 | Pubmed ID: 15047922 Induction of Melanoma Phenotypes in Human Skin by Growth Factors and Ultraviolet B Cancer Research. Feb, 2004 | Pubmed ID: 14871803 [Melanoma-stroma Interactions and Melanoma Progression] Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. Oct, 2003 | Pubmed ID: 16281812 Human Melanoblasts in Culture: Expression of BRN2 and Synergistic Regulation by Fibroblast Growth Factor-2, Stem Cell Factor, and Endothelin-3 The Journal of Investigative Dermatology. Nov, 2003 | Pubmed ID: 14708619 First International Melanoma Research Congress Cancer Biology & Therapy. Nov-Dec, 2003 | Pubmed ID: 14688485 The Great Escape: Another Way for Melanoma to Leave Physiological Control? The Journal of Investigative Dermatology. Oct, 2003 | Pubmed ID: 14632176 Reciprocal Regulation of MelCAM and AKT in Human Melanoma Oncogene. Oct, 2003 | Pubmed ID: 14534536 Axis of Evil: Molecular Mechanisms of Cancer Metastasis Oncogene. Sep, 2003 | Pubmed ID: 14528277 VEGF-A and AlphaVbeta3 Integrin Synergistically Rescue Angiogenesis Via N-Ras and PI3-K Signaling in Human Microvascular Endothelial Cells FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2003 | Pubmed ID: 14519669 Cisplatin Down-regulation of Cellular Fas-associated Death Domain-like Interleukin-1beta-converting Enzyme-like Inhibitory Proteins to Restore Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Melanoma Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2003 | Pubmed ID: 14519653 Suppression of BRAF(V599E) in Human Melanoma Abrogates Transformation Cancer Research. Sep, 2003 | Pubmed ID: 14500344 BRAF As a Potential Therapeutic Target in Melanoma and Other Malignancies Cancer Cell. Aug, 2003 | Pubmed ID: 12957284 Slit-Robo: Neuronal Guides Signal in Tumor Angiogenesis Cancer Cell. Jul, 2003 | Pubmed ID: 12892705 High Levels of CUG-initiated FGF-2 Expression Cause Chromatin Compaction, Decreased Cardiomyocyte Mitosis, and Cell Death Molecular and Cellular Biochemistry. Apr, 2003 | Pubmed ID: 12841351 Fibroblast Growth Factor-2 but Not Mel-CAM And/or Beta3 Integrin Promotes Progression of Melanocytes to Melanoma Experimental Dermatology. Jun, 2003 | Pubmed ID: 12823444 Tumors As Elusive Targets of T-cell-based Active Immunotherapy Trends in Immunology. Jun, 2003 | Pubmed ID: 12810110 Function and Regulation of Melanoma-stromal Fibroblast Interactions: when Seeds Meet Soil Oncogene. May, 2003 | Pubmed ID: 12789292 The Vascular Phenotype of Melanoma Metastasis Clinical & Experimental Metastasis. 2003 | Pubmed ID: 12741681 P16INK4A and Familial Melanoma Methods in Molecular Biology (Clifton, N.J.). 2003 | Pubmed ID: 12710687 Stimulation of Human Colonic Epithelial Cells by Leukemia Inhibitory Factor is Dependent on Collagen-embedded Fibroblasts in Organotypic Culture FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2003 | Pubmed ID: 12692084 Stroma Formation and Angiogenesis by Overexpression of Growth Factors, Cytokines, and Proteolytic Enzymes in Human Skin Grafted to SCID Mice The Journal of Investigative Dermatology. Apr, 2003 | Pubmed ID: 12648235 Constitutive Mitogen-activated Protein Kinase Activation in Melanoma is Mediated by Both BRAF Mutations and Autocrine Growth Factor Stimulation Cancer Research. Feb, 2003 | Pubmed ID: 12591721 Regulation of Notch1 and Dll4 by Vascular Endothelial Growth Factor in Arterial Endothelial Cells: Implications for Modulating Arteriogenesis and Angiogenesis Molecular and Cellular Biology. Jan, 2003 | Pubmed ID: 12482957 Differential Response of Primary and Metastatic Melanomas to Neutrophils Attracted by IL-8 International Journal of Cancer. Journal International Du Cancer. Jan, 2003 | Pubmed ID: 12471616 Epidermal Growth Factor Receptor Mediates Increased Cell Proliferation, Migration, and Aggregation in Esophageal Keratinocytes in Vitro and in Vivo The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12435727 Melanoma Development and Progression: a Conspiracy Between Tumor and Host Differentiation; Research in Biological Diversity. Dec, 2002 | Pubmed ID: 12492494 BRAF and RAS Mutations in Human Lung Cancer and Melanoma Cancer Research. Dec, 2002 | Pubmed ID: 12460918 New Approaches to the Biology of Melanoma: a Workshop of the National Institutes of Health Pathology B Study Section The American Journal of Pathology. Nov, 2002 | Pubmed ID: 12414540 Cell-surface Proteolysis, Growth Factor Activation and Intercellular Communication in the Progression of Melanoma Critical Reviews in Oncology/hematology. Oct, 2002 | Pubmed ID: 12398996 The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast Placenta. Nov, 2002 | Pubmed ID: 12398810 P53 Alone or in Combination with Antisense Cyclin D1 Induces Apoptosis and Reduces Tumor Size in Human Melanoma Cancer Gene Therapy. Oct, 2002 | Pubmed ID: 12224020 Prospective Molecular Profiling of Melanoma Metastases Suggests Classifiers of Immune Responsiveness Cancer Research. Jul, 2002 | Pubmed ID: 12097256 Fibroblast-dependent Differentiation of Human Microvascular Endothelial Cells into Capillary-like 3-dimensional Networks FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2002 | Pubmed ID: 12060671 Cyclin D1 is a Candidate Oncogene in Cutaneous Melanoma Cancer Research. Jun, 2002 | Pubmed ID: 12036934 Adenovirus-mediated Ex Vivo Gene Transfer of Human Vascular Endothelial Growth Factor in a Rabbit Laryngotracheal Reconstruction Model The Annals of Otology, Rhinology, and Laryngology. Apr, 2002 | Pubmed ID: 11991579 Melanoma-stroma Interactions: Structural and Functional Aspects The Lancet Oncology. Jan, 2002 | Pubmed ID: 11905603 Insulin-like Growth Factor-I-induced Migration of Melanoma Cells is Mediated by Interleukin-8 Induction Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research. Feb, 2002 | Pubmed ID: 11864912 Osteonectin/SPARC Induction by Ectopic Beta(3) Integrin in Human Radial Growth Phase Primary Melanoma Cells Cancer Research. Jan, 2002 | Pubmed ID: 11782382 Photocarcinogenesis in Human Adult Skin Grafts Carcinogenesis. Jan, 2002 | Pubmed ID: 11756239 Mechanism for Elimination of a Tumor Suppressor: Aberrant Splicing of a Brain-specific Exon Causes Loss of Function of Bin1 in Melanoma Proceedings of the National Academy of Sciences of the United States of America. Aug, 1999 | Pubmed ID: 10449755 Induction of P21(WAF1/CIP1) and Inhibition of Cdk2 Mediated by the Tumor Suppressor P16(INK4a) Molecular and Cellular Biology. May, 1999 | Pubmed ID: 10207115 Adenoviral Gene Transfer of Beta3 Integrin Subunit Induces Conversion from Radial to Vertical Growth Phase in Primary Human Melanoma The American Journal of Pathology. Nov, 1998 | Pubmed ID: 9811334 Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery JoVE 62906 면역학 및 감염병학 En melanom patient-derived xenograft modell Min Xiao1, Vito W. Rebecca1, Meenhard Herlyn1 1Wistar Institute JoVE 59508 암 연구학 Den tredimensionella human hud Rekonstruera Modell: ett verktyg för att studera normal hud och melanom Progression Ling Li1, Mizuho Fukunaga-Kalabis1, Meenhard Herlyn1 1Molecular and Cellular Oncogenesis Program, The Wistar Institute JoVE 2937 생체공학
Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery JoVE 62906 면역학 및 감염병학
En melanom patient-derived xenograft modell Min Xiao1, Vito W. Rebecca1, Meenhard Herlyn1 1Wistar Institute JoVE 59508 암 연구학
Den tredimensionella human hud Rekonstruera Modell: ett verktyg för att studera normal hud och melanom Progression Ling Li1, Mizuho Fukunaga-Kalabis1, Meenhard Herlyn1 1Molecular and Cellular Oncogenesis Program, The Wistar Institute JoVE 2937 생체공학