Michael X. Zhu Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston Biography Publications Institution JoVE Articles Michael X. Zhu has not added a biography. If you are Michael X. Zhu and would like to personalize this page please email our Author Liaison for assistance. Publications Heteromeric Heat-sensitive TRP Channels Exhibit Distinct Temperature and Chemical Response The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 22184123 Hysteresis of Gating Underlines Sensitization of TRPV3 Channels The Journal of General Physiology. Nov, 2011 | Pubmed ID: 22006988 TRPM8 Acute Desensitization is Mediated by Calmodulin and Requires PIP(2): Distinction from Tachyphylaxis Journal of Neurophysiology. Dec, 2011 | Pubmed ID: 21900509 Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21795696 Ca2+: a Versatile Master Key for Intracellular Signaling Cascades Science China. Life Sciences. Aug, 2011 | Pubmed ID: 21786190 Rapid and Efficient Generation of Functional Motor Neurons from Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor Codes Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011 | Pubmed ID: 21772256 Extracellular Spermine Exacerbates Ischemic Neuronal Injury Through Sensitization of ASIC1a Channels to Extracellular Acidosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011 | Pubmed ID: 21307247 Cyclic Adenosine Diphosphate Ribose Activates Ryanodine Receptors, Whereas NAADP Activates Two-pore Domain Channels The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21216967 An Emerging Role for NAADP-mediated Ca2+ Signaling in the Pancreatic β-cell Islets. Sep-Oct, 2010 | Pubmed ID: 21099331 Agonist-activated Ca2+ Influx Occurs at Stable Plasma Membrane and Endoplasmic Reticulum Junctions Journal of Cell Science. Dec, 2010 | Pubmed ID: 21062895 TPC2 is a Novel NAADP-sensitive Ca2+ Release Channel, Operating As a Dual Sensor of Luminal PH and Ca2+ The Journal of Biological Chemistry. Nov, 2010 | Pubmed ID: 20720007 Negative Allosteric Modulators That Target Human Alpha4beta2 Neuronal Nicotinic Receptors The Journal of Pharmacology and Experimental Therapeutics. Sep, 2010 | Pubmed ID: 20551292 Two-pore Channels for Integrative Ca Signaling Communicative & Integrative Biology. Jan, 2010 | Pubmed ID: 20539775 The Roles of ATF3, an Adaptive-response Gene, in High-fat-diet-induced Diabetes and Pancreatic Beta-cell Dysfunction Molecular Endocrinology (Baltimore, Md.). Jul, 2010 | Pubmed ID: 20519332 Identification of Translational Activators of Glial Glutamate Transporter EAAT2 Through Cell-based High-throughput Screening: an Approach to Prevent Excitotoxicity Journal of Biomolecular Screening. Jul, 2010 | Pubmed ID: 20508255 Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca(2+) Signaling and Endolysosomal Trafficking Current Biology : CB. Apr, 2010 | Pubmed ID: 20346675 TPCs: Endolysosomal Channels for Ca2+ Mobilization from Acidic Organelles Triggered by NAADP FEBS Letters. May, 2010 | Pubmed ID: 20159015 Calcium Signaling Via Two-pore Channels: Local or Global, That is the Question American Journal of Physiology. Cell Physiology. Mar, 2010 | Pubmed ID: 20018950 Activation of TRPA1 Channels by Fenamate Nonsteroidal Anti-inflammatory Drugs Pflügers Archiv : European Journal of Physiology. Mar, 2010 | Pubmed ID: 19888597 Potencies of Cocaine Methiodide on Major Cocaine Targets in Mice PloS One. 2009 | Pubmed ID: 19855831 Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility in Vivo Gastroenterology. Oct, 2009 | Pubmed ID: 19549525 The Acid Test: the Discovery of Two-pore Channels (TPCs) As NAADP-gated Endolysosomal Ca(2+) Release Channels Pflügers Archiv : European Journal of Physiology. Sep, 2009 | Pubmed ID: 19475418 NAADP Mobilizes Calcium from Acidic Organelles Through Two-pore Channels Nature. May, 2009 | Pubmed ID: 19387438 Zinc Activates Damage-sensing TRPA1 Ion Channels Nature Chemical Biology. Mar, 2009 | Pubmed ID: 19202543 Dopamine Modulates an MGluR5-mediated Depolarization Underlying Prefrontal Persistent Activity Nature Neuroscience. Feb, 2009 | Pubmed ID: 19169252 Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery The Journal of Pharmacology and Experimental Therapeutics. Feb, 2009 | Pubmed ID: 18984653 Sensorimotor Enhancement in Mouse Mutants Lacking the Purkinje Cell-specific Gi/o Modulator, Pcp2(L7) Molecular and Cellular Neurosciences. Jan, 2009 | Pubmed ID: 18930827 Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-bisphosphate The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18230622 Calcium Plays a Central Role in the Sensitization of TRPV3 Channel to Repetitive Stimulations The Journal of Biological Chemistry. Mar, 2008 | Pubmed ID: 18178557 The TRPV3 Mutation Associated with the Hairless Phenotype in Rodents is Constitutively Active Cell Calcium. Apr, 2008 | Pubmed ID: 17706768 The Axon-dendrite Targeting of Kv3 (Shaw) Channels is Determined by a Targeting Motif That Associates with the T1 Domain and Ankyrin G The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2007 | Pubmed ID: 18094255 Understanding the Role of Voltage Gating of Polymodal TRP Channels The Journal of Physiology. Dec, 2007 | Pubmed ID: 18056113 Beta-nicotinamide Adenine Dinucleotide is an Inhibitory Neurotransmitter in Visceral Smooth Muscle Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17913880 Analogs of Methyllycaconitine As Novel Noncompetitive Inhibitors of Nicotinic Receptors: Pharmacological Characterization, Computational Modeling, and Pharmacophore Development Molecular Pharmacology. May, 2007 | Pubmed ID: 17308033 Potentiation of TRPV3 Channel Function by Unsaturated Fatty Acids Journal of Cellular Physiology. Jul, 2006 | Pubmed ID: 16557504 TRPC3 and TRPC4 Associate to Form a Redox-sensitive Cation Channel. Evidence for Expression of Native TRPC3-TRPC4 Heteromeric Channels in Endothelial Cells The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16537542 Thermal Sensitivity of Isolated Vagal Pulmonary Sensory Neurons: Role of Transient Receptor Potential Vanilloid Receptors American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2006 | Pubmed ID: 16513770 Cellular Cholesterol Controls TRPC3 Function: Evidence from a Novel Dominant-negative Knockdown Strategy The Biochemical Journal. May, 2006 | Pubmed ID: 16448384 Activation of the Endothelial Store-operated ISOC Ca2+ Channel Requires Interaction of Protein 4.1 with TRPC4 Circulation Research. Nov, 2005 | Pubmed ID: 16254212 Calmodulin and Calcium Interplay in the Modulation of TRPC5 Channel Activity. Identification of a Novel C-terminal Domain for Calcium/calmodulin-mediated Facilitation The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 15987684 Inhibition of TRPC5 Channels by Ca2+-binding Protein 1 in Xenopus Oocytes Pflügers Archiv : European Journal of Physiology. Aug, 2005 | Pubmed ID: 15895247 The Selectivity Filter of the Cation Channel TRPM4 The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15845551 2-aminoethoxydiphenyl Borate Stimulates Pulmonary C Neurons Via the Activation of TRPV Channels American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2005 | Pubmed ID: 15653710 Regulation of the Ca2+ Sensitivity of the Nonselective Cation Channel TRPM4 The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15590641 Junctate is a Key Element in Calcium Entry Induced by Activation of InsP3 Receptors And/or Calcium Store Depletion The Journal of Cell Biology. Aug, 2004 | Pubmed ID: 15302852 An Alternative Splicing Product of the Murine Trpv1 Gene Dominant Negatively Modulates the Activity of TRPV1 Channels The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15234965 2-aminoethoxydiphenyl Borate is a Common Activator of TRPV1, TRPV2, and TRPV3 The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15194687 TRPC Channel Interactions with Calmodulin and IP3 Receptors Novartis Foundation Symposium. 2004 | Pubmed ID: 15104175 Ca(2+) Signaling by TRPC3 Involves Na(+) Entry and Local Coupling to the Na(+)/Ca(2+) Exchanger The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14736881 Characterization of a Human Peptide Deformylase: Implications for Antibacterial Drug Design Biochemistry. Aug, 2003 | Pubmed ID: 12924944 Epidermal Growth Factor-induced Depletion of the Intracellular Ca2+ Store Fails to Activate Capacitative Ca2+ Entry in a Human Salivary Cell Line The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12368284 Expression and Role of TRPC Proteins in Human Platelets: Evidence That TRPC6 Forms the Store-independent Calcium Entry Channel Blood. Oct, 2002 | Pubmed ID: 12351388 Calmodulin Regulates Ca(2+)-dependent Feedback Inhibition of Store-operated Ca(2+) Influx by Interaction with a Site in the C Terminus of TrpC1 Molecular Cell. Apr, 2002 | Pubmed ID: 11983166 A Unified Nomenclature for the Superfamily of TRP Cation Channels Molecular Cell. Feb, 2002 | Pubmed ID: 11864597 Rapid Activation of Protein Tyrosine Kinase and Phospholipase C-gamma2 and Increase in Cytosolic Free Calcium Are Required by Ehrlichia Chaffeensis for Internalization and Growth in THP-1 Cells Infection and Immunity. Feb, 2002 | Pubmed ID: 11796624 Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3 Jialie Luo1, Yingmin Zhu1, Michael X. Zhu1, Hongzhen Hu1 1Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston JoVE 3149 생체공학
Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3 Jialie Luo1, Yingmin Zhu1, Michael X. Zhu1, Hongzhen Hu1 1Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston JoVE 3149 생체공학