Michelle Sargent Division of Molecular Cardiovascular Biology Cincinnati Children's Hospital Medical Center Biography Publications Institution JoVE Articles Michelle Sargent has not added a biography. If you are Michelle Sargent and would like to personalize this page please email our Author Liaison for assistance. Publications MCUb Induction Protects the Heart From Postischemic Remodeling Circulation Research. 07, 2020 | Pubmed ID: 32299299 Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart Via Direct Injection but Not by Vascular Infusion Circulation. 03, 2020 | Pubmed ID: 32202933 An Acute Immune Response Underlies the Benefit of Cardiac Stem cell Therapy Nature. 01, 2020 | Pubmed ID: 31775156 Disruption of Valosin-containing Protein Activity Causes Cardiomyopathy and Reveals Pleiotropic Functions in Cardiac Homeostasis The Journal of Biological Chemistry. 05, 2019 | Pubmed ID: 31006653 ERK1/2 Signaling Induces Skeletal Muscle Slow Fiber-type Switching and Reduces Muscular Dystrophy Disease Severity JCI Insight. 04, 2019 | Pubmed ID: 30964448 Thrombospondin-3 Augments Injury-induced Cardiomyopathy by Intracellular Integrin Inhibition and Sarcolemmal Instability Nature Communications. 01, 2019 | Pubmed ID: 30622267 Genetic Lineage Tracing of Sca-1 Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart Circulation. 12, 2018 | Pubmed ID: 29991486 Defective Flux of Thrombospondin-4 Through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy Molecular and Cellular Biology. 07, 2018 | Pubmed ID: 29712757 Specialized Fibroblast Differentiated States Underlie Scar Formation in the Infarcted Mouse Heart The Journal of Clinical Investigation. 05, 2018 | Pubmed ID: 29664017 Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure Circulation. 09, 2018 | Pubmed ID: 29653926 Autophagic Cell Death is Dependent on Lysosomal Membrane Permeability Through Bax and Bak ELife. 11, 2017 | Pubmed ID: 29148970 Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression Journal of the American College of Cardiology. Aug, 2017 | Pubmed ID: 28818206 TGFBI Functions Similar to Periostin but is Uniquely Dispensable During Cardiac Injury PloS One. 2017 | Pubmed ID: 28750100 Mitsugumin 29 Regulates T-tubule Architecture in the Failing Heart Scientific Reports. 07, 2017 | Pubmed ID: 28706255 Caveolae-localized L-type Ca2+ Channels Do Not Contribute to Function or Hypertrophic Signalling in the Mouse Heart Cardiovascular Research. Jun, 2017 | Pubmed ID: 28402392 Fibroblast-Specific Genetic Manipulation of P38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis Circulation. Aug, 2017 | Pubmed ID: 28356446 Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart PloS One. 2016 | Pubmed ID: 27764156 Thrombospondin Expression in Myofibers Stabilizes Muscle Membranes ELife. 09, 2016 | Pubmed ID: 27669143 Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice The Journal of Biological Chemistry. May, 2016 | Pubmed ID: 26966179 Genetic Overexpression of Serpina3n Attenuates Muscular Dystrophy in Mice Human Molecular Genetics. Mar, 2016 | Pubmed ID: 26744329 Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling Molecular and Cellular Biology. Jan, 2016 | Pubmed ID: 26459760 Cardiac-specific Deletion of Protein Phosphatase 1β Promotes Increased Myofilament Protein Phosphorylation and Contractile Alterations Journal of Molecular and Cellular Cardiology. Oct, 2015 | Pubmed ID: 26334248 STIM1 Elevation in the Heart Results in Aberrant Ca²⁺ Handling and Cardiomyopathy Journal of Molecular and Cellular Cardiology. Oct, 2015 | Pubmed ID: 26241845 The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart Cell Reports. Jul, 2015 | Pubmed ID: 26119742 Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death PloS One. 2015 | Pubmed ID: 26061004 Genetic Analysis of Connective Tissue Growth Factor As an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling Molecular and Cellular Biology. Jun, 2015 | Pubmed ID: 25870108 P38α MAPK Underlies Muscular Dystrophy and Myofiber Death Through a Bax-dependent Mechanism Human Molecular Genetics. Oct, 2014 | Pubmed ID: 24876160 Enhanced Ca²⁺ Influx from STIM1-Orai1 Induces Muscle Pathology in Mouse Models of Muscular Dystrophy Human Molecular Genetics. Jul, 2014 | Pubmed ID: 24556214 Bax and Bak Function As the Outer Membrane Component of the Mitochondrial Permeability Pore in Regulating Necrotic Cell Death in Mice ELife. Aug, 2013 | Pubmed ID: 23991283 A Thrombospondin-dependent Pathway for a Protective ER Stress Response Cell. Jun, 2012 | Pubmed ID: 22682248 Decreased Cardiac L-type Ca²⺠Channel Activity Induces Hypertrophy and Heart Failure in Mice The Journal of Clinical Investigation. Jan, 2012 | Pubmed ID: 22133878 Mitigation of Muscular Dystrophy in Mice by SERCA Overexpression in Skeletal Muscle The Journal of Clinical Investigation. Mar, 2011 | Pubmed ID: 21285509 Genetic Deletion of Myostatin from the Heart Prevents Skeletal Muscle Atrophy in Heart Failure Circulation. Jan, 2010 | Pubmed ID: 20065166 Calcineurin Protects the Heart in a Murine Model of Dilated Cardiomyopathy Journal of Molecular and Cellular Cardiology. Jun, 2010 | Pubmed ID: 19854199 Calcium Influx is Sufficient to Induce Muscular Dystrophy Through a TRPC-dependent Mechanism Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19864620 Genetic Manipulation of Dysferlin Expression in Skeletal Muscle: Novel Insights into Muscular Dystrophy The American Journal of Pathology. Nov, 2009 | Pubmed ID: 19834057 ASK1 Regulates Cardiomyocyte Death but Not Hypertrophy in Transgenic Mice Circulation Research. Nov, 2009 | Pubmed ID: 19815822 Plasma Membrane Ca2+-ATPase Isoform 4 Antagonizes Cardiac Hypertrophy in Association with Calcineurin Inhibition in Rodents The Journal of Clinical Investigation. Apr, 2009 | Pubmed ID: 19287093 Cardiac Myosin Binding Protein-C Phosphorylation in a {beta}-myosin Heavy Chain Background Circulation. Mar, 2009 | Pubmed ID: 19237661 Genetic Manipulation of Periostin Expression in the Heart Does Not Affect Myocyte Content, Cell Cycle Activity, or Cardiac Repair Circulation Research. Jan, 2009 | Pubmed ID: 19038863 DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18753132 Genetic and Pharmacologic Inhibition of Mitochondrial-dependent Necrosis Attenuates Muscular Dystrophy Nature Medicine. Apr, 2008 | Pubmed ID: 18345011 Cardiomyocyte GATA4 Functions As a Stress-responsive Regulator of Angiogenesis in the Murine Heart The Journal of Clinical Investigation. Nov, 2007 | Pubmed ID: 17975667 Inducible and Myocyte-specific Inhibition of PKCalpha Enhances Cardiac Contractility and Protects Against Infarction-induced Heart Failure American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2007 | Pubmed ID: 17921332 Genetic Disruption of Calcineurin Improves Skeletal Muscle Pathology and Cardiac Disease in a Mouse Model of Limb-girdle Muscular Dystrophy The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17289669 Cardiac Myosin Binding Protein C Phosphorylation is Cardioprotective Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17075052 Age-dependent Effect of Myostatin Blockade on Disease Severity in a Murine Model of Limb-girdle Muscular Dystrophy The American Journal of Pathology. Jun, 2006 | Pubmed ID: 16723712 Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts Demetria M. Fischesser1,2, Evan C. Meyer3, Michelle Sargent2, Jeffery D. Molkentin2 1Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 2Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, 3Confocal Imaging Core, Cincinnati Children's Hospital Medical Center JoVE 62023 의학
Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts Demetria M. Fischesser1,2, Evan C. Meyer3, Michelle Sargent2, Jeffery D. Molkentin2 1Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 2Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, 3Confocal Imaging Core, Cincinnati Children's Hospital Medical Center JoVE 62023 의학