Muthiah Manoharan Alnylam Pharmaceuticals, Inc. Biography Publications Institution JoVE Articles Muthiah Manoharan has not added a biography. If you are Muthiah Manoharan and would like to personalize this page please email our Author Liaison for assistance. Publications Angewandte Chemie (International Ed. in English). Jul, 2012 | Pubmed ID: 22782619 Molecularly Self-assembled Nucleic Acid Nanoparticles for Targeted in Vivo SiRNA Delivery Nature Nanotechnology. 2012 | Pubmed ID: 22659608 RNA (New York, N.Y.). Mar, 2012 | Pubmed ID: 22294662 Mechanistic Insights into LDL Nanoparticle-mediated SiRNA Delivery Bioconjugate Chemistry. Jan, 2012 | Pubmed ID: 22142191 Experimental Neurology. Jan, 2012 | Pubmed ID: 22119622 MicroRNA 194 是烫 6 成人肝脏和控件表达式中的转录因子 1 HNF1α Tcf1) 的目标。 Hepatology (Baltimore, Md.). Jan, 2012 | Pubmed ID: 21887698 Bioconjugate Chemistry. Aug, 2011 | Pubmed ID: 21755983 Angewandte Chemie (International Ed. in English). Mar, 2011 | Pubmed ID: 21351337 Nucleic Acids Research. Jun, 2011 | Pubmed ID: 21345934 The Journal of Organic Chemistry. Mar, 2011 | Pubmed ID: 21299239 Nucleic Acids Research. Apr, 2011 | Pubmed ID: 21183463 Chemistry & Biology. Dec, 2010 | Pubmed ID: 21168770 Organic Letters. Dec, 2010 | Pubmed ID: 21049912 Nucleic Acids Research. Nov, 2010 | Pubmed ID: 20610434 Analytical Biochemistry. Oct, 2010 | Pubmed ID: 20599656 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20534471 Targeted Delivery of RNAi Therapeutics with Endogenous and Exogenous Ligand-based Mechanisms Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2010 | Pubmed ID: 20461061 Organic Letters. May, 2010 | Pubmed ID: 20420425 Nucleic Acids Research. Aug, 2010 | Pubmed ID: 20403811 Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2010 | Pubmed ID: 20170694 Analytical Biochemistry. Jun, 2010 | Pubmed ID: 20156415 Rational Design of Cationic Lipids for SiRNA Delivery Nature Biotechnology. Feb, 2010 | Pubmed ID: 20081866 Antimicrobial Agents and Chemotherapy. Sep, 2009 | Pubmed ID: 19506055 Chemical Communications (Cambridge, England). Apr, 2009 | Pubmed ID: 19333476 发展的系统性交付给肝脏 Lipidoid SiRNA 配方。 Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2009 | Pubmed ID: 19259063 Durable Protection from Herpes Simplex Virus-2 Transmission Following Intravaginal Application of SiRNAs Targeting Both a Viral and Host Gene Cell Host & Microbe. Jan, 2009 | Pubmed ID: 19154990 Oligonucleotides. Mar, 2009 | Pubmed ID: 19093781 治疗 RNAi 敏锐地针对 PCSK9 降低了在啮齿类动物的血浆胆固醇和低密度脂蛋白胆固醇的非人灵长类动物。 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18695239 交付 RNAi 疗法的脂状材料组合库。 Nature Biotechnology. May, 2008 | Pubmed ID: 18438401 Journal of Medicinal Chemistry. May, 2008 | Pubmed ID: 18399648 A Viral MicroRNA Functions As an Orthologue of Cellular MiR-155 Nature. Dec, 2007 | Pubmed ID: 18075594 有效 RNAi 介导的基因沉默不间断的内源性 MicroRNA 通路。 Nature. Oct, 2007 | Pubmed ID: 17898712 Nucleic Acids Research. 2007 | Pubmed ID: 17881374 Nature Biotechnology. Oct, 2007 | Pubmed ID: 17873866 特异性、 双面退化和亚细胞定位的 Antagomirs。 Nucleic Acids Research. 2007 | Pubmed ID: 17439965 Cell. Apr, 2007 | Pubmed ID: 17382377 Nucleosides, Nucleotides & Nucleic Acids. 2007 | Pubmed ID: 17365794 ACS Chemical Biology. Apr, 2006 | Pubmed ID: 17163665 Nature Chemical Biology. Dec, 2006 | Pubmed ID: 17108989 Journal of Medicinal Chemistry. Apr, 2006 | Pubmed ID: 16610796 Biochemistry. Apr, 2006 | Pubmed ID: 16566588 Nature. May, 2006 | Pubmed ID: 16565705 沉默的 Microrna 在体内与 'antagomirs'。 Nature. Dec, 2005 | Pubmed ID: 16258535 Journal of Medicinal Chemistry. Oct, 2005 | Pubmed ID: 16220989 Nucleic Acids Research. 2005 | Pubmed ID: 16170156 影响的 Stereoelectronic 对寡核苷酸的生物物理特性的影响探讨: RNA 亲和、 核酸酶抵抗和十 2'-O-核糖核酸酸修改的晶体结构的综合分析。 Biochemistry. Jun, 2005 | Pubmed ID: 15966728 Nature Medicine. Mar, 2005 | Pubmed ID: 15723075 Methods in Enzymology. 2005 | Pubmed ID: 15644187 Nucleic Acids Research. 2004 | Pubmed ID: 15602001 Current Opinion in Chemical Biology. Dec, 2004 | Pubmed ID: 15556399 Journal of the American Chemical Society. Nov, 2004 | Pubmed ID: 15547979 Nature. Nov, 2004 | Pubmed ID: 15538359 The Journal of Gene Medicine. Oct, 2004 | Pubmed ID: 15386737 Nucleic Acids Research. 2004 | Pubmed ID: 15247346 2'-O-[2-(胍盐) 乙基]-修改寡核苷酸: 双面打印和三缸结构对稳定作用。 Organic Letters. Jun, 2004 | Pubmed ID: 15176796 Nucleic Acids Research. 2004 | Pubmed ID: 14762210 Nucleic Acids Research. Supplement (2001). 2003 | Pubmed ID: 14510407 C 5 氨基甲酸炔丙嘧啶含寡体外和体内的评价。 Antisense & Nucleic Acid Drug Development. 2003 | Pubmed ID: 12954113 Organic Letters. Aug, 2003 | Pubmed ID: 12916967 Organic Letters. Jun, 2003 | Pubmed ID: 12790517 Nucleic Acids Research. Apr, 2003 | Pubmed ID: 12682357 Journal of the American Chemical Society. Mar, 2003 | Pubmed ID: 12603111 2'-O-[2-(amino)-2-oxoethyl] 寡核苷酸。 Organic Letters. Feb, 2003 | Pubmed ID: 12583729 Bioconjugate Chemistry. Jan-Feb, 2003 | Pubmed ID: 12526688 RNA (New York, N.Y.). Dec, 2002 | Pubmed ID: 12515389 Angewandte Chemie (International Ed. in English). Jan, 2002 | Pubmed ID: 12491456 高亲和性肽核酸齐聚含三环胞嘧啶类似物。 Organic Letters. Dec, 2002 | Pubmed ID: 12465896 提高对人血清白蛋白反义寡核苷酸绑定: 布洛芬共轭的戏剧性效果。 Chembiochem : a European Journal of Chemical Biology. Dec, 2002 | Pubmed ID: 12465035 Nature Biotechnology. Dec, 2002 | Pubmed ID: 12426578 2'-O-[2-(甲) 乙基]-修改寡核苷酸: 改进蛋白绑定属性和高绑定到目标 RNA 的亲和与 2'-O-[2-(methoxy)-ethyl]-modified 寡核苷酸的相似之处。 Biochemistry. Oct, 2002 | Pubmed ID: 12269806 The Journal of Pharmacology and Experimental Therapeutics. Aug, 2002 | Pubmed ID: 12130724 Antisense & Nucleic Acid Drug Development. Apr, 2002 | Pubmed ID: 12074364 European Journal of Biochemistry / FEBS. May, 2002 | Pubmed ID: 12027896 Biochemistry. Jan, 2002 | Pubmed ID: 11802733 The Journal of Organic Chemistry. Jan, 2002 | Pubmed ID: 11798305 原位膀胱肿瘤模型和评价治疗膀胱萨纳 Moo Rim Kang*1, Glen Yang*1, Klaus Charisse2, Hila Epstein-Barash2, Muthiah Manoharan2, Long-Cheng Li1 1Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 2Alnylam Pharmaceuticals, Inc. JoVE 4207 의학
原位膀胱肿瘤模型和评价治疗膀胱萨纳 Moo Rim Kang*1, Glen Yang*1, Klaus Charisse2, Hila Epstein-Barash2, Muthiah Manoharan2, Long-Cheng Li1 1Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 2Alnylam Pharmaceuticals, Inc. JoVE 4207 의학