Omar Abdel-Wahab Human Oncology and Pathogenesis Program, Department of Medicine Memorial Sloan-Kettering Cancer Center Biography Publications Institution JoVE Articles Omar Abdel-Wahab has not added a biography. If you are Omar Abdel-Wahab and would like to personalize this page please email our Author Liaison for assistance. Publications Frequent ASXL2 Mutations in Acute Myeloid Leukemia Patients with T(8;21)/RUNX1-RUNX1T1 Chromosomal Translocations Blood. Jun, 2014 | Pubmed ID: 24973361 Selective Activity of the Histone Deacetylase Inhibitor AR-42 Against Leukemia Stem Cells: a Novel Potential Strategy in Acute Myeloid Leukemia Molecular Cancer Therapeutics. Jun, 2014 | Pubmed ID: 24934933 Hematopoietic Stem Cell Origin of BRAFV600E Mutations in Hairy Cell Leukemia Science Translational Medicine. May, 2014 | Pubmed ID: 24871132 Consensus Guidelines for the Diagnosis and Clinical Management of Erdheim-Chester Disease Blood. May, 2014 | Pubmed ID: 24850756 Current Pre-clinical and Clinical Advances in the BCR-ABL1-positive and -negative Chronic Myeloproliferative Neoplasms Haematologica. May, 2014 | Pubmed ID: 24790057 Integrated Genomic Analysis Illustrates the Central Role of JAK-STAT Pathway Activation in Myeloproliferative Neoplasm Pathogenesis Blood. May, 2014 | Pubmed ID: 24740812 Recent Discoveries in Molecular Characterization of Acute Myeloid Leukemia Current Hematologic Malignancy Reports. Jun, 2014 | Pubmed ID: 24609756 Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-mutant Malignancies Cancer Discovery. May, 2014 | Pubmed ID: 24589925 D-2-hydroxyglutarate Produced by Mutant IDH2 Causes Cardiomyopathy and Neurodegeneration in Mice Genes & Development. Mar, 2014 | Pubmed ID: 24589777 Collaborating Constitutive and Somatic Genetic Events in Myeloid Malignancies: ASXL1 Mutations in Patients with Germline GATA2 Mutations Haematologica. Feb, 2014 | Pubmed ID: 24497555 Emerging Therapeutic Paradigms to Target the Dysregulated Janus Kinase/signal Transducer and Activator of Transcription Pathway in Hematological Malignancies Leukemia & Lymphoma. Feb, 2014 | Pubmed ID: 24206094 Focus on the Epigenome in the Myeloproliferative Neoplasms Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2013 | Pubmed ID: 24319229 The Importance of Subclonal Genetic Events in MDS Blood. Nov, 2013 | Pubmed ID: 24263953 Deletion of Asxl1 Results in Myelodysplasia and Severe Developmental Defects in Vivo The Journal of Experimental Medicine. Nov, 2013 | Pubmed ID: 24218140 Myelodysplastic Syndromes Are Induced by Histone Methylation–altering ASXL1 Mutations The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24216483 Detection of an NRAS Mutation in Erdheim-Chester Disease Blood. Aug, 2013 | Pubmed ID: 23929840 Antagonistic Activities of the Immunomodulator and PP2A-activating Drug FTY720 (Fingolimod, Gilenya) in Jak2-driven Hematologic Malignancies Blood. Sep, 2013 | Pubmed ID: 23926298 Molecular Analysis of Patients with Polycythemia Vera or Essential Thrombocythemia Receiving Pegylated Interferon α-2a Blood. Aug, 2013 | Pubmed ID: 23782935 Importance of Genetics in the Clinical Management of Chronic Myelomonocytic Leukemia Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2013 | Pubmed ID: 23690427 EZH2 is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation Cancer Cell. May, 2013 | Pubmed ID: 23680150 Serum 2-hydroxyglutarate Levels Predict Isocitrate Dehydrogenase Mutations and Clinical Outcome in Acute Myeloid Leukemia Blood. Jun, 2013 | Pubmed ID: 23641016 Mutations in Epigenetic Modifiers in the Pathogenesis and Therapy of Acute Myeloid Leukemia Blood. May, 2013 | Pubmed ID: 23640996 GM-CSF-dependent PSTAT5 Sensitivity is a Feature with Therapeutic Potential in Chronic Myelomonocytic Leukemia Blood. Jun, 2013 | Pubmed ID: 23632888 Regulation of C-Myc Ubiquitination Controls Chronic Myelogenous Leukemia Initiation and Progression Cancer Cell. Mar, 2013 | Pubmed ID: 23518350 Macrophages Support Pathological Erythropoiesis in Polycythemia Vera and β-thalassemia Nature Medicine. Apr, 2013 | Pubmed ID: 23502961 Notch Pathway Activation Targets AML-initiating Cell Homeostasis and Differentiation The Journal of Experimental Medicine. Feb, 2013 | Pubmed ID: 23359070 Mutational Analysis of Therapy-related Myelodysplastic Syndromes and Acute Myelogenous Leukemia Haematologica. Jun, 2013 | Pubmed ID: 23349305 HDL and Glut1 Inhibition Reverse a Hypermetabolic State in Mouse Models of Myeloproliferative Disorders The Journal of Experimental Medicine. Feb, 2013 | Pubmed ID: 23319699 The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23264629 Sequential Azacitidine Plus Lenalidomide Combination for Elderly Patients with Untreated Acute Myeloid Leukemia Haematologica. Apr, 2013 | Pubmed ID: 23242596 Translocation T(11;17) in De Novo Myelodysplastic Syndrome Not Associated with Acute Myeloid or Acute Promyelocytic Leukemia Acta Haematologica. 2013 | Pubmed ID: 23147462 Acute Myeloid Leukemia with Translocation T(8;16) Presents with Features Which Mimic Acute Promyelocytic Leukemia and is Associated with Poor Prognosis Leukemia Research. Jan, 2013 | Pubmed ID: 23102703 Clinical and Pathologic Impact of Select Chromatin-modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma European Urology. May, 2013 | Pubmed ID: 23036577 Refining the Prognostic Importance of the Diversity of FLT3 Internal Tandem Duplications Leukemia & Lymphoma. Jan, 2013 | Pubmed ID: 22775313 2-Hydroxyglutarate in IDH Mutant Acute Myeloid Leukemia: Predicting Patient Responses, Minimal Residual Disease and Correlations with Methylcytosine and Hydroxymethylcytosine Levels Leukemia & Lymphoma. Feb, 2013 | Pubmed ID: 22680765 Interpreting New Molecular Genetics in Myelodysplastic Syndromes Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2012 | Pubmed ID: 23233561 Progression of RAS-mutant Leukemia During RAF Inhibitor Treatment The New England Journal of Medicine. Dec, 2012 | Pubmed ID: 23134356 Epigenetic Alterations in Hematopoietic Malignancies International Journal of Hematology. Oct, 2012 | Pubmed ID: 23015417 Role of TET2 and ASXL1 Mutations in the Pathogenesis of Myeloproliferative Neoplasms Hematology/oncology Clinics of North America. Oct, 2012 | Pubmed ID: 23009937 Recurrent Somatic TET2 Mutations in Normal Elderly Individuals with Clonal Hematopoiesis Nature Genetics. Nov, 2012 | Pubmed ID: 23001125 Proposed Criteria for Response Assessment in Patients Treated in Clinical Trials for Myeloproliferative Neoplasms in Blast Phase (MPN-BP): Formal Recommendations from the Post-myeloproliferative Neoplasm Acute Myeloid Leukemia Consortium Leukemia Research. Dec, 2012 | Pubmed ID: 22938832 The Role of Mutations in Epigenetic Regulators in Myeloid Malignancies Nature Reviews. Cancer. Sep, 2012 | Pubmed ID: 22898539 ASXL1 Mutations Promote Myeloid Transformation Through Loss of PRC2-mediated Gene Repression Cancer Cell. Aug, 2012 | Pubmed ID: 22897849 Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation Science (New York, N.Y.). Sep, 2012 | Pubmed ID: 22878500 Validation of a Prognostic Model and the Impact of Mutations in Patients with Lower-risk Myelodysplastic Syndromes Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2012 | Pubmed ID: 22869879 CD25 Expression Status Improves Prognostic Risk Classification in AML Independent of Established Biomarkers: ECOG Phase 3 Trial, E1900 Blood. Sep, 2012 | Pubmed ID: 22855599 Heterodimeric JAK-STAT Activation As a Mechanism of Persistence to JAK2 Inhibitor Therapy Nature. Sep, 2012 | Pubmed ID: 22820254 Molecular Genetics of Acute Myeloid Leukemia: Clinical Implications and Opportunities for Integrating Genomics into Clinical Practice Hematology (Amsterdam, Netherlands). Apr, 2012 | Pubmed ID: 22507776 Unraveling the Genetic Underpinnings of Myeloproliferative Neoplasms and Understanding Their Effect on Disease Course and Response to Therapy: Proceedings from the 6th International Post-ASH Symposium American Journal of Hematology. May, 2012 | Pubmed ID: 22460584 Genetic Analysis of Patients with Leukemic Transformation of Myeloproliferative Neoplasms Shows Recurrent SRSF2 Mutations That Are Associated with Adverse Outcome Blood. May, 2012 | Pubmed ID: 22431577 Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia The New England Journal of Medicine. Mar, 2012 | Pubmed ID: 22417203 IDH Mutation Impairs Histone Demethylation and Results in a Block to Cell Differentiation Nature. Mar, 2012 | Pubmed ID: 22343901 Disordered Epigenetic Regulation in the Pathophysiology of Myeloproliferative Neoplasms Current Hematologic Malignancy Reports. Mar, 2012 | Pubmed ID: 22170482 FISHing for TET2: Utility of FISH for TET2 Deletions Detection in Clinical Samples Leukemia Research. Jan, 2012 | Pubmed ID: 21917313 Mutations in Epigenetic Modifiers in Myeloid Malignancies and the Prospect of Novel Epigenetic-targeted Therapy Advances in Hematology. 2012 | Pubmed ID: 21811504 Molecular Alterations Underlying Eosinophilic and Mast Cell Malignancies Discovery Medicine. Dec, 2011 | Pubmed ID: 22204765 Nuclear JAK2 Blood. Dec, 2011 | Pubmed ID: 22194397 Clinical Implications of Novel Mutations in Epigenetic Modifiers in AML Hematology/oncology Clinics of North America. Dec, 2011 | Pubmed ID: 22093580 The Spliceosome As an Indicted Conspirator in Myeloid Malignancies Cancer Cell. Oct, 2011 | Pubmed ID: 22014568 Janus Kinase-2 Inhibition Induces Durable Tolerance to Alloantigen by Human Dendritic Cell-stimulated T Cells Yet Preserves Immunity to Recall Antigen Blood. Nov, 2011 | Pubmed ID: 21917753 TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation Cell Stem Cell. Sep, 2011 | Pubmed ID: 21885017 Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-renewal and Myeloid Transformation Cancer Cell. Jul, 2011 | Pubmed ID: 21723200 Clinical Effect of Point Mutations in Myelodysplastic Syndromes The New England Journal of Medicine. Jun, 2011 | Pubmed ID: 21714648 Ddx18 is Essential for Cell-cycle Progression in Zebrafish Hematopoietic Cells and is Mutated in Human AML Blood. Jul, 2011 | Pubmed ID: 21653321 A Novel Tumour-suppressor Function for the Notch Pathway in Myeloid Leukaemia Nature. May, 2011 | Pubmed ID: 21562564 Aberrant Epigenetic and Genetic Marks Are Seen in Myelodysplastic Leukocytes and Reveal Dock4 As a Candidate Pathogenic Gene on Chromosome 7q The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21532034 JAK2V617F-mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation Cancer Cell. Feb, 2011 | Pubmed ID: 21316606 Genetics of the Myeloproliferative Neoplasms Current Opinion in Hematology. Mar, 2011 | Pubmed ID: 21307773 ETV6-ABL1-positive "chronic Myeloid Leukemia": Clinical and Molecular Response to Tyrosine Kinase Inhibition Haematologica. Feb, 2011 | Pubmed ID: 21193423 Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation Cancer Cell. Dec, 2010 | Pubmed ID: 21130701 A Mathematical Framework to Determine the Temporal Sequence of Somatic Genetic Events in Cancer Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010 | Pubmed ID: 20864632 HSP90 is a Therapeutic Target in JAK2-dependent Myeloproliferative Neoplasms in Mice and Humans The Journal of Clinical Investigation. Oct, 2010 | Pubmed ID: 20852385 The Notch/Hes1 Pathway Sustains NF-κB Activation Through CYLD Repression in T Cell Leukemia Cancer Cell. Sep, 2010 | Pubmed ID: 20832754 Recent Advances in the Treatment of Acute Myeloid Leukemia F1000 Medicine Reports. 2010 | Pubmed ID: 20798782 Depletion of L3MBTL1 Promotes the Erythroid Differentiation of Human Hematopoietic Progenitor Cells: Possible Role in 20q- Polycythemia Vera Blood. Oct, 2010 | Pubmed ID: 20585043 Metabolism and the Leukemic Stem Cell The Journal of Experimental Medicine. Apr, 2010 | Pubmed ID: 20368582 The Common Feature of Leukemia-associated IDH1 and IDH2 Mutations is a Neomorphic Enzyme Activity Converting Alpha-ketoglutarate to 2-hydroxyglutarate Cancer Cell. Mar, 2010 | Pubmed ID: 20171147 Efficacy of the JAK2 Inhibitor INCB16562 in a Murine Model of MPLW515L-induced Thrombocytosis and Myelofibrosis Blood. Apr, 2010 | Pubmed ID: 20154217 Genetic Analysis of Transforming Events That Convert Chronic Myeloproliferative Neoplasms to Leukemias Cancer Research. Jan, 2010 | Pubmed ID: 20068184 Cytogenetic Correlates of TET2 Mutations in 199 Patients with Myeloproliferative Neoplasms American Journal of Hematology. Jan, 2010 | Pubmed ID: 19957346 Genetic Characterization of TET1, TET2, and TET3 Alterations in Myeloid Malignancies Blood. Jul, 2009 | Pubmed ID: 19420352 Primary Myelofibrosis: Update on Definition, Pathogenesis, and Treatment Annual Review of Medicine. 2009 | Pubmed ID: 18947294 Warfarin-induced Skin Necrosis in a Patient with Heparin-induced Thrombocytopenia: Two Diseases or One? Acta Haematologica. 2008 | Pubmed ID: 19018128 Functional Evaluation of the Grafted Wall with Porcine-derived Small Intestinal Submucosa (SIS) to a Stomach Defect in Rats Surgery. Sep, 2007 | Pubmed ID: 17723890 An 87-year-old Woman with Respiratory Distress and Alveolar Hemorrhage After Transfusion Chest. Nov, 2006 | Pubmed ID: 17099045 Effect of Fresh-frozen Plasma Transfusion on Prothrombin Time and Bleeding in Patients with Mild Coagulation Abnormalities Transfusion. Aug, 2006 | Pubmed ID: 16934060 Current Usage of Intravenous Immune Globulin and the Rationale Behind It: the Massachusetts General Hospital Data and a Review of the Literature Transfusion. May, 2006 | Pubmed ID: 16686841 Modulation of Chemotherapy Resistance in Regional Therapy: a Novel Therapeutic Approach to Advanced Extremity Melanoma Using Intra-arterial Temozolomide in Combination with Systemic O6-benzylguanine Molecular Cancer Therapeutics. Mar, 2006 | Pubmed ID: 16546988 Optimizing a Novel Regional Chemotherapeutic Agent Against Melanoma: Hyperthermia-induced Enhancement of Temozolomide Cytotoxicity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2006 | Pubmed ID: 16397054 Cotransfection of DC with TLR4 and MART-1 RNA Induces MART-1-specific Responses The Journal of Surgical Research. Apr, 2005 | Pubmed ID: 15820257 The Role of Hyperthermia in Regional Alkylating Agent Chemotherapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2004 | Pubmed ID: 15355925 In-transit Melanoma: the Role of Alkylating-agent Resistance in Regional Therapy Journal of the American College of Surgeons. Sep, 2004 | Pubmed ID: 15325612 Modulation of Resistance to Regional Chemotherapy in the Extremity Melanoma Model Surgery. Aug, 2004 | Pubmed ID: 15300182 Immunotherapy of Surgical Malignancies Current Problems in Surgery. Jan, 2004 | Pubmed ID: 14749625 Induction of Anti-melanoma CTL Response Using DC Transfected with Mutated MRNA Encoding Full-length Melan-A/MART-1 Antigen with an A27L Amino Acid Substitution Cellular Immunology. Aug, 2003 | Pubmed ID: 14609574 الفخذ نخاع العظم الطموح في الفئران لايف Young Rock Chung1, Eunhee Kim1, Omar Abdel-Wahab1 1Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan-Kettering Cancer Center 의학
الفخذ نخاع العظم الطموح في الفئران لايف Young Rock Chung1, Eunhee Kim1, Omar Abdel-Wahab1 1Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan-Kettering Cancer Center 의학