Ottavio Arancio Taub Institute for Research on Alzheimer's Disease and Aging Brain Columbia University Biography Publications Institution JoVE Articles Ottavio Arancio has not added a biography. If you are Ottavio Arancio and would like to personalize this page please email our Author Liaison for assistance. Publications β- but Not γ-secretase Proteolysis of APP Causes Synaptic and Memory Deficits in a Mouse Model of Dementia EMBO Molecular Medicine. Dec, 2011 | Pubmed ID: 22170863 APP Heterozygosity Averts Memory Deficit in Knockin Mice Expressing the Danish Dementia BRI2 Mutant The EMBO Journal. Jun, 2011 | Pubmed ID: 21587206 Endogenous Amyloid-β is Necessary for Hippocampal Synaptic Plasticity and Memory Annals of Neurology. May, 2011 | Pubmed ID: 21472769 A Selective Role for ARMS/Kidins220 Scaffold Protein in Spatial Memory and Trophic Support of Entorhinal and Frontal Cortical Neurons Experimental Neurology. Jun, 2011 | Pubmed ID: 21419124 Inhibition of Amyloid-beta (Abeta) Peptide-binding Alcohol Dehydrogenase-Abeta Interaction Reduces Abeta Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011 | Pubmed ID: 21307267 Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-linked Synaptic Dysfunction and Cognitive Deficits The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010 | Pubmed ID: 21147981 Danish Dementia Mice Suggest That Loss of Function and Not the Amyloid Cascade Causes Synaptic Plasticity and Memory Deficits Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21098268 Memory Deficits Due to Familial British Dementia BRI2 Mutation Are Caused by Loss of BRI2 Function Rather Than Amyloidosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2010 | Pubmed ID: 21048150 The Ankyrin Repeat-rich Membrane Spanning (ARMS)/Kidins220 Scaffold Protein is Regulated by Activity-dependent Calpain Proteolysis and Modulates Synaptic Plasticity The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20943655 Microglial Receptor for Advanced Glycation End Product-dependent Signal Pathway Drives Beta-amyloid-induced Synaptic Depression and Long-term Depression Impairment in Entorhinal Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2010 | Pubmed ID: 20739563 The ARMS/Kidins220 Scaffold Protein Modulates Synaptic Transmission Molecular and Cellular Neurosciences. Oct, 2010 | Pubmed ID: 20547223 MAPK, Beta-amyloid and Synaptic Dysfunction: the Role of RAGE Expert Review of Neurotherapeutics. Nov, 2009 | Pubmed ID: 19903023 Reversal of Long-term Dendritic Spine Alterations in Alzheimer Disease Models Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805389 Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2009 | Pubmed ID: 19625751 Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-beta Load in an Alzheimer's Disease Mouse Model The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2009 | Pubmed ID: 19553447 Glutaminase-deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2009 | Pubmed ID: 19516252 Endocannabinoid System: Emerging Role from Neurodevelopment to Neurodegeneration Mini Reviews in Medicinal Chemistry. Apr, 2009 | Pubmed ID: 19356123 Abeta-dependent Inhibition of LTP in Different Intracortical Circuits of the Visual Cortex: the Role of RAGE Journal of Alzheimer's Disease : JAD. 2009 | Pubmed ID: 19221410 Protection Against Beta-amyloid Induced Abnormal Synaptic Function and Cell Death by Ginkgolide J Neurobiology of Aging. Feb, 2009 | Pubmed ID: 17640772 PIP2: a New Key Player in Alzheimer's Disease Cellscience. Jul, 2008 | Pubmed ID: 20577650 Picomolar Amyloid-beta Positively Modulates Synaptic Plasticity and Memory in Hippocampus The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008 | Pubmed ID: 19118188 Small Molecule, Non-peptide P75 Ligands Inhibit Abeta-induced Neurodegeneration and Synaptic Impairment PloS One. 2008 | Pubmed ID: 18978948 Cyclophilin D Deficiency Attenuates Mitochondrial and Neuronal Perturbation and Ameliorates Learning and Memory in Alzheimer's Disease Nature Medicine. Oct, 2008 | Pubmed ID: 18806802 Acute Ethanol Suppresses Glutamatergic Neurotransmission Through Endocannabinoids in Hippocampal Neurons Journal of Neurochemistry. Nov, 2008 | Pubmed ID: 18796007 Role of Phosphodiesterase 5 in Synaptic Plasticity and Memory Neuropsychiatric Disease and Treatment. Apr, 2008 | Pubmed ID: 18728748 A Role for CGMP-dependent Protein Kinase II in AMPA Receptor Trafficking and Synaptic Plasticity Channels (Austin, Tex.). Jul-Aug, 2008 | Pubmed ID: 18728399 Inhibition of Calpains Improves Memory and Synaptic Transmission in a Mouse Model of Alzheimer Disease The Journal of Clinical Investigation. Aug, 2008 | Pubmed ID: 18596919 Synaptojanin 1-linked Phosphoinositide Dyshomeostasis and Cognitive Deficits in Mouse Models of Down's Syndrome Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18591654 Isolation and Characterization of "Reprotoxin", a Novel Protein Complex from Daboia Russelii Snake Venom Biochimie. Oct, 2008 | Pubmed ID: 18573307 A Transgenic Rat That Develops Alzheimer's Disease-like Amyloid Pathology, Deficits in Synaptic Plasticity and Cognitive Impairment Neurobiology of Disease. Jul, 2008 | Pubmed ID: 18504134 Retromer Deficiency Observed in Alzheimer's Disease Causes Hippocampal Dysfunction, Neurodegeneration, and Abeta Accumulation Proceedings of the National Academy of Sciences of the United States of America. May, 2008 | Pubmed ID: 18480253 Oligomeric Amyloid-beta Peptide Disrupts Phosphatidylinositol-4,5-bisphosphate Metabolism Nature Neuroscience. May, 2008 | Pubmed ID: 18391946 Receptor for Advanced Glycation End Product-dependent Activation of P38 Mitogen-activated Protein Kinase Contributes to Amyloid-beta-mediated Cortical Synaptic Dysfunction The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2008 | Pubmed ID: 18367618 A Neuronal Microtubule-interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease The Journal of Pharmacology and Experimental Therapeutics. Apr, 2008 | Pubmed ID: 18199809 RAGE: a Potential Target for Abeta-mediated Cellular Perturbation in Alzheimer's Disease Current Molecular Medicine. Dec, 2007 | Pubmed ID: 18331231 Oligomers of Beta-amyloid Peptide Inhibit BDNF-induced Arc Expression in Cultured Cortical Neurons Current Alzheimer Research. Dec, 2007 | Pubmed ID: 18220514 A GluR1-cGKII Interaction Regulates AMPA Receptor Trafficking Neuron. Nov, 2007 | Pubmed ID: 18031684 Alpha-synuclein Involvement in Hippocampal Synaptic Plasticity: Role of NO, CGMP, CGK and CaMKII The European Journal of Neuroscience. Jun, 2007 | Pubmed ID: 17610578 Neurotrophins, Synaptic Plasticity and Dementia Current Opinion in Neurobiology. Jun, 2007 | Pubmed ID: 17419049 Involvement of the Nitric Oxide Pathway in Synaptic Dysfunction Following Amyloid Elevation in Alzheimer's Disease Reviews in the Neurosciences. 2006 | Pubmed ID: 17180876 Estimation of the Mean from Sums with Unknown Numbers of Summands Biometrics. Sep, 2006 | Pubmed ID: 16984336 Early Presynaptic Changes During Plasticity in Cultured Hippocampal Neurons The EMBO Journal. Sep, 2006 | Pubmed ID: 16957772 Ubiquitin Hydrolase Uch-L1 Rescues Beta-amyloid-induced Decreases in Synaptic Function and Contextual Memory Cell. Aug, 2006 | Pubmed ID: 16923396 Fibrillar Beta-amyloid Impairs the Late Phase of Long Term Potentiation Current Alzheimer Research. Jul, 2006 | Pubmed ID: 16842092 BDNF-mediated Neurotransmission Relies Upon a Myosin VI Motor Complex Nature Neuroscience. Aug, 2006 | Pubmed ID: 16819522 Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2006 | Pubmed ID: 16399702 Amyloid-beta Peptide Inhibits Activation of the Nitric Oxide/cGMP/cAMP-responsive Element-binding Protein Pathway During Hippocampal Synaptic Plasticity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2005 | Pubmed ID: 16033898 Synaptic Fatigue is More Pronounced in the APP/PS1 Transgenic Mouse Model of Alzheimer's Disease Current Alzheimer Research. Apr, 2005 | Pubmed ID: 15974910 ABAD Enhances Abeta-induced Cell Stress Via Mitochondrial Dysfunction FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2005 | Pubmed ID: 15665036 Persistent Improvement in Synaptic and Cognitive Functions in an Alzheimer Mouse Model After Rolipram Treatment The Journal of Clinical Investigation. Dec, 2004 | Pubmed ID: 15578094 Alpha-Synuclein Produces a Long-lasting Increase in Neurotransmitter Release The EMBO Journal. Nov, 2004 | Pubmed ID: 15510220 RAGE Potentiates Abeta-induced Perturbation of Neuronal Function in Transgenic Mice The EMBO Journal. Oct, 2004 | Pubmed ID: 15457210 Calpain Mediates Calcium-induced Activation of the Erk1,2 MAPK Pathway and Cytoskeletal Phosphorylation in Neurons: Relevance to Alzheimer's Disease The American Journal of Pathology. Sep, 2004 | Pubmed ID: 15331404 Cell Cultures from Animal Models of Alzheimer's Disease As a Tool for Faster Screening and Testing of Drug Efficacy Journal of Molecular Neuroscience : MN. 2004 | Pubmed ID: 15314245 Progressive Age-related Development of Alzheimer-like Pathology in APP/PS1 Mice Annals of Neurology. Jun, 2004 | Pubmed ID: 15174014 ABAD Directly Links Abeta to Mitochondrial Toxicity in Alzheimer's Disease Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15087549 Presynaptic CaMKII is Necessary for Synaptic Plasticity in Cultured Hippocampal Neurons Neuron. Apr, 2004 | Pubmed ID: 15066270 Calpain Inhibitors, a Treatment for Alzheimer's Disease: Position Paper Journal of Molecular Neuroscience : MN. 2003 | Pubmed ID: 14501020 Receptor Protein Tyrosine Phosphatase Alpha is Essential for Hippocampal Neuronal Migration and Long-term Potentiation The EMBO Journal. Aug, 2003 | Pubmed ID: 12912911 Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants Science (New York, N.Y.). Aug, 2003 | Pubmed ID: 12907793 Usefulness of Behavioral and Electrophysiological Studies in Transgenic Models of Alzheimer's Disease Neurochemical Research. Jul, 2003 | Pubmed ID: 12737525 Amyloid Beta -peptide Inhibition of the PKA/CREB Pathway and Long-term Potentiation: Reversibility by Drugs That Enhance CAMP Signaling Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12244210 Calpain Inhibitors: a Treatment for Alzheimer's Disease Journal of Molecular Neuroscience : MN. Aug-Oct, 2002 | Pubmed ID: 12212771 Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices Mauro Fa1, Ian J. Orozco1, Yitshak I. Francis1, Faisal Saeed1, Yimin Gong1, Ottavio Arancio1 1Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University JoVE 1884 신경과학
Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices Mauro Fa1, Ian J. Orozco1, Yitshak I. Francis1, Faisal Saeed1, Yimin Gong1, Ottavio Arancio1 1Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University JoVE 1884 신경과학