Paul Gadue Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Biography Publications Institution JoVE Articles Paul Gadue has not added a biography. If you are Paul Gadue and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Monogenic Diabetes Using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A Cell Stem Cell. Aug, 2019 | Pubmed ID: 31374199 Generation of Spinocerebellar Ataxia Type 2 Induced Pluripotent Stem Cell Lines, CHOPi002-A and CHOPi003-A, from Patients with Abnormal CAG Repeats in the Coding Region of the ATXN2 Gene Stem Cell Research. 01, 2019 | Pubmed ID: 30611021 Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. 02, 2019 | Pubmed ID: 30358158 Generation of a Human Juvenile Myelomonocytic Leukemia IPSC Line, CHOPi001-A, with a Mutation in CBL Stem Cell Research. 08, 2018 | Pubmed ID: 30096712 GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells The Journal of Clinical Investigation. 07, 2018 | Pubmed ID: 29889101 Exploring the Interaction Between EIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain Neuroscience. 02, 2018 | Pubmed ID: 29289717 Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2017 | Pubmed ID: 28982668 GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells Stem Cell Reports. 03, 2017 | Pubmed ID: 28196690 Generation of Human Control IPS Cell Line CHOPWT10 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Mar, 2016 | Pubmed ID: 27345999 Generation of Hermansky Pudlak Syndrome Type 2 (HPS2) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345985 Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345974 Generation of Human Control IPS Cell Line CHOPWT9 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Jan, 2016 | Pubmed ID: 27345777 A Doxycycline-Inducible System for Genetic Correction of IPSC Disease Models Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 25630922 Generation of Poikiloderma with Neutropenia (PN) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Nov, 2015 | Pubmed ID: 26987923 OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus During Human ES Cell Differentiation into Definitive Endoderm Stem Cell Reports. Oct, 2015 | Pubmed ID: 26411902 Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells The Journal of Clinical Investigation. Jun, 2015 | Pubmed ID: 25961454 Comparative Analysis of Human Ex Vivo-generated Platelets Vs Megakaryocyte-generated Platelets in Mice: a Cautionary Tale Blood. Jun, 2015 | Pubmed ID: 25852052 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25621499 Hematopoietic Differentiation of Pluripotent Stem Cells in Culture Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25062629 Utilization of the AAVS1 Safe Harbor Locus for Hematopoietic Specific Transgene Expression and Gene Knockdown in Human ES Cells Stem Cell Research. May, 2014 | Pubmed ID: 24631742 The Negative Impact of Wnt Signaling on Megakaryocyte and Primitive Erythroid Progenitors Derived from Human Embryonic Stem Cells Stem Cell Research. Mar, 2014 | Pubmed ID: 24412757 High-level Transgene Expression in Induced Pluripotent Stem Cell-derived Megakaryocytes: Correction of Glanzmann Thrombasthenia Blood. Jan, 2014 | Pubmed ID: 24335497 Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines Blood. Sep, 2013 | Pubmed ID: 23940280 Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients Blood. Aug, 2013 | Pubmed ID: 23744582 AAV-mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models PloS One. 2013 | Pubmed ID: 23667438 Associées à La Trisomie 21 Vices Humain Hématopoïèse Primitif, Révélé Par Le Biais De Cellules Souches Pluripotentes Induites Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045704 Lignes De Progéniteurs Endodermique Autorenouvellement Générés à Partir De Cellules Souches Pluripotentes Humaines Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 Essai De Criblage à Haut Débit Pour La Différenciation Des Cellules Souches Embryonnaires Humaines Corps Embryoïdes Current Protocols in Stem Cell Biology. Mar, 2012 | Pubmed ID: 22415836 Une Niche De Cellules Endothéliales Induit La Spécification Hépatique Par Le Biais De Répression Double De Wnt Et L'encoche De Signalisation Stem Cells (Dayton, Ohio). Feb, 2011 | Pubmed ID: 21732480 ES De Souris Et Les Cellules IPS Peuvent Former Similaire Endoderme Définitif Malgré Les Différences Dans Les Gènes Imprimés The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 Un Test De Dépistage à Haut Débit Multiplex Pour L'optimisation Des Protocoles De Différenciation Sans Sérum De Cellules Souches Embryonnaires Humaines Stem Cell Research. Mar, 2011 | Pubmed ID: 21169079 Régénération Du Foie De Cellules Souches Pluripotentes Induites Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 21119691 Génération De Poumon Transgène Libres Des Cellules Souches Spécifiques à Certaines Maladies Humaines Pluripotentes Induites à L'aide D'une Seule Cellule De Tige Des Gènes Soumis à Accises Cassette Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 Compétence Transcriptionnelle Et La Correction Active D'exhausteurs De Tissu-spécifique De Facteurs De Transcription Définies Dans Les Cellules Souches Pluripotentes Embryonnaires Et Induits Genes & Development. Dec, 2009 | Pubmed ID: 20008934 Cellules Souches Déchiffrer L'hématopoïèse Sac Vitellin Blood. Aug, 2009 | Pubmed ID: 19696206 Génération D'anticorps Monoclonaux Spécifiques Pour Les Molécules De Surface Cellulaire Exprimée Sur L'endoderme De Souris Au Début Stem Cells (Dayton, Ohio). Sep, 2009 | Pubmed ID: 19522011 Les Cellules épidermiques Rev Up Reprogrammation Nature Biotechnology. Nov, 2008 | Pubmed ID: 18997762 Engourdi Intervient Dans L'interaction Entre Wnt Et Encoche Pour Moduler Une Spécification érythropoïétique Primitive De L'hémangioblaste Development (Cambridge, England). Oct, 2008 | Pubmed ID: 18799543 Wnt, Activine Et BMP Signaling Réglementent Les étapes Distinctes Dans La Voie Du Développement De Cellules Souches Embryonnaires Au Sang Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371422 Identification Et Le Ciblage Du Locus ROSA26 Dans Les Cellules Souches Embryonnaires Humaines Nature Biotechnology. Dec, 2007 | Pubmed ID: 18037879 BMP-4 Est Requis Par Une Spécification Hépatique De L'endoderme Définitif Dérivées De Cellules Souches Embryonnaires Souris Nature Biotechnology. Nov, 2006 | Pubmed ID: 17086172 Wnt Et Signalisation TGF-bêta Sont Requis Pour L'induction D'un Modèle in Vitro De Formation De La Ligne Primitive à L'aide De Cellules Souches Embryonnaires Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17077151 Couche De Germe Induction De Cellules Souches Embryonnaires Experimental Hematology. Sep, 2005 | Pubmed ID: 16140142 Le Développement Des Cellules Chez Les Souris Mutantes Fyn Par Un TCR Restauration De NK T Révèle Une Exigence Pour Fyn Durant L'ontogenèse De Cellules NK T Au Début Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15128794 La Tyrosine Kinase Du Récepteur De Mer : Expression Et Fonction Suggèrent Un Rôle Dans L'immunité Innée European Journal of Immunology. Aug, 2003 | Pubmed ID: 12884290 Précurseurs Des Cellules NK T Pièce Régulation Différentielle De Cytokine Et Nécessitent L'Itk Pour Maturation Efficace Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12193707 Génération de modifications génomiques définies à l'aide de CRISPR-CAS9 dans les cellules souches pluripotentes humaines Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 유전학 Génération de l'homme cellules souches pluripotentes induites à partir de sang périphérique en utilisant le vecteur lentiviral STEMCCA Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 생물학
Génération de modifications génomiques définies à l'aide de CRISPR-CAS9 dans les cellules souches pluripotentes humaines Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 유전학
Génération de l'homme cellules souches pluripotentes induites à partir de sang périphérique en utilisant le vecteur lentiviral STEMCCA Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 생물학