Pavel Georgiev Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences Biography Publications Institution JoVE Articles Pavel Georgiev has not added a biography. If you are Pavel Georgiev and would like to personalize this page please email our Author Liaison for assistance. Publications Mechanisms of Enhancer-promoter Communication and Chromosomal Architecture in Mammals and Frontiers in Genetics. 2022 | Pubmed ID: 36531247 BTB Domains: A Structural View of Evolution, Multimerization, and Protein-protein Interactions BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Nov, 2022 | Pubmed ID: 36449605 Structure of the DNMT3B ADD Domain Suggests the Absence of a DNMT3A-like Autoinhibitory Mechanism Biochemical and Biophysical Research Communications. Sep, 2022 | Pubmed ID: 35760008 Comparative Interactome Analysis of the PRE DNA-binding Factors: Purification of the Combgap-, Zeste-, Psq-, and Adf1-associated Proteins Cellular and Molecular Life Sciences : CMLS. Jun, 2022 | Pubmed ID: 35676368 Structural Insights into Highly Similar Spatial Organization of Zinc-finger Associated Domains with a Very Low Sequence Similarity Structure (London, England : 1993). Jul, 2022 | Pubmed ID: 35580610 Dimerization Activity of a Disordered N-Terminal Domain from CLAMP Protein International Journal of Molecular Sciences. Mar, 2022 | Pubmed ID: 35409222 Mechanisms of CP190 Interaction with Architectural Proteins in Drosophila Melanogaster International Journal of Molecular Sciences. Nov, 2021 | Pubmed ID: 34830280 Redundant Enhancers in the Iab-5 Domain Cooperatively Activate Abd-B in the A5 and A6 Abdominal Segments of Drosophila Development (Cambridge, England). Oct, 2021 | Pubmed ID: 34473267 Drosophila Architectural Protein CTCF is Not Essential for Fly Survival and is Able to Function Independently of CP190 Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. Oct, 2021 | Pubmed ID: 34311130 Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types Cancers. Jun, 2021 | Pubmed ID: 34202528 Boundaries Potentiate Polycomb Response Element-mediated Silencing BMC Biology. Jun, 2021 | Pubmed ID: 34078365 Mechanism and Functional Role of the Interaction Between CP190 and the Architectural Protein Pita in Drosophila Melanogaster Epigenetics & Chromatin. Mar, 2021 | Pubmed ID: 33752739 Structural Basis of Diversity and Homodimerization Specificity of Zinc-finger-associated Domains in Drosophila Nucleic Acids Research. Feb, 2021 | Pubmed ID: 33638995 A Non-stop Identity Complex (NIC) Supervises Enterocyte Identity and Protects from Premature Aging ELife. Feb, 2021 | Pubmed ID: 33629655 Mapping of Functional Elements of the Fab-6 Boundary Involved in the Regulation of the Abd-B Hox Gene in Drosophila Melanogaster Scientific Reports. Feb, 2021 | Pubmed ID: 33603202 Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes International Journal of Molecular Sciences. Jan, 2021 | Pubmed ID: 33445415 The Insulator Functions of the Polydactyl C2H2 Zinc Finger Protein CTCF: Necessity Versus Sufficiency Science Advances. Mar, 2020 | Pubmed ID: 32232161 N-terminal Domain of the Architectural Protein CTCF Has Similar Structural Organization and Ability to Self-association in Bilaterian Organisms Scientific Reports. Feb, 2020 | Pubmed ID: 32060375 Small Drosophila Zinc Finger C2H2 Protein with an N-terminal Zinc Finger-associated Domain Demonstrates the Architecture Functions Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. Jan, 2020 | Pubmed ID: 31706027 HIPP1 Stabilizes the Interaction Between CP190 and Su(Hw) in the Drosophila Insulator Complex Scientific Reports. Dec, 2019 | Pubmed ID: 31836797 Distinct Elements Confer the Blocking and Bypass Functions of the Bithorax Boundary Genetics. Nov, 2019 | Pubmed ID: 31551239 The Simultaneous Interaction of MSL2 with CLAMP and DNA Provides Redundancy in the Initiation of Dosage Compensation in Males Development (Cambridge, England). Aug, 2019 | Pubmed ID: 31320325 Complete Reconstitution of Bypass and Blocking Functions in a Minimal Artificial Insulator from Complex Proceedings of the National Academy of Sciences of the United States of America. Jul, 2019 | Pubmed ID: 31209019 Removal of Extra Sequences with I-SceI in Combination with CRISPR/Cas9 Technique for Precise Gene Editing in Drosophila BioTechniques. Apr, 2019 | Pubmed ID: 30987444 The Same Domain of Su(Hw) is Required for Enhancer Blocking and Direct Promoter Repression Scientific Reports. Mar, 2019 | Pubmed ID: 30926937 Transcription Termination Sequences Support the Expression of Transgene Product Secreted with Milk Transgenic Research. Aug, 2019 | Pubmed ID: 30919251 Functional Dissection of the Developmentally Restricted BEN Domain Chromatin Boundary Factor Insensitive Epigenetics & Chromatin. Jan, 2019 | Pubmed ID: 30602385 Boundaries Mediate Long-distance Interactions Between Enhancers and Promoters in the Drosophila Bithorax Complex PLoS Genetics. Dec, 2018 | Pubmed ID: 30540750 The Bithorax Complex Iab-7 Polycomb Response Element Has a Novel Role in the Functioning of the Fab-7 Chromatin Boundary PLoS Genetics. Aug, 2018 | Pubmed ID: 30110328 Conserved Sequences in the Drosophila Mod(mdg4) Intron Promote Poly(A)-independent Transcription Termination and Trans-splicing Nucleic Acids Research. Nov, 2018 | Pubmed ID: 30102331 The BEN Domain Protein Insensitive Binds to the Chromatin Boundary To Establish Proper Segmental Identity in Genetics. Oct, 2018 | Pubmed ID: 30082280 Role of Su(Hw) Zinc Finger 10 and Interaction with CP190 and Mod(mdg4) Proteins in Recruiting the Su(Hw) Complex to Chromatin Sites in Drosophila PloS One. 2018 | Pubmed ID: 29474480 Interactions Between BTB Domain of CP190 and Two Adjacent Regions in Su(Hw) Are Required for the Insulator Complex Formation Chromosoma. Mar, 2018 | Pubmed ID: 28939920 Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons Molecular Neurobiology. Jun, 2018 | Pubmed ID: 28707074 Opbp is a New Architectural/insulator Protein Required for Ribosomal Gene Expression Nucleic Acids Research. Dec, 2017 | Pubmed ID: 29036346 Multiple Interactions Are Involved in a Highly Specific Association of the Mod(mdg4)-67.2 Isoform with the Su(Hw) Sites in Open Biology. Oct, 2017 | Pubmed ID: 29021216 Architectural Protein Pita Cooperates with DCTCF in Organization of Functional Boundaries in Bithorax Complex Development (Cambridge, England). Jul, 2017 | Pubmed ID: 28619827 The GAGA Factor Regulatory Network: Identification of GAGA Factor Associated Proteins PloS One. 2017 | Pubmed ID: 28296955 Boundaries of Loop Domains (insulators): Determinants of Chromosome Form and Function in Multicellular Eukaryotes BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Mar, 2017 | Pubmed ID: 28133765 Transvection in Drosophila: Trans-interaction Between Yellow Enhancers and Promoter is Strongly Suppressed by a Cis-promoter Only in Certain Genomic Regions Chromosoma. Jun, 2017 | Pubmed ID: 27300555 EAST Affects the Activity of Su(Hw) Insulators by Two Different Mechanisms in Drosophila Melanogaster Chromosoma. Mar, 2017 | Pubmed ID: 27136940 Large-scale ATP-independent Nucleosome Unfolding by a Histone Chaperone Nature Structural & Molecular Biology. Dec, 2016 | Pubmed ID: 27820806 Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex PLoS Genetics. 07, 2016 | Pubmed ID: 27428541 Architectural Proteins Pita, Zw5,and ZIPIC Contain Homodimerization Domain and Support Specific Long-range Interactions in Drosophila Nucleic Acids Research. Sep, 2016 | Pubmed ID: 27137890 Transcriptional Read-through is Not Sufficient to Induce an Epigenetic Switch in the Silencing Activity of Polycomb Response Elements Proceedings of the National Academy of Sciences of the United States of America. Dec, 2015 | Pubmed ID: 26504232 EAST Organizes Drosophila Insulator Proteins in the Interchromosomal Nuclear Compartment and Modulates CP190 Binding to Chromatin PloS One. 2015 | Pubmed ID: 26489095 Functional Role of Dimerization and CP190 Interacting Domains of CTCF Protein in Drosophila Melanogaster BMC Biology. Aug, 2015 | Pubmed ID: 26248466 The Boundary Paradox in the Bithorax Complex Mechanisms of Development. Nov, 2015 | Pubmed ID: 26215349 Eukaryotic Enhancers: Common Features, Regulation, and Participation in Diseases Cellular and Molecular Life Sciences : CMLS. Jun, 2015 | Pubmed ID: 25715743 Two New Insulator Proteins, Pita and ZIPIC, Target CP190 to Chromatin Genome Research. Jan, 2015 | Pubmed ID: 25342723 Highly Conserved ENY2/Sus1 Protein Binds to Drosophila CTCF and is Required for Barrier Activity Epigenetics. Sep, 2014 | Pubmed ID: 25147918 Mechanisms and Proteins Involved in Long-distance Interactions Frontiers in Genetics. 2014 | Pubmed ID: 24600469 Making Connections: Insulators Organize Eukaryotic Chromosomes into Independent Cis-regulatory Networks BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2014 | Pubmed ID: 24277632 Chromatin Insulators and Long-distance Interactions in Drosophila FEBS Letters. Jan, 2014 | Pubmed ID: 24211836 Transcription Through Enhancers Suppresses Their Activity in Drosophila Epigenetics & Chromatin. Sep, 2013 | Pubmed ID: 24279291 Effective Blocking of the White Enhancer Requires Cooperation Between Two Main Mechanisms Suggested for the Insulator Function PLoS Genetics. 2013 | Pubmed ID: 23861668 New Properties of Drosophila Scs and Scs' Insulators PloS One. 2013 | Pubmed ID: 23638134 Insulator Protein Su(Hw) Recruits SAGA and Brahma Complexes and Constitutes Part of Origin Recognition Complex-binding Sites in the Drosophila Genome Nucleic Acids Research. Jun, 2013 | Pubmed ID: 23609538 SUMO Conjugation is Required for the Assembly of Drosophila Su(Hw) and Mod(mdg4) into Insulator Bodies That Facilitate Insulator Complex Formation Journal of Cell Science. Apr, 2012 | Pubmed ID: 22375064 Insulators Form Gene Loops by Interacting with Promoters in Drosophila Development (Cambridge, England). Sep, 2011 | Pubmed ID: 21862564 Drosophila BTB/POZ Domains of "ttk Group" Can Form Multimers and Selectively Interact with Each Other Journal of Molecular Biology. Sep, 2011 | Pubmed ID: 21821048 Selective Interactions of Boundaries with Upstream Region of Abd-B Promoter in Drosophila Bithorax Complex and Role of DCTCF in This Process Nucleic Acids Research. Apr, 2011 | Pubmed ID: 21149269 Insulators, Not Polycomb Response Elements, Are Required for Long-range Interactions Between Polycomb Targets in Drosophila Melanogaster Molecular and Cellular Biology. Feb, 2011 | Pubmed ID: 21135119 Interaction Between a Pair of Gypsy Insulators or Between Heterologous Gypsy and Wari Insulators Modulates Flp Site-specific Recombination in Drosophila Melanogaster Chromosoma. Aug, 2010 | Pubmed ID: 20354861 E(y)2/Sus1 is Required for Blocking PRE Silencing by the Wari Insulator in Drosophila Melanogaster Chromosoma. Jun, 2010 | Pubmed ID: 20082086 Drosophila Mini-white Model System: New Insights into Positive Position Effects and the Role of Transcriptional Terminators and Gypsy Insulator in Transgene Shielding Nucleic Acids Research. Jan, 2010 | Pubmed ID: 19854952 Zeste Can Facilitate Long-range Enhancer-promoter Communication and Insulator Bypass in Drosophila Melanogaster Chromosoma. Oct, 2009 | Pubmed ID: 19578867 Orientation-dependent Interaction Between Drosophila Insulators is a Property of This Class of Regulatory Elements Nucleic Acids Research. Dec, 2008 | Pubmed ID: 18987002 Enhancer-promoter Communication is Regulated by Insulator Pairing in a Drosophila Model Bigenic Locus Molecular and Cellular Biology. Sep, 2008 | Pubmed ID: 18573869 Functional Interaction Between the Fab-7 and Fab-8 Boundaries and the Upstream Promoter Region in the Drosophila Abd-B Gene Molecular and Cellular Biology. Jun, 2008 | Pubmed ID: 18426914 'Insulator Bodies' Are Aggregates of Proteins but Not of Insulators EMBO Reports. May, 2008 | Pubmed ID: 18369369 Red Flag on the White Reporter: a Versatile Insulator Abuts the White Gene in Drosophila and is Omnipresent in Mini-white Constructs Nucleic Acids Research. Feb, 2008 | Pubmed ID: 18086699 Drosophila Gypsy Insulator and Yellow Enhancers Regulate Activity of Yellow Promoter Through the Same Regulatory Element Chromosoma. Apr, 2008 | Pubmed ID: 17994318 Long-distance Interactions Between Regulatory Elements Are Suppressed at the End of a Terminally Deficient Chromosome in Drosophila Melanogaster Chromosoma. Feb, 2008 | Pubmed ID: 17876596 New Properties of Drosophila Fab-7 Insulator Genetics. Sep, 2007 | Pubmed ID: 17890362 Characterization of Drosophila Telomeric Retroelement TAHRE: Transcription, Transpositions, and RNAi-based Regulation of Expression Molecular Biology and Evolution. Nov, 2007 | Pubmed ID: 17890237 Evolutionarily Conserved E(y)2/Sus1 Protein is Essential for the Barrier Activity of Su(Hw)-dependent Insulators in Drosophila Molecular Cell. Jul, 2007 | Pubmed ID: 17643381 Study of the Functional Interaction Between Mcp Insulators from the Drosophila Bithorax Complex: Effects of Insulator Pairing on Enhancer-promoter Communication Molecular and Cellular Biology. Apr, 2007 | Pubmed ID: 17283051 Integrity of the Mod(mdg4)-67.2 BTB Domain is Critical to Insulator Function in Drosophila Melanogaster Molecular and Cellular Biology. Feb, 2007 | Pubmed ID: 17101769 Two Isoforms of Drosophila TRF2 Are Involved in Embryonic Development, Premeiotic Chromatin Condensation, and Proper Differentiation of Germ Cells of Both Sexes Molecular and Cellular Biology. Oct, 2006 | Pubmed ID: 17015475 Telomere Elongation is Under the Control of the RNAi-based Mechanism in the Drosophila Germline Genes & Development. Feb, 2006 | Pubmed ID: 16452506 Study of Long-distance Functional Interactions Between Su(Hw) Insulators That Can Regulate Enhancer-promoter Communication in Drosophila Melanogaster Molecular and Cellular Biology. Feb, 2006 | Pubmed ID: 16428433 Transposition of Regulatory Elements by P-Element-Mediated Rearrangements in Drosophila Melanogaster Genetics. Apr, 2006 | Pubmed ID: 16387869 Handling Three Regulatory Elements in One Transgene: Combined Use of Cre-lox, FLP-FRT, and I-Scel Recombination Systems BioTechniques. Dec, 2005 | Pubmed ID: 16382906 Pairing Between Gypsy Insulators Facilitates the Enhancer Action in Trans Throughout the Drosophila Genome Molecular and Cellular Biology. Nov, 2005 | Pubmed ID: 16227580 Drosophila Telomeres: the Non-telomerase Alternative Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2005 | Pubmed ID: 16132809 The Mcp Element from the Bithorax Complex Contains an Insulator That is Capable of Pairwise Interactions and Can Facilitate Enhancer-promoter Communication Molecular and Cellular Biology. May, 2005 | Pubmed ID: 15831473 The Ku Protein Complex is Involved in Length Regulation of Drosophila Telomeres Genetics. May, 2005 | Pubmed ID: 15781709 A Novel Multidomain Transcription Coactivator SAYP Can Also Repress Transcription in Heterochromatin The EMBO Journal. Jan, 2005 | Pubmed ID: 15616585 Drosophila Su(Hw) Insulator Can Stimulate Transcription of a Weakened Yellow Promoter over a Distance Genetics. Jul, 2005 | Pubmed ID: 15520254 Interaction Between the GAGA Factor and Mod(mdg4) Proteins Promotes Insulator Bypass in Drosophila Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004 | Pubmed ID: 15465920 The Mod(mdg4) Component of the Su(Hw) Insulator Inserted in the P Transposon Can Repress Its Mobility in Drosophila Melanogaster Genetics. Jul, 2004 | Pubmed ID: 15280241 An Endogenous Su(Hw) Insulator Separates the Yellow Gene from the Achaete-scute Gene Complex in Drosophila Development (Cambridge, England). Jul, 2003 | Pubmed ID: 12783795 Transvection at the End of the Truncated Chromosome in Drosophila Melanogaster Genetics. Apr, 2003 | Pubmed ID: 12702682 Enhancer of Terminal Gene Conversion, a New Mutation in Drosophila Melanogaster That Induces Telomere Elongation by Gene Conversion Genetics. Nov, 2002 | Pubmed ID: 12454074 P Element-mediated Duplications of Genomic Regions in Drosophila Melanogaster Chromosoma. Jul, 2002 | Pubmed ID: 12111335 The Gypsy Insulators Flanking Yellow Enhancers Do Not Form a Separate Transcriptional Domain in Drosophila Melanogaster: the Enhancers Can Activate an Isolated Yellow Promoter Genetics. Apr, 2002 | Pubmed ID: 11973309 Heterochromatin Protein 1 is Involved in Control of Telomere Elongation in Drosophila Melanogaster Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940677 The Novel Transcription Factor E(y)2 Interacts with TAF(II)40 and Potentiates Transcription Activation on Chromatin Templates Molecular and Cellular Biology. Aug, 2001 | Pubmed ID: 11438676 Attachment of HeT-A Sequences to Chromosomal Termini in Drosophila Melanogaster May Occur by Different Mechanisms Molecular and Cellular Biology. Oct, 2000 | Pubmed ID: 11003659 TAFII40 Protein is Encoded by the E(y)1 Gene: Biological Consequences of Mutations Molecular and Cellular Biology. May, 1999 | Pubmed ID: 10207100 The Su(Hw) Insulator Can Disrupt Enhancer-promoter Interactions when Located More Than 20 Kilobases Away from the Drosophila Achaete-scute Complex Molecular and Cellular Biology. May, 1999 | Pubmed ID: 10207068 चुनौतीपूर्ण प्रोटीन-प्रोटीन इंटरैक्शन के परीक्षण के लिए एक समय-कुशल उपकरण के रूप में बैक्टीरिया कोशिकाओं में सह-अभिव्यक्ति के साथ युग्मित पुलडाउन परख Artem Bonchuk1,2, Nikolay Zolotarev1, Konstantin Balagurov1,2, Olga Arkova2, Pavel Georgiev1 1Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 2Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences JoVE 64541 생화학
चुनौतीपूर्ण प्रोटीन-प्रोटीन इंटरैक्शन के परीक्षण के लिए एक समय-कुशल उपकरण के रूप में बैक्टीरिया कोशिकाओं में सह-अभिव्यक्ति के साथ युग्मित पुलडाउन परख Artem Bonchuk1,2, Nikolay Zolotarev1, Konstantin Balagurov1,2, Olga Arkova2, Pavel Georgiev1 1Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 2Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences JoVE 64541 생화학