Robert M. Graham

Publications

• Standardised Method for Cardiomyocyte Isolation and Purification from Individual Murine Neonatal, Infant, and Adult Hearts
  Journal of Molecular and Cellular Cardiology. May, 2022  |   Pubmed ID: 35644482
• Adverse Events After Spontaneous Coronary Artery Dissection
  Heart (British Cardiac Society). May, 2022  |   Pubmed ID: 35641180
• Cardiovascular Magnetic Resonance for Rejection Surveillance After Cardiac Transplantation
  Circulation. May, 2022  |   Pubmed ID: 35621277
• Remuscularization with Triiodothyronine and β-blocker Therapy Reverses Post-ischemic Left Ventricular Dysfunction and Adverse Remodeling
  Scientific Reports. May, 2022  |   Pubmed ID: 35614155
• Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing
  Circulation. Genomic and Precision Medicine. May, 2022  |   Pubmed ID: 35583931
• Accuracy of Vascular Tortuosity Measures Using Computational Modelling
  Scientific Reports. 01, 2022  |   Pubmed ID: 35039557
• Vascular Stiffness in Aging and Disease
  Frontiers in Physiology. 2021  |   Pubmed ID: 34950048
• Mechanism-Based Cardiac Regeneration Strategies in Mammals
  Frontiers in Cell and Developmental Biology. 2021  |   Pubmed ID: 34708043
• Involvement of GPR37L1 in Murine Blood Pressure Regulation and Human Cardiac Disease Pathophysiology
  American Journal of Physiology. Heart and Circulatory Physiology. 10, 2021  |   Pubmed ID: 34533400
• The Ca-activated Cation Channel TRPM4 is a Positive Regulator of Pressure Overload-induced Cardiac Hypertrophy
  ELife. 06, 2021  |   Pubmed ID: 34190686
• Everolimus for the Prevention of Calcineurin-Inhibitor-Induced Left Ventricular Hypertrophy After Heart Transplantation (RADTAC Study)
  JACC. Heart Failure. 04, 2021  |   Pubmed ID: 33795116
• Thyroid Hormone Plus Dual-specificity Phosphatase-5 SiRNA Increases the Number of Cardiac Muscle Cells and Improves Left Ventricular Contractile Function in Chronic Doxorubicin-injured Hearts
  Theranostics. 2021  |   Pubmed ID: 33754028
• Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload
  Frontiers in Cell and Developmental Biology. 2021  |   Pubmed ID: 33659256
• Retraction Note: Orphan Receptor Ligand Discovery by Pickpocketing Pharmacological Neighbors
  Nature Chemical Biology. Apr, 2021  |   Pubmed ID: 33649604
• Adaptation to Exercise-induced Stress is Not Dependent on Cardiomyocyte α-adrenergic Receptors
  Journal of Molecular and Cellular Cardiology. 06, 2021  |   Pubmed ID: 33647309
• Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women
  Heart, Lung & Circulation. Jan, 2021  |   Pubmed ID: 32713767
• Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner
  Frontiers in Pharmacology. 2020  |   Pubmed ID: 33633567
• DUSP5 Expression in Left Ventricular Cardiomyocytes of Young Hearts Regulates Thyroid Hormone (T3)-induced Proliferative ERK1/2 Signaling
  Scientific Reports. 12, 2020  |   Pubmed ID: 33318551
• The N-terminus of GPR37L1 is Proteolytically Processed by Matrix Metalloproteases
  Scientific Reports. 11, 2020  |   Pubmed ID: 33203955
• Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation From Genome Sequencing
  Circulation. Genomic and Precision Medicine. 12, 2020  |   Pubmed ID: 33125268
• Pressure Overload by Suprarenal Aortic Constriction in Mice Leads to Left Ventricular Hypertrophy Without C-Kit Expression in Cardiomyocytes
  Scientific Reports. 09, 2020  |   Pubmed ID: 32948799
• Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation
  Frontiers in Immunology. 2020  |   Pubmed ID: 32793209
• Platelet-derived Growth Factor-AB Improves Scar Mechanics and Vascularity After Myocardial Infarction
  Science Translational Medicine. 01, 2020  |   Pubmed ID: 31894101
• Redox Activation of JNK2α2 Mediates Thyroid Hormone-stimulated Proliferation of Neonatal Murine Cardiomyocytes
  Scientific Reports. 11, 2019  |   Pubmed ID: 31776360
• Generation of VCCRIi001-A, a Human Induced Pluripotent Stem Cell Line, from a Patient with Spontaneous Coronary Artery Dissection
  Stem Cell Research. 12, 2019  |   Pubmed ID: 31707208
• A Vascular Smooth Muscle Cell X-box Binding Protein 1 and Transglutaminase 2 Regulatory Circuit Limits Neointimal Hyperplasia
  PloS One. 2019  |   Pubmed ID: 30943188
• The Australian Cardiovascular Alliance-Towards an Integrated Whole-of-Nation Strategy to Address Our Major Health Burden
  Heart, Lung & Circulation. Feb, 2019  |   Pubmed ID: 30654944
• Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection
  Journal of the American College of Cardiology. 01, 2019  |   Pubmed ID: 30621952
• Identification of Clinically Actionable Variants from Genome Sequencing of Families with Congenital Heart Disease
  Genetics in Medicine : Official Journal of the American College of Medical Genetics. 05, 2019  |   Pubmed ID: 30293987
• Cardiac Hypertrophy Limits Infarct Expansion After Myocardial Infarction in Mice
  Scientific Reports. 04, 2018  |   Pubmed ID: 29666426
• Orphan Receptor GPR37L1 Contributes to the Sexual Dimorphism of Central Cardiovascular Control
  Biology of Sex Differences. 04, 2018  |   Pubmed ID: 29625592
• A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data
  Circulation. Genomic and Precision Medicine. 03, 2018  |   Pubmed ID: 29555671
• The Mystery and Enigma of Spontaneous Coronary Artery Dissection
  Heart, Lung & Circulation. Apr, 2018  |   Pubmed ID: 29501270
• Orphan Receptor Ligand Discovery by Pickpocketing Pharmacological Neighbors
  Nature Chemical Biology. 02, 2017  |   Pubmed ID: 27992882
• Pathophysiological Trends During Withdrawal of Life Support: Implications for Organ Donation After Circulatory Death
  Transplantation. Dec, 2016  |   Pubmed ID: 27861290
• Angiotensin Type 2-receptor (AT2R) Activation Induces Hypotension in Apolipoprotein E-deficient Mice by Activating Peroxisome Proliferator-activated Receptor-γ
  American Journal of Cardiovascular Disease. 2016  |   Pubmed ID: 27679746
• Outcomes of Patients with Spontaneous Coronary Artery Dissection
  Open Heart. 2016  |   Pubmed ID: 27621835
• Gestational Stress Induces the Unfolded Protein Response, Resulting in Heart Defects
  Development (Cambridge, England). 07, 2016  |   Pubmed ID: 27436040
• IGF-1 Degradation by Mouse Mast Cell Protease 4 Promotes Cell Death and Adverse Cardiac Remodeling Days After a Myocardial Infarction
  Proceedings of the National Academy of Sciences of the United States of America. 06, 2016  |   Pubmed ID: 27274047
• Metalloprotease Cleavage of the N Terminus of the Orphan G Protein-coupled Receptor GPR37L1 Reduces Its Constitutive Activity
  Science Signaling. Apr, 2016  |   Pubmed ID: 27072655
• Targeted Doxorubicin Delivery to Brain Tumors Via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors As a Model
  PloS One. 2016  |   Pubmed ID: 27050167
• Ablation of Cardiac Myosin Binding Protein-C Disrupts the Super-relaxed State of Myosin in Murine Cardiomyocytes
  Journal of Molecular and Cellular Cardiology. 05, 2016  |   Pubmed ID: 27021517
• Identifying Ligands at Orphan GPCRs: Current Status Using Structure-based Approaches
  British Journal of Pharmacology. 10, 2016  |   Pubmed ID: 26837045
• Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer
  Scientific Reports. Jan, 2016  |   Pubmed ID: 26785754
• Cardiac Regeneration Therapies - Targeting Neuregulin 1 Signalling
  Heart, Lung & Circulation. Jan, 2016  |   Pubmed ID: 26476583
• Cardiomyocytes Replicate and Their Numbers Increase in Young Hearts
  Cell. Nov, 2015  |   Pubmed ID: 26544928
• Overexpression of Cardiomyocyte α1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2015  |   Pubmed ID: 26338300
• Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study
  Frontiers in Endocrinology. 2015  |   Pubmed ID: 26175717
• Irreversible Triggers for Hypertrophic cardiomyopathy Are Established in the Early Postnatal Period
  Journal of the American College of Cardiology. Feb, 2015  |   Pubmed ID: 25677315
• Introduction to the Special Issue on Heart Regeneration and Rejuvenation
  Stem Cell Research. Nov, 2014  |   Pubmed ID: 25459518
• Thyroid Hormone Action in Postnatal Heart Development
  Stem Cell Research. Nov, 2014  |   Pubmed ID: 25087894
• RhoA/ROCK Signaling and Pleiotropic α1A-adrenergic Receptor Regulation of Cardiac Contractility
  PloS One. 2014  |   Pubmed ID: 24919197
• A Proliferative Burst During Preadolescence Establishes the Final Cardiomyocyte Number
  Cell. May, 2014  |   Pubmed ID: 24813607
• Glucose Homeostasis in Mice is Transglutaminase 2 Independent
  PloS One. 2013  |   Pubmed ID: 23717413
• Functional Characterization of a Novel Mutation in NKX2-5 Associated with Congenital Heart Disease and Adult-Onset Cardiomyopathy
  Circulation. Cardiovascular Genetics. May, 2013  |   Pubmed ID: 23661673
• Granulocyte Colony Stimulating Factor in Chronic Angina to Stimulate Neovascularisation: a Placebo Controlled Crossover Trial
  Heart (British Cardiac Society). Feb, 2012  |   Pubmed ID: 22115984
• The Ontogeny of Cardiac Regeneration
  Circulation Research. May, 2011  |   Pubmed ID: 21617133
• Regulation of Murine Cardiac Contractility by Activation of α(1A)-adrenergic Receptor-operated Ca(2+) Entry
  Cardiovascular Research. Jul, 2011  |   Pubmed ID: 21546445
• A Recombinant Human Neuregulin-1 Peptide Improves Preservation of the Rodent Heart After Prolonged Hypothermic Storage
  Transplantation. May, 2011  |   Pubmed ID: 21364498
• The Elusive π-helix
  Journal of Structural Biology. Jan, 2011  |   Pubmed ID: 20828621
• Reproducibility of Adenosine Stress Cardiovascular Magnetic Resonance in Multi-vessel Symptomatic Coronary Artery Disease
  Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance. Jul, 2010  |   Pubmed ID: 20663155
• Transglutaminases and Disease: Lessons from Genetically Engineered Mouse Models and Inherited Disorders
  Physiological Reviews. Jul, 2009  |   Pubmed ID: 19584319
• Safety and Efficacy of Consecutive Cycles of Granulocyte-colony Stimulating Factor, and an Intracoronary CD133+ Cell Infusion in Patients with Chronic Refractory Ischemic Heart Disease: the G-CSF in Angina Patients with IHD to Stimulate Neovascularization (GAIN I) Trial
  American Heart Journal. Nov, 2008  |   Pubmed ID: 19061712
• Wide Turn Diversity in Protein Transmembrane Helices Implications for G-protein-coupled Receptor and Other Polytopic Membrane Protein Structure and Function
  Molecular Pharmacology. Apr, 2008  |   Pubmed ID: 18202304
• Actions and Therapeutic Potential of G-CSF and GM-CSF in Cardiovascular Disease
  Journal of Molecular and Cellular Cardiology. Jan, 2007  |   Pubmed ID: 17109881
• Profound Thrombocytopenia Related to G-CSF
  American Journal of Hematology. Mar, 2007  |   Pubmed ID: 17034024
• Mechanism of Allosteric Regulation of Transglutaminase 2 by GTP
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006  |   Pubmed ID: 17179049
• Cross-linking Transglutaminases with G Protein-coupled Receptor Signaling
  Science's STKE : Signal Transduction Knowledge Environment. Sep, 2006  |   Pubmed ID: 16985237
• Mutation of a Critical Arginine in the GTP-binding Site of Transglutaminase 2 Disinhibits Intracellular Cross-linking Activity
  The Journal of Biological Chemistry. May, 2006  |   Pubmed ID: 16522628
• The Alpha(1D)-adrenergic Receptor: Cinderella or Ugly Stepsister
  Molecular Pharmacology. Jan, 2006  |   Pubmed ID: 16246907
• Molecular Basis of Exopeptidase Activity in the C-terminal Domain of Human Angiotensin I-converting Enzyme: Insights into the Origins of Its Exopeptidase Activity
  The Journal of Biological Chemistry. Feb, 2005  |   Pubmed ID: 15615692
• Involvement of Chymase-mediated Angiotensin II Generation in Blood Pressure Regulation
  The Journal of Clinical Investigation. Jul, 2004  |   Pubmed ID: 15232618
• Evolutionary Specialization of a Tryptophan Indole Group for Transition-state Stabilization by Eukaryotic Transglutaminases
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2003  |   Pubmed ID: 14566064
• Molecular Mechanisms of Inherited Cardiomyopathies
  Physiological Reviews. Oct, 2002  |   Pubmed ID: 12270949
• Mutation of a Single TMVI Residue, Phe(282), in the Beta(2)-adrenergic Receptor Results in Structurally Distinct Activated Receptor Conformations
  Biochemistry. May, 2002  |   Pubmed ID: 11993999
• Phe(303) in TMVI of the Alpha(1B)-adrenergic Receptor is a Key Residue Coupling TM Helical Movements to G-protein Activation
  Biochemistry. Jan, 2002  |   Pubmed ID: 11781098