Ronald A. Li Cardiovascular Research Center Icahn School of Medicine at Mount Sinai Biography Publications Institution JoVE Articles Ronald A. Li has not added a biography. If you are Ronald A. Li and would like to personalize this page please email our Author Liaison for assistance. Publications Fusion with Stem Cell Makes the Hepatocellular Carcinoma Cells Similar to Liver Tumor-initiating Cells BMC Cancer. Month, 2015 | Pubmed ID: 26846780 Morphometric Analysis of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes: Determining the Maturation State of a Population by Quantifying Parameters in Individual Cells Stem Cells International. Month, 2015 | Pubmed ID: 26351464 Uniaxial Cyclic Stretch Stimulates TRPV4 to Induce Realignment of Human Embryonic Stem Cell-derived Cardiomyocytes Journal of Molecular and Cellular Cardiology. Oct, 2015 | Pubmed ID: 26259779 Consensus Comparative Analysis of Human Embryonic Stem Cell-derived Cardiomyocytes PloS One. Month, 2015 | Pubmed ID: 25938587 Correction of Human Phospholamban R14del Mutation Associated with Cardiomyopathy Using Targeted Nucleases and Combination Therapy Nature Communications. Month, 2015 | Pubmed ID: 25923014 Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation Circulation. Cardiovascular Genetics. Jun, 2015 | Pubmed ID: 25759434 Phospholamban As a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-derived Ventricular Cardiomyocytes and Engineered 3-dimensional Tissue Constructs Circulation. Arrhythmia and Electrophysiology. Feb, 2015 | Pubmed ID: 25504561 Engineering a Freestanding Biomimetic Cardiac Patch Using Biodegradable Poly(lactic-co-glycolic Acid) (PLGA) and Human Embryonic Stem Cell-derived Ventricular Cardiomyocytes (hESC-VCMs) Macromolecular Bioscience. Mar, 2015 | Pubmed ID: 25420623 Cardiovascular Regeneration Stem Cell Research & Therapy. Month, 2014 | Pubmed ID: 25689157 N-cadherin Prevents the Premature Differentiation of Anterior Heart Field Progenitors in the Pharyngeal Mesodermal Microenvironment Cell Research. Dec, 2014 | Pubmed ID: 25367124 Nitric Oxide and Protein Kinase G Act on TRPC1 to Inhibit 11,12-EET-induced Vascular Relaxation Cardiovascular Research. Oct, 2014 | Pubmed ID: 25139746 A Simple, Cost-effective but Highly Efficient System for Deriving Ventricular Cardiomyocytes from Human Pluripotent Stem Cells Stem Cells and Development. Jul, 2014 | Pubmed ID: 24564569 Developmental Cues for the Maturation of Metabolic, Electrophysiological and Calcium Handling Properties of Human Pluripotent Stem Cell-derived Cardiomyocytes Stem Cell Research & Therapy. Month, 2014 | Pubmed ID: 24467782 Small Molecule-mediated Directed Differentiation of Human Embryonic Stem Cells Toward Ventricular Cardiomyocytes Stem Cells Translational Medicine. Jan, 2014 | Pubmed ID: 24324277 Advancing Functional Engineered Cardiac Tissues Toward a Preclinical Model of Human Myocardium FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2014 | Pubmed ID: 24174427 Mechanistic Basis of Excitation-contraction Coupling in Human Pluripotent Stem Cell-derived Ventricular Cardiomyocytes Revealed by Ca2+ Spark Characteristics: Direct Evidence of Functional Ca2+-induced Ca2+ Release Heart Rhythm : the Official Journal of the Heart Rhythm Society. Jan, 2014 | Pubmed ID: 24096168 Transcriptome-guided Functional Analyses Reveal Novel Biological Properties and Regulatory Hierarchy of Human Embryonic Stem Cell-derived Ventricular Cardiomyocytes Crucial for Maturation PloS One. Month, 2013 | Pubmed ID: 24204964 Calcium Signalling of Human Pluripotent Stem Cell-derived Cardiomyocytes The Journal of Physiology. Nov, 2013 | Pubmed ID: 24018947 Driving Vascular Endothelial Cell Fate of Human Multipotent Isl1+ Heart Progenitors with VEGF Modified MRNA Cell Research. Oct, 2013 | Pubmed ID: 24018375 Modified MRNA Directs the Fate of Heart Progenitor Cells and Induces Vascular Regeneration After Myocardial Infarction Nature Biotechnology. Oct, 2013 | Pubmed ID: 24013197 Human Pluripotent Stem Cell-derived Cardiomyocytes for Heart Regeneration, Drug Discovery and Disease Modeling: from the Genetic, Epigenetic, and Tissue Modeling Perspectives Stem Cell Research & Therapy. Month, 2013 | Pubmed ID: 23953772 Effect of Engineered Anisotropy on the Susceptibility of Human Pluripotent Stem Cell-derived Ventricular Cardiomyocytes to Arrhythmias Biomaterials. Nov, 2013 | Pubmed ID: 23942210 Generation and Characterization of Spiking and Nonspiking Oligodendroglial Progenitor Cells from Embryonic Stem Cells Stem Cells (Dayton, Ohio). Dec, 2013 | Pubmed ID: 23940003 Epigenetic Regulation of the Electrophysiological Phenotype of Human Embryonic Stem Cell-derived Ventricular Cardiomyocytes: Insights for Driven Maturation and Hypertrophic Growth Stem Cells and Development. Oct, 2013 | Pubmed ID: 23656529 Functional Role of TRPV4-KCa2.3 Signaling in Vascular Endothelial Cells in Normal and Streptozotocin-induced Diabetic Rats Hypertension. Jul, 2013 | Pubmed ID: 23648706 Mechanism-based Facilitated Maturation of Human Pluripotent Stem Cell-derived Cardiomyocytes Circulation. Arrhythmia and Electrophysiology. Feb, 2013 | Pubmed ID: 23392582 Overexpression of Kir2.1 Channel in Embryonic Stem Cell-derived Cardiomyocytes Attenuates Posttransplantation Proarrhythmic Risk in Myocardial Infarction Heart Rhythm : the Official Journal of the Heart Rhythm Society. Feb, 2013 | Pubmed ID: 23041574 The B-MYB Transcriptional Network Guides Cell Cycle Progression and Fate Decisions to Sustain Self-renewal and the Identity of Pluripotent Stem Cells PloS One. Month, 2012 | Pubmed ID: 22936984 Role of TRPM2 in H(2)O(2)-induced Cell Apoptosis in Endothelial Cells PloS One. Month, 2012 | Pubmed ID: 22916222 Pluripotent Stem Cell-based Heart Regeneration: from the Developmental and Immunological Perspectives Birth Defects Research. Part C, Embryo Today : Reviews. Mar, 2012 | Pubmed ID: 22457181 Probing the Mechanobiological Properties of Human Embryonic Stem Cells in Cardiac Differentiation by Optical Tweezers Journal of Biomechanics. Jan, 2012 | Pubmed ID: 22104169 Label-free Identification and Characterization of Human Pluripotent Stem Cell-derived Cardiomyocytes Using Second Harmonic Generation (SHG) Microscopy Journal of Biophotonics. Jan, 2012 | Pubmed ID: 22083829 MicroRNA Profiling Predicts a Variance in the Proliferative Potential of Cardiac Progenitor Cells Derived from Neonatal and Adult Murine Hearts Journal of Molecular and Cellular Cardiology. Jan, 2012 | Pubmed ID: 22062954 Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-derived Cardiomyocytes PloS One. Month, 2011 | Pubmed ID: 22110643 Shrink-film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and Their Cardiac Derivatives Advanced Materials (Deerfield Beach, Fla.). Dec, 2011 | Pubmed ID: 22065428 Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells Under Atmospheric Oxygen Level Cellular Reprogramming. Dec, 2011 | Pubmed ID: 22029419 Enhanced Cell Sorting and Manipulation with Combined Optical Tweezer and Microfluidic Chip Technologies Lab on a Chip. Nov, 2011 | Pubmed ID: 21918752 Human Pluripotent Stem Cell-based Approaches for Myocardial Repair: from the Electrophysiological Perspective Molecular Pharmaceutics. Oct, 2011 | Pubmed ID: 21879736 Electrically Guiding Migration of Human Induced Pluripotent Stem Cells Stem Cell Reviews. Nov, 2011 | Pubmed ID: 21373881 Multiscale Biomimetic Topography for the Alignment of Neonatal and Embryonic Stem Cell-derived Heart Cells Tissue Engineering. Part C, Methods. May, 2011 | Pubmed ID: 21235325 Manipulations of MicroRNA in Human Pluripotent Stem Cells and Their Derivatives Methods in Molecular Biology (Clifton, N.J.). Month, 2011 | Pubmed ID: 21042988 Proarrhythmic Risk of Embryonic Stem Cell-derived Cardiomyocyte Transplantation in Infarcted Myocardium Heart Rhythm : the Official Journal of the Heart Rhythm Society. Dec, 2010 | Pubmed ID: 20833268 Dynamic MicroRNA Expression Programs During Cardiac Differentiation of Human Embryonic Stem Cells: Role for MiR-499 Circulation. Cardiovascular Genetics. Oct, 2010 | Pubmed ID: 20733065 Attenuation of Left Ventricular Adverse Remodeling with Epicardial Patching After Myocardial Infarction Journal of Cardiac Failure. Jul, 2010 | Pubmed ID: 20610235 Translational Potential of Human Embryonic and Induced Pluripotent Stem Cells for Myocardial Repair: Insights from Experimental Models Thrombosis and Haemostasis. Jul, 2010 | Pubmed ID: 20539906 Automaticity and Conduction Properties of Bio-artificial Pacemakers Assessed in an in Vitro Monolayer Model of Neonatal Rat Ventricular Myocytes Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Aug, 2010 | Pubmed ID: 20472688 Exogenous Expression of HIF-1 Alpha Promotes Cardiac Differentiation of Embryonic Stem Cells Journal of Molecular and Cellular Cardiology. Jun, 2010 | Pubmed ID: 20116384 Electrophysiological Properties of Human Induced Pluripotent Stem Cells American Journal of Physiology. Cell Physiology. Mar, 2010 | Pubmed ID: 19955484 Probing the Bradycardic Drug Binding Receptor of HCN-encoded Pacemaker Channels Pflugers Archiv : European Journal of Physiology. Nov, 2009 | Pubmed ID: 19756722 Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy Timothy J. Cashman1, Rebecca Josowitz2, Bruce D. Gelb2, Ronald A. Li1,3, Nicole C. Dubois2, Kevin D. Costa1 1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, 3Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong JoVE 53447 생체공학
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy Timothy J. Cashman1, Rebecca Josowitz2, Bruce D. Gelb2, Ronald A. Li1,3, Nicole C. Dubois2, Kevin D. Costa1 1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, 3Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong JoVE 53447 생체공학