Rui Jorge Nobre CNC-UC - Center for Neuroscience and Cell Biology University of Coimbra Biography Publications Institution JoVE Articles Rui Jorge Nobre has not added a biography. If you are Rui Jorge Nobre and would like to personalize this page please email our Author Liaison for assistance. Publications Viral-based Animal Models in Polyglutamine Disorders Brain : a Journal of Neurology. Apr, 2024 | Pubmed ID: 38284949 RNA-based Liposomes for Oral Cancer: From Biophysical Characterization to Biological Evaluation International Journal of Biological Macromolecules. Feb, 2024 | Pubmed ID: 38199539 Extracellular Vesicle-based Delivery of Silencing Sequences for the Treatment of Machado-Joseph Disease/spinocerebellar Ataxia Type 3 Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2023 | Pubmed ID: 37025062 Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography Versus Ultracentrifugation Biomolecules. Feb, 2023 | Pubmed ID: 36830647 A New Protocol for Whole-brain Biodistribution Analysis of AAVs by Tissue Clearing, Light-sheet Microscopy and Semi-automated Spatial Quantification Gene Therapy. Dec, 2022 | Pubmed ID: 36316447 Cerebellar Morphometric and Spectroscopic Biomarkers for Machado-Joseph Disease Acta Neuropathologica Communications. Mar, 2022 | Pubmed ID: 35305685 MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3 Nucleic Acid Therapeutics. Jun, 2022 | Pubmed ID: 34878314 Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening Pharmaceutics. Oct, 2021 | Pubmed ID: 34683891 Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research Molecular Therapy. Methods & Clinical Development. Sep, 2020 | Pubmed ID: 32913880 The Blood-brain Barrier is Disrupted in Machado-Joseph Disease/spinocerebellar Ataxia Type 3: Evidence from Transgenic Mice and Human Post-mortem Samples Acta Neuropathologica Communications. Aug, 2020 | Pubmed ID: 32867861 Trehalose Alleviates the Phenotype of Machado-Joseph Disease Mouse Models Journal of Translational Medicine. Apr, 2020 | Pubmed ID: 32272938 Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies The Journal of Molecular Diagnostics : JMD. Jun, 2020 | Pubmed ID: 32205289 Antisense Oligonucleotide Therapeutics in Neurodegenerative Diseases: the Case of Polyglutamine Disorders Brain : a Journal of Neurology. Feb, 2020 | Pubmed ID: 31738395 Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2018 | Pubmed ID: 30087083 Gene Therapies for Polyglutamine Diseases Advances in Experimental Medicine and Biology. 2018 | Pubmed ID: 29427115 Extracellular Vesicles: Novel Promising Delivery Systems for Therapy of Brain Diseases Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2017 | Pubmed ID: 28687495 Hypoxia Mimetic Induces Lipid Accumulation Through Mitochondrial Dysfunction and Stimulates Autophagy in Murine Preadipocyte Cell Line Biochimica Et Biophysica Acta. General Subjects. Mar, 2017 | Pubmed ID: 27939617 Gene Therapy for the CNS Using AAVs: The Impact of Systemic Delivery by AAV9 Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2016 | Pubmed ID: 27637390 Calpain Inhibition Reduces Ataxin-3 Cleavage Alleviating Neuropathology and Motor Impairments in Mouse Models of Machado-Joseph Disease Human Molecular Genetics. Sep, 2014 | Pubmed ID: 24817574 Gene Therapy for Parkinson's and Alzheimer's Diseases: from the Bench to Clinical Trials Current Pharmaceutical Design. 2011 | Pubmed ID: 21902665 Author Spotlight: Improved Method for Production and Purification of Adeno-Associated Viral Vectors Miguel M. Lopes*1,2,3, Sara M. Lopes*1,2,3, Rafael Baganha1,2,4, Carina Henriques1,2,5, Ana C. Silva1,2,3, Diana D. Lobo1,2,3, Luísa Cortes1,2,3,6, Luís Pereira de Almeida*1,2,4,5, Rui Jorge Nobre*1,2,3,4 1CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, 2CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3IIIUC - Institute for Interdisciplinary Research, University of Coimbra, 4ViraVector - Viral Vectors for Gene Transfer Core Facility, University of Coimbra, 5FFUC - Faculty of Pharmacy, University of Coimbra, 6MICC-CNC - Microscopy Imaging Center of Coimbra - CNC, University of Coimbra JoVE 66550 생체공학
Author Spotlight: Improved Method for Production and Purification of Adeno-Associated Viral Vectors Miguel M. Lopes*1,2,3, Sara M. Lopes*1,2,3, Rafael Baganha1,2,4, Carina Henriques1,2,5, Ana C. Silva1,2,3, Diana D. Lobo1,2,3, Luísa Cortes1,2,3,6, Luís Pereira de Almeida*1,2,4,5, Rui Jorge Nobre*1,2,3,4 1CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, 2CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3IIIUC - Institute for Interdisciplinary Research, University of Coimbra, 4ViraVector - Viral Vectors for Gene Transfer Core Facility, University of Coimbra, 5FFUC - Faculty of Pharmacy, University of Coimbra, 6MICC-CNC - Microscopy Imaging Center of Coimbra - CNC, University of Coimbra JoVE 66550 생체공학