Sakthivel Sadayappan Department of Cell and Molecular Physiology Loyola University Chicago Biography Publications Institution JoVE Articles Sakthivel Sadayappan has not added a biography. If you are Sakthivel Sadayappan and would like to personalize this page please email our Author Liaison for assistance. Publications Increase in Cardiac Myosin Binding Protein-C Plasma Levels is a Sensitive and Cardiac-specific Biomarker of Myocardial Infarction American Journal of Cardiovascular Disease. 2013 | Pubmed ID: 23785583 Agonist Activated PKCβII Translocation and Modulation of Cardiac Myocyte Contractile Function Scientific Reports. 2013 | Pubmed ID: 23756828 Myofilament Ca2+ Desensitization Mediates Positive Lusitropic Effect of Neuronal Nitric Oxide Synthase in Left Ventricular Myocytes from Murine Hypertensive Heart Journal of Molecular and Cellular Cardiology. Jul, 2013 | Pubmed ID: 23624088 Perturbed Length-dependent Activation in Human Hypertrophic Cardiomyopathy with Missense Sarcomeric Gene Mutations Circulation Research. May, 2013 | Pubmed ID: 23508784 GSK3β Phosphorylates Newly Identified Site in the Proline-alanine-rich Region of Cardiac Myosin-binding Protein C and Alters Cross-bridge Cycling Kinetics in Human: Short Communication Circulation Research. Feb, 2013 | Pubmed ID: 23277198 In Vivo and in Vitro Cardiac Responses to Beta-adrenergic Stimulation in Volume-overload Heart Failure Journal of Molecular and Cellular Cardiology. Apr, 2013 | Pubmed ID: 23220155 Cardiac Myosin Binding Protein-C: Redefining Its Structure and Function Biophysical Reviews. Jun, 2012 | Pubmed ID: 22707987 Interleukin-10 Treatment Attenuates Pressure Overload-induced Hypertrophic Remodeling and Improves Heart Function Via Signal Transducers and Activators of Transcription 3-dependent Inhibition of Nuclear Factor-κB Circulation. Jul, 2012 | Pubmed ID: 22705886 Protein Kinase D Increases Maximal Ca2+-activated Tension of Cardiomyocyte Contraction by Phosphorylation of CMyBP-C-Ser315 American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2012 | Pubmed ID: 22636676 Protein Kinase C Depresses Cardiac Myocyte Power Output and Attenuates Myofilament Responses Induced by Protein Kinase A Journal of Muscle Research and Cell Motility. Dec, 2012 | Pubmed ID: 22527640 Pathogenic Properties of the N-terminal Region of Cardiac Myosin Binding Protein-C in Vitro Journal of Muscle Research and Cell Motility. May, 2012 | Pubmed ID: 22527638 Cardiac Myosin Binding Protein-C: a Potential Early-stage, Cardiac-specific Biomarker of Ischemia-reperfusion Injury Biomarkers in Medicine. Feb, 2012 | Pubmed ID: 22296197 Structural Insight into Unique Cardiac Myosin-binding Protein-C Motif: a Partially Folded Domain The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22235120 Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy with Normal Systolic Function Circulation. Heart Failure. Jan, 2012 | Pubmed ID: 22178992 Unique Single Molecule Binding of Cardiac Myosin Binding Protein-C to Actin and Phosphorylation-dependent Inhibition of Actomyosin Motility Requires 17 Amino Acids of the Motif Domain Journal of Molecular and Cellular Cardiology. Jan, 2012 | Pubmed ID: 21978630 Cardiac Myosin Binding Protein-C is a Potential Diagnostic Biomarker for Myocardial Infarction Journal of Molecular and Cellular Cardiology. Jan, 2012 | Pubmed ID: 21971072 Roles for Cardiac MyBP-C in Maintaining Myofilament Lattice Rigidity and Prolonging Myosin Cross-bridge Lifetime Biophysical Journal. Oct, 2011 | Pubmed ID: 21961592 A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function Circulation Research. Jul, 2011 | Pubmed ID: 21597010 Novel Role for P90 Ribosomal S6 Kinase in the Regulation of Cardiac Myofilament Phosphorylation The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21148481 Analysis of Cardiac Myosin Binding Protein-C Phosphorylation in Human Heart Muscle Journal of Molecular and Cellular Cardiology. Dec, 2010 | Pubmed ID: 20850451 Targeted Genome-wide Enrichment of Functional Regions PloS One. 2010 | Pubmed ID: 20585402 Distinct Sarcomeric Substrates Are Responsible for Protein Kinase D-mediated Regulation of Cardiac Myofilament Ca2+ Sensitivity and Cross-bridge Cycling The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 20018870 Phosphorylation and Function of Cardiac Myosin Binding Protein-C in Health and Disease Journal of Molecular and Cellular Cardiology. May, 2010 | Pubmed ID: 19962384 Inducible Expression of Active Protein Phosphatase-1 Inhibitor-1 Enhances Basal Cardiac Function and Protects Against Ischemia/reperfusion Injury Circulation Research. Apr, 2009 | Pubmed ID: 19299645 Cardiac Myosin Binding Protein-C Phosphorylation in a {beta}-myosin Heavy Chain Background Circulation. Mar, 2009 | Pubmed ID: 19237661 A Common MYBPC3 (cardiac Myosin Binding Protein C) Variant Associated with Cardiomyopathies in South Asia Nature Genetics. Feb, 2009 | Pubmed ID: 19151713 The Death of Transcriptional Chauvinism in the Control and Regulation of Cardiac Contractility Annals of the New York Academy of Sciences. Mar, 2008 | Pubmed ID: 18375572 Role of the Acidic N' Region of Cardiac Troponin I in Regulating Myocardial Function FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2008 | Pubmed ID: 17984178 Control of in Vivo Left Ventricular [correction] Contraction/relaxation Kinetics by Myosin Binding Protein C: Protein Kinase A Phosphorylation Dependent and Independent Regulation Circulation. Nov, 2007 | Pubmed ID: 17984378 Cardiac Transgenic and Gene Transfer Strategies Converge to Support an Important Role for Troponin I in Regulating Relaxation in Cardiac Myocytes Circulation Research. Aug, 2007 | Pubmed ID: 17615373 Distribution and Structure-function Relationship of Myosin Heavy Chain Isoforms in the Adult Mouse Heart The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17575272 Novel Mitochondrial DNA Mutations Implicated in Noonan Syndrome International Journal of Cardiology. Aug, 2007 | Pubmed ID: 17092585 Cardiac Myosin Binding Protein C Phosphorylation is Cardioprotective Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17075052 PKC-betaII Sensitizes Cardiac Myofilaments to Ca2+ by Phosphorylating Troponin I on Threonine-144 Journal of Molecular and Cellular Cardiology. Nov, 2006 | Pubmed ID: 17010989 Cardiac Isoform of Alpha-2 Macroglobulin--a New Biomarker for Myocardial Infarcted Diabetic Patients Atherosclerosis. May, 2006 | Pubmed ID: 16102773 Cardiac Myosin-binding Protein-C Phosphorylation and Cardiac Function Circulation Research. Nov, 2005 | Pubmed ID: 16224063 Transgenic Rabbit Model for Human Troponin I-based Hypertrophic Cardiomyopathy Circulation. May, 2005 | Pubmed ID: 15867176 In Vivo and in Vitro Analysis of Cardiac Troponin I Phosphorylation The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15507454 Novel Deletions in MYH7 and MYBPC3 Identified in Indian Families with Familial Hypertrophic Cardiomyopathy Journal of Molecular and Cellular Cardiology. Jun, 2003 | Pubmed ID: 12788380 A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay Diederik W.D. Kuster1, David Barefield1, Suresh Govindan1, Sakthivel Sadayappan1 1Department of Cell and Molecular Physiology, Loyola University Chicago JoVE 50786 생물학
A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay Diederik W.D. Kuster1, David Barefield1, Suresh Govindan1, Sakthivel Sadayappan1 1Department of Cell and Molecular Physiology, Loyola University Chicago JoVE 50786 생물학