Timothy C. Chambers Department of Biochemistry and Molecular Biology University of Arkansas for Medical Sciences Biography Publications Institution JoVE Articles Timothy C. Chambers has not added a biography. If you are Timothy C. Chambers and would like to personalize this page please email our Author Liaison for assistance. Publications Activity of Resveratrol Triesters Against Primary Acute Lymphoblastic Leukemia Cells Bioorganic & Medicinal Chemistry Letters. Jun, 2017 | Pubmed ID: 28499732 Mitotic Arrest-induced Phosphorylation of Mcl-1 Revisited Using Two-dimensional Gel Electrophoresis and Phosphoproteomics: Nine Phosphorylation Sites Identified Oncotarget. Nov, 2016 | Pubmed ID: 27738316 Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells Cancer Research. 06, 2016 | Pubmed ID: 27197148 CDK1/2 Toolbox in Need of an Upgrade Cell Cycle (Georgetown, Tex.). Jul, 2016 | Pubmed ID: 27104300 BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells Cancer Research. Apr, 2015 | Pubmed ID: 25649768 Cyclin B1 Overexpression Induces Cell Death Independent of Mitotic Arrest PloS One. 2014 | Pubmed ID: 25415322 Molecular Analysis of Functional Redundancy Among Anti-apoptotic Bcl-2 Proteins and Its Role in Cancer Cell Survival Experimental Cell Research. Apr, 2014 | Pubmed ID: 24556425 Identification of a Mitotic Death Signature in Cancer Cell Lines Cancer Letters. Feb, 2014 | Pubmed ID: 24099917 Metabolic Transformation of Antitumor Acridinone C-1305 but Not C-1311 Via Selective Cellular Expression of UGT1A10 Increases Cytotoxic Response: Implications for Clinical Use Drug Metabolism and Disposition: the Biological Fate of Chemicals. Feb, 2013 | Pubmed ID: 23160818 Cyclin-dependent Kinase-1 (Cdk1)/cyclin B1 Dictates Cell Fate After Mitotic Arrest Via Phosphoregulation of Antiapoptotic Bcl-2 Proteins The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 22965228 Cdk1/cyclin B Plays a Key Role in Mitotic Arrest-induced Apoptosis by Phosphorylation of Mcl-1, Promoting Its Degradation and Freeing Bak from Sequestration Biochemical Pharmacology. Jan, 2012 | Pubmed ID: 22024133 Cyclin-dependent Kinase 1-mediated Bcl-xL/Bcl-2 Phosphorylation Acts As a Functional Link Coupling Mitotic Arrest and Apoptosis Molecular and Cellular Biology. Feb, 2010 | Pubmed ID: 19917720 Synthesis and Anticancer Activity of Sclerophytin-inspired Hydroisobenzofurans Bioorganic & Medicinal Chemistry Letters. Dec, 2009 | Pubmed ID: 19896844 Regulation of Bax by C-Jun NH2-terminal Kinase and Bcl-xL in Vinblastine-induced Apoptosis Biochemical Pharmacology. Aug, 2009 | Pubmed ID: 19427996 P21 Functions in a Post-mitotic Block Checkpoint in the Apoptotic Response to Vinblastine Biochemical and Biophysical Research Communications. Mar, 2009 | Pubmed ID: 19161984 Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18974096 Key Role for Bak Activation and Bak-Bax Interaction in the Apoptotic Response to Vinblastine Molecular Cancer Therapeutics. Jul, 2008 | Pubmed ID: 18645031 Distinct Signaling Pathways of Microtubule Inhibitors--vinblastine and Taxol Induce JNK-dependent Cell Death but Through AP-1-dependent and AP-1-independent Mechanisms, Respectively The FEBS Journal. Apr, 2008 | Pubmed ID: 18341588 Induction of Apoptosis by Vinblastine Via C-Jun Autoamplification and P53-independent Down-regulation of P21WAF1/CIP1 Molecular Pharmacology. Jan, 2008 | Pubmed ID: 18094076 Inducible Overexpression of C-Jun in MCF7 Cells Causes Resistance to Vinblastine Via Inhibition of Drug-induced Apoptosis and Senescence at a Step Subsequent to Mitotic Arrest Biochemical Pharmacology. Feb, 2007 | Pubmed ID: 17126817 Superhigh-sensitivity Photothermal Monitoring of Individual Cell Response to Antitumor Drug Journal of Biomedical Optics. Nov-Dec, 2006 | Pubmed ID: 17212557 Vinblastine-induced Apoptosis is Mediated by Discrete Alterations in Subcellular Location, Oligomeric Structure, and Activation Status of Specific Bcl-2 Family Members The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16574665 Role of C-Jun in Cellular Sensitivity to the Microtubule Inhibitor Vinblastine Biochemical and Biophysical Research Communications. Oct, 2005 | Pubmed ID: 16111654 Characterization of Vinblastine-induced Bcl-xL and Bcl-2 Phosphorylation: Evidence for a Novel Protein Kinase and a Coordinated Phosphorylation/dephosphorylation Cycle Associated with Apoptosis Induction Oncogene. Jan, 2005 | Pubmed ID: 15531923 Coordinating Epidermal Growth Factor-induced Motility Promotes Efficient Wound Closure American Journal of Physiology. Cell Physiology. Jan, 2005 | Pubmed ID: 15371256 Subcellular Localization As a Limiting Factor for Utilization of Decoy Oligonucleotides Nucleic Acids Research. Oct, 2004 | Pubmed ID: 15498923 Inhibition of Cell Proliferation and Cell Cycle Progression by Specific Inhibition of Basal JNK Activity: Evidence That Mitotic Bcl-2 Phosphorylation is JNK-independent The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14704147 The JNK, ERK and P53 Pathways Play Distinct Roles in Apoptosis Mediated by the Antitumor Agents Vinblastine, Doxorubicin, and Etoposide Biochemical Pharmacology. Aug, 2003 | Pubmed ID: 12907245 C-Jun NH2-terminal Kinase-mediated Signaling is Essential for Pseudomonas Aeruginosa ExoS-induced Apoptosis Infection and Immunity. Jun, 2003 | Pubmed ID: 12761120 Molecular Analysis of the Multidrug Transporter, P-glycoprotein Cytotechnology. Sep, 1998 | Pubmed ID: 19002782 केंद्रापसारक Elutriation द्वारा विभिंन कोशिका चक्र चरणों में प्राथमिक तीव्र लिम्फोब्लासटिक ल्यूकेमिया कोशिकाओं की तैयारी Magdalena Delgado*1, Anisha Kothari*1, Walter N. Hittelman2, Timothy C. Chambers1 1Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 2Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center JoVE 56418 암 연구학
केंद्रापसारक Elutriation द्वारा विभिंन कोशिका चक्र चरणों में प्राथमिक तीव्र लिम्फोब्लासटिक ल्यूकेमिया कोशिकाओं की तैयारी Magdalena Delgado*1, Anisha Kothari*1, Walter N. Hittelman2, Timothy C. Chambers1 1Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 2Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center JoVE 56418 암 연구학