Wenshe Ray Liu Department of Chemistry Texas A&M University Biography Publications Institution JoVE Articles Wenshe Ray Liu Dr. Wenshe Liu received his BS degree from Peking University in 2000 and his Ph.D. degree under the supervision of Dr. Michael D. Toney from University of California-Davis in 2005. Following two years of postdoctoral training in Dr. Peter G. Schultz group in the Scripps Research Institute, he started his independent research group as an assistant professor at Texas A&M University in 2007. Dr. Liu was promoted to the associate professor rank in 2013 and furthered to the full professor rank in 2016. He is currently holding the Emile and Marta Schweikert endowed professorship in the Texas A&M Chemistry Department. Dr. Liu was originally trained to work on both enzymology and protein crystallography during his Ph.D. study and later switched to organic chemistry and molecular biology during his postdoctoral training. His current research group has two operating branches. One is organic synthesis and the other is molecular and biological chemistry. The technical basis of research in Liu group is the amber suppression based noncanonical amino acid mutagenesis, targeted questions being different. One focus is to build methods for the synthesis of chromatin with specific lysine modifications for the illustration of how these modifications influence chromatin structures, interactions with transcription factors, recognition by epigenetic enzymes, and the control of other modifications in chromatin. The second focus is to develop techniques for integrating one or two noncanonical amino acids into phage displayed peptide libraries. These noncanonical amino acids serve as active chemical handles to cyclize peptide libraries, anchor enzyme/protein active sites, and expand chemical diversities of libraries by reacting with other small molecules. The ultimate goal of this research direction is to identify tight and selective inhibitors of epigenetic enzymes that can be applied for cancer treatment. Publications A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors* ChemMedChem. Dec, 2020 | Pubmed ID: 33283984 An Optimal "Click" Formulation Strategy for Antibody-drug Conjugate Synthesis Bioorganic & Medicinal Chemistry. Dec, 2020 | Pubmed ID: 33071032 The Molecular Basis of Tight Nuclear Tethering and Inactivation of CGAS Nature. Nov, 2020 | Pubmed ID: 32911481 Targeting the SARS-CoV-2 Main Protease to Repurpose Drugs for COVID-19 BioRxiv : the Preprint Server for Biology. May, 2020 | Pubmed ID: 32511370 Expressed Protein Ligation Without Intein Journal of the American Chemical Society. 04, 2020 | Pubmed ID: 32212692 An Amber Obligate Active Site-directed Ligand Evolution Technique for Phage Display Nature Communications. 03, 2020 | Pubmed ID: 32170178 Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV Chembiochem : a European Journal of Chemical Biology. 03, 2020 | Pubmed ID: 32022370 A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library Angewandte Chemie (International Ed. in English). 10, 2019 | Pubmed ID: 31398275 Covalent Inhibition in Drug Discovery ChemMedChem. 05, 2019 | Pubmed ID: 30816012 A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7 Journal of the American Chemical Society. 02, 2019 | Pubmed ID: 30653310 Using Amber and Ochre Nonsense Codons to Code Two Different Noncanonical Amino Acids in One Protein Gene Methods in Molecular Biology (Clifton, N.J.). Month, 2018 | Pubmed ID: 29404996 Genetically Encoded Fluorophenylalanines Enable Insights into the Recognition of Lysine Trimethylation by an Epigenetic Reader Chemical Communications (Cambridge, England). Oct, 2016 | Pubmed ID: 27711380 The "π-Clamp" Offers a New Strategy for Site-Selective Protein Modification Chembiochem : a European Journal of Chemical Biology. 05, 2016 | Pubmed ID: 26928847 Phospha-Michael Addition As a New Click Reaction for Protein Functionalization Chembiochem : a European Journal of Chemical Biology. Mar, 2016 | Pubmed ID: 26756316 Genetically Encoded Unstrained Olefins for Live Cell Labeling with Tetrazine Dyes Chemical Communications (Cambridge, England). Nov, 2014 | Pubmed ID: 25224663 A Genetically Encoded Aldehyde for Rapid Protein Labelling Chemical Communications (Cambridge, England). Jul, 2014 | Pubmed ID: 24756176 Pyrrolysyl-tRNA Synthetase: an Ordinary Enzyme but an Outstanding Genetic Code Expansion Tool Biochimica Et Biophysica Acta. Jun, 2014 | Pubmed ID: 24631543 The Nitrilimine-alkene Cycloaddition is an Ultra Rapid Click Reaction Chemical Communications (Cambridge, England). Mar, 2014 | Pubmed ID: 24519550 The Genetic Incorporation of Thirteen Novel Non-canonical Amino Acids Chemical Communications (Cambridge, England). Mar, 2014 | Pubmed ID: 24473369 Synthesis of Proteins with Defined Posttranslational Modifications Using the Genetic Noncanonical Amino Acid Incorporation Approach Molecular BioSystems. Jan, 2011 | Pubmed ID: 21088799 Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli Chesley Marie Rowlett1, Wenshe Ray Liu1 1Department of Chemistry, Texas A&M University JoVE 62113 생화학
Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli Chesley Marie Rowlett1, Wenshe Ray Liu1 1Department of Chemistry, Texas A&M University JoVE 62113 생화학