Young Kee Shin Research Institute of Pharmaceutical Science, Department of Pharmacy, College of Pharmacy Seoul National University Biography Publications Institution JoVE Articles Young Kee Shin has not added a biography. If you are Young Kee Shin and would like to personalize this page please email our Author Liaison for assistance. Publications Human Papillomavirus: Current and Future RNAi Therapeutic Strategies for Cervical Cancer Journal of Clinical Medicine. 2015 | Pubmed ID: 26239469 Basal Buffer Systems for a Newly Glycosylated Recombinant Human Interferon-β with Biophysical Stability and DoE Approaches European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Oct, 2015 | Pubmed ID: 26215462 Anoctamin 1 (TMEM16A) is Essential for Testosterone-induced Prostate Hyperplasia Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26153424 Human Papillomavirus E6/E7-Specific SiRNA Potentiates the Effect of Radiotherapy for Cervical Cancer in Vitro and in Vivo International Journal of Molecular Sciences. 2015 | Pubmed ID: 26035754 Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative Molecules (Basel, Switzerland). 2014 | Pubmed ID: 25268715 Molecular Function and Regulation of Long Non-coding RNAs: Paradigms with Potential Roles in Cancer Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Nov, 2014 | Pubmed ID: 25266799 Design and Synthesis of a Macrosphelide A-biotin Chimera Organic & Biomolecular Chemistry. Sep, 2014 | Pubmed ID: 25098405 SMAD4 Suppresses AURKA-induced Metastatic Phenotypes Via Degradation of AURKA in a TGFβ-independent Manner Molecular Cancer Research : MCR. Dec, 2014 | Pubmed ID: 25061104 Glycoengineering of Interferon-β 1a Improves Its Biophysical and Pharmacokinetic Properties PloS One. 2014 | Pubmed ID: 24858932 MET is a Potential Target for Use in Combination Therapy with EGFR Inhibition in Triple-negative/basal-like Breast Cancer International Journal of Cancer. Journal International Du Cancer. May, 2014 | Pubmed ID: 24615768 Overexpression of Cancer-Associated Genes Via Epigenetic Derepression Mechanisms in Gynecologic Cancer Frontiers in Oncology. 2014 | Pubmed ID: 24551595 High Level of CDK4 Amplification is a Poor Prognostic Factor in Well-differentiated and Dedifferentiated Liposarcoma Histology and Histopathology. Jan, 2014 | Pubmed ID: 23852861 Long Non-coding RNAs in Hematologic Malignancies: Road to Translational Research Frontiers in Genetics. 2013 | Pubmed ID: 24312125 Synthesis and Biological Evaluation of a Polyyne-containing Sphingoid Base Probe As a Chemical Tool Bioconjugate Chemistry. Aug, 2013 | Pubmed ID: 23926922 Prognostic Significance of CD151 Overexpression in Non-small Cell Lung Cancer Lung Cancer (Amsterdam, Netherlands). Jul, 2013 | Pubmed ID: 23570797 Regulation of Ovarian Cancer Stem Cells or Tumor-initiating Cells International Journal of Molecular Sciences. 2013 | Pubmed ID: 23528891 Low SP1 Expression Differentially Affects Intestinal-type Compared with Diffuse-type Gastric Adenocarcinoma PloS One. 2013 | Pubmed ID: 23437057 CD24⁺ Ovary Cancer Cells Exhibit an Invasive Mesenchymal Phenotype Biochemical and Biophysical Research Communications. Mar, 2013 | Pubmed ID: 23396061 Tob1 Induces Apoptosis and Inhibits Proliferation, Migration and Invasion of Gastric Cancer Cells by Activating Smad4 and Inhibiting β‑catenin Signaling International Journal of Oncology. Sep, 2012 | Pubmed ID: 22710759 High MET Copy Number and MET Overexpression: Poor Outcome in Non-small Cell Lung Cancer Patients Histology and Histopathology. Feb, 2012 | Pubmed ID: 22207554 A Prognostic Model for Lymph Node-negative Breast Cancer Patients Based on the Integration of Proliferation and Immunity Breast Cancer Research and Treatment. Apr, 2012 | Pubmed ID: 21667120 The Synergistic Therapeutic Effect of Cisplatin with Human Papillomavirus E6/E7 Short Interfering RNA on Cervical Cancer Cell Lines in Vitro and in Vivo International Journal of Cancer. Journal International Du Cancer. Apr, 2012 | Pubmed ID: 21630254 Claudin-4 Overexpression is Associated with Epigenetic Derepression in Gastric Carcinoma Laboratory Investigation; a Journal of Technical Methods and Pathology. Nov, 2011 | Pubmed ID: 21844869 Epigenetic Regulation of Cancer-associated Genes in Ovarian Cancer International Journal of Molecular Sciences. 2011 | Pubmed ID: 21541038 Cancer-associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis PLoS Genetics. Mar, 2011 | Pubmed ID: 21483803 The Potential RNAi-based Combination Therapeutics Archives of Pharmacal Research. Jan, 2011 | Pubmed ID: 21468909 Triple-negative, Basal-like, and Quintuple-negative Breast Cancers: Better Prediction Model for Survival BMC Cancer. 2010 | Pubmed ID: 20860845 The Transcription Factor MIST1 is a Novel Human Gastric Chief Cell Marker Whose Expression is Lost in Metaplasia, Dysplasia, and Carcinoma The American Journal of Pathology. Sep, 2010 | Pubmed ID: 20709804 LYN is a Mediator of Epithelial-mesenchymal Transition and a Target of Dasatinib in Breast Cancer Cancer Research. Mar, 2010 | Pubmed ID: 20215510 Merkel Cell Carcinoma: Our Experience with Seven Patients in Korea and a Literature Review Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS. Dec, 2010 | Pubmed ID: 20207211 Derepression of CLDN3 and CLDN4 During Ovarian Tumorigenesis is Associated with Loss of Repressive Histone Modifications Carcinogenesis. Jun, 2010 | Pubmed ID: 20053926 Resveratrol Suppresses Growth of Human Ovarian Cancer Cells in Culture and in a Murine Xenograft Model: Eukaryotic Elongation Factor 1A2 As a Potential Target Cancer Research. Sep, 2009 | Pubmed ID: 19738051 Identification of Novel Reference Genes Using Multiplatform Expression Data and Their Validation for Quantitative Gene Expression Analysis PloS One. 2009 | Pubmed ID: 19584937 Expression of Sonic Hedgehog Signaling Molecules in Normal, Hyperplastic and Carcinomatous Endometrium Pathology International. May, 2009 | Pubmed ID: 19432668 Magnolia Officinalis Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element-binding Protein-1c Journal of Pharmacological Sciences. Apr, 2009 | Pubmed ID: 19372631 Honokiol Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element Binding Protein-1c and the Expression of Its Downstream Lipogenesis Genes Toxicology and Applied Pharmacology. Apr, 2009 | Pubmed ID: 19371623 A Novel Mutation in the Linker Domain of the Signal Transducer and Activator of Transcription 3 Gene, P.Lys531Glu, in Hyper-IgE Syndrome The Journal of Allergy and Clinical Immunology. Apr, 2009 | Pubmed ID: 19348930 Enhanced CD24 Expression in Endometrial Carcinoma and Its Expression Pattern in Normal and Hyperplastic Endometrium Histology and Histopathology. Mar, 2009 | Pubmed ID: 19130400 Liver X Receptor Mediates Hepatitis B Virus X Protein-induced Lipogenesis in Hepatitis B Virus-associated Hepatocellular Carcinoma Hepatology (Baltimore, Md.). Apr, 2009 | Pubmed ID: 19105208 Inhibitory Effects of Oligonol on Phorbol Ester-induced Tumor Promotion and COX-2 Expression in Mouse Skin: NF-kappaB and C/EBP As Potential Targets Cancer Letters. Jan, 2009 | Pubmed ID: 18848748 Expression of Bmi-1 Protein in Tumor Tissues is Associated with Favorable Prognosis in Breast Cancer Patients Breast Cancer Research and Treatment. Jan, 2009 | Pubmed ID: 18228133 Extensive Alteration in the Expression Profiles of TGFB Pathway Signaling Components and TP53 is Observed Along the Gastric Dysplasia-carcinoma Sequence Histology and Histopathology. Dec, 2008 | Pubmed ID: 18830930 Involvement of Promyelocytic Leukemia Protein in the Ethanol-induced Apoptosis in Mouse Embryo Fibroblasts Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. Jul, 2008 | Pubmed ID: 18591875 Identification of Formaldehyde-responsive Genes by Suppression Subtractive Hybridization Toxicology. Jan, 2008 | Pubmed ID: 18045764 The Clinical Significance of Serum N-terminal Pro-brain Natriuretic Peptide in Systemic Sclerosis Patients Clinical Rheumatology. Apr, 2008 | Pubmed ID: 17899307 Overexpression of Interleukin-10 in Sentinel Lymph Node with Breast Cancer Annals of Surgical Oncology. Nov, 2007 | Pubmed ID: 17762971 Clinical Significance of CD99 Down-regulation in Gastric Adenocarcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2007 | Pubmed ID: 17473187 Overexpression of CD24: Association with Invasiveness in Urothelial Carcinoma of the Bladder Archives of Pathology & Laboratory Medicine. Feb, 2007 | Pubmed ID: 17284113 Inactivation of SMAD4 Tumor Suppressor Gene During Gastric Carcinoma Progression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2007 | Pubmed ID: 17200344 Resveratrol Modulates Phorbol Ester-induced Pro-inflammatory Signal Transduction Pathways in Mouse Skin in Vivo: NF-kappaB and AP-1 As Prime Targets Biochemical Pharmacology. Nov, 2006 | Pubmed ID: 16999939 Enhanced Expression of Hedgehog Signaling Molecules in Squamous Cell Carcinoma of Uterine Cervix and Its Precursor Lesions Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Aug, 2006 | Pubmed ID: 16778829 Combining Multiple Microarrays in the Presence of Controlling Variables Bioinformatics (Oxford, England). Jul, 2006 | Pubmed ID: 16705015 Increased Expression of Sonic Hedgehog and Altered Methylation of Its Promoter Region in Gastric Cancer and Its Related Lesions Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. May, 2006 | Pubmed ID: 16528374 Resveratrol Inhibits Phorbol Ester-induced Expression of COX-2 and Activation of NF-kappaB in Mouse Skin by Blocking IkappaB Kinase Activity Carcinogenesis. Jul, 2006 | Pubmed ID: 16474181 Aberrant Hypermethylation of RASSF1A Promoter in Ovarian Borderline Tumors and Carcinomas Virchows Archiv : an International Journal of Pathology. Mar, 2006 | Pubmed ID: 16315018 Rapid Divergency of Rodent CD99 Orthologs: Implications for the Evolution of the Pseudoautosomal Region Gene. Jul, 2005 | Pubmed ID: 15978751 HUlip, a Human Homologue of Unc-33-like Phosphoprotein of Caenorhabditis Elegans; Immunohistochemical Localization in the Developing Human Brain and Patterns of Expression in Nervous System Tumors Journal of Neuro-oncology. May, 2005 | Pubmed ID: 15933812 Cytoplasmic CD24 Expression in Advanced Ovarian Serous Borderline Tumors Gynecologic Oncology. May, 2005 | Pubmed ID: 15863133 Human Lysyl-tRNA Synthetase is Secreted to Trigger Proinflammatory Response Proceedings of the National Academy of Sciences of the United States of America. May, 2005 | Pubmed ID: 15851690 [6]-Gingerol Inhibits COX-2 Expression by Blocking the Activation of P38 MAP Kinase and NF-kappaB in Phorbol Ester-stimulated Mouse Skin Oncogene. Apr, 2005 | Pubmed ID: 15735738 The Novel Cytokine P43 Stimulates Dermal Fibroblast Proliferation and Wound Repair The American Journal of Pathology. Feb, 2005 | Pubmed ID: 15681823 The Haploinsufficient Tumor Suppressor P18 Upregulates P53 Via Interactions with ATM/ATR Cell. Jan, 2005 | Pubmed ID: 15680327 Solution Structure of the Cytoplasmic Domain of Human CD99 Type I Molecules and Cells. Aug, 2004 | Pubmed ID: 15359120 An Immunohistochemical Study of the Expression of Adhesion Molecules in Gallbladder Lesions The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. May, 2004 | Pubmed ID: 15100237 Targeted Cytotoxic Effect of Anti-JL1 Immunotoxin Against a Human Leukemic Cell Line and Its Clinical Implications Cancer Immunology, Immunotherapy : CII. Aug, 2003 | Pubmed ID: 12768327 Cloning, Genomic Organization, Alternative Transcripts and Expression Analysis of CD99L2, a Novel Paralog of Human CD99, and Identification of Evolutionary Conserved Motifs Gene. Mar, 2003 | Pubmed ID: 12706889 An Improved Protocol of Biotinylated Tyramine-based Immunohistochemistry Minimizing Nonspecific Background Staining The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jan, 2003 | Pubmed ID: 12502763 The Enhanced Reactivity of Endogenous Biotin-like Molecules by Antigen Retrieval Procedures and Signal Amplification with Tyramine The Histochemical Journal. Mar-Apr, 2002 | Pubmed ID: 12495214 Mutations of the Immunoglobulin Heavy Chain Variable Region Gene in CD99-deficient BJAB Cell Line Molecules and Cells. Apr, 2002 | Pubmed ID: 12018845 Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines Nirmal Rajasekaran1, Myung Ryurl Oh3, Sung-Su Kim1, Si Eun Kim3, Young Deug Kim4, Hyun-Jeung Choi2, Bohyun Byun2, Young Kee Shin1,2 1Research Institute of Pharmaceutical Science, Department of Pharmacy, College of Pharmacy, Seoul National University, 2The Center for Anti-Cancer CDx, N-Bio, Seoul National University, 3ABION CRO, 4ABION Inc., R&D Center JoVE 53190 생물학
Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines Nirmal Rajasekaran1, Myung Ryurl Oh3, Sung-Su Kim1, Si Eun Kim3, Young Deug Kim4, Hyun-Jeung Choi2, Bohyun Byun2, Young Kee Shin1,2 1Research Institute of Pharmaceutical Science, Department of Pharmacy, College of Pharmacy, Seoul National University, 2The Center for Anti-Cancer CDx, N-Bio, Seoul National University, 3ABION CRO, 4ABION Inc., R&D Center JoVE 53190 생물학