Zheng-Rong Lu Department of Biomedical Engineering Case Western Reserve University Biography Publications Institution JoVE Articles Zheng-Rong Lu has not added a biography. If you are Zheng-Rong Lu and would like to personalize this page please email our Author Liaison for assistance. Publications Peptide Targeted Tripod Macrocyclic Gd(III) Chelates for Cancer Molecular MRI Biomaterials. Oct, 2013 | Pubmed ID: 23863450 Design and Evaluation of New PH-sensitive Amphiphilic Cationic Lipids for SiRNA Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2013 | Pubmed ID: 23796431 Molecular Magnetic Resonance Imaging of Tumors with a PTPµ Targeted Contrast Agent Translational Oncology. Jun, 2013 | Pubmed ID: 23730413 Synthesis and Evaluation of a Polydisulfide with Gd-DOTA Monoamide Side Chains As a Biodegradable Macromolecular Contrast Agent for MR Blood Pool Imaging Contrast Media & Molecular Imaging. May-Jun, 2013 | Pubmed ID: 23606425 Synthesis and Evaluation of a Targeted Nanoglobular Dual-Modal Imaging Agent for MR Imaging and Image-Guided Surgery of Prostate Cancer Pharmaceutical Research. Mar, 2013 | Pubmed ID: 23471641 Molecular MRI of Liver Fibrosis by a Peptide-targeted Contrast Agent in an Experimental Mouse Model Investigative Radiology. Jan, 2013 | Pubmed ID: 23192162 Gadolinium-based Contrast Agents for Magnetic Resonance Cancer Imaging Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. Jan-Feb, 2013 | Pubmed ID: 23047730 Single Cell Molecular Recognition of Migrating and Invading Tumor Cells Using a Targeted Fluorescent Probe to Receptor PTPmu International Journal of Cancer. Journal International Du Cancer. Apr, 2013 | Pubmed ID: 22987116 Albumin Pre-coating Enhances Intracellular SiRNA Delivery of Multifunctional Amphiphile/siRNA Nanoparticles International Journal of Nanomedicine. 2012 | Pubmed ID: 23055731 Synthesis and Evaluation of a Peptide Targeted Small Molecular Gd-DOTA Monoamide Conjugate for MR Molecular Imaging of Prostate Cancer Bioconjugate Chemistry. Aug, 2012 | Pubmed ID: 22812444 MR Molecular Imaging of Prostate Cancer with a Peptide-targeted Contrast Agent in a Mouse Orthotopic Prostate Cancer Model Pharmaceutical Research. Apr, 2012 | Pubmed ID: 22139536 Polydisulfide Manganese(II) Complexes As Non-gadolinium Biodegradable Macromolecular MRI Contrast Agents Journal of Magnetic Resonance Imaging : JMRI. Mar, 2012 | Pubmed ID: 22031457 Ocular Pharmacokinetic Study Using Tâ‚ Mapping and Gd-chelate- Labeled Polymers Pharmaceutical Research. Dec, 2011 | Pubmed ID: 21691891 Integrin Targeted MR Imaging Theranostics. 2011 | Pubmed ID: 21547154 Synthesis and Evaluation of Nanoglobular Macrocyclic Mn(II) Chelate Conjugates As Non-gadolinium(III) MRI Contrast Agents Bioconjugate Chemistry. May, 2011 | Pubmed ID: 21473650 Polydisulfide Based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents Israel Journal of Chemistry. Aug, 2010 | Pubmed ID: 21331318 Synthesis and Evaluation of Nanoglobule-cystamine-(Gd-DO3A), a Biodegradable Nanosized Magnetic Resonance Contrast Agent for Dynamic Contrast-enhanced Magnetic Resonance Urography International Journal of Nanomedicine. 2010 | Pubmed ID: 20957222 New Amphiphilic Carriers Forming PH-sensitive Nanoparticles for Nucleic Acid Delivery Langmuir : the ACS Journal of Surfaces and Colloids. Sep, 2010 | Pubmed ID: 20672851 [Findings of Electric Bronchoscopy in 67 Children with Recurrent Wheezing] Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics. Jun, 2010 | Pubmed ID: 20540854 An Effective Targeted Nanoglobular Manganese(II) Chelate Conjugate for Magnetic Resonance Molecular Imaging of Tumor Extracellular Matrix Molecular Pharmaceutics. Aug, 2010 | Pubmed ID: 20481565 Stability and Biodistribution of a Biodegradable Macromolecular MRI Contrast Agent Gd-DTPA Cystamine Copolymers (GDCC) in Rats Pharmaceutical Research. Jul, 2010 | Pubmed ID: 20393871 Peptide-targeted Nanoglobular Gd-DOTA Monoamide Conjugates for Magnetic Resonance Cancer Molecular Imaging Biomacromolecules. Mar, 2010 | Pubmed ID: 20131758 Molecular Imaging of HPMA Copolymers: Visualizing Drug Delivery in Cell, Mouse and Man Advanced Drug Delivery Reviews. Feb, 2010 | Pubmed ID: 20060431 Noninvasive Evaluation of Antiangiogenic Effect in a Mouse Tumor Model by DCE-MRI with Gd-DTPA Cystamine Copolymers Molecular Pharmaceutics. Feb, 2010 | Pubmed ID: 19958031 Rapid Simultaneous Acquisition of T1 and T2 Mapping Images Using Multishot Double Spin-echo EPI and Automated Variations of TR and TE (ms-DSEPI-T12) NMR in Biomedicine. Jan, 2010 | Pubmed ID: 19777499 Application of a Biodegradable Macromolecular Contrast Agent in Dynamic Contrast-enhanced MRI for Assessing the Efficacy of Indocyanine Green-enhanced Photothermal Cancer Therapy Journal of Magnetic Resonance Imaging : JMRI. Aug, 2009 | Pubmed ID: 19629979 Tumor Characterization with Dynamic Contrast Enhanced Magnetic Resonance Imaging and Biodegradable Macromolecular Contrast Agents in Mice Pharmaceutical Research. Sep, 2009 | Pubmed ID: 19597972 Targeted Intracellular Codelivery of Chemotherapeutics and Nucleic Acid with a Well-defined Dendrimer-based Nanoglobular Carrier Biomaterials. Oct, 2009 | Pubmed ID: 19595449 Targeted Systemic Delivery of a Therapeutic SiRNA with a Multifunctional Carrier Controls Tumor Proliferation in Mice Molecular Pharmaceutics. May-Jun, 2009 | Pubmed ID: 19296675 A Peptide-targeted Delivery System with PH-sensitive Amphiphilic Cell Membrane Disruption for Efficient Receptor-mediated SiRNA Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2009 | Pubmed ID: 19135104 Structural Effect on Degradability and in Vivo Contrast Enhancement of Polydisulfide Gd(III) Complexes As Biodegradable Macromolecular MRI Contrast Agents Magnetic Resonance Imaging. May, 2009 | Pubmed ID: 18814987 A Peptide Targeted Contrast Agent Specific to Fibrin-fibronectin Complexes for Cancer Molecular Imaging with MRI Bioconjugate Chemistry. Dec, 2008 | Pubmed ID: 19053180 Characterization of Tumor Angiogenesis with Dynamic Contrast-enhanced MRI and Biodegradable Macromolecular Contrast Agents in Mice Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Dec, 2008 | Pubmed ID: 19025902 Synthesis and Evaluation of Globular Gd-DOTA-monoamide Conjugates with Precisely Controlled Nanosizes for Magnetic Resonance Angiography Biomacromolecules. Oct, 2008 | Pubmed ID: 18771313 Contrast-enhanced MRI-guided Photodynamic Cancer Therapy with a Pegylated Bifunctional Polymer Conjugate Pharmaceutical Research. Sep, 2008 | Pubmed ID: 18584312 Gadolinium-conjugated TiO2-DNA Oligonucleotide Nanoconjugates Show Prolonged Intracellular Retention Period and T1-weighted Contrast Enhancement in Magnetic Resonance Images Nanomedicine : Nanotechnology, Biology, and Medicine. Sep, 2008 | Pubmed ID: 18567541 A Multifunctional and Reversibly Polymerizable Carrier for Efficient SiRNA Delivery Biomaterials. Jan, 2008 | Pubmed ID: 17923154 [Determination of the Lung Function by Impulse Oscillometry in 549 Healthy Children in Chengdu Area] Zhonghua Er Ke Za Zhi. Chinese Journal of Pediatrics. Oct, 2007 | Pubmed ID: 18211755 Novel Polymerizable Surfactants with PH-sensitive Amphiphilicity and Cell Membrane Disruption for Efficient SiRNA Delivery Bioconjugate Chemistry. Nov-Dec, 2007 | Pubmed ID: 17939730 Conjugation of Poorly Absorptive Drugs with Mucoadhesive Polymers for the Improvement of Oral Absorption of Drugs Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2007 | Pubmed ID: 17888541 RGD Targeted Poly(L-glutamic Acid)-cystamine-(Gd-DO3A) Conjugate for Detecting Angiogenesis Biomarker Alpha(v) Beta3 Integrin with MRT, Mapping International Journal of Nanomedicine. 2007 | Pubmed ID: 17722547 In Vivo Evaluation of a PAMAM-cystamine-(Gd-DO3A) Conjugate As a Biodegradable Macromolecular MRI Contrast Agent Experimental Biology and Medicine (Maywood, N.J.). Sep, 2007 | Pubmed ID: 17720954 Synthesis, Characterization, and Gene Delivery of Poly-L-lysine Octa(3-aminopropyl)silsesquioxane Dendrimers: Nanoglobular Drug Carriers with Precisely Defined Molecular Architectures Molecular Pharmaceutics. Sep-Oct, 2007 | Pubmed ID: 17705440 Polymer Platforms for Drug Delivery and Biomedical Imaging Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2007 | Pubmed ID: 17662500 Modification of Gd-DTPA Cystine Copolymers with PEG-1000 Optimizes Pharmacokinetics and Tissue Retention for Magnetic Resonance Angiography Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Jul, 2007 | Pubmed ID: 17659618 A Novel Environment-sensitive Biodegradable Polydisulfide with Protonatable Pendants for Nucleic Acid Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2007 | Pubmed ID: 17582638 Noninvasive Visualization of Pharmacokinetics, Biodistribution and Tumor Targeting of Poly[N-(2-hydroxypropyl)methacrylamide] in Mice Using Contrast Enhanced MRI Pharmaceutical Research. Jun, 2007 | Pubmed ID: 17387601 Application of Biomedical Imaging in Drug Discovery and Development Pharmaceutical Research. Jun, 2007 | Pubmed ID: 17380256 Gadolinium(III)-based Blood-pool Contrast Agents for Magnetic Resonance Imaging: Status and Clinical Potential Expert Opinion on Drug Delivery. Mar, 2007 | Pubmed ID: 17335412 Biodistribution and Pharmacokinetics of Colon-specific HPMA Copolymer--9-aminocamptothecin Conjugate in Mice Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2007 | Pubmed ID: 17150276 Polydisulfide Gd(III) Chelates As Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents International Journal of Nanomedicine. 2006 | Pubmed ID: 17722260 Contrast-enhanced Magnetic Resonance Angiography with Biodegradable (Gd-DTPA)-cystamine Copolymers: Comparison with MS-325 in a Swine Model Molecular Pharmaceutics. Sep-Oct, 2006 | Pubmed ID: 17009855 Noninvasive Visualization of in Vivo Drug Delivery of Poly(L-glutamic Acid) Using Contrast-enhanced MRI Molecular Pharmaceutics. Sep-Oct, 2006 | Pubmed ID: 17009849 Biodegradable Cystamine Spacer Facilitates the Clearance of Gd(III) Chelates in Poly(glutamic Acid) Gd-DO3A Conjugates for Contrast-enhanced MR Imaging Magnetic Resonance Imaging. Sep, 2006 | Pubmed ID: 16916710 Contrast Enhanced MRI-guided Photodynamic Therapy for Site-specific Cancer Treatment Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Oct, 2006 | Pubmed ID: 16902981 Pharmacokinetics, Biodistribution and Contrast Enhanced MR Blood Pool Imaging of Gd-DTPA Cystine Copolymers and Gd-DTPA Cystine Diethyl Ester Copolymers in a Rat Model Pharmaceutical Research. Aug, 2006 | Pubmed ID: 16850267 Gd-DTPA L-cystine Bisamide Copolymers As Novel Biodegradable Macromolecular Contrast Agents for MR Blood Pool Imaging Pharmaceutical Research. Jun, 2006 | Pubmed ID: 16729223 Effect of Size and Charge on Pharmacokinetics and in Vivo MRI Contrast Enhancement of Biodegradable Polydisulfide Gd(III) Complexes Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2006 | Pubmed ID: 16631270 Colon-specific 9-aminocamptothecin-HPMA Copolymer Conjugates Containing a 1,6-elimination Spacer Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2006 | Pubmed ID: 16290118 PEG-g-poly(GdDTPA-co-L-cystine): Effect of PEG Chain Length on in Vivo Contrast Enhancement in MRI Biomacromolecules. Jul-Aug, 2005 | Pubmed ID: 16004476 Pharmacokinetics and Tissue Retention of (Gd-DTPA)-cystamine Copolymers, a Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agent Pharmaceutical Research. Apr, 2005 | Pubmed ID: 15846467 Contrast-enhanced MRI with New Biodegradable Macromolecular Gd(III) Complexes in Tumor-bearing Mice Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Apr, 2005 | Pubmed ID: 15799038 PEG-g-poly(GdDTPA-co-L-cystine): a Biodegradable Macromolecular Blood Pool Contrast Agent for MR Imaging Bioconjugate Chemistry. Nov-Dec, 2004 | Pubmed ID: 15546211 Extracellular Biodegradable Macromolecular Gadolinium(III) Complexes for MRI Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Jan, 2004 | Pubmed ID: 14705042 Poly(l-glutamic Acid) Gd(III)-DOTA Conjugate with a Degradable Spacer for Magnetic Resonance Imaging Bioconjugate Chemistry. Jul-Aug, 2003 | Pubmed ID: 12862423 Targeted Delivery of Doxorubicin by HPMA Copolymer-hyaluronan Bioconjugates Pharmaceutical Research. Apr, 2002 | Pubmed ID: 12033370 Influence of the Structure of Drug Moieties on the in Vitro Efficacy of HPMA Copolymer-geldanamycin Derivative Conjugates Pharmaceutical Research. Feb, 2002 | Pubmed ID: 11883637 Design of Novel Bioconjugates for Targeted Drug Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2002 | Pubmed ID: 11772458 MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent Xueming Wu1, Daniel Lindner2, Guan-Ping Yu1, Susann Brady-Kalnay3, Zheng-Rong Lu1 1Department of Biomedical Engineering, Case Western Reserve University, 2Department of Translational Hematology & Oncology Research, Cleveland Clinic, Case Western Reserve University, 3Department of Molecular Biology & Microbiology, Case Western Reserve University JoVE 50565 의학
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent Xueming Wu1, Daniel Lindner2, Guan-Ping Yu1, Susann Brady-Kalnay3, Zheng-Rong Lu1 1Department of Biomedical Engineering, Case Western Reserve University, 2Department of Translational Hematology & Oncology Research, Cleveland Clinic, Case Western Reserve University, 3Department of Molecular Biology & Microbiology, Case Western Reserve University JoVE 50565 의학