Chapter 11
Control of Gene Expression
![Cell-Specific Gene Expression](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11605.jpg)
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same…
![Regulation of Expression Occurs at Multiple Steps](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11606.jpg)
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves…
![Cooperative Binding of Transcription Regulators](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11608.jpg)
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences…
![Prokaryotic Transcriptional Activators and Repressors](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11609.jpg)
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the…
![Co-activators and Co-repressors](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11612.jpg)
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in…
![Master Transcription Regulators](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11617.jpg)
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often…
![mRNA Stability and Gene Expression](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11626.jpg)
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes,…
![MicroRNAs](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13151.jpg)
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present…
![TChIP-Seq: Cell-Type-Specific Epigenome Profiling](https://cloudfront.jove.com/files/thumbs/58298_t.png)
Epigenetic regulation plays central roles in gene expression. Since histone modification was discovered in the 1960s, its physiological and…
![Visualizing and Tracking Endogenous mRNAs in Live <em>Drosophila melanogaster</em> Egg Chambers](https://cloudfront.jove.com/files/thumbs/58545_t.png)
Fluorescence-based imaging techniques, in combination with developments in light microscopy, have revolutionized how cell biologists conduct live…