JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
Chapters
- 00:05Title
- 00:38Introduction
- 00:54Surgical Preparation
- 02:07Surgery
- 05:11Maintaining Catheter Patency
- 07:14Hyperinsulinemic-Euglycemic Clamp
- 09:54Representative Results
- 10:51Conclusion
The hyperinsulinemic-euglycemic clamp is the "gold standard" for the assessment of insulin action. Insulin is infused at a constant rate stimulating glucose uptake. The amount of exogenous glucose infused to counter this drop is indicative of insulin sensitivity. Here the procedure is performed on a conscious, unrestrained rat.
Tags
Hyperinsulinemic-euglycemic ClampType 2 DiabetesInsulin SensitivityBlood Glucose LevelsInsulin ProductionInsulin UtilizationGold-standardHyperinsulinemic-euglycemic Clamp ProcedureInfusion Of InsulinDrop In Blood GlucoseExogenous GlucoseVenous CirculationHomeostasisInsulin Sensitivity AssessmentChronically Catheterized RatAnesthesia InductionCarotid Artery CatheterizationJugular Vein CatheterizationHeparinized Saline FlushWeight Gain MonitoringFastingInsulin And D50 Infusion
