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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
 

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

Article DOI: 10.3791/4036-v • 09:12 min • August 11th, 2012
August 11th, 2012 •
1, 2, 2, 3, 1,4
1Institute of Medical Microbiology and Hygiene, University of Lübeck, 2Institute of Anatomie, University of Lübeck, 3Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, University of Lübeck, 4Medical Clinic III, University Hospital of Schleswig-Holstein, University of Lübeck

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We describe an ex vivo infection model for visualisation of direct interactions from bacterial pathogens with human fallopian tube cells. The whole organ tissue model was established to investigate C. trachomatis induced pathology to the female fallopian tube under "life-like" conditions.

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C. Trachomatis Genital Tract Infections Ascending Infections Chronic Inflammatory Damage Pelvic Inflammatory Disease (PID) Tubal Occlusion Infertility Epithelial Cell Lines HEp-2 Cells HeLa-229 Mice Native Tissue Pathophysiology Signaling Cascades IFN-γ Mediated JAK/STAT Signaling Pathway Whole Organ Fallopian Tube Model Human Fallopian Tube Cells Ex Vivo Serovar D Scanning Electron Microscopy (SEM) Transmission Electron Microscopy
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