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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents
 

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Article DOI: 10.3791/4086-v • 09:44 min • September 11th, 2012
September 11th, 2012 •
1, 1, 1, 1, 1, 1
1Department of Surgery, University of Bonn

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요약
Automatic Translation

Postoperative ileus (POI) is a complication of abdominal surgery leading to increased morbidity and a prolonged hospital stay. Because prophylactic or therapeutic strategies are lacking intensified research is necessary. Therefore we established a standardized and feasible mouse model to investigate the pathophysiology of POI and to study potential therapeutic options.

Tags

Functional Assessment Intestinal Motility Gut Wall Inflammation Rodents Standardized Model Intestinal Manipulation Gastrointestinal Tract Human Diseases Animal Research Models Cellular And Molecular Intestinal Pathology Tunica Mucosa Muscularis Externa Immunocompetent Organ Resident Immunocytes Inflammation Of The Bowel Wall Postoperative Ileus Abdominal Surgery Proinflammatory Mediators IL-6 IL-1β Nitric Oxide (NO) Immunocytes Extravasate Polymorphonuclear Neutrophils (PMN) Monocytes Intestinal Paralysis Increased Risk Of Aspiration Bacterial Translocation Infectious Complications Sepsis Multi Organ Failure
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