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Immunology and Infection

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JoVE Journal Immunology and Infection
Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
 

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation

Article DOI: 10.3791/4208-v • 14:43 min • October 1st, 2012
October 1st, 2012 •
1, 1, 1, 1, 1
1Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, The University of California Los Angeles, Los Angeles

챕터

요약
Automatic Translation

Bone marrow transplantation provides a way to change the genotype of the bone marrow derived cells. If the gene of interest is expressed in both bone marrow derived cells and non-bone marrow derived cells, bone marrow transplantation can change the bone marrow derived cells to a different genotype without changing the non-bone marrow derived cell genotype.

Tags

Gene Expression Immune Cells Non-immune Cells Mouse Colitis Bone Marrow Transplantation Gene-of-interest Knockout Mice Genotype Irradiation Donor Bone Marrow Recipient Mice Wild-type Mice CD Molecules (CD45.1 And CD45.2)
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