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Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation
 

Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation

Article DOI: 10.3791/4308-v • 08:28 min • September 13th, 2012
September 13th, 2012 •
1, 1, 1, 1
1Department of Mechanical Engineering, Boston University

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요약
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Phase-shift nanoemulsions (PSNE) can be vaporized using high intensity focused ultrasound to enhance localized heating and improve thermal ablation in tumors. In this report, the preparation of stable PSNE with a narrow size distribution is described. Furthermore, the impact of vaporized PSNE on ultrasound-mediated ablation is demonstrated in tissue-mimicking phantoms.

Tags

Synthesis Phase-shift Nanoemulsions Narrow Size Distributions Acoustic Droplet Vaporization Bubble-enhanced Ultrasound-mediated Ablation High-intensity Focused Ultrasound (HIFU) Lipid-coated Perfluorocarbon Droplets Localized Heating Thermal Ablation Tumors Vasculature Nanoparticles Fenestrations Passive Accumulation Droplet Size Control Preparation Stable Droplets Sonicating Liquid Perfluorocarbon Extrusion Filters Pore Sizes Size Distribution Measurement Dynamic Light Scattering Polyacrylamide Hydrogels In Vitro Experiments
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