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A Sensitive Method to Quantify Senescent Cancer Cells
 

A Sensitive Method to Quantify Senescent Cancer Cells

Article DOI: 10.3791/50494-v 09:18 min August 2nd, 2013
August 2nd, 2013

챕터

요약

Whether senescence prevents or promotes tumorigenesis remains controversial. Since chemotherapeutical drugs can induce cancer cells to senesce, studying senescence is essential for proposing new therapies. However, the standard and broadly used β-galactosidase assay presents major drawbacks. We propose here a rapid and sensitive flow cytometry-based assay to quantify senescence.

Tags

Keywords: Senescence Cancer Cells Cell Cycle Arrest β-galactosidase Assay Flow Cytometry Cellular Markers Chemotherapeutic Drugs Tumorigenesis
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