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Bioengineering

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JoVE Journal Bioengineering
Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
 

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Article DOI: 10.3791/50532-v • 10:03 min • January 20th, 2014
January 20th, 2014 •
*1, *1, 1, 1,2
1Department of Cell and Developmental Biology, University College London, 2Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Hospital
* These authors contributed equally

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요약
Automatic Translation

Induced pluripotent stem cell (iPSC)-derived myogenic progenitors are promising candidates for cell therapy strategies to treat muscular dystrophies. This protocol describes transplantation and functional measurements required to evaluate the engraftment and differentiation of iPSC-derived mesoangioblasts (a type of muscle progenitors) in mouse models of acute and chronic muscle regeneration.

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Keywords: Induced Pluripotent Stem Cells Mesoangioblast-like Myogenic Progenitors Muscular Dystrophy Genetic Correction MyoD Overexpression In Vitro Differentiation In Vivo Transplantation Acute And Chronic Muscle Regeneration Functional Tests Cell Engraftment Differentiation
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