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Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
 

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

Article DOI: 10.3791/50983-v • 10:18 min • June 29th, 2014
June 29th, 2014 •
*1, *1, 2, 3, 1
1Cardio Vascular Disease Biology, Rajiv Gandhi Centre for Biotechnology, 2Animal Research Facility, Rajiv Gandhi Centre for Biotechnology, 3Cardiology Department, Sree Chitra Tirunal Institute for Medical Sciences & Technology
* These authors contributed equally

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요약
Automatic Translation

We describe a stepwise procedure for creating pressure overload and left ventricular hypertrophy in Wistar rats by constriction of the ascending aorta using a small metallic clip. This model is extensively used for studying remodeling changes during cardiac hypertrophy and for identifying and evaluating strategies for regression of such changes.

Tags

Keywords: Ascending Aortic Constriction Pressure Overload Cardiac Hypertrophy Heart Failure Surgical Model Rats Trachea Intubation Aorta Constriction Doppler-echocardiography Cardiac Remodeling Contractile Properties
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