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Chapters
- 00:05Title
- 01:29Harvesting of the Mucosal Graft
- 02:43Surgical Implantation of Mucosal Graft
- 04:49Administration of Dosing Solution
- 06:44Analysis of Transmucosal Delivery
- 07:32Results: Fluorescent Microscope Image of a Mouse Brain Slice Following Transmucosal Dosing
- 07:57Conclusion
A mouse model of human endoscopic skull base reconstruction has been developed that creates a semipermeable interface between the brain and nose using nasal mucosal grafts. This method allows researchers to study delivery to the central nervous system of high molecular weight therapeutics which are otherwise excluded by the blood-brain barrier when administered systemically.
