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异位黏膜移植程序直接给药到小鼠的大脑

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Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

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异位黏膜移植程序直接给药到小鼠的大脑

DOI:

10.3791/51452-v

•

08:25 min

•

July 16, 2014

•

Richie E. Kohman, Xue Han, Benjamin S. Bleier

¹Department of Biomedical Engineering,Boston University, ²Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary,Harvard Medical School

Chapters

00:05Title
01:29Harvesting of the Mucosal Graft
02:43Surgical Implantation of Mucosal Graft
04:49Administration of Dosing Solution
06:44Analysis of Transmucosal Delivery
07:32Results: Fluorescent Microscope Image of a Mouse Brain Slice Following Transmucosal Dosing
07:57Conclusion

Summary

자동 번역

已开发人力内镜颅底重建的小鼠模型，会使用鼻腔粘膜移植大脑和鼻子之间的半透界面。这种方法使研究人员能够研究发货到全身给药时，被排除在外，否则由血脑屏障高分子量治疗中枢神经系统。

Tags

Mucosal Engrafting Brain Drug Delivery Blood-brain Barrier Bypass Nasal Mucosa Transcranial Catheter Surgical BBB Defect Preclinical Testing Neurological Disease Psychiatric Disease

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