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JoVE Journal Medicine
Real-time Cytotoxicity Assays in Human Whole Blood
 

Real-time Cytotoxicity Assays in Human Whole Blood

Article DOI: 10.3791/51941-v • 08:27 min • November 7th, 2014
November 7th, 2014 •
*1, *1, 2, 1
1Research and Development, Adheren, Inc, 2Research and Development, Eureka Therapeutics
* These authors contributed equally

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요약
Automatic Translation

The whole blood cytotoxicity assay (WCA) is a cytotoxicity assay developed by incorporating high-throughput cell positioning technology with fluorescence microscopy and automated image processing. Here, we describe how lymphoma cells treated with an anti-CD20 antibody can be analyzed real-time in human whole blood to provide quantitative cellular cytotoxicity analysis.

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Keywords: Real-time Cytotoxicity Assay Human Whole Blood Cell-based Assay Cell Cytotoxicity Tumor Cell Populations Antibody Drugs Cell Death Cell Killing Cell Survival Time-dependent Cytotoxicity Dose-dependent Cytotoxicity Lymphoma Leukemia Solid Tumor Ex Vivo
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