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JoVE Journal Medicine
Humant Dupuytrens
 
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Humant Dupuytrens

Article DOI: 10.3791/52534-v • 08:59 min • April 18th, 2015
April 18th, 2015 •
1, 2, 3, 4, 4,5, 1,6
1Department of Molecular Cell Biology, Cancer Genomics Centre and Centre for Biomedical Genetics, Leiden University Medical Center, 2Department of Orthopedic Surgery, Academic Medical Center, 3Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center, 4Department of Orthopedic Surgery, Mayo Clinic, 5Department of Biochemistry and Molecular Biology, Mayo Clinic, 6Department of Dermatology, Leiden University Medical Center

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Dupuytrens sygdom (DD) er en fibroproliferativ sygdom i håndfladen. Her præsenterer vi en protokol til kultur resektion prøver fra DD i en tredimensional (3D) dyrkningssystem. Sådanne kortsigtede kultur system tillader bevarelse af 3D-struktur og molekylære egenskaber af fibrøst væv.

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Medicine fibrose Dupuytrens sygdom TGFp 3D dyrkningssystem forbindelse skærm ekstracellulære matrix
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