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JoVE Journal Bioengineering
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
 

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Article DOI: 10.3791/53603-v • 08:13 min • February 16th, 2016
February 16th, 2016 •
1,2, 1, 1, 3, 1,4,5
1Department of Genetics, Erasmus MC, Rotterdam, 2Department of Experimental Cardiology, Erasmus MC, Rotterdam, 3PerkinElmer, Inc., 4Department of Vascular Surgery, Erasmus MC, Rotterdam, 5Department of Radiation Oncology, Erasmus MC, Rotterdam

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요약
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This method outlines the use of Quantum Micro-Computed Tomography (MicroCT) to assess cardiac morphology, function, perfusion, metabolism and viability with iodinated contrast agent in mice with experimentally-induced myocardial ischemia. The technique can be applied for non-destructive high-throughput longitudinal in vivo imaging of various animal models of human heart disease.

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Keywords: Cardiac Micro-computed Tomography Myocardial Structure Myocardial Function Myocardial Perfusion Myocardial Viability Cardiac Ischemia Cardiac Pathophysiology Cardiac Disease Development Cardiac Parameters Non-invasive Evaluation Preclinical Tool Mouse Model Left Coronary Artery Ligation Infarct Induction MicroCT Imaging
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