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JoVE Journal Biochemistry
Verfahren zur Identifizierung von niedermolekularen Inhibitoren des Protein-Protein-Wechselwirkung zwischen HCN1- und TRIP8b
 
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Verfahren zur Identifizierung von niedermolekularen Inhibitoren des Protein-Protein-Wechselwirkung zwischen HCN1- und TRIP8b

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

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Die Wechselwirkung zwischen HCN-Kanäle und deren Hilfsuntereinheit als ein therapeutisches Ziel in der Major Depressive Disorder identifiziert worden. Hier wird eine Fluoreszenzpolarisationsgestütztes Verfahren zur Identifizierung von Kleinmolekül-Inhibitoren dieser Protein-Protein-Interaktion, dargestellt.

Tags

Biochemie Heft 117 High-Throughput-Screening Arzneimittelforschung Protein-Protein-Wechselwirkungen Fluoreszenzpolarisation HCN TRIP8b
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