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JoVE Journal Cancer Research
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
 

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Article DOI: 10.3791/55043-v • 08:59 min • January 5th, 2017
January 5th, 2017 •
1, 1, 2, 2, 1
1Department of Otolaryngology, University of Pittsburgh Medical Center, 2University of Pittsburgh Cancer Institute, Hillman Cancer Center

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요약
Automatic Translation

Perineural invasion (PNI) is a common feature of head and neck squamous cell carcinoma (HNSCC), conferring lower survival rates. Its mechanisms are poorly understood. Utilizing neurites generated from murine dorsal root ganglia confined to a semisolid matrix, the pathways involved in the PNI of HNSCC cell lines can be investigated.

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Keywords: Perineural Invasion Head And Neck Squamous Cell Carcinoma Dorsal Root Ganglion DRG Dissection Mouse Model Spinal Cord Peripheral Nerve Tissue Dissection Microscopic Procedures
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